Living Situation Affects Adherence to Combination Antiretroviral Therapy in HIV-Infected Adolescents in Rwanda: A Qualitative Study

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Mutwa, Philippe R ^a,b,k   Van Nuil, Jennifer Ilo ^c,d,e   Asiimwe Kateera, Brenda ^b,k   Kestelyn, Evelyne ^b,e,k   Vyankandondera, Joseph ^a,e,i   Pool, Robert ^j   Ruhirimbura, John ^h   Kanakuze, Chantal ^h   Reiss, Peter ^b,k   Geelen, Sibyl ^b,f,k   van de Wijgert, Janneke ^b,d,e,k   Boer, Kimberly R ^b,g,k  

^a Centre Hospitalier Universitaire de Kigali   (Rwanda)

^b AMSTERDAM INSTITUTE FOR GLOBAL HEALTH AND DEVELOPMENT   (Netherlands)

^c WAYNE STATE UNIVERSITY   (United States)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

^e Projet Rinda Ubuzima ^*  (Rwanda)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g ROYAL TROPICAL INSTITUTE   (Netherlands)

^h Treatment and Research on HIV/AIDS Centre (TRAC plus)   (Rwanda)

ⁱ Belgian Development Agency   (Rwanda)

^j UNIVERSITY OF AMSTERDAM   (Netherlands)

^k NONE

more..

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NEVIRAPINE; STAVUDINE; ZIDOVUDINE;

ADOLESCENT; ADOLESCENT HEALTH; ADULT; ARTICLE; ATTITUDE TO AIDS; ATTITUDE TO HEALTH; CHILD; CLINICAL ARTICLE; DEMOGRAPHY; FEMALE; FOSTER CARE; HEALTH CARE ACCESS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSTITUTIONALIZATION; INTERPERSONAL COMMUNICATION; MALE; ORPHANAGE; PATIENT ATTITUDE; PATIENT COMPLIANCE; PRIVACY; PUBLIC HEALTH PROBLEM; QUALITY OF LIFE; RWANDA; SCHOOL CHILD; SOCIAL ENVIRONMENT; SOCIAL STIGMA; SOCIAL SUPPORT;

ADOLESCENT; ANTI-HIV AGENTS; CAREGIVERS; CHILD; CHILD, ORPHANED; DISCLOSURE; DRUG THERAPY, COMBINATION; FAMILY CHARACTERISTICS; FEMALE; HIV INFECTIONS; HUMANS; MALE; MEDICATION ADHERENCE; PRIVACY; QUALITATIVE RESEARCH; RWANDA; SCHOOLS; SOCIAL STIGMA; SOCIAL SUPPORT; YOUNG ADULT;

EID: 84875693166     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060073     Document Type: Article

References (40)

1. Rwanda Ministry of Health (2011) Annual report 2010-2011.
2. Edmonds A, Yotebieng M, Lusiama J, Matumona Y, Kitetele F, et al. (2011) The effect of highlyactive antiretroviral therapy on the survival of HIV-infected children in a resource-deprived setting: a cohort study. PLoS Med 8: e1001044.
3. Palladino C, Bellon JM, Jarrin I, Gurbindo MD, de Jose MI, et al. (2009) Impact of highly active antiretroviral therapy (HAART) on AIDS and death in a cohort of vertically HIV type 1-infected children: 1980-2006. AIDS Res Hum Retroviruses 25: 1091-1097.
4. Haubrich RH, Little SJ, Currier JS, Forthal DN, Kemper CA, et al. (1999) The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response. California Collaborative Treatment Group. AIDS 13: 1099-1107.
5. Volberding PA, Deeks SG, (2010) Antiretroviral therapy and management of HIV infection. Lancet 376: 49-62.
6. Wood E, Hogg RS, Yip B, Harrigan PR, O'Shaughnessy MV, et al. (2004) The impact of adherence on CD4 cell count responses among HIV-infected patients. J Acquir Immune Defic Syndr 35: 261-268.
7. Davies MA, Moultrie H, Eley B, Rabie H, van CG, et al. (2011) Virologic failure and second-line antiretroviral therapy in children in South Africa-the IeDEA Southern Africa collaboration. J Acquir Immune Defic Syndr 56: 270-278.
8. Meyers TM, Yotebieng M, Kuhn L, Moultrie H, (2011) Antiretroviral therapy responses among children attending a large public clinic in Soweto, South Africa. Pediatr Infect Dis J 30: 974-979.
9. Mutwa PR, Boer KR, Rusine BJ, Muganga N, Tuyishimire D, et al. (2012) Long-term effectiveness of combination antiretroviral therapy and prevalence of HIV-drug resistance in HIV-1 infected children and adolescents in Rwanda. In press.
10. Ballif M, Ledergerber B, Battegay M, Cavassini M, Bernasconi E, et al. (2009) Impact of previous virological treatment failures and adherence on the outcome of antiretroviral therapy in 2007. PLoS One 4: e8275.
11. Fielding KL, Charalambous S, Stenson AL, Pemba LF, Martin DJ, et al. (2008) Risk factors for poor virological outcome at 12 months in a workplace-based antiretroviral therapy programme in South Africa: a cohort study. BMC Infect Dis 8 93: 1471-2334.
12. Lucas GM, (2005) Antiretroviral adherence, drug resistance, viral fitness and HIV disease progression: a tangled web is woven. J Antimicrob Chemother 55: 413-416.
13. Shet A, Markowitz M, (2006) Transmitted multidrug resistant HIV-1: new and investigational therapeutic approaches. Curr Opin Investig Drugs 7: 709-720.
14. Taniguchi T, Nurutdinova D, Grubb JR, Onen NF, Shacham E, et al. (2012) Transmitted drug-resistant HIV type 1 remains prevalent and impacts virologic outcomes despite genotype-guided antiretroviral therapy. AIDS Res Hum Retroviruses 28: 259-264.
15. Carpenter CC, Cooper DA, Fischl MA, Gatell JM, Gazzard BG, et al. (2000) Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel. JAMA 283: 381-390.
16. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, et al. (2000) Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med 133: 21-30.
17. Paterson DI, Swindells S, Mohr J, Brester M, Vergis EN, et al. (1999) How much adherence is enough: A prospective study of adherence to protease inhibitor therapy using MEMSCaps. [abstract 92] 6th Conference on Retroviruses and Opportunistic Infections, Chicago, January 1999.
18. Birungi H, Obare F, Katahoire A, Kibenge D (2011) HIV Infection and Schooling Experiences of Adolescents in Uganda. In: Letamo G, editor. Social and Psychological Aspects of HIV/AIDS and Their Ramifications. New York: Intech.
19. Kikuchi K, Poudel KC, Muganda J, Majyambere A, Otsuka K, et al. (2012) High Risk of ART Non-Adherence and Delay of ART Initiation among HIV Positive Double Orphans in Kigali, Rwanda. PLoS One 7: e41998.
20. Weigel R, Makwiza I, Nyirenda J, Chiunguzeni D, Phiri S, et al. (2009) Supporting children to adhere to anti-retroviral therapy in urban Malawi: multi method insights. BMC Pediatr 9 45: 1471-2431.
21. Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM, (2008) A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries. Pediatr Infect Dis J 27: 686-691.
22. Krueger RA (1994) Focus Groups: a Practical Guide for Applied Research. Thousand Oaks, CA: Sage.
23. Rwanda Ministry of Health (2008) Rwanda National Strategic Plan on HIV and AIDS, 2009-2012.
24. Wasti SP, Simkhada P, Randall J, Freeman JV, van Teijlingen E, (2012) Factors influencing adherence to antiretroviral treatment in Nepal: a mixed-methods study. PLoS One 7: e35547.
25. Wasti SP, van Teijlingen E, Simkhada P, Randall J, Baxter S, et al. (2012) Factors influencing adherence to antiretroviral treatment in Asian developing countries: a systematic review. Trop Med Int Health 17: 71-81.
26. Haberer J, Mellins C, (2009) Pediatric adherence to HIV antiretroviral therapy. Curr HIV/AIDS Rep 6: 194-200.
27. Vreeman RC, Wiehe SE, Ayaya SO, Musick BS, Nyandiko WM, (2008) Association of antiretroviral and clinic adherence with orphan status among HIV-infected children in Western Kenya. J Acquir Immune Defic Syndr 49: 163-170.
28. Vreeman RC, Nyandiko WM, Ayaya SO, Walumbe EG, Marrero DG, et al. (2010) The perceived impact of disclosure of pediatric HIV status on pediatric antiretroviral therapy adherence, child well-being, and social relationships in a resource-limited setting. AIDS Patient Care STDS 24: 639-649.
29. Chesney MA, (2000) Factors affecting adherence to antiretroviral therapy. Clin Infect Dis 30 (Suppl 2): S171-S176.
30. Kumarasamy N, Safren SA, Raminani SR, Pickard R, James R, et al. (2005) Barriers and facilitators to antiretroviral medication adherence among patients with HIV in Chennai, India: a qualitative study. AIDS Patient Care STDS 19: 526-537.
31. Malee K, Williams P, Montepiedra G, McCabe M, Nichols S, et al. (2011) Medication adherence in children and adolescents with HIV infection: associations with behavioral impairment. AIDS Patient Care STDS 25: 191-200.
32. Safren SA, Kumarasamy N, James R, Raminani S, Solomon S, et al. (2005) ART adherence, demographic variables and CD4 outcome among HIV-positive patients on antiretroviral therapy in Chennai, India. AIDS Care 17: 853-862.
33. Unge C, Sodergard B, Marrone G, Thorson A, Lukhwaro A, et al. (2010) Long-term adherence to antiretroviral treatment and program drop-out in a high-risk urban setting in sub-Saharan Africa: a prospective cohort study. PLoS One 5: e13613.
34. Williams PL, Storm D, Montepiedra G, Nichols S, Kammerer B, et al. (2006) Predictors of adherence to antiretroviral medications in children and adolescents with HIV infection. Pediatrics 118: e1745-e1757.
35. Curioso WH, Kepka D, Cabello R, Segura P, Kurth AE, (2010) Understanding the facilitators and barriers of antiretroviral adherence in Peru: a qualitative study. BMC Public Health 10 13: 1471-2458.
36. Fetzer BC, Mupenda B, Lusiama J, Kitetele F, Golin C, et al. (2011) Barriers to and facilitators of adherence to pediatric antiretroviral therapy in a sub-Saharan setting: insights from a qualitative study. AIDS Patient Care STDS 25: 611-621.
37. Ware NC, Idoko J, Kaaya S, Biraro IA, Wyatt MA, et al. (2009) Explaining adherence success in sub-Saharan Africa: an ethnographic study. PLoS Med 6: e11.
38. Bikaako-Kajura W, Luyirika E, Purcell DW, Downing J, Kaharuza F, et al. (2006) Disclosure of HIV status and adherence to daily drug regimens among HIV-infected children in Uganda. AIDS Behav 10: S85-S93.
39. Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM, (2008) A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries. Pediatr Infect Dis J 27: 686-691.
40. Nugent NR, Brown LK, Belzer M, Harper GW, Nachman S, et al. (2010) Youth living with HIV and problem substance use: elevated distress is associated with nonadherence and sexual risk. J Int Assoc Physicians AIDS Care (Chic) 9: 113-115.