A Mechanism for upper airway stability during slow wave sleep

Sleep

Volumn 36, Issue 4, 2013, Pages 555-563

  McSharry, David G ^a   Saboisky, Julian P ^b   DeYoung, Pam ^a   Matteis, Paul ^a   Jordan, Amy S ^c   Trinder, John ^c   Smales, Erik ^a   Hess, Lauren ^a   Guo, Mengshuang ^a   Malhotra, Atul ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Apnea; Genioglossus; Lung; Single motor unit; Sleep

Indexed keywords

ADULT; AIRWAY DYNAMICS; APNEA HYPOPNEA INDEX; ARTICLE; BREATHING; BREATHING PATTERN; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; ELECTROMYOGRAPHY; END TIDAL CARBON DIOXIDE TENSION; EXPIRATION DATE; FEMALE; GENIOGLOSSUS; HUMAN; INSPIRATORY CAPACITY; MALE; MOTOR UNIT; POLYSOMNOGRAPHY; PRIORITY JOURNAL; SLEEP DISORDERED BREATHING; SLEEP TIME; SLOW WAVE SLEEP; TIDAL VOLUME; TONGUE;

APNEA; GENIOGLOSSUS; LUNG; SINGLE MOTOR UNIT; SLEEP;

ADULT; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; FEMALE; HUMANS; MALE; MOTOR NEURONS; MUSCLE, SKELETAL; POLYSOMNOGRAPHY; RECRUITMENT, NEUROPHYSIOLOGICAL; RESPIRATORY MECHANICS; RESPIRATORY MUSCLES; SLEEP; TONGUE;

EID: 84875692576     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.2544     Document Type: Article

References (29)

1. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-5.
2. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005;365:1046-53.
3. McNicholas WT, Bonsigore MR. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J 2007;29:156-78.
4. Mulgrew AT, Nasvadi G, Butt A, et al. Risk and severity of motor vehicle crashes in patients with obstructive sleep apnoea/hypopnoea. Thorax 2008;63:536-41.
5. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005;353:2034-41.
6. Wolkove N, Baltzan M, Kamel H, Dabrusin R, Palayew M. Long-term compliance with continuous positive airway pressure in patients with obstructive sleep apnea. Can Respir J 2008;15:365-9.
7. Lojander J, Maasilta P, Partinen M, Brander PE, Salmi T, Lehtonen H. Nasal- CPAP, surgery, and conservative management for treatment of obstructive sleep apnea syndrome. A randomized study. Chest 1996;110:114-9.
8. Ratnavadivel R, Chau N, Stadler D, Yeo A, McEvoy RD, Catcheside PG. Marked reduction in obstructive sleep apnea severity in slow wave sleep. J Clin Sleep Med 2009;5:519-24.
9. Jordan AS, White DP, Lo YL, et al. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea. Sleep 2009;32:361-8.
10. Basner RC, Ringler J, Schwartzstein RM, Weinberger SE, Weiss JW. Phasic electromyographic activity of the genioglossus increases in normals during slow-wave sleep. Respir Physiol 1991;83:189-200.
11. Pillar G, Malhotra A, Fogel RB, et al. Upper airway muscle responsiveness to rising PCO(2) during NREM sleep. J Appl Physiol 2000;89:1275-82.
12. Tangel DJ, Mezzanotte WS, Sandberg EJ, White DP. Influences of NREM sleep on the activity of tonic vs. inspiratory phasic muscles in normal men. J Appl Physiol 1992;73:1058-66.
13. Kernell D. Principles of force gradation in skeletal muscles. Neural Plast 2003;10:69-76.
14. Eastwood PR, Allison GT, Shepherd KL, Szollosi I, Hillman DR. Heterogeneous activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodes. J Appl Physiol 2003;94:1849-58.
15. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Washington, DC: US Government Printing Office, Public Health Service, 1968.
16. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The report of an American Academy of Sleep Medicine Task Force. Sleep 1999;22:667-89.
17. Saboisky JP, Butler JE, Fogel RB, et al. Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing. J Neurophysiol 2006;95:2213-21.
18. Saboisky JP, Butler JE, McKenzie DK, et al. Neural drive to human genioglossus in obstructive sleep apnoea. J Physiol 2007;585:135-46.
19. Tsuiki S, Ono T, Ishiwata Y, Kuroda T. Functional divergence of human genioglossus motor units with respiratory-related activity. Eur Respir J 2000;15:906-10.
20. Malhotra A, Trinder J, Fogel R, et al. Postural effects on pharyngeal protective reflex mechanisms. Sleep 2004;27:1105-12.
21. Lo YL, Jordan AS, Malhotra A, et al. Genioglossal muscle response to CO2 stimulation during NREM sleep. Sleep 2006;29:470-7.
22. Saboisky JP, Jordan AS, Eckert DJ, et al. Recruitment and rate-coding strategies of the human genioglossus muscle. J Appl Physiol 2010;109:1939-49.
23. Trinder J, Kay A, Kleiman J, Dunai J. Gender differences in airway resistance during sleep. J Appl Physiol 1997;83:1986-97.
24. Wiegand DA, Latz B, Zwillich CW, Wiegand L. Upper airway resistance and geniohyoid muscle activity in normal men during wakefulness and sleep. J Appl Physiol 1990;69:1252-61.
25. Wilkinson V, Malhotra A, Nicholas CL, et al. Discharge patterns of human genioglossus motor units during sleep onset. Sleep 2008;31:525-33.
26. Richardson PA, Bailey EF.Tonically discharging genioglossus motor units show no evidence of rate coding with hypercapnia. J Neurophysiol 2010; 103: 1315-21.
27. Nicholas CL, Bei B, Worsnop C, et al. Motor unit recruitment in human genioglossus muscle in response to hypercapnia. Sleep 2010;33:1529-38.
28. Saboisky J, Eckert D, Malhotra A. Stable breathing through deeper sleeping. Thorax 2010;65:95-6.
29. Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in obstructive sleep apnoea. Expert Opin Ther Targets 2009;13:795-809.