A phase II study of induction carboplatin and gemcitabine followed by chemoradiotherapy for the treatment of locally advanced nasopharyngeal carcinoma

Oral Oncology

Volumn 49, Issue 5, 2013, Pages 468-474

  Lim, Annette M ^a,b   Corry, June ^a,b   Collins, Marnie ^a   Peters, Lester ^a,b   Hicks, Rodney J ^a,b   D'Costa, Ieta ^a   Coleman, Andrew ^a   Chua, Margaret ^a   Solomon, Benjamin ^a,b   Rischin, Danny ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Carboplatin; Chemoradiotherapy; Gemcitabine; Induction chemotherapy; Nasopharyngeal carcinoma; Neo adjuvant chemotherapy

Indexed keywords

CARBOPLATIN; CISPLATIN; GEMCITABINE;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANOREXIA; ANXIETY; ARTICLE; ASPIRATION PNEUMONIA; CANCER STAGING; CHEMORADIOTHERAPY; CHOLESTASIS; CLINICAL ARTICLE; CONSTIPATION; COUGHING; DEHYDRATION; DEPRESSION; DERMATITIS; DIARRHEA; DRUG TOLERABILITY; DYSPHAGIA; ESOPHAGITIS; ESOPHAGUS PAIN; FATIGUE; FEMALE; HEADACHE; HEARTBURN; HICCUP; HUMAN; HYPERGLYCEMIA; HYPOKALEMIA; INDUCTION CHEMOTHERAPY; INFECTION; INSOMNIA; MALE; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; NAUSEA; NEUTROPENIA; OTALGIA; OTITIS; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; RASH; SALIVARY GLAND; SIDE EFFECT; SORE THROAT; STOMATITIS; TASTE; TINNITUS; TRISMUS; VOICE; VOMITING;

ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CARCINOMA; CHEMORADIOTHERAPY; CISPLATIN; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INDUCTION CHEMOTHERAPY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; RADIOTHERAPY, INTENSITY-MODULATED; REMISSION INDUCTION; RIBONUCLEOTIDE REDUCTASES; SURVIVAL RATE; YOUNG ADULT;

EID: 84875691715     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2012.12.012     Document Type: Article

References (19)

1. M. Al-Sarraf, M. LeBlanc, P.G. Giri, K.K. Fu, J. Cooper, and T. Vuong Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099 J Clin Oncol 16 1998 1310 1317 (Pubitemid 28175745)
2. J.C. Lin, J.S. Jan, C.Y. Hsu, W.M. Liang, R.S. Jiang, and W.Y. Wang Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival J Clin Oncol 21 2003 631 637
3. A.T. Chan, S.F. Leung, R.K. Ngan, P.M. Teo, W.H. Lau, and W.H. Kwan Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma J Natl Cancer Inst 97 2005 536 539 (Pubitemid 40590436)
4. J. Wee, E.H. Tan, B.C. Tai, H.B. Wong, S.S. Leong, and T. Tan Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with american joint committee on Cancer/International union against cancer stage III and IV nasopharyngeal cancer of the endemic variety J Clin Oncol 23 2005 6730 6738 (Pubitemid 46190268)
5. A.W. Lee, S.Y. Tung, D.T. Chua, R.K. Ngan, R. Chappell, and R. Tung Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma J Natl Cancer Inst 102 2010 1188 1198
6. A.W.M. Lee, S.Y. Tung, A.T.C. Chan, R. Chappell, Y.-T. Fu, and T.-X. Lu Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 66 2006 142 151 (Pubitemid 44175659)
7. Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, et al. Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma. Cochrane Database Syst Rev:CD004329; 2006.
8. J.A. Langendijk, C.R. Leemans, J. Buter, J. Berkhof, and B.J. Slotman The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature J Clin Oncol 22 2004 4604 4612 (Pubitemid 41185128)
9. B. Baujat, H. Audry, J. Bourhis, A.T. Chan, H. Onat, and D.T. Chua Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients Int J Radiat Oncol Biol Phys 64 2006 47 56 (Pubitemid 41831208)
10. W. Bae, J. Hwang, H. Shim, S. Cho, J. Lee, and S.-C. Lim Phase II study of docetaxel, cisplatin, and 5-FU induction chemotherapy followed by chemoradiotherapy in locoregionally advanced nasopharyngeal cancer Cancer Chemother Pharmacol 65 2010 589 595
11. L. Chen, C.-S. Hu, X.-Z. Chen, G.-Q. Hu, Z.-B. Cheng, and Y. Sun Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial Lancet Oncol 13 2012 163 171
12. G. Fountzilas, E. Ciuleanu, M. Bobos, A. Kalogera-Fountzila, A.G. Eleftheraki, and G. Karayannopoulou Induction chemotherapy followed by concomitant radiotherapy and weekly cisplatin versus the same concomitant chemoradiotherapy in patients with nasopharyngeal carcinoma: a randomized phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG) with biomarker evaluation Ann Oncol 23 2012 427 435
13. E.P. Hui, B.B. Ma, S.F. Leung, A.D. King, F. Mo, and M.K. Kam Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma J Clin Oncol 27 2009 242 249
14. D. Rischin, J. Corry, J. Smith, J. Stewart, P. Hughes, and L. Peters Excellent disease control and survival in patients with advanced nasopharyngeal cancer treated with chemoradiation J Clin Oncol 20 2002 1845 1852 (Pubitemid 34273275)
15. M. Ekenel, S. Keskin, M. Basaran, C. Ozdemir, R. Meral, and M. Altun Induction chemotherapy with docetaxel and cisplatin is highly effective for locally advanced nasopharyngeal carcinoma Oral Oncol 47 2011 660 664
16. T.-K. Yau, A.W.-M. Lee, D.H.-M. Wong, R.M.-W. Yeung, E.W.-K. Chan, and W.-T. Ng Induction chemotherapy with cisplatin and gemcitabine followed by accelerated radiotherapy and concurrent cisplatin in patients with stage IV(A-B) nasopharyngeal carcinoma Head Neck 28 2006 880 887 (Pubitemid 44497863)
17. A.W. Lee, S.Y. Tung, R.K. Ngan, R. Chappell, D.T. Chua, and T.X. Lu Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials Eur J Cancer 47 2011 656 666
18. A.W.M. Lee, T.K. Yau, D.H.M. Wong, E.W.K. Chan, R.M.W. Yeung, and W.T. Ng Treatment of stage IV(A-B) nasopharyngeal carcinoma by induction-concurrent chemoradiotherapy and accelerated fractionation Int J Radiat Oncol Biol Phys 63 2005 1331 1338 (Pubitemid 41628026)
19. A.W. Lee, K.Y. Lau, W.M. Hung, W.T. Ng, M.C. Lee, and C.W. Choi Potential improvement of tumor control probability by induction chemotherapy for advanced nasopharyngeal carcinoma Radiother Oncol 87 2008 204 210