Uraemic pruritus: Relief of itching by gabapentin and pregabalin

Nephron - Clinical Practice

Volumn 122, Issue 3-4, 2012, Pages 75-79

  Rayner, Hugh ^a   Baharani, Jyoti ^a   Smith, Steve ^a   Suresh, Vijayan ^a   Dasgupta, Indranil ^a  

^a UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Chronic kidney disease; Dialysis; Gabapentin; Itch; Pregabalin; Pruritus; Uraemia

Indexed keywords

4 AMINOBUTYRIC ACID; AMINE; ANALGESIC AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; GABAPENTIN; PREGABALIN;

ADULT; AGED; ANALOGS AND DERIVATIVES; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; MALE; MIDDLE AGED; PREVALENCE; PRURITUS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTOR; TREATMENT OUTCOME; UNITED KINGDOM; UREMIA; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AMINES; ANALGESICS; COMORBIDITY; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-AMINOBUTYRIC ACID; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; PREVALENCE; PRURITUS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; TREATMENT OUTCOME; UREMIA;

EID: 84875684179     PISSN: None     EISSN: 16602110     Source Type: Journal    
DOI: 10.1159/000349943     Document Type: Article

References (13)

1. Pisoni RL, Wikstrom B, Elder SJ, Akizawa T, Asano Y, Keen ML, Saran R, Mendelssohn DC, Young EW, Port FK: Pruritus in haemodialysis patients: international results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2006; 21: 3495-3505
2. Gunal AI, Ozalp G, Yoldas TK, Gunal SY, Kirciman E, Celiker H: Gabapentin therapy for pruritus in haemodialysis patients: A randomized, placebo-controlled, double-blind trial. Nephrol Dial Transplant 2004; 19: 3137-3139
3. Manenti L, Vaglio A, Costantino E, Danisi D, Oliva B, Pini S, Prati E, Testori A: Gabapentin in the treatment of itch: An index case and a pilot evaluation. J Nephrol 2005; 18: 86-91
4. Naini AE, Harandi AA, Khanbabapour S, Shahidi S, Seirafiyan S, Mohseni M: Gabapentin: A promising drug for the treatment of uremic pruritus. Saudi J Kidney Dis Transpl 2007; 18: 378-381
5. Razeghi E, Eskandari D, Ganji MR, Meysamie AP, Togha M, Khashayar P: Gabapentin and uremic pruritus in hemodialysis patients. Ren Fail 2009; 31: 85-90
6. Aperis G, Paliouras C, Zervos A, Arvanitis A, Alivanis P: The use of pregabalin in the treatment of uraemic pruritus in haemodialysis patients. J Ren Care 2010; 36: 180-185
7. Solak Y, Biyik Z, Atalay H, Gaipov A, Guney F, Turk S, Covic A, Goldsmith D, Kanbay M: Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance hemodialysis patients: A prospective crossover study. Nephrology (Carlton) 2012; 17: 710-717
8. Manenti L, Tansinda P, Vaglio A: Uraemic pruritus. Clinical characteristics, pathophysiology and treatment. Drugs 2009; 69: 251-263
9. Ahuja RB, Gupta R, Gupta G, Shrivastava P: A comparative analysis of cetirizine, gabapentin and their combination in the relief of postburn pruritus. Burns 2011; 37: 203-207
10. Lee SH, Baig M, Rusciano V, Dutcher JP: Novel management of pruritus in patients treated with IL-2 for metastatic renal cell carcinoma and malignant melanoma. J Immunotherapy 2010; 33: 1010-1013
11. Bergasa NV, McGee M, Ginsburg IH, Engler D: Gabapentin in patients with the pruritus of cholestasis: A double-blind, randomized, placebo-controlled trial. Hepatology 2006; 44: 1317-1323
12. Mathur VS, Lindberg J, Germain M, Block G, Tumlin J, Smith M, Grewal M, McGuire D, ITCH National Registry Investigators: A longitudinal study of uremic pruritus in hemodialysis patients. Clin J Am Soc Nephrol 2010; 5: 1410-1419
13. Biyik Z, Solak Y, Atalay H, Gaipov A, Guney F, Turk S: Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: A randomized prospective crossover trial. Int Urol Nephrol 2012, DOI 10.1007/s11255-012-0193-1.