Circadian clock gene expression is impaired in gestational diabetes mellitus

Gynecological Endocrinology

Volumn 29, Issue 4, 2013, Pages 331-335

  Pappa, Kalliopi I ^a,b   Gazouli, Maria ^b   Anastasiou, Eleni ^c   Iliodromiti, Zoe ^a   Antsaklis, Aristides ^a   Anagnou, Nicholas P ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^c ALEXANDRA HOSPITAL   (Greece)

Author keywords

Circadian rhythms; Clock genes; Gestational diabetes mellitus; Glucosylated hemoglobin HbA1C; Type 2 diabetes

Indexed keywords

CRYPTOCHROME 1; CRYPTOCHROME 2; GLUCOSE; HEMOGLOBIN A1C; INSULIN; MESSENGER RNA; PEPTIDES AND PROTEINS; PER1 PROTEIN; PER2 PROTEIN; PER3 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BMAL1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR CLOCK 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; CIRCADIAN RHYTHM; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIET RESTRICTION; DIET THERAPY; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GREECE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TREATMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PRIORITY JOURNAL;

ADULT; ARNTL TRANSCRIPTION FACTORS; CIRCADIAN RHYTHM; CLOCK PROTEINS; CRYPTOCHROMES; DIABETES MELLITUS, TYPE 2; DIABETES, GESTATIONAL; FEMALE; GENE EXPRESSION; HUMANS; PERIOD CIRCADIAN PROTEINS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PREGNANCY;

EID: 84875675991     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2012.743018     Document Type: Article

References (20)

1. Marcheva B, Ramsey KM, Affinati A, Bass J. Clock gene and metabolic diseases. J Appl Physiol 2009;107:1638-46.
2. Gekakis N, Staknis D, Nguyen HB, et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science 1998;280:1564-9.
3. Vitaterna MH, Selby CP, Todo T, et al. Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A 1999;96:12114-19.
4. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature 2002;418:935-41.
5. Yang X, Downes M, Yu RT, et al. Nuclear receptor expression links the circadian clock to metabolism. Cell 2006;126:801-10.
6. Ando T, Takamura T, Matsuzawa-Nagata N, et al. Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. Diabetologia 2009;52:329-35.
7. Stamenkovic JA, Olsson AH, Nagorny CL, et al. Regulation of core clock genes in human islets. Metabolism. 2012;61:978-85.
8. Marcheva B, Ramsey KM, Buhr ED, et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 2010;466:627-31.
9. Woon PY, Kaisaki PJ, Bragança J, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc NatI Acad Sci USA 2007;104:14412-17.
10. Gómez-Abellán P, Hernández-Morante JJ, Luján JA, et al. Clock genes are implicated in the human metabolic syndrome. Int J Obes 2008;32:121-8.
11. Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes 2008;32:658-62.
12. Catalano PM, Huston L, Amini SB, Kalhan SC. Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol 1999;180:903-16.
13. Pappa KI, Gazouli M, Economou K, et al. Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population. Gynecol Endocrin 2011;27:267-72.
14. Doria A, Patti ME, Kahn CR. The emerging genetic architecture of type 2 diabetes. Cell Metab 2010;16:1152-6.
15. Watanabe RM. Inherited destiny? Genetics and gestational diabetes mellitus. Genome Med 2011;3:18.
16. Kwak SH, Kim SH, Cho YM, et al. A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes 2012;61:531-41.
17. American Diabetes Association. Gestational diabetes mellitus. Diabetes Care 2004;27:S88-90.
18. Marcinkevage JA, Narayan KM. Gestational diabetes mellitus: taking it to heart. Prim Care Diabetes 2011;5:81-8.
19. Hirota T, Okano T, Kokame K, et al. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1fibroblasts. J Biol Chem 2002;277:44244-51.
20. Green GB, Takahashi JS, Bass J. The meter of metabolism. Cell 2008;134:728-42.