Reduced glucocorticoid receptor protein expression in children with critical illness

Hormone Research in Paediatrics

Volumn 79, Issue 3, 2013, Pages 169-178

  Indyk, Justin A ^a   Candido Vitto, Cristina ^a   Wolf, Irene M ^c   Venkataraman, Shekhar ^a   Munoz, Ricardo ^a   Saladino, Richard A ^b   Witchel, Selma F ^a   Defranco, Donald B ^c  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b Department of Pediatrics ^*  (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenal insufficiency; Cortisol; Glucocorticoid receptor; Pediatrics; Sepsis

Indexed keywords

GLOBULIN; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; CYTOPLASMIC RECEPTOR; GLUCOCORTICOID;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; FEMALE; HUMAN; HYDROCORTISONE URINE LEVEL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCHOOL CHILD; SEPSIS; SEPTIC SHOCK; TRAUMATIC BRAIN INJURY; ACUTE DISEASE; ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; BODY MASS; CORTICOSTEROID THERAPY; CRITICALLY ILL PATIENT; CYTOPLASM; HORMONE SUBSTITUTION; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHYROIDISM; PEDIATRICS; SALIVA LEVEL; THYROID FUNCTION;

ADOLESCENT; BRAIN INJURIES; CARRIER PROTEINS; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; CYTOPLASM; FEMALE; HUMANS; HYDROCORTISONE; INFANT; LEUKOCYTES, MONONUCLEAR; MALE; PILOT PROJECTS; PROSPECTIVE STUDIES; RECEPTORS, GLUCOCORTICOID; SALIVA; SEPSIS; SHOCK, SEPTIC;

EID: 84875672797     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000348290     Document Type: Article

References (39)

1. Chrousos GP, Kino T: Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 2007; 10:213-219. (Pubitemid 46789478)
2. Biddie SC, Conway-Campbell BL, Lightman SL: Dynamic regulation of glucocorticoid signalling in health and disease. Rheumatology 2012; 51:403-412.
3. Heitzer MD, Wolf IM, Sanchez ER, Witchel SF, DeFranco DB: Glucocorticoid receptor physiology. Rev Endocr Metab Disord 2007; 8: 321-330.
4. De Bosscher K, Haegeman G: Minireview: latest perspectives on antiinflammatory actions of glucocorticoids. Mol Endocrinol 2009; 23: 281-291.
5. Nicolaides NC, Galata Z, Kino T, Chrousos GP, Charmandari E: The human glucocorticoid receptor: molecular basis of biologic function. Steroids 2010; 75:1-12.
6. DeFranco DB: Navigating steroid hormone receptors through the nuclear compartment. Mol Endocrinol 2002; 16:1449-1455.
7. Wolf IM, Heitzer MD, Grubisha M, DeFranco DB: Coactivators and nuclear receptor transactivation. J Cell Biochem 2008; 104: 1580-1586.
8. Henley DE, Lightman SL: New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience 2011; 180:1-8.
9. Sher ER, Leung DY, Surs W, Kam JC, Zieg G, Kamada AK, Szepler SJ: Steroid-resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994; 93:33-39.
10. Yehuda R, Halligan SL, Grossman R, Golier JA, Wong C: The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without post-traumatic stress disorder. Biol Psychiatry 2002; 52:393-403. (Pubitemid 35266730)
11. Schlechte JA, Ginsberg BH, Sherman BM: Regulation of the glucocorticoid receptor in human lymphocytes. J Steroid Biochem 1982; 16:69-74. (Pubitemid 12158105)
12. Siebig S, Meinel A, Rogler G, Kleble E, Wreda CE, Gelbmann C, Froh S, Rockmann F, Bruennler T, Schoelmerich J, Langgartner J: Decreased cytosolic glucocorticoid receptor levels in critically ill patients. Anaesth Intensive Care 2010; 38:133-140.
13. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arit W, Keh D, Briegel J, Beishuizen A, Dimopoulou I, Tsagarakis S, Singer M, Chrousos GP, Zaloga G, Bokhari F, Vogeser M: Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008; 36:1937-1949.
14. Cooper MS, Stewart PM: Adrenal insufficiency in critical illness. J Intensive Care Med 2007; 22:348-362. (Pubitemid 350132181)
15. Venkataraman S, Munoz R, Candido C, Witchel SF: The hypothalamic- pituitary-adrenal axis in critical illness. Rev Endocr Metab Disord 2007; 8:365-373.
16. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payden D, Briegel J: Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358:111-124.
17. Annane D, Bellissant E, Bollaert PE, Brigel J, Confalonieri M, De Gaudio R, Keh D, Kupfer Y, Oppert M, Meduri GU: Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA 2009; 301:2362-2375.
18. Cardona ML: Adrenal insufficiency in critical illness. Acta Pediatr Esp 1950; 8:421-429.
19. Zimmerman JJ, Williams MD: Adjunctive corticosteroid therapy in pediatric severe sepsis: observations from the RESOLVE study. Pediatr Crit Care Med 2011; 12:2-8.
20. Zimmerman JJ: A history of adjunctive gluco-corticoid treatment for pediatric sepsis: moving beyond steroid pulp fiction toward evidence-based medicine. Pediatr Crit Care Med 2007; 8:530-539. (Pubitemid 350076458)
21. Menon K, Lawson M: Identification of adrenal insufficiency in pediatric critical illness. Pediatr Crit Care Med 2007; 8:276-278. (Pubitemid 46743740)
22. Venkatesh B, Cohen J: Adrenocortical (dys) function in septic shock - a sick euadrenal state. Best Pract Res Clin Endocrinol Metab 2011; 25:719-733.
23. Cohen J, Venkatesh B: Assessment of tissue cortisol activity. Crit Care Resusc 2009; 11: 287-289.
24. den Brinker M, Hokken-Koelega AC, Hazelzet JA, de Jong FH, Hop WC, Joosten KF: One single dose of etomidate negatively influences adrenocortical performance for at least 24h in children with meningococcal sepsis. Intensive Care Med 2008; 34:163-168.
25. Manary MD, Muglia LJ, Vogt SK, Varasheski KE: Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection. Metabolism 2006; 55:550-554.
26. Samarasinghe RA, Di Maio R, Volonte D, Galbiati F, Lewis M, Romero G, DeFranco DB: Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation. Proc Natl Acad Sci USA 2011; 108: 16657-16662.
27. van den Akker EL, Koper JW, Joosten K, de-Jong FH, Hazelzet JA, Lamberts SW, Hokken-Koelega AC: Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis. Intensive Care Med 2009; 35:1247-1254.
28. Oakley RH, Cidlowski JA: Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids. J Biol Chem 2011; 286:3177-3184.
29. Molijn GJ, Koper JW, van Uffelen CJ, de Jong FH, Brinkmann AO, Bruining HA, Lamberts SW: Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock. Clin Endocrinol 1995; 43:197-203.
30. Wong HR, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Willson DF, Freishtat RJ, Anas N, Meyer K, Checchia PA, Monaco M, Odom K, Shanley TP: Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med 2009; 7:34-46.
31. Flaster H, Bernhagen J, Calandra T, Bucala R: The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol 2007; 21: 1267-1280. (Pubitemid 46984737)
32. Jewell CM, Cidlowski JA: Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression. J Clin Endocrinol Metab 2007; 92: 3268-3277. (Pubitemid 47236402)
33. Arafah BM: Hypothalamic pituitary adrenal function during critical illness: limitations of current assessment methods. J Clin Endocrinol Metab 2006; 91:3725-3745. (Pubitemid 44536835)
34. Ho JT, Al-Musalhi H, Chapman MJ, Quach T, Thomas PD, Bagley CJ, Lewis JG, Torpy DJ: Septic shock and sepsis: a comparison of total and free plasma cortisol levels. J Clin Endocrinol Metab 2006; 91:105-114. (Pubitemid 43069125)
35. Kleindienst A, Brabant G, Bock C, Maser-Gluth C, Buchfelder M: Neuroendocrine function following traumatic brain injury and subsequent intensive care treatment: a prospective longitudinal evaluation. J Neurotrauma 2009; 26:1435-1446.
36. Zimmerman JJ, Barker RM, Jack R: Initial observations regarding free cortisol quantification logistics among critically ill children. Intensive Care Med 2010; 36:1914-1922.
37. Zimmerman JJ, Donaldson A, Barker RM, Meert KL, Harrison R, Carcillo JA, Anand KJ, Newth CJ, Berger J, Willson DF, Jack R, Nicholson C, Dean JM: Real-time free cortisol quantification among critically ill children. Pediatr Crit Care Med 2011; 12:525-531.
38. Mesotten D, Vanhorebeek I, Van den Berghe G: The altered adrenal axis and treatment with glucocorticoids during critical illness. Nat Clin Pract Endocrinol Metab 2008; 4: 496-505.
39. Marketon JL, Sternberg EM: The glucocorticoid receptor: a revisited target for toxins. Toxins (Basel) 2010; 2:1357-1380.