Identifying HIF activity in three-dimensional cultures of islet-like clusters

International Journal of Artificial Organs

Volumn 36, Issue 3, 2013, Pages 175-183

  Skiles, Matthew L ^a   Wilder, Nathan B ^a   Sahai, Suchit ^a   Blanchette, James O ^a  

^a The Department of Mechanical Engineering   (United States)

Author keywords

Cell hypoxia; Diabetes mellitus; Encapsulation; Insulin

Indexed keywords

CELLS; CYTOLOGY; VIRUSES;

3D SYSTEMS; CELL CLUSTERS; CELL HYPOXIA; CELL/B.E; DIABETES MELLITUS; FLUORESCENT SYSTEMS; HYPOXIC CELLS; INSULIN SECRETION; RE-AGGREGATION; THREE-DIMENSIONAL CULTURE;

INSULIN;

GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1;

ANIMAL CELL; ARTICLE; CELL ENCAPSULATION; CELL HYPOXIA; CELL STRUCTURE; CELL TRANSPLANTATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE IMAGING; HYPOXIA; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; THREE DIMENSIONAL IMAGING;

EID: 84875670161     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.5301/ijao.5000193     Document Type: Article

References (32)

1. Carlsson PO, Palm F, Andersson A, Liss P. Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes. 2001;50(3): 489-495.
2. Davalli AM, Ogawa Y, Ricordi C, Scharp DW, Bonner-Weir S, Weir GC. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation. 1995;59(6):817-820.
3. Miao G, Ostrowski RP, Mace J, et al. Dynamic production of hypoxia-inducible factor-1α in early transplanted islets. Am J Transplant. 2006;6(11):2636-2643.
4. Cornolti R, Figliuzzi M, Remuzzi A. Effect of micro-and macroencapsulation on oxygen consumption by pancreatic is-lets. Cell Transplant. 2009;18(2):195-201.
5. de Groot M, Schuurs TA, Keizer PPM, Fekken S, Leuvenink HGD, van Schilfgaarde R. Response of encapsulated rat pancreatic islets to hypoxia. Cell Transplant. 2003;12(8):867-875
6. Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta. 2011;1813:1263-1268.
7. Lo JF, Wang Y, Blake A, et al. Islet preconditioning via multimodal microfluidic modulation of intermittent hypoxia. Anal Chem. 2012;84(4):1987-1993.
8. Schuit FC, Huypens P, Heimberg H, Pipeleers DG. Glucose sensing in pancreatic β-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes. 2001;50(1):1-11.
9. Cavallari G, Zuellig RA, Lehmann R, Weber M, Moritz W. Rat pancreatic islet size standardization by the "hanging drop" technique. Transplant Proc. 2007;39(6):2018-2020.
10. Jiang BH, Semenza GL, Bauer C, Marti HH. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol. 1996;271(4 Pt 1): C1172-C1180.
11. Cassavaugh J, Lounsbury KM. Hypoxia-mediated biological control. J Cell Biochem. 2011;112(3):735-744.
12. Cantley J, Selman C, Shukla D, et al. Deletion of the von Hippel-Lindau gene in pancreatic β-cells impairs glucose homeostasis in mice. J Clin Invest. 2009;119(1):125-135.
13. Puri S, Cano DA, Hebrok M. A role for von Hippel-Lindau protein in pancreatic β-cell function. Diabetes. 2009;58(2): 433-441.
14. Zehetner J, Danzer C, Collins S, et al. PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic β-cells. Genes Dev. 2008;22(22):3135-3146.
15. Moroz E, Carlin S, Dyomina K, et al. Real-time imaging on of HIF-1α stabilization and degradation. PLoS ONE. 2009; 4(4):e5077.
16. Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. Am J Physiol. 1998;275(4 Pt 1):L818-L826.
17. Bracken CP, Fedele AO, Linke S, et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment. J Biol Chem. 2006;281(32):22575-22585.
18. Lendahl U, Lee KL, Yang H, Poellinger L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet. 2009;10(12):821-832.
19. Maxwell PH, Pugh CW, Ratcliffe PJ. Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. Proc Natl Acad Sci U S A. 1993;90(6):2423-2427.
20. Skiles ML, Fancy R, Topiwala P, Sahai S, Blanchette JO. Correlating hypoxia with insulin secretion using a fluorescent hypoxia detection system. J Biomed Mater Res. 2011; 97B(1):148-155.
21. Lin-Gibson S, Bencherif S, Cooper JA, et al. Synthesis and characterization of PEG dimethacrylates and their hydrogels. Biomacromolecules. 2004;5(4):1280-1287.
22. Dionne KE, Colton CK, Yarmush ML. Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans. Diabetes. 1993;42(1):12-21.
23. Dionne KE, Colton CK, Yarmush ML. Effect of oxygen on isolated pancreatic tissue. Trans Am Soc Artif Intern Organs. 1989;35(3):739-741.
24. Grist SM, Chrostowski L, Cheung KC. Optical oxygen sensors for applications in microfluidic cell culture. Sensors (Basel). 2010;10(10):9286-9316.
25. Springett R, Swartz HM. Measurements of oxygen in vivo: overview and perspectives on methods to measure oxygen within cells and tissues. Antioxid Redox Signal. 2007; 9(8):1295-1301.
26. Luther MJ, Davies E, Muller D, et al. Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures. Am J Physiol Endocrinol Metab. 2005;288(3):E502-E509.
27. 2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes. 1999;48(7):1402-1408.
28. Lin CC, Anseth KS. Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing β-cell function. Proc Natl Acad Sci U S A. 2011;108(16):6380-6385.
29. Luther MJ, Hauge-Evans A, Souza KLA, et al. MIN6 β-cell interactions influence insulin secretory responses to nutrients and non-nutrients. Biochem Biophys Res Commun. 2006;343(1):99-104.
30. Schietke R, et al. The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia. Insights into cellular transformation processes mediated by HIF-1. J Biol Chem. 2010;285(9):6658-6669.
31. Evans AJ, Russell RC, Roche O, et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol. 2007;27(1): 157-169.
32. Lee DY, Park SJ, Nam JH, Byun Y. Optimal aggregation of dissociated islet cells for functional islet-like cluster. J Biomater Sci Polym Ed. 2008;19(4):441-452.