Enhancement of immune response induced by DNA vaccine cocktail expressing complete LACK and TSA genes against Leishmania major

APMIS

Volumn 121, Issue 4, 2013, Pages 290-298

  Ghaffarifar, Fatemeh ^a   Jorjani, Ogholniaz ^a,b   Sharifi, Zohreh ^c   Dalimi, Abdolhossein ^a   Hassan, Zuhair M ^a   Tabatabaie, Fatemeh ^a,d   Khoshzaban, Fariba ^e   Hezarjaribi, Hajar Ziaei ^a,f  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b GOLESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c HIGH INSTITUTE FOR RESEARCH AND EDUCATION IN TRANSFUSION MEDICINE   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHAHED UNIVERSITY   (Iran)

^f MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cocktail pcTSA+pcLACK; DNA vaccine; Immune responses; Leishmania major

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE; IMMUNE RESPONSE; IMMUNIZATION; LEISHMANIA HOMOLOGUE OF RECEPTOR FOR ACTIVATED C KINASE GENE; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLEEN CELL; SURVIVAL RATE; THIOL SPECIFIC ANTIOXIDANT GENE;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN G; LEISHMANIA MAJOR; LEISHMANIASIS VACCINES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PEROXIREDOXINS; PROTOZOAN PROTEINS; VACCINES, DNA;

EID: 84875646700     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2012.02968.x     Document Type: Article

References (36)

1. Ovendale PJ, Martin TI, Webb JR, Campos-Neto A, Reed SG, Badaro R, Stromberg EJ. Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family. Infect Immun 1998;66:3279-89.
2. Mendez S, Belkaid Y, Seder RA, Sacks D, Sender R. Optimization of DNA vaccination against cutaneous leishmaniasis. Vaccine 2002;20:3702-8.
3. Brodskyn C, de Oliveira CI, Barral A, Barral-Netto M. Vaccines in the leishmaniasis: advances in the last five years. Exp Rev of Vaccines 2003;2:705-17.
4. Campos-Neto A, Porrozzi R, Greeson K, Coler RN, Webb JR, Seiky YAW, et al. Protection against cutaneous Leishmaniasis induced by recombinant antigens in murine and nonhumans primate models of the human disease. Infect Immun 2001;69:4103-8.
5. Ashford RW, Bates PA. Leishmaniasis in the Old World. In: Collier L, Balows A, Sussman M, editors. Topley & Wilson's Microbiology and Microbial Infections. Vol 5, 9th edn. New York: Oxford University Press, 1998: 215-4.
6. Taslimi Y, Zadeh-Vakili A, Taheri T, Doustdari F, Salmanian AH, Rafati S. Immunization with the hybrid protein vaccine, consisting of leishmania major cysteine proteinases type I(CPB) and type II (CPA), partially protects against leishmaniasis. Vaccine 2004;22:1930-40.
7. Webb JR, Kaufmann D, Campos-Neto A, Reed SG. Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis. J Immunol 1996;157:5034-41.
8. Ahmed SB, Bahloul C, Robbana C, Askri S, Dellagi K. A comparative evaluation of different DNA vaccine candidates against experimental murine leishmaniasis due to Leishmania major. Vaccine 2004;22:1631-9.
9. Mendez S, Gurunathan S, Kamhawi S, Sacks D. The potency and durability of DNA-and protein-based vaccines against Leishmania major evaluated using low-dose, interadermal challenge. J Immunol 2001;166:5122-8.
10. Gurunathan S, Saks DL, Brown DR, Reiner SL, Chavest H, Glaichenhaus N, et al. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med 1997;186:1137-47.
11. Monnerat S, Martinez-Calvillo S, Worthey E, Myler PJ, Stuart KD, Fasel N. Genomic organization and gene expression in a chromosomal region of Leishmania major. Mol Biochem Parasitol 2004;134:233-43.
12. Mugneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N. Expression cloning of a protective leishmania antigen. Science 1995;268:563-6.
13. Perez-Jimenez E, Kochan G, Gherardi MM, Esteban M. MVA-LACK as a safe and efficient vector for vaccination against leishmaniasis. Microbes Infect 2006;8:810-22.
14. Campos-Neto A, Webb JR, Greeson K, Coler RN, Skeiky YAW, Reed SG. Vaccination with plasmid DNA encoding TSA/LmSTI1 Leishmanial fusion proteins confers protection against Leishmania major Infection in Susceptible BALB/c Mice. Infect Immun 2002;70:2828-36.
15. Ahmed SB, Touihri L, Chtourou Y, Dellagi K, Bahloul C. DNA based vaccination with a cocktail of plasmids encoding immunodominant Leishmania (Leishmania) major antigens confers full protection in BALB/c mice. Vaccine 2009;27:99-106.
16. McPherson MJ, Moller SG. PCR: The Basics from Background to Bench. Chapter 2, Understanding PCR. Abingdon, UK: BIOS Scientific Publishers, 2000.
17. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, Vol 1, 2nd edn. New York: Cold Spring Harbor Laboratory Press, 1989.
18. Boffey SA. Agarose gel electrophoresis of DNA. In: Walker JM, editors. Methods in Molecular Biology, Vol. 2 Nucleic Acids. Totowa, NJ: Humana Press, 1984:43-50.
19. Gaastra W, Jorgensen PL. The extraction and isolation of DNA from gels. In: Walker JM, editors. Methods in Molecular Biology, Vol. 2. Nucleic Acids. 1984:67-76.
20. Bothwell AL, Yancopulos GD, Alt FW. Methods for cloning and analysis of eukaryotic genes, Jones and Bartlett Publishers. Section 1990;10:247-60.
21. Feliciecello I, Chinali G. A modified alkaline lysis method for the preparation of highly purified plasmid DNA from E.coli. Anal Biochem 1993;212:394-401.
22. Hanahan D. Studies on transformation on E.coli with plasmids. J Mol Biol 1983;98:503-517.
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
24. Ghaffarifar F, Tabatabaie F, Dalimi A, Sharifi Z, Hassan MZ, Mahdavi M. Cloning of a recombinant plasmid encoding thiol-specific antioxidant antigen (TSA) gene of leishmania major and expression in the chinese hamster ovary cell line. Malays J Med Sci 2012;19:15-19.
25. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
26. Crowther JR. ELISA, Theory and Practice. New Jersey: Humana Press, 1995.
27. Buffer PA, Sulahian A, Garin YJF, Nassar N, Derouin F. Culture microtitration:a sensitive method for quantifying Leishmania infantum in tissues of infected mice. Antimicrob Agents Chemother 1995;216:7-8.
28. Tabatabaie F, Ghaffarifar F, Dalimi A, Sharifi Z, Zavaran A. Cloning and sequencing of Leishmania major Thiol-Specific- Antioxidant Antigen (TSA) gene. Iranian J Parasitol 2007;2(4):30-41.
29. Jorjani O, Ghaffarifar F, Dalimi ., Sharifi Z, Hassan ZM. Cloning and sequencing of Leishmania major Leishmania homologue of receptors for activated C kinase (LACK) gene. Modarres J Med Sci: Pathobiol 2009;11:19-30. (In Persian)
30. Handman E. Leishmaniasis: current status of vaccine development. Clin Microbiol Rev 2001;14:229-43.
31. Araujo Z, EI Bouhdidi A, Heremans H, Van Marck E, Castes M, Carlier Y. Vaccinaion of mice with a combination of BCG and killed Leishmania promastigotes reduces acute Trypanosoma cruzi infection by promoting INF-γ response. Vaccine 1999;17:957-64.
32. Ivory C, Chadee K. DNA vaccines: designing strategies against parasite infections. Genet Vaccines Ther 2004;2:1-8.
33. Kochan G, Perez-Jimenez E, Gherardi MM, Esteban M. MVA-LACK as a safe and efficient vector for vaccination against leishmaniasis. Microb Infect 2006;8:810-22.
34. Afonso LC, Scharton TM, Vieira LQ, Wysocka M, Trinchieri G, Scott P. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994;263:235-7.
35. Tabatabaie F, Ghaffarifar F, Dalimi Asl A, Sharifi Z. A survey on the effects of leishmania major TSA - encoded DNA vaccine against experimental leishmaniasis in BALB/c mice. Int J Infec Dis 2008;12:e374-5.
36. Tabatabaie F, Ghaffarifar F, Dalimi Asl A, Sharifi Z, Hassan ZM. Enhancement of cellular and antibody immune responses to Leishmania major TSA-encoded DNA vaccine following immunization and after challenging with Leishmania major. Biochem Cell Arch 2008;8:35-43.