Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies

Research Synthesis Methods

Volumn 3, Issue 2, 2012, Pages 98-110

  Higgins, J P T ^a,b   Jackson, D ^a   Barrett, J K ^a   Lu, G ^c   Ades, A E ^c   White, I R ^a  

^a MRC BIOSTATISTICS UNIT   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

incoherence; inconsistency; mixed treatment comparisons; multiple treatments meta analysis; network meta analysis

Indexed keywords

EID: 84875625927     PISSN: None     EISSN: 17592887     Source Type: Journal    
DOI: 10.1002/jrsm.1044     Document Type: Conference Paper

References (21)

1. Caldwell DM, Ades AE, Higgins JPT. 2005. Simultaneous comparison of multiple treatments: combining direct and indirect evidence. BMJ 331: 897–900.
2. Chan AW, Altman DG. 2005. Epidemiology and reporting of randomised trials published in PubMed journals. The Lancet 365: 1159–1162.
3. Cooper NJ, Sutton AJ, Morris D, Ades AE, Welton NJ. 2009. Addressing between-study heterogeneity and inconsistency in mixed treatment comparisons: application to stroke prevention treatments in individuals with non-rheumatic atrial fibrillation. Statistics in Medicine 28: 1861–1881.
4. Dias S, Welton NJ, Caldwell DM, Ades AE. 2010. Checking consistency in mixed treatment comparison meta-analysis. Statistics in Medicine 29: 932–944.
5. Gartlehner G, Moore CG. 2008. Direct versus indirect comparisons: a summary of the evidence. International Journal of Technology Assessment in Health Care 24: 170–177.
6. Gleser LJ, Olkin I. 1994. Stochastically dependent effect sizes. In The Handbook of Research Synthesis, Cooper H, Hedges LV (eds). Russell Sage Foundation: New York; 339–356.
7. Hasselblad V. 1998. Meta-analysis of multitreatment studies. Medical Decision Making 18: 37–43.
8. Higgins JPT. 2008. Commentary: heterogeneity in meta-analysis should be expected and appropriately quantified. International Journal of Epidemiology 37: 1158–1160.
9. Higgins JPT, Whitehead A. 1996. Borrowing strength from external trials in a meta-analysis. Statistics in Medicine 15: 2733–2749.
10. Ioannidis JPA. 2009. Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. Canadian Medical Association Journal 181: 488–493.
11. Lu G, Ades AE. 2004. Combination of direct and indirect evidence in mixed treatment comparisons. Statistics in Medicine 23: 3105–3124.
12. Lu G, Ades AE. 2006. Assessing evidence inconsistency in mixed treatment comparisons. Journal of the American Statistical Association 101: 447–459.
13. Lu G, Ades A. 2009. Modeling between-trial variance structure in mixed treatment comparisons. Biostatistics 10: 792–805.
14. Lu G, Welton NJ, Higgins JPT, White IR, Ades AE. 2011. Linear inference for mixed treatment comparison meta-analysis: a two-stage approach. Research Synthesis Methods 2: 43–60.
15. Lumley T. 2002. Network meta-analysis for indirect treatment comparisons. Statistics in Medicine 21: 2313–2324.
16. O'Regan C, Ghement I, Eyawo O, Guyatt GH, Mills EJ. 2009. Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison. Trials 10: 86.
17. Salanti G, Higgins JPT, Ades AE, Ioannidis JP. 2008. Evaluation of networks of randomized trials. Statistical Methods in Medical Research 17: 279–301.
18. Salanti G, Marinho V, Higgins JPT. 2009. A case study of multiple-treatments meta-analysis demonstrates that covariates should be considered. Journal of Clinical Epidemiology 62: 857–864.
19. Song F, Xiong T, Parekh-Bhurke S, Loke YK, Sutton AJ, Eastwood AJ, Holland R, Chen YF, Glenny AM, Deeks JJ, Altman DG. 2011. Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study. BMJ 343: d4909.
20. White IR. 2011. Multivariate random-effects meta-regression. The Stata Journal 11: 255–270.
21. White IR, Barrett JK, Jackson D, Higgins JPT. 2012. Consistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regression. Research Synthesis Methods. DOI: 10.1002/jrsm.1045