Ninety days of repeated gavage administration of Rhodiola imbricata extract in rats

Journal of Applied Toxicology

Volumn 33, Issue 5, 2013, Pages 350-356

  Tulsawani, Rajkumar ^a   Meena, Dharmendra Kumar ^a   Shukla, Hem ^a   Sharma, Priyanka ^a   Meena, Ram Niwas ^a   Gupta, Vanita ^a   Kumar, Ratan ^a   Divekar, Harish Madan ^a   Sawhney, Ramesh Chand ^a  

^a DEFENCE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES   (India)

Author keywords

Adaptogen; Rhodiola; Safety assessment; Sub chronic; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CREATINE KINASE; GAMMA GLUTAMYLTRANSFERASE; IMMUNOMODULATING AGENT; PLANT EXTRACT; RHODIOLA IMBRICATA EXTRACT; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; ERYTHROCYTE; EXPERIMENTAL ANIMAL; FEEDING; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SINGLE DRUG DOSE; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RHODIOLA;

ANIMALIA; RATTUS; RHODIOLA;

EID: 84875588766     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1739     Document Type: Article

References (33)

1. Arora R, Chawla R, Sagar R, Prasad J, Singh S, Kumar R. 2005. Evaluation of radioprotective activities of Rhodiola imbricata Edgew - a high altitude plant. Mol. Cell. Biochem. 273: 209-223.
2. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. 2000. Rhodiola rosea in stress induced fatigue - a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 7(5): 365-371.
3. Gupta V, Saggu S, Tulsawani RK, Sawhney RC, Kumar R. 2008. A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome. Food Chem. Toxicol. 46: 1645-1652.
4. Jaijoy K, Soonthornchareinnon N, Lertprasertsuke N, Panthong A, Sireeratawong S. 2010. Acute and chronic oral toxicity of standardized water extract from the fruit of Phyllanthus emblica Linn. Int. J. Appl. Res. Nat. Prod. 3(1): 48-58.
5. Kanupriya, Prasad D, Sairam M, Kumar R, Sawhney RC, Sharma SK, Ilavazhagan G, Kumar D, Banerjee PK. 2005. Cytoprotective and antioxidant activity of Rhodiola imbricata against tert-butyl hydroperoxide injury in U-937 human macrophages. Mol. Cell. Biochem. 275(1-2): 1-6.
6. Kelly GS. 2001. Rhodiola rosea: a possible plant adaptogen. Altern. Med. Rev. 6: 293.
7. Khanum F, Bawa AS, Singh B. 2005. Rhodiola rosea: a versatile adaptogen. Compr. Rev. Food. Sci. 4: 55-58.
8. Komorov VL (ed). 1939. Genus 698. Rhodiola L. In Flora of the USSR volume IX, Rosales and Sarraceniales. Izdatel'Stro Akad. Nauk SSSR: Moscow; 20-36. [Israel Program for Scientific Translation: Jerusalem, 1971.]
9. Kurkin VA, Zapesochnaya GG. 1986. Chemical composition and pharmacological properties of Rhodiola rosea. Chem. Pharm. J. (Moscow) 20(10): 1231-1244.
10. Kurmukov AG, Aizikov MI, Rakhitove SS. 1986. Pharmacology of the plant polyphenol epigalokhin. Farmakol. Toksikol. 49(2): 45-48.
11. Linnaeus C. 1749. Materia Medica. Liber I. De plantis. Lars Salvius: Stockholm; 168.
12. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275.
13. Mao Y, Li Y, Yao N. 2007. Simultaneous determination of salidroside and tyrosol in extracts of Rhodiola L. by microwave assisted extraction and high-performance liquid chromatography. J. Pharm. Biomed. Anal. 45(3): 510-515.
14. McManus JFA, Mowry RW. 1965. General methods for study of cell and its structure. In Staining Methods: Histologic and Histochemical, McManus JFA, Mowry RW (eds). Harper: New York; 73-90.
15. Mishra KP, Padwad YS, Jain M, Karan D, Ganju L, Sawhney RC. 2006. Aqueous extract of Rhodiola imbricata rhizome stimulates proinflammatory mediators via phosphorylated IkB and transcription factor nuclear factor-kB. Immunopharmacol. Immunotoxicol. 28(2): 201-212.
16. Mishra KP, Padwad YS, Datta A, Ganju L, Sairam M, Banerjee PK, Sawhney RC. 2008. Aqueous extract of Rhodiola imbricata rhizome inhibits proliferation of an erythroleukemic cell line K-562 by inducing apoptosis and cell cycle arrest at G2/M phase. Immunobiology 213: 125-131.
17. Mook-Jung I, Kim H, Fan W, Tezuka Y, Kadota S, Nishizo H, Jung MW. 2002. Neuroproective effects of constituents of the original crude drugs, Rhodiola imbricate, R. sachalinensis and Tokakujoki-to, against beta-amyloid toxicity, oxidative stress and apoptosis. Biol. Pharm. Bull. 25: 1101-1104.
18. Nan JX, Jiang YZ, Park EJ, Ko G, Kim YC, Sohn DH. 2003. Protective effect of Rhodiola sacchalinensis extract on carbon tetrachloride-induced liver injury in rats. J. Ethnopharmacol. 84: 143-148.
19. Nongporn Hutadilok T, Wantana R, Chatchai W, Ruthaiwan B. 2010. Acute and sub chronic toxicity evaluation of the hydroethanolic extract of mangosteen pericarp. J. Med. Plants Res. 4(10): 969-974.
20. OECD. 1998. Test guideline 408. Repeated dose 90-day oral toxicity study in rodents. In OECD Guidelines for the Testing of Chemicals. Organization for Economic Cooperation and Development: Paris.
21. Ohsugi M, Fan Wenzhe, Hase K, Xiong Q, Tezuka Y, Komatsu K, Namba T, Saitoh T, Taziwa K, Kadota S. 1999. Active-oxygen scavenging activity of traditional nourishing tonic herbal medicines and active constituents of Rhodiola sacra. J. Ethanopharmacol. 67: 111-119.
22. Perfumi M, Mattioli L. 2007. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother. Res. 21(1): 37-43.
23. Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Petkov VV, Todorov I. 1986. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol. Pharmacol. Bulg. 12(1): 3-16.
24. Petkov VD, Stancheva SL, Tocuschieva L, Petkov VV. 1990. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). Gen. Pharmacol. 21(1): 71-5.
25. Rege NN, Thatte UM, Dahanukar SA. 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother. Res. 13(4): 275-291.
26. Riley V. 1960. Adaptation of orbital bleeding technique to rapid serial blood studies. Proc. Soc. Exp. Biol. Med. 104: 751-754.
27. Ruan X, Hou P, Zhou J, Wang Q, Li G. 2001. Analysis on the trace elements and amino acid content in xinjiang six series Rhodiola L. plant. Guang Pu Yu Guang Pu Fen Xi 21(4): 542-544.
28. Saratikov AS, Krasnov EA. 1987. Rhodiola rosea is a Valuable Medicinal Plant (Golden Root). Tomsk State University Press: Tomsk.
29. Saratikov A, Marina TF, Fisanova LL. 1978. Effect of golden root extract on processes of serotonin synthesis in central nervous system. J. Biol. Sci. 6: 142.
30. Singleton VL, Rossi JA. 1965. Colorimetric determination of total phenolic with phosho-molybidic-phospho-tungstic acid reagents. Am. J. Enol. Viticult. 16: 44-158.
31. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. 2000. A doubleblind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of student caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7(2): 85-89.
32. Stanley OA, Florence CN, David DA, Gloria AA, Sunday D, Kazeem SI, Matthew D, Patrick ECN, Charles W, Karynius G. 2005. Toxicity studies in rats fed nature cure bitters. Afr. J. Biotech. 4(1): 72-78.
33. Udintsev SN, Schakhov VP. 1991. Decrease of cyclophosphamide haematotoxicity by Rhodiola rosea root extract in mice with Ehrlich and Lewis transplantable tumors. Eur. J. Cancer 27(9): 1182.