Acute and subchronic toxicity evaluation of the hydroethanolic extract of mangosteen pericarp

Journal of Medicinal Plants Research

Volumn 4, Issue 10, 2010, Pages 969-974

  Hutadilok Towatana, Nongporn ^a   Reanmongkol, Wantana ^a   Wattanapiromsakul, Chatchai ^a   Bunkrongcheap, Ruthaiwan ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

Acute toxicity; Garcinia mangostana; Hydroethanolic extract; Mangosteen; Pericarp; Subchronic toxicity

Indexed keywords

ALCOHOL DERIVATIVE; EPICATECHIN; HYDROETHANOL; MANGOSTEEN EXTRACT; PLANT EXTRACT; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; BODY GROWTH; CHEMICAL COMPOSITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; ERYTHROCYTE CONCENTRATE; FEMALE; FLUID INTAKE; FOOD INTAKE; FRUIT; GARCINIA MANGOSTANA; HEALTH STATUS; HISTOPATHOLOGY; LEUKOCYTE COUNT; LIVER PARENCHYMA; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PERICARP; PHYTOCHEMISTRY; RAT; SEX DIFFERENCE; SINGLE DRUG DOSE; TOXICITY TESTING;

ANIMALIA; GARCINIA MANGOSTANA; MUS; RATTUS NORVEGICUS;

EID: 77954067920     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Balentine DA, Harbowy ME, Graham HN (1998). Tea: the plant and its manufacture; chemistry and consumption of the beverage. In: Spiller GA (ed.) Caffeine. Boca Raton: CRC Press pp. 35-72.
2. Boehm O, Zur B, Koch A, Tran N, Freyenhagen R, Hartmann M, Zacharowski K (2007). Erratum: Clinical chemistry reference database for Wistar rats and C57/BL6 mice. Biol. Chem. 388: 1255-1256.
3. Chairungsrilerd N, Furukawa KI, Ohta T, Nozoe S, Ohizumi Y (1998). Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn-Schmiedeberg's Arch. Pharmacol. 357: 25-31.
4. Chen SX, Wan M, Loh BN (1996). Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med. 62: 381-382.
5. Dufour DR (2006). Liver disease. In: Burtis CA et al. (eds.) Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. St. Louis: Elsevier Saunders pp. 1777-1848.
6. Gopalakrishnan G, Banumathi B, Suresh G (1997). Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J. Nat. Prod. 60: 519-524.
7. Johnson AM (1999). Low levels of plasma proteins: malnutrition or inflammation? Clin. Chem. Lab. Med. 37: 91-96.
8. Jujun P, Pootakham K, Pongpaibul Y, Duangrat C, Tharavichitkul P (2008). Acute and repeated dose 28-day oral toxicity study of Garcinia mangostana Linn. rind extract. CMU J. Nat. Sci. 7: 199-208.
9. Killingsworth LM (1979). Plasma protein patterns in health and disease. Crit. Rev. Clin. Lab. Sci. 11: 1-30.
10. Mahabusarakam W, Kuaha K, Wilairat P, Taylor WC (2006). Prenylated xanthones as potential antiplasmodial substances. Planta Med. 72: 912-916.
11. Mahabusarakam W, Wiriyachitra P, Taylor WC (1987). Chemical constituents of Garcinia mangostana. J. Nat. Prod. 50: 474-478.
12. Marzo F, Urdaneta E, Santidrian S (2002). Liver proteolytic activity in tannic acid-fed birds. Poult. Sci. 81: 92-94.
13. Matsuda H, Tanaka A, Itakura A (2000). Immunology and hematology. In: Krinke GJ (ed.) The Laboratory Rat. London: Academic Press pp. 437-446.
14. Morton JF (1987). Mangosteen, Garcinia mangostana Linn. In: Morton JF (ed.) Fruits of Warm Climates. Miami: Julia F Morton pp. 301-304.
15. Nagakawa Y, Iinuma M, Naoe T, Nozawa Y, Akao Y (2007). Characterized mechanism of α-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increase miRNA-143 expression in human colorectal cancer DLD-1 cells. Bioorg. Med. Chem. 15: 562-568.
16. Organization for Economic Cooperation and Development (OECD) (2001). Guidelines for the testing of chemicals, No. 420: Acute oral toxicity-fixed dose procedure. Paris: OECD.
17. Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM (2008). Medicinal properties of mangosteen (Garcinia mangostana). Food Chem. Toxicol. 46: 3227-3239.
18. Sakagami Y, Iinuma M, Piyasena KG, Dharmaratne HR (2005). Antibacterial activity of alpha-mangostin against vancomycin resistant enterococci (VRE) and synergism with antibiotics. Phytomed. 12: 203-208.
19. Salunkhe DK, Chavan JK, Kadam SS (1990). Nutritional consequences of dietary tannins. In: Salunkhe DK et al. (eds.) Dietary Tannins: Consequences and Remedies. Boca Raton: CRC Press pp. 113-135.
20. Sornprasit A, Sripiyarattanakul K, Chuay-Yim P, Tanakittiham P (1987). Preliminary toxicological study of mangostin. Songklanakarin J. Sci. Technol. 9: 51-57.
21. Tewtrakul S, Wattanapiromsakul C, Mahabusarakam W (2009). Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells. J. Ethnopharmacol. 121: 379-382.
22. Williams P, Ongsakul M, Proudfoot J, Croft K, Beilin L (1995). Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Rad. Res. 23: 175-184.
23. Wong LP, Klemer PJ (2008). Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am. J. Kidney Dis. 51: 829-833.
24. Yu L, Zhao M, Yang B, Zhao Q, Jiang Y (2007). Phenolics from hull of Garcinia mangostana fruit and their antioxidant activities. Food Chem. 104: 176-181.