Nanocrystalline hydroxyapatite bone graft combined with bioresorbable collagen membrane in the treatment of periodontal intrabony defects: A randomized controlled clinical trial

Journal of Indian Society of Periodontology

Volumn 16, Issue 4, 2012, Pages 562-568

  Singh, Vijendra P ^a   Nayak, Dilip G ^b   Uppoor, Ashita S ^b   Shah, Dipen ^c  

^a Sardar Patel Post Graduate Institute of Dental and Medical Sciences   (India)

^b MANIPAL COLLEGE OF DENTAL SCIENCES   (India)

^c AMC Dental College   (India)

Author keywords

Bone graft; collagen membrane; nanocrystalline hydroxyapatite; periodontal regeneration

Indexed keywords

EID: 84875509987     PISSN: 0972124X     EISSN: 09751580     Source Type: Journal    
DOI: 10.4103/0972-124X.106912     Document Type: Article

References (33)

1. Webster TJ, Ergun C, Doremus RH, Siegel RW, Bizios R. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials 2000;21:1803-10.
2. Chris Arts JJ, Verdonschot N, Schreurs BW, Buma P. The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting. Biomaterials 2006;27:1110-8.
3. Schnettler R, Dingeldein E. Inorganic bone substitutes.Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications. New York: Marcell Dekker; 2002. p. 401-32.
4. Schnettler R, Stahl JP, Alt V, Pavlidis T, Dingeldein E, Wenisch S. Calcium phosphate-based bone substitutes. Eur J Trauma 2004;4:219-29.
5. Huber FX, Belyaev O, Hillmeier J, Kock HJ, Huber C, Meeder PJ, Berger I. First histological observations on the incorporation of a novel nanocrystalline hydroxyapatite paste (Ostims ®) in human cancellous bone. BMC Musculoskeletal Disorders 2006;7:50.
6. Strietzel FP, Reichart PA, Graf H. Lateral alveolar ridge augmentation using a synthetic nano-crystalline hydroxyapatite bone substitution material (Ostims ®) Preliminary clinical and histological results. Clin Oral Implant Res 2007;18:743-751.
7. Schwarz F, Bieling K, Latz T, Nuesry E, Becker J. Healing of intrabony periimplantitis defects following application of a nanocrystalline hydroxyapatite (Ostims ®) or a bovine-derived xenograft (Bio-Osst) in combination with a collagen membrane (Bio-Gide). A case series. J Clin Periodontol 2006;33:491-9.
8. Blumenthal N, Steinberg J. The use of collagen membrane barriers in conjunction with combined demineralized bone collagen gel implants in human infrabony defects. J Periodontol 1990;61:319-27.
9. Camargo PM, Lekovic V, Weinlaender M, Nedic M, Vasilic N, Wolinsky LE, Kenney EB. A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans. J Clin Periodontol 2000;27:889-96.
10. Divya PV, Nandakumar K. Local drug delivery-PerioCol ® in periodontics. Trends Biomater Artif Organs 2006;19:74-80.
11. Sella MN, Kohavi D, Krausz E, Steinberg D, Rosen G. Enzymatic degradation of collagen-guided tissue regeneration membranes by periodontal bacteria. Clin Oral Implants Res 2003;14:263-8.
12. Rothamel D, Schwarz F, Sager M, Herten M, Sculean A, Becker J. Biodegradation of differently cross-linked collagen membranes: an experimental study in rats. Clin Oral Implants Res 2005;16:369-78.
13. Paolantonio M. Combined Periodontal Regenerative Technique in Human Intrabony Defects by Collagen Membranes and Anorganic Bovine Bone. A Controlled Clinical Study. J Periodontol 2002;73:158-66.
14. Cortellini P, Pini PG, Tonetti MS. Periodontal regeneration of human intrabony defects with titanium reinforced membranes. A controlled clinical trial. J Periodontol 1995;66:797-803.
15. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects: A systematic review. Ann Periodontol 2003;8:227-65.
16. Schwarz F, Sculean A, Bieling K, Ferrari D, Rothamel D, Becker J. Two-year clinical results following treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane. J Clin Periodontol 2008;35:80-7.
17. Christgau M, Schamlz G, Wenzel A, Hiller KA. Periodontal regeneration of intrabony defects with resorbable and nonresorbable membranes: 30-month results. J Clin Periodontol 1997;24:17-27.
18. Trombelli L. Which reconstructive procedures are effective for treating the periodontal intraosseous defect? Periodontology 2000. 2005;37:88-105.
19. Kilic AR, Efeoglu E, Yilmaz S. Guided tissue regeneration in conjunction with hydroxyapatite-collagen grafts for intrabony defects. A clinical and radiological evaluation. J Clin Periodontol 1997;24:372-83.
20. Lundgarden D, Slotte C. Reconstruction of anatomically complicated periodontal defects using a bioresorbable GTR barrier supported by bone mineral. A 6-month follow-up study of 6 cases. J Clin Periodontol 1999;26:56-62.
21. Sculean A, Berakdar M, Chiantella GC, Donos N, Arweiler NB, Brecx M. Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled clinical study. J Clin Periodontol 2003;30:73-80.
22. Tonetti MS, Cortellini P, Lang NP, Suvan JE, Adriaens P, Dubravec D, et al. Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial. J Clin Periodontol 2004;31:770-6.
23. Silness J and Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964; 22:121-35.
24. Loe H, Silness J. Periodontal disease in pregnancy. I. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1963;21:533-51.
25. Scabbia A, Trombelli L. A comparative study on the use of a HA/collagen/chondroitin sulphate biomaterial (Biostites) and a bovine-derived HA xenograft (Bio-Osss) in the treatment of deep intra-osseous defects. J Clin Periodontol 2004;31:348-55.
26. Goldman HM, Cohen DW. The Infrabony Pocket: Classification and Treatment. J Periodontol 1958;10:272-91.
27. Kasaj A, Rohrig B, Zafiropoulos GG, Willershausen B. Clinical evaluation of nanocrystalline hydroxyapatite paste in the treatment of human periodontal bony defects-A randomized controlled clinical trial: 6-month results. J Periodontol 2008;79:394-400.
28. Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human intrabony defects. I. Clinical measures. J Periodontol 1993:64:254-60.
29. Sculean A, Nikolidakis D, Schwarz F. Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials-biological foundation and preclinical evidence. A systematic review. J Clin Periodontol 2008;35:106-16.
30. Reddy MS, Jeffcoat MK. Methods of assessing periodontal Regeneration. Periodontology 2000. 1999;19:87-103.
31. Zybutz M, Rapoport D, Laurell L, Persson GR. Comparisons of clinical and radiographic measurements of interproximal vertical defects before and 1 year after surgical treatments. J Clin Periodontol 2000;27:179-86.
32. Needleman I, Tucker R, Giedrys-Leeper E, Worthington H. A systematic review of guided tissue regeneration for periodontal infrabony defects. J Periodontol Res 2002;37:380-8.
33. Wenzel A, Warrer K, Karring T. Digital subtraction radiography in assessing bone changes in periodontal defects following guided tissue regeneration. J Clin Periodontol 1992;19:208-13.