Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone: A multicenter randomized controlled clinical trial

Journal of Clinical Periodontology

Volumn 31, Issue 9, 2004, Pages 770-776

  Tonetti, Maurizio S ^a   Cortellini, Pierpaolo ^a   Lang, Niklaus P ^b   Suvan, Jean E ^a   Adriaens, Patrick ^a,c   Dubravec, Dominik ^d   Fonzar, Alberto ^d   Fourmousis, Ioannis ^e   Rasperini, Giulio ^d   Rossi, Roberto ^d   Silvestri, Maurizio ^f   Topoll, Heinz ^d   Wallkamm, Beat ^b,d   Zybutz, Michael ^d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BERN   (Switzerland)

^c ICPDOI   (Belgium)

^d University of Athens ^*

^e UNIVERSITY OF ATHENS   (Greece)

^f UNIVERSITY OF PAVIA   (Italy)

Author keywords

Bone replacement graft; Guided tissue regeneration; Intrabony defects; Periodontal regeneration; Randomized controlled clinical trial

Indexed keywords

ADAPTATION; ADULT; ARTICLE; BONE DEFECT; BONE REGENERATION; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEBRIDEMENT; FEMALE; FOLLOW UP; GINGIVA BLEEDING; HUMAN; INSTRUMENTATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SAMPLE SIZE; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SURGICAL TECHNIQUE; TOOTH PAPILLA; TOOTH PLAQUE; TOOTH ROOT; TREATMENT OUTCOME; WOUND CLOSURE;

EID: 4444235986     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2004.00562.x     Document Type: Article

References (28)

1. Camargo, P. M., Levkovic, V., Weinlaender, M., Nedic, M., Vasilic, M., Wolinsky, L. E. & Kenney, E. B. (2000) A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans. Journal of Clinical Periodontology 27, 889-896.
2. Camelo, M., Nevins, M. L., Lynch, S. E., Schenk, R. K., Simion, M. & Nevins, M. (2001) Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane. International Journal of Periodontics and Restorative Dentistry 21, 109-119.
3. Camelo, M., Nevins, M. L., Schenk, R. K., Simion, M., Rasperini, G., Lynch, S. E. & Nevins, M. (1998) Clinical, radiographic, and histologic evaluation of human periodontal defects treated with Bio-Oss and Bio-Gide. International Journal of Periodontics and Restorative Dentistry 18, 321-331.
4. Cortellini, P., Pini-Prato, G. P. & Tonetti, M. S. (1993) Periodontal regeneration of human infrabony defects. I. Clinical measures. Journal of Periodontology 64, 254-260.
5. Cortellini, P., Pini-Prato, G. & Tonetti, M. (1995) The modified papilla preservation technique. A new surgical approach for interproxymal regenerative procedures. Journal of Periodontology 66, 261-266.
6. Cortellini, P., Pini Prato, G. & Tonetti, M. (1999) The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. International Journal of Periodontics and Restorative Dentistry 19, 589-599.
7. Cortellini, P. & Tonetti, M. (2000) Focus on intrabony defects: guided tissue regeneration. Periodontology 2000 22, 104-132.
8. Cortellini, P., Tonetti, M., Lang, N., Suvan, J., Zucchelli, G., Vangsted, T., Silvestri, M., Rossi, R., McClain, P., Fonzar, A., Dubravec, D. & Adriaens, P. (2001) The simplified papilla preservation flap in the regenerative treatment of deep intrabony defects. A multicentre randomized controlled clinical trial evaluating clinical outcomes and postoperative morbidity. Journal of Periodontology 72, 1702-1712.
9. Falk, H., Laurell, L., Ravald, N., Teiwik, A. & Persson, R. (1997) Guided tissue regeneration therapy of 203 consecutively treated intrabony defects using a bioabsorbable matrix barrier. Clinical and radiographic findings. Journal of Periodontology 68, 571-581.
10. Fleiss, J. (1986) Analysis of data from multicenter trials. Controlled Clinical Trials 7, 267-275.
11. Goldberg, J. & Koury, K. (1989) Design and analysis of multicenter trials. In: Statistical Methodology in the Pharmaceutical Sciences, eds. Berry, D., pp. 201-237. New York: Marcel Dekker Inc.
12. Mellonig, J. T. (2000) Human histologic evaluation of a bovine-derived bone xenograft in the treatment of periodontal osseous defects. International Journal of Periodontics and Restorative Dentistry 20, 19-29.
13. Murphy, K. G. & Gunsolley, M. (2003) Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Annals of Periodontology, 8, 266-302.
14. Needleman, I., Tucker, R., Giedrys-Leeper, E. & Worthington, H. (2002) A systematic review of guided tissue regeneration for periodontal infrabony defects. Journal of Periodontal Research 37, 380-388.
15. Nevins, M. L., Camelo, M., Lynch, S. E., Schenk, R. K. & Nevins, M. (2003) Evaluation of periodontal regeneration following grafting intrabony defects with bio-oss collagen: a human histologic report. International Journal of Periodontics and Restorative Dentistry 23, 9-17.
16. O'Leary, T. J., Drake, R. B. & Naylor, J. E. (1972) The plaque control record. Journal of Periodontology 43, 38.
17. Paolantonio, M. (2002) Combined periodontal regenerative technique in human intrabony defects by collagen membranes and anorganic bovine bone. A controlled clinical study. Journal of Periodontology 73, 158-166.
18. Richardson, C. R., Mellonig, J. T., Brunsvold, M. A., McDonnell, H. T. & Cochran, D. L. (1999) Clinical evaluation of Bio-Oss: a bovine-derived xenograft for the treatment of periodontal osseous defects in humans. Journal of Clinical Periodontology 26, 421-428.
19. Rosen, P., Reynolds, M. & Bowers, G. (2000) The treatment of intrabony defects with bone grafts. Periodontology 2000 22, 88-103.
20. Sculean, A., Berakdar, M., Chiantella, G. C., Donos, N., Arweiler, N. B. & Brecx, M. (2003) Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled clinical study. Journal of Clinical Periodontology 30, 73-80.
21. Stavropoulos, A., Karring, E. S., Kostopoulos, L. & Karring, T. (2003) Deproteinized bovine bone and gentamicin as an adjunct to GTR in the treatment of intrabony defects: a randomized controlled clinical study. Journal of Clinical Periodontology 30, 486-495.
22. Tonetti, M., Cortellini, P., Suvan, J., Adriaens, P., Baldi, C., Dubravec, D., Fonzar, A., Fourmousis, I., Magnani, C., Muller-Campanile, V., Patroni, S., Sanz Alonso, M., Vangsted, T., Zabalegui, I., Pini-Prato, G. & Lang, N. (1998) Evaluation of generalizability of the added benefit of GTR in the treatment of deep intrabony defects. A phase iv multicenter randomized controlled clinical trial. Journal of Periodontology 69, 1183-1192.
23. Tonetti, M., Pini-Prato, G. & Cortellini, P. (1993) Periodontal regeneration of human infrabony defects. IV. Determinants of the healing response. Journal of Periodontology 64, 934-940.
24. Tonetti, M., Pini-Prato, G. & Cortellini, P. (1995) Effect of cigarette smoking on periodontal healing following GTR in infrabony defects. A preliminary retrospective study. Journal of Clinical Periodontology 22, 229-234.
25. Tonetti, M., Pini-Prato, G. & Cortellini, P. (1996) Factors affecting the healing response of intrabony defects following guided tissue regeneration and access flap surgery. Journal of Clinical Periodontology 23, 548-556.
26. Tonetti, M. S., Lang, N. P., Cortellini, P., Suvan, J. E., Adriaens, P., Dubravec, D., Fonzar, A., Fourmousis, I., Mayfield, L., Rossi, R., Silvestri, M., Tiedemann, C., Topoll, H., Vangsted, T. & Wallkamm, B. (2002) Enamel matrix proteins in the regenerative therapy of deep intrabony defects. Journal of Clinical Periodontology 29, 317-325.
27. Trombelli, L., Heitz-Mayfield, L. J., Needleman, I., Moles, D. & Scabbia, A. (2002) A systematic review of graft materials and biological agents for periodontal intraosseous defects. Journal of Clinical Periodontology 29 (Suppl. 3), 117-135, discussion 160-162.
28. Yamada, S., Shima, N., Kitamura, H. & Sugito, H. (2002) Effect of porous xenographic bone graft with collagen barrier membrane on periodontal regeneration. International Journal of Periodontics and Restorative Dentistry 22, 389-397.