Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer

Journal of Histochemistry and Cytochemistry

Volumn 61, Issue 3, 2013, Pages 206-217

  Bao, Xiangxiang ^a   Zhao, Shan ^a   Lius, Ting ^a   Liu, Yang ^a   Liu, Yueyang ^a   Yang, Xingsheng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

apoptosis; immunohistochemistry; Ki 67; ovarian cancer; PRMT5; proliferation; RNAi

Indexed keywords

KI 67 ANTIGEN; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CANCER INVASION; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL GROWTH; CELL PROLIFERATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; OVARY CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; E2F1 TRANSCRIPTION FACTOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; OVARY; PROGNOSIS; PROTEIN-ARGININE N-METHYLTRANSFERASES; RNA, SMALL INTERFERING; SURVIVAL ANALYSIS; UP-REGULATION; YOUNG ADULT;

EID: 84875499792     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155413475452     Document Type: Article

References (43)

1. Aggarwal P,Vaites LP,Kim JK,Mellert H,Gurung B,Nakagawa H,Herlyn M,Hua X,Rustgi AK,McMahon SB,Diehl JA.Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.Cancer Cell. 2010;18:329-340.
2. Ali-Fehmi R,Che M,Khalifeh I,Malone JM,Morris R,Lawrence WD,Munkarah AR.The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma.Cancer. 2003;98:1423-1429.
3. Ancelin K,Lange UC,Hajkova P,Schneider R,Bannister AJ,Kouzarides T,Surani MA.Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.Nat Cell Biol. 2006;8:623-630.
4. Auersperg N,Ota T,Mitchell GW.Early events in ovarian epithelial carcinogenesis: progress and problems in experimental approaches.Int J Gynecol Cancer. 2002;12:691-703.
5. Bedford MT.Arginine methylation at a glance.J Cell Sci. 2007;120:4243-4246.
6. Bedford MT,Clarke SG.Protein arginine methylation in mammals: who, what, and why.Mol Cell. 2009;33:1-13.
7. Bedford MT,Richard S.Arginine methylation an emerging regulator of protein function.Mol Cell. 2005;18:263-272.
8. Branscombe TL,Frankel A,Lee JH,Cook JR,Yang Z,Pestka S,Clarke S.PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.J Biol Chem. 2001;276:32971-32976.
9. Cho EC,Zheng S,Munro S,Liu G,Carr SM,Moehlenbrink J,Lu YC,Stimson L,Khan O,Konietzny R, et al.Arginine methylation controls growth regulation by E2F-1.EMBO J. 2012;17:1-13.
10. Dacwag CS,Bedford MT,Sif S,Imbalzano AN.Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.Mol Cell Biol. 2009;29:1909-1921.
11. Dacwag CS,Ohkawa Y,Pal S,Sif S,Imbalzano AN.The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.Mol Cell Biol. 2007;27:384-394.
12. Eckert D,Biermann K,Nettersheim D,Gillis AJ,Steger K,Jack HM,Muller AM,Looijenga LH,Schorle H.Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors.BMC Dev Biol. 2008;8:106.
13. Fabbrizio E,El Messaoudi S,Polanowska J,Paul C,Cook JR,Lee JH,Negre V,Rousset M,Pestka S,Le Cam A, et al.Negative regulation of transcription by the type II arginine methyltransferase PRMT5.EMBO Rep. 2002;3:641-645.
14. Gilks CB.Subclassification of ovarian surface epithelial tumors based on correlation of histologic and molecular pathologic data.Int J Gynecol Pathol. 2004;23:200-205.
15. Hou Z,Peng H,Ayyanathan K,Yan KP,Langer EM,Longmore GD,Rauscher FJ.The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL- dependent transcriptional repression.Mol Cell Biol. 2008;28:3198-3207.
16. Jordan S,Green A,Webb P.Benign epithelial ovarian tumours: cancer precursors or markers for ovarian cancer risk?.Cancer Causes Control. 2006;17:623-632.
17. Kim JM,Sohn HY,Yoon SY,Oh JH,Yang JO,Kim JH,Song KS,Rho SM,Yoo HS,Kim YS, et al.Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells.Clin Cancer Res. 2005;11:473-482.
18. Kobel M,Kalloger SE,Boyd N,McKinney S,Mehl E,Palmer C,Leung S,Bowen NJ,Ionescu DN,Rajput A, et al.Ovarian carcinoma subtypes are different diseases: implications for biomarker studies.PLoS Med. 2008;5:e232.
19. Krause CD,Yang ZH,Kim YS,Lee JH,Cook JR,Pestka S.Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential. Pharmacol Ther. 2007;113:50-87.
20. Lazzerini Denchi E,Helin K.E2F1 is crucial for E2F-dependent apoptosis.EMBO Rep. 2005;6:661-668.
21. Liang JJ,Wang Z,Chiriboga L,Greco MA,Shapiro E,Huang H,Yang XJ,Huang J,Peng Y,Melamed J, et al.The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.J Urol. 2007;177:1918-1922.
22. Liu F,Zhao X,Perna F,Wang L,Koppikar P,Abdel-Wahab O,Harr MW,Levine RL,Xu H,Tefferi A, et al.JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.Cancer Cell. 2011;19:283-294.
23. Mallappa C,Hu YJ,Shamulailatpam P,Tae S,Sif S,Imbalzano AN.The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4.Nucleic Acids Res. 2011;39:1243-1255.
24. Pal S,Baiocchi RA,Byrd JC,Grever MR,Jacob ST,Sif S.Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.EMBO J. 2007;26:3558-3569.
25. Pal S,Sif S.Interplay between chromatin remodelers and protein arginine methyltransferases.J Cell Physiol. 2007;213:306-315.
26. Pal S,Vishwanath SN,Erdjument-Bromage H,Tempst P,Sif S.Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.Mol Cell Biol. 2004;24:9630-9645.
27. Pal S,Yun R,Datta A,Lacomis L,Erdjument-Bromage H,Kumar J,Tempst P,Sif S.mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.Mol Cell Biol. 2003;23:7475-7487.
28. Polager S,Ginsberg D.E2F-at the crossroads of life and death.Trends Cell Biol. 2008;18:528-535.
29. Pollack BP,Kotenko SV,He W,Izotova LS,Barnoski BL,Pestka S.The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.J Biol Chem. 1999;274:31531-31542.
30. Powers MA,Fay MM,Factor RE,Welm AL,Ullman KS.Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4.Cancer Res. 2011;71:5579-5587.
31. Ren J,Wang Y,Liang Y,Zhang Y,Bao S,Xu Z.Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.J Biol Chem. 2010;285:12695-12705.
32. Richard S,Morel M,Cleroux P.Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5(PRMT5).Biochem J. 2005;388:379-386.
33. Salazar H,Godwin AK,Daly MB,Laub PB,Hogan WM,Rosenblum N,Boente MP,Lynch HT,Hamilton TC.Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophorectomies.J Natl Cancer Inst. 1996;88:1810-1820.
34. Scoumanne A,Zhang J,Chen X.PRMT5 is required for cell-cycle progression and p53 tumor suppressor function.Nucleic Acids Res. 2009;37:4965-4976.
35. Siegel R,Naishadham D,Jemal A.Cancer statistics.CA Cancer J Clin. 2012;62:10-29.
36. Suh DS,Yoon MS,Choi KU,Kim JY.Significance of E2F-1 overexpression in epithelial ovarian cancer.Int J Gynecol Cancer. 2008;18:492-498.
37. Tabata T,Kokura K,Ten Dijke P,Ishii S.Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5.Genes Cells. 2009;14:17-28.
38. Tanaka H,Hoshikawa Y,Oh-hara T,Koike S,Naito M,Noda T,Arai H,Tsuruo T,Fujita N.PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via nuclear factor-kappaB activation.Mol Cancer Res. 2009;7:557-569.
39. TrotterJ. 2004. WinMDI (Windows Multiple Document Interface for Flow Cytometry), version 2.8. Available from http://facs.scripps.edu/software.html.
40. Vital-ReyesVRodriguez-BurfordCChhiengDCOelschlagerDKReyes-FuentesABarnesMGrizzleWE. 2006. Celecoxib inhibits cellular growth, decreases Ki-67 expression and modifies apoptosis in ovarian cancer cell lines. Arch Med Res37:689-695.
41. Wang L,Pal S,Sif S.Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.Mol Cell Biol. 2008;28:6262-6277.
42. Yang M,Sun J,Sun X,Shen Q,Gao Z,Yang C.Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis.PLoS Genet. 2009;5:e1000514.
43. Zhou Z,Sun X,Zou Z,Sun L,Zhang T,Guo S,Wen Y,Liu L,Wang Y,Qin J, et al.PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130.Cell Res. 2010;20:1023-1033.