An improved recombination-based in vivo expression technology-like reporter system reveals differential cyaA gene activation in Bordetella species

Infection and Immunity

Volumn 81, Issue 4, 2013, Pages 1295-1305

  Byrd, Matthew S ^a   Mason, Eliza ^a   Henderson, Michael W ^a   Scheller, Erich V ^a   Cotter, Peggy A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CYAA PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BORDETELLA; BORDETELLA BRONCHISEPTICA; BORDETELLA PERTUSSIS; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REPORTER GENE; RESPIRATORY TRACT INFECTION;

ADENYLATE CYCLASE TOXIN; ANIMAL EXPERIMENTATION; ANIMALS; BORDETELLA BRONCHISEPTICA; BORDETELLA PERTUSSIS; GENE EXPRESSION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REPORTER; GENETICS, MICROBIAL; MICE; MICE, INBRED BALB C; MOLECULAR BIOLOGY; PLASMIDS; RECOMBINATION, GENETIC; TRANSCRIPTIONAL ACTIVATION; VIRULENCE FACTORS;

EID: 84875493044     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01445-12     Document Type: Article

References (41)

1. Gross R, Keidel K, Schmitt K. 2010. Resemblance and divergence: the "new" members of the genus Bordetella. Med. Microbiol. Immunol. 199: 155-163.
2. Gerlach G, von Wintzingerode F, Middendorf B, Gross R. 2001. Evolutionary trends in the genus Bordetella. Microbes Infect. 3:61-72.
3. Cotter PA, Miller JF. 2001. Bordetella, p 619-674. In Groisman EA (ed), Principles of bacterial pathogenesis. Academic Press, San Diego, CA. 4. Cotter PA, Jones AM. 2003. Phosphorelay control of virulence gene expression in Bordetella. Trends Microbiol. 11:367-373.
4. Cummings CA, Bootsma HJ, Relman DA, Miller JF. 2006. Species- and strain-specific control of a complex, flexible regulon by Bordetella BvgAS. J. Bacteriol. 188:1775-1785.
5. Martinez de Tejada G, Cotter PA, Heininger U, Camilli A, Akerley BJ, Mekalanos JJ, Miller JF. 1998. Neither the Bvg-phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice. Infect. Immun. 66:2762-2768.
6. Cotter PA, Miller JF. 1994. BvgAS-mediated signal transduction: analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model. Infect. Immun. 62:3381-3390.
7. Nicholson TL, Brockmeier SL, Loving CL, Register KB, Kehrli ME, Stibitz SE, Shore SM. 2012. Phenotypic modulation of the virulent Bvg phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine. Infect. Immun. 80:1025-1036.
8. Cotter PA, Miller JF. 1997. A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvg-regulated antigens. Mol. Microbiol. 24:671-685.
9. Stockbauer KE, Fuchslocher B, Miller JF, Cotter PA. 2001. Identification and characterization of BipA, a Bordetella Bvg-intermediate phase protein. Mol. Microbiol. 39:65-78.
10. Jones AM, Boucher PE, Williams CL, Stibitz S, Cotter PA. 2005. Role of BvgA phosphorylation and DNA binding affinity in control of Bvgmediated phenotypic phase transition in Bordetella pertussis. Mol. Microbiol. 58:700-713.
11. Boucher PE, Murakami K, Ishihama A, Stibitz S. 1997. Nature of DNA binding and RNA polymerase interaction of the Bordetella pertussis BvgA transcriptional activator at the fha promoter. J. Bacteriol. 179:1755-1763.
12. Boucher PE, Yang MS, Stibitz S. 2001. Mutational analysis of the highaffinity BvgA binding site in the fha promoter of Bordetella pertussis. Mol. Microbiol. 40:991-999.
13. Chen Q, Decker KB, Boucher PE, Hinton D, Stibitz S. 2010. Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA. Mol. Microbiol. 77:1326-1340.
14. Williams CL, Cotter PA. 2007. Autoregulation is essential for precise temporal and steady-state regulation by the Bordetella BvgAS phosphorelay. J. Bacteriol. 189:1974-1982.
15. Akerley BJ, Cotter PA, Miller JF. 1995. Ectopic expression of the flagellar regulon alters development of the bordetella-host interaction. Cell 80: 611-620.
16. Cróinín TÓ, Grippe VK, Merkel TJ. 2005. Activation of the vrg6 promoter of Bordetella pertussis by RisA. J. Bacteriol. 187:1648-1658.
17. Steffen P, Goyard S, Ullmann A. 1996. Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis. EMBO J. 15:102.
18. Miller JF, Roy CR, Falkow S. 1989. Analysis of Bordetella pertussis virulence gene regulation by use of transcriptional fusions in Escherichia coli. J. Bacteriol. 171:6345-6348.
19. Scarlato V, Prugnola A, Aricó B, Rappuoli R. 1990. Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis. Proc. Natl. Acad. Sci. U. S. A. 87:6753-6757.
20. McPheat WL, Wardlaw AC, Novotny P. 1983. Modulation of Bordetella pertussis by nicotinic acid. Infect. Immun. 41:516-522.
21. Martinez de Tejada G, Miller JF, Cotter PA. 1996. Comparative analysis of the virulence control systems of Bordetella pertussis and Bordetella bronchiseptica. Mol. Microbiol. 22:895-908.
22. Aricó B, Scarlato V, Prugnola A, Rappuoli R. 1991. Sequential activation and environmental regulation of virulence genes in Bordetella pertussis. EMBO J. 10:3971.
23. Veal-Carr WL, Stibitz S. 2005. Demonstration of differential virulence gene promoter activation in vivo in Bordetella pertussis using RIVET. Mol. Microbiol. 55:788-798.
24. Camilli A, Beattie DT, Mekalanos JJ. 1994. Use of genetic recombination as a reporter of gene expression. Proc. Natl. Acad. Sci. U. S. A. 91:2634-2638.
25. Hoang TT, Karkhoff-Schweizer RR, Kutchma AJ, Schweizer HP. 1998. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene 212:77-86.
26. Stainer DW, Scholte MJ. 1970. A simple chemically defined medium for the production of phase I Bordetella pertussis. J. Gen. Microbiol. 63:211-220.
27. Inatsuka CS, Xu Q, Vujkovic-Cvijin I, Wong S, Stibitz S, Miller JF, Cotter PA. 2010. Pertactin is required for Bordetella species to resist neutrophil-mediated clearance. Infect. Immun. 78:2901-2909.
28. Lopez CM, Rholl DA, Trunck LA, Schweizer HP. 2009. Versatile dualtechnology system for markerless allele replacement in Burkholderia pseudomallei. Appl. Environ. Microbiol. 75:6496-6503.
29. Choi KH, Mima T, Casart Y, Rholl D, Kumar A, Beacham IR, Schweizer HP. 2008. Genetic tools for select-agent-compliant manipulation of Burkholderia pseudomallei. Appl. Environ. Microbiol. 74:1064-1075.
30. Norris MH, Kang Y, Wilcox B, Hoang TT. 2010. Stable, site-specific fluorescent tagging constructs optimized for burkholderia species. Appl. Environ. Microbiol. 76:7635-7640.
31. Menozzi FD, Mutombo R, Renauld G, Gantiez C, Hannah JH, Leininger E, Brennan MJ, Locht C. 1994. Heparin-inhibitable lectin activity of the filamentous hemagglutinin adhesin of Bordetella pertussis. Infect. Immun. 62:769-778.
32. Akerley BJ, Miller JF. 1993. Flagellin gene transcription in Bordetella bronchiseptica is regulated by the BvgAS virulence control system. J. Bacteriol. 175:3468-3479.
33. Merkel TJ, Stibitz S, Keith JM, Leef M, Shahin R. 1998. Contribution of regulation by the bvg locus to respiratory infection of mice by Bordetella pertussis. Infect. Immun. 66:4367-4373.
34. Rediers H, Rainey PB, Vanderleyden J, De Mot R. 2005. Unraveling the secret lives of bacteria: use of in vivo expression technology and differential fluorescence induction promoter traps as tools for exploring nichespecific gene expression. Microbiol. Mol. Biol. Rev. 69:217-261.
35. Gort AS, Miller VL. 2000. Identification and characterization of Yersinia enterocolitica genes induced during systemic infection. Infect. Immun. 68:6633-6642.
36. Wang J, Mushegian A, Lory S, Jin S. 1996. Large-scale isolation of candidate virulence genes of Pseudomonas aeruginosa by in vivo selection. Proc. Natl. Acad. Sci. U. S. A. 93:10434-10439.
37. Bron PA, Grangette C, Mercenier A, de Vos WM, Kleerebezem M. 2004. Identification of Lactobacillus plantarum genes that are induced in the gastrointestinal tract of mice. J. Bacteriol. 186:5721-5729.
38. Choi KH, Gaynor JB, White KG, Lopez C, Bosio CM, Karkhoff- Schweizer RR, Schweizer HP. 2005. A Tn7-based broad-range bacterial cloning and expression system. Nat. Methods 2:443-448.
39. Zaretzky FR, Gray MC, Hewlett EL. 2002. Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction. Mol. Microbiol. 45:1589-1598.
40. Henderson MW, Inatsuka CS, Sheets AJ, Williams CL, Benaron DJ, Donato GM, Gray MC, Hewlett EL, Cotter PA. 2012. Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation. Infect. Immun. 80:2061-2075.
41. Lee SH, Hava DL, Waldor MK, Camilli A. 1999. Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection. Cell 99:625-634.