Expression Levels of Obesity-Related Genes Are Associated with Weight Change in Kidney Transplant Recipients

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Cashion, Ann ^a,b   Stanfill, Ansley ^a   Thomas, Fridtjof ^a   Xu, Lijing ^c   Sutter, Thomas ^c   Eason, James ^a,d   Ensell, Mang ^a   Homayouni, Ramin ^c  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b NATIONAL INSTITUTE OF NURSING RESEARCH   (United States)

^c UNIVERSITY OF MEMPHIS   (United States)

^d METHODIST UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN M; CARBOXYPEPTIDASE H; CCAAT ENHANCER BINDING PROTEIN ALPHA; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; LEPTIN; METHIONINE SULFOXIDE REDUCTASE A;

ACYL COENZYME A DEHYDROGENASE 10 GENE; ADULT; ANGIOPOIETIN LIKE 2 GENE; APOLIPOPROTEIN M GENE; ARTICLE; CARBOXYPEPTIDASE E GENE; CCAAT ENHANCER BINDING PROTEIN ALPHA GENE; DNA POLYMORPHISM; EXOSTOSES 2 GENE; FEM 1 HOMOLOG A GENE; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GERANYLGERANYL DIPHOSPHATE SYNTHASE 1 GENE; GLUTATHIONE S TRANSFERASE KAPPA 1 GENE; GRAFT RECIPIENT; GROWTH RECEPTOR BOUND PROTEI 14 GENE; HEXOSE 6 PHOSPHATE DEHYDROGENASE GENE; HUMAN; KIDNEY TRANSPLANTATION; LEPTIN GENE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METHIONINE SULFOXIDE REDUCTASE A GENE; MITOCHONDRIAL CARRIER HOMOLOG 2 GENE; MOLECULAR PATHOLOGY; NEUROPEPTIDE Y RECEPTOR Y1 GENE; NEUROPEPTIDE Y RECEPTOR Y5 GENE; OBESITY; POLYMERASE 1 AND TRANSCRIPT RELEASE FACTOR GENE; PROSPECTIVE STUDY; PROTEIN PHOSPHATASE 1 REGULATORY 3C GENE; REPLICATION INITIATOR 1 GENE; SUBCUTANEOUS FAT; WEIGHT CHANGE; WEIGHT GAIN;

ADULT; AGED; CLUSTER ANALYSIS; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE ANNOTATION; OBESITY; PRINCIPAL COMPONENT ANALYSIS; TRANSCRIPTOME; WEIGHT GAIN; YOUNG ADULT;

EID: 84875480419     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059962     Document Type: Article

References (37)

1. Patel MG, (1998) The effect of dietary intervention on weight gains after renal transplantation. J Ren Nutr 8: 137-141.
2. Baum CL, (2001) Weight gain and cardiovascular risk after organ transplantation. JPEN J Parenter Enteral Nutr 25: 114-119.
3. van den Ham EC, Kooman JP, Christiaans MH, Nieman FH, van Hooff JP, (2003) Weight changes after renal transplantation: a comparison between patients on 5-mg maintenance steroid therapy and those on steroid-free immunosuppressive therapy. Transpl Int 16: 300-306.
4. Elster EA, Leeser DB, Morrissette C, Pepek JM, Quiko A, et al. (2008) Obesity following kidney transplantation and steroid avoidance immunosuppression. Clin Transplant 22: 354-359.
5. Cupples CK, Cashion AK, Cowan PA, Tutor RS, Wicks MN, et al. (2012) Characterizing dietary intake and physical activity affecting weight gain in kidney transplant recipients. Prog Transplant 22: 62-70.
6. Dolinkova M, Dostalova I, Lacinova Z, Michalsky D, Haluzikova D, et al. (2008) The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol Cell Endocrinol 291: 63-70.
7. Klimcakova E, Roussel B, Marquez-Quinones A, Kovacova Z, Kovacikova M, et al. (2011) Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. J Clin Endocrinol Metab 96: E73-82.
8. Dahlman I, Arner P, (2007) Obesity and polymorphisms in genes regulating human adipose tissue. Int J Obes (Lond) 31: 1629-1641.
9. Baglioni S, Cantini G, Poli G, Francalanci M, Squecco R, et al. (2012) Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cell. PLoS one 7: e36569.
10. Pratley RE, Ren K, Milner MR, Sell SM, (2000) Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans. Mol Genet Metab 70: 19-26.
11. Korsic M, Gotovac K, Nikolac M, Dusek T, Skegro M, et al. (2012) Gene expression in visceral and subcutaneous adipose tissue in overweight women. Front Biosci (Elite Ed) 4: 2834-2844.
12. Cheung CY, Tso AW, Cheung BM, Xu A, Ong KL, et al. (2010) Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population. J Clin Endocrinol Metab 95: 1395-1403.
13. Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, et al. (2009) Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr 90: 951-959.
14. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-948.
15. Cashion A, Sánchez Z, Cowan P, Hathaway D, Costello A, et al. (2007) Changes in weight during the first year after kidney transplantation. Prog Transplant 17: 40-47.
16. Clunk JM, Lin CY, Curtis JJ, (2001) Variables affecting weight gain in renal transplant recipients. Am J Kidney Dis 38: 349-353.
17. US Renal Data System (2007) USRDS 2007 Annual Data Report.
18. Kasiske BL, Snyder JJ, Gilbertson D, Matas AJ, (2003) Diabetes mellitus after kidney transplantation in the United States. American Journal of Transplantation 3: 178-185.
19. Rodriguez-Acebes S, Palacios N, Botella-Carretero JI, Olea N, Crespo L, et al. (2010) Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: distinct expression of cell-cycle- and differentiation-related genes. BMC Med Genomics 3: 61.
20. Ramis JM, Franssen-van Hal NL, Kramer E, Llado I, Bouillaud F, et al. (2002) Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects. Cell Mol Life Sci 59: 1960-1971.
21. Wardlaw SL, (2011) Hypothalamic proopiomelanocortin processing and the regulation of energy balance. Eur J Pharmacol 660: 213-219.
22. Cawley NX, Zhou J, Hill JM, Abebe D, Romboz S, et al. (2004) The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology 145: 5807-5819.
23. Zhang H, Li S, Wang M, Vukusic B, Pristupa ZB, et al. (2009) Regulation of dopamine transporter activity by carboxypeptidase E. Mol Brain 2: 10.
24. Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, et al. (2001) Brain dopamine and obesity. Lancet 357: 354-357.
25. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF, (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7: 1189-1192.
26. Kalra SP, (2008) Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition 24: 820-826.
27. Xu N, Nilsson-Ehle P, Ahren B, (2004) Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects. J Nutr Biochem 15: 579-582.
28. Luo G, Zhang X, Nilsson-Ehle P, Xu N, (2004) Apolipoprotein M. Lipids Health Dis 3: 21.
29. Ooi EM, Watts GF, Chan DC, Nielsen LB, Plomgaard P, et al. (2010) Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men. Atherosclerosis 210: 326-330.
30. Dullaart RP, Plomgaard P, de Vries R, Dahlback B, Nielsen LB, (2009) Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness. Clin Chim Acta 406: 129-133.
31. Cashion A, Umberger R, Goodwin S, Sutter T, (2011) Collection and storage of human blood and adipose for genomic analysis of clinical sample. Res Nurs Health 34: 408-418.
32. Mehta R, Birerdinc A, Hossain N, Afendy A, Chandhoke V, et al. (2010) Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples. BMC Mol Biol 11: 39.
33. Yuan JS, Wang D, Stewart CN Jr, (2008) Statistical methods for efficiency adjusted real-time PCR quantification. Biotechnol J 3: 112-123.
34. Storey JD, Tibshirani R, (2003) Statistical methods for identifying differentially expressed genes in DNA microarrays. Methods Mol Biol 224: 149-157.
35. Zhang B, Kirov S, Snoddy J, (2005) WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 33: W741-748.
36. Duncan D, Prodduturi N, Zhang B, (2010) WebGestalt2: An updated and expanded web-based gene set analysis toolkit. BMC Bioinformatics 11: P10.
37. Homayouni R, Heinrich K, Wei L, Berry MW, (2005) Gene clustering by latent semantic indexing of MEDLINE abstracts. Bioinformatics 21: 104-115.