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Volumn 8, Issue 3, 2013, Pages

JAK2 V617F Genotype Is a Strong Determinant of Blast Transformation in Primary Myelofibrosis

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; PHENYLALANINE; VALINE;

EID: 84875474755     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059791     Document Type: Article
Times cited : (16)

References (37)
  • 1
    • 84855656900 scopus 로고    scopus 로고
    • One thousand patients with primary myelofibrosis: the mayo clinic experience
    • Tefferi A, Lasho TL, Jimma T, Finke CM, Gangat N, et al. (2012) One thousand patients with primary myelofibrosis: the mayo clinic experience. Mayo Clin Proc 87: 25-33.
    • (2012) Mayo Clin Proc , vol.87 , pp. 25-33
    • Tefferi, A.1    Lasho, T.L.2    Jimma, T.3    Finke, C.M.4    Gangat, N.5
  • 2
    • 37049039725 scopus 로고    scopus 로고
    • JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
    • Barosi G, Bergamaschi G, Marchetti M, Vannucchi AM, Guglielmelli P, et al. (2007) JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood 110: 4030-4036.
    • (2007) Blood , vol.110 , pp. 4030-4036
    • Barosi, G.1    Bergamaschi, G.2    Marchetti, M.3    Vannucchi, A.M.4    Guglielmelli, P.5
  • 3
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • Cervantes F, Dupriez B, Pereira A, Passamonti F, Reilly JT, et al. (2009) New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood 113: 2895-2901.
    • (2009) Blood , vol.113 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3    Passamonti, F.4    Reilly, J.T.5
  • 4
    • 33344471678 scopus 로고    scopus 로고
    • V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
    • Campbell PJ, Griesshammer M, Döhner K, Döhner H, Kusec R, et al. (2006) V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood 107: 2098-2100.
    • (2006) Blood , vol.107 , pp. 2098-2100
    • Campbell, P.J.1    Griesshammer, M.2    Döhner, K.3    Döhner, H.4    Kusec, R.5
  • 5
    • 30844444135 scopus 로고    scopus 로고
    • The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates
    • Tefferi A, Lasho TL, Schwager SM, Steensma DP, Mesa RA, et al. (2005) The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates. Br J Haematol 131: 320-328.
    • (2005) Br J Haematol , vol.131 , pp. 320-328
    • Tefferi, A.1    Lasho, T.L.2    Schwager, S.M.3    Steensma, D.P.4    Mesa, R.A.5
  • 6
    • 77950994977 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms
    • Thoennissen NH, Krug UO, Lee DH, Kawamata N, Iwanski GB, et al. (2010) Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms. Blood115: 2882-2890.
    • (2010) Blood , vol.115 , pp. 2882-2890
    • Thoennissen, N.H.1    Krug, U.O.2    Lee, D.H.3    Kawamata, N.4    Iwanski, G.B.5
  • 7
    • 33746054198 scopus 로고    scopus 로고
    • JAK2(V617F) and leukemic transformation in myelofibrosis with myeloid metaplasia
    • Mesa RA, Powell H, Lasho T, Dewald G, McClure R, et al. (2006) JAK2(V617F) and leukemic transformation in myelofibrosis with myeloid metaplasia. Leuk Res 30: 1457-1460.
    • (2006) Leuk Res , vol.30 , pp. 1457-1460
    • Mesa, R.A.1    Powell, H.2    Lasho, T.3    Dewald, G.4    McClure, R.5
  • 8
    • 52649131772 scopus 로고    scopus 로고
    • The natural history and treatment outcome of blast phase BCR-ABL-myeloproliferative neoplasms
    • Tam CS, Nussenzveig RM, Popat U, Bueso-Ramos CE, Thomas DA, et al. (2008) The natural history and treatment outcome of blast phase BCR-ABL-myeloproliferative neoplasms. Blood 112: 1628-1637.
    • (2008) Blood , vol.112 , pp. 1628-1637
    • Tam, C.S.1    Nussenzveig, R.M.2    Popat, U.3    Bueso-Ramos, C.E.4    Thomas, D.A.5
  • 9
    • 79953208053 scopus 로고    scopus 로고
    • What is the role of JAK2(V617F) mutation in leukemic transformation of myeloproliferative neoplasms?
    • Lopes da Silva R, Ribeiro P, Lourenço A, Santos SC, Santos M, et al. (2011) What is the role of JAK2(V617F) mutation in leukemic transformation of myeloproliferative neoplasms? Lab Hematol 17: 12-16.
    • (2011) Lab Hematol , vol.17 , pp. 12-16
    • Lopes da Silva, R.1    Ribeiro, P.2    Lourenço, A.3    Santos, S.C.4    Santos, M.5
  • 10
    • 42449124578 scopus 로고    scopus 로고
    • Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival
    • Tefferi A, Lasho TL, Huang J, Finke C, Mesa RA, et al. (2008) Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. Leukemia 22: 756-761.
    • (2008) Leukemia , vol.22 , pp. 756-761
    • Tefferi, A.1    Lasho, T.L.2    Huang, J.3    Finke, C.4    Mesa, R.A.5
  • 11
    • 70349580685 scopus 로고    scopus 로고
    • Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele
    • Guglielmelli P, Barosi G, Specchia G, Rambaldi A, Lo Coco F, et al. (2009) Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele. Blood 114: 1477-1483.
    • (2009) Blood , vol.114 , pp. 1477-1483
    • Guglielmelli, P.1    Barosi, G.2    Specchia, G.3    Rambaldi, A.4    Lo Coco, F.5
  • 14
    • 84859972864 scopus 로고    scopus 로고
    • Evidence that Prefibrotic Myelofibrosis Is Aligned along a Clinical and Biological Continuum Featuring Primary Myelofibrosis
    • Barosi G, Rosti V, Bonetti E, Campanelli R, Carolei A, et al. (2012) Evidence that Prefibrotic Myelofibrosis Is Aligned along a Clinical and Biological Continuum Featuring Primary Myelofibrosis. PLoS One 7(4): e35631.
    • (2012) PLoS One , vol.7 , Issue.4
    • Barosi, G.1    Rosti, V.2    Bonetti, E.3    Campanelli, R.4    Carolei, A.5
  • 16
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, et al. (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365: 1054-1061.
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3    East, C.4    Fourouclas, N.5
  • 17
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes
    • Steensma DP, Dewald GW, Lasho TL, Powell HL, McClure RF, et al. (2005) The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes. Blood 106: 1207-1209.
    • (2005) Blood , vol.106 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3    Powell, H.L.4    McClure, R.F.5
  • 18
    • 33748684367 scopus 로고    scopus 로고
    • The JAK2-V617F mutation is frequently presentat diagnosis in patients with essential thrombocythemia and polycythemia vera
    • Lippert E, Boissinot M, Kralovics R, Girodon F, Dobo I, et al. (2006) The JAK2-V617F mutation is frequently presentat diagnosis in patients with essential thrombocythemia and polycythemia vera. Blood 108: 1865-1867.
    • (2006) Blood , vol.108 , pp. 1865-1867
    • Lippert, E.1    Boissinot, M.2    Kralovics, R.3    Girodon, F.4    Dobo, I.5
  • 19
    • 34248364065 scopus 로고    scopus 로고
    • Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT)
    • Mesa RA, Verstovsek S, Cervantes F, Barosi G, Reilly JT, et al. (2007) Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT). Leuk Res 31: 737-740.
    • (2007) Leuk Res , vol.31 , pp. 737-740
    • Mesa, R.A.1    Verstovsek, S.2    Cervantes, F.3    Barosi, G.4    Reilly, J.T.5
  • 20
    • 1542532754 scopus 로고    scopus 로고
    • A proportional hazards model for the subdistribution of a competing risk
    • Fine J P, Gray R J, (1999) A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 94: 496-509.
    • (1999) J Am Stat Assoc , vol.94 , pp. 496-509
    • Fine, J.P.1    Gray, R.J.2
  • 21
    • 77956439565 scopus 로고    scopus 로고
    • A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications
    • Passamonti F, Rumi E, Pietra D, Elena C, Boveri E, et al. (2010) A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications. Leukemia 24: 1574-1579.
    • (2010) Leukemia , vol.24 , pp. 1574-1579
    • Passamonti, F.1    Rumi, E.2    Pietra, D.3    Elena, C.4    Boveri, E.5
  • 22
    • 81355148731 scopus 로고    scopus 로고
    • Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm
    • Rumi E, Harutyunyan A, Elena C, Pietra D, Klampfl T, et al. (2011) Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm. Am J Hematol 86: 974-979.
    • (2011) Am J Hematol , vol.86 , pp. 974-979
    • Rumi, E.1    Harutyunyan, A.2    Elena, C.3    Pietra, D.4    Klampfl, T.5
  • 23
    • 79960124540 scopus 로고    scopus 로고
    • Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms
    • Anand S, Stedham F, Beer P, Gudgin E, Ortmann CA, et al. (2011) Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms. Blood 118: 177-181.
    • (2011) Blood , vol.118 , pp. 177-181
    • Anand, S.1    Stedham, F.2    Beer, P.3    Gudgin, E.4    Ortmann, C.A.5
  • 24
    • 51649087754 scopus 로고    scopus 로고
    • JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders
    • Plo I, Nakatake M, Malivert L, de Villartay JP, Giraudier S, et al. (2008) JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders. Blood 112: 1402-1412.
    • (2008) Blood , vol.112 , pp. 1402-1412
    • Plo, I.1    Nakatake, M.2    Malivert, L.3    de Villartay, J.P.4    Giraudier, S.5
  • 25
    • 58149089846 scopus 로고    scopus 로고
    • Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders
    • Zhao R, Follows GA, Beer PA, Scott LM, Huntly BJ, et al. (2008) Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders. N Engl J Med 359: 2778-2789.
    • (2008) N Engl J Med , vol.359 , pp. 2778-2789
    • Zhao, R.1    Follows, G.A.2    Beer, P.A.3    Scott, L.M.4    Huntly, B.J.5
  • 26
    • 70349975711 scopus 로고    scopus 로고
    • JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    • Dawson MA, Bannister AJ, Göttgens B, Foster SD, Bartke T, et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461: 819-822.
    • (2009) Nature , vol.461 , pp. 819-822
    • Dawson, M.A.1    Bannister, A.J.2    Göttgens, B.3    Foster, S.D.4    Bartke, T.5
  • 27
    • 84858008200 scopus 로고    scopus 로고
    • JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms
    • Nakatake M, Monte-Mor B, Debili N, Casadevall N, Ribrag V, et al. (2012) JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms. Oncogene 31: 1323-1333.
    • (2012) Oncogene , vol.31 , pp. 1323-1333
    • Nakatake, M.1    Monte-Mor, B.2    Debili, N.3    Casadevall, N.4    Ribrag, V.5
  • 28
    • 34347394712 scopus 로고    scopus 로고
    • Leukemic blasts in transformed JAK2-V617F positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation
    • Theocharides A, Boissinot M, Girodon F, Garand R, Teo SS, et al. (2007) Leukemic blasts in transformed JAK2-V617F positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood 110: 375-379.
    • (2007) Blood , vol.110 , pp. 375-379
    • Theocharides, A.1    Boissinot, M.2    Girodon, F.3    Garand, R.4    Teo, S.S.5
  • 29
    • 33749434271 scopus 로고    scopus 로고
    • Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation
    • Campbell PJ, Baxter EJ, Beer PA, Scott LM, Bench AJ, et al. (2006) Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation. Blood 108: 3548-3555.
    • (2006) Blood , vol.108 , pp. 3548-3555
    • Campbell, P.J.1    Baxter, E.J.2    Beer, P.A.3    Scott, L.M.4    Bench, A.J.5
  • 30
    • 77950977381 scopus 로고    scopus 로고
    • Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm
    • Beer PA, Delhommeau F, LeCouédic JP, Dawson MA, Chen E, et al. (2010) Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood 115: 2891-2900.
    • (2010) Blood , vol.115 , pp. 2891-2900
    • Beer, P.A.1    Delhommeau, F.2    LeCouédic, J.P.3    Dawson, M.A.4    Chen, E.5
  • 31
    • 83555166230 scopus 로고    scopus 로고
    • Primary myelofibrosis with or without mutant MPL: comparison of survival and clinical features involving 603 patients
    • Pardanani A, Guglielmelli P, Lasho TL, Pancrazzi A, Finke CM, et al. (2011) Primary myelofibrosis with or without mutant MPL: comparison of survival and clinical features involving 603 patients. Leukemia 25: 1834-1839.
    • (2011) Leukemia , vol.25 , pp. 1834-1839
    • Pardanani, A.1    Guglielmelli, P.2    Lasho, T.L.3    Pancrazzi, A.4    Finke, C.M.5
  • 33
    • 84870406696 scopus 로고    scopus 로고
    • Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myeloproliferative/myelodysplastic disorders: an analysis of 636 cases
    • Schnittger S, Bacher U, Alpermann T, Reiter A, Ulke M, et al. (2012) Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myeloproliferative/myelodysplastic disorders: an analysis of 636 cases. Haematologica Jun 24[Epub ahead of print].
    • (2012) Haematologica
    • Schnittger, S.1    Bacher, U.2    Alpermann, T.3    Reiter, A.4    Ulke, M.5
  • 34
    • 77958021645 scopus 로고    scopus 로고
    • LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
    • Pardanani A, Lasho T, Finke C, Oh ST, Gotlib J, et al. (2010) LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. Leukemia 24: 1713-1718.
    • (2010) Leukemia , vol.24 , pp. 1713-1718
    • Pardanani, A.1    Lasho, T.2    Finke, C.3    Oh, S.T.4    Gotlib, J.5
  • 35
    • 77954658823 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
    • Tefferi A, Lasho TL, Abdel-Wahab O, Guglielmelli P, Patel J, et al. (2010) IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia 24: 1302-1309.
    • (2010) Leukemia , vol.24 , pp. 1302-1309
    • Tefferi, A.1    Lasho, T.L.2    Abdel-Wahab, O.3    Guglielmelli, P.4    Patel, J.5
  • 36
    • 84858830394 scopus 로고    scopus 로고
    • Leukemia risk models in primary myelofibrosis: an International Working Group study
    • Tefferi A, Pardanani A, Gangat N, Begna KH, Hanson CA, et al. (2012) Leukemia risk models in primary myelofibrosis: an International Working Group study. Leukemia Jan 13[Epub ahead of print].
    • (2012) Leukemia
    • Tefferi, A.1    Pardanani, A.2    Gangat, N.3    Begna, K.H.4    Hanson, C.A.5
  • 37
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, et al. (2012) JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 366: 787-798.
    • (2012) N Engl J Med , vol.366 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3    Gisslinger, H.4    Waltzman, R.5


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