SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2306-2312

Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors

(10) Xie, Yunfeng a Chen, Xianjie b Qin, Jie c Kong, Xiangqian d Ye, Fei d Jiang, Yuren a Liu, Hong d Jiang, Hualiang b,d Marmorstein, Ronen c Luo, Cheng d

a CENTRAL SOUTH UNIVERSITY (China)

b NANJING UNIVERSITY (China)

c WISTAR INSTITUTE (United States)

d SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

Author keywords

Anticancer agents; BRAF; Kinase inhibitors; Virtual screening

Indexed keywords

ANTINEOPLASTIC AGENT; ARQ 736; B RAF KINASE INHIBITOR; CEP 32496; LGX 818; MITOGEN ACTIVATED PROTEIN KINASE; N (THIOPHEN 2 YL)BENZAMIDE DERIVATIVE; REBASTINIB; RG 7256; UNCLASSIFIED DRUG;

ARTICLE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; GENE MUTATION; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; MELANOMA; MOLECULAR DOCKING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

BENZAMIDES; CELL PROLIFERATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MODELS, MOLECULAR; PROTO-ONCOGENE PROTEINS B-RAF; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875457131 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.02.072 Document Type: Article

Times cited : (5)

References (30)

1
- 84859805869
- M. Okaniwa, M. Hirose, T. Imada, T. Ohashi, Y. Hayashi, T. Miyazaki, T. Arita, M. Yabuki, K. Kakoi, J. Kato, T. Takagi, T. Kawamoto, S. Yao, A. Sumita, S. Tsutsumi, T. Tottori, H. Oki, B.C. Sang, J. Yano, K. Aertgeerts, S. Yoshida, and T. Ishikawa J. Med. Chem. 55 2012 3452
- (2012) J. Med. Chem. , vol.55 , pp. 3452
- Okaniwa, M.¹ Hirose, M.² Imada, T.³ Ohashi, T.⁴ Hayashi, Y.⁵ Miyazaki, T.⁶ Arita, T.⁷ Yabuki, M.⁸ Kakoi, K.⁹ Kato, J.¹⁰ Takagi, T.¹¹ Kawamoto, T.¹² Yao, S.¹³ Sumita, A.¹⁴ Tsutsumi, S.¹⁵ Tottori, T.¹⁶ Oki, H.¹⁷ Sang, B.C.¹⁸ Yano, J.¹⁹ Aertgeerts, K.²⁰ Yoshida, S.²¹ Ishikawa, T.²² more..

2
- 84872844536
- T. Gui, Y. Sun, A. Shimokado, and Y. Muragaki J. Signal Transduct. 2012 2012 289243
- (2012) J. Signal Transduct. , vol.2012 , pp. 289243
- Gui, T.¹ Sun, Y.² Shimokado, A.³ Muragaki, Y.⁴

3
- 0030898417
- M.J. Robinson, and M.H. Cobb Curr. Opin. Cell Biol. 9 1997 180
- (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 180
- Robinson, M.J.¹ Cobb, M.H.²

4
- 84894510577
- H. Park, Y. Jeong, and S. Hong Bioorg. Med. Chem. Lett. 1027 2012 22
- (2012) Bioorg. Med. Chem. Lett. , vol.1027 , pp. 22
- Park, H.¹ Jeong, Y.² Hong, S.³

5
- 77955355464
- A. Zambon, D. Menard, B.M. Suijkerbuijk, I. Niculescu-Duvaz, S. Whittaker, D. Niculescu-Duvaz, A. Nourry, L. Davies, H.A. Manne, F. Lopes, N. Preece, D. Hedley, L.M. Ogilvie, R. Kirk, R. Marais, and C.J. Springer J. Med. Chem. 53 2010 5639
- (2010) J. Med. Chem. , vol.53 , pp. 5639
- Zambon, A.¹ Menard, D.² Suijkerbuijk, B.M.³ Niculescu-Duvaz, I.⁴ Whittaker, S.⁵ Niculescu-Duvaz, D.⁶ Nourry, A.⁷ Davies, L.⁸ Manne, H.A.⁹ Lopes, F.¹⁰ Preece, N.¹¹ Hedley, D.¹² Ogilvie, L.M.¹³ Kirk, R.¹⁴ Marais, R.¹⁵ Springer, C.J.¹⁶

6
- 53549110555
- C. Luo, P. Xie, and R. Marmorstein J. Med. Chem. 51 2008 6121
- (2008) J. Med. Chem. , vol.51 , pp. 6121
- Luo, C.¹ Xie, P.² Marmorstein, R.³

7
- 84855648341
- A. Zambon, I. Niculescu-Duvaz, D. Niculescu-Duvaz, R. Marais, and C.J. Springer Bioorg. Med. Chem. Lett. 22 2012 789
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 789
- Zambon, A.¹ Niculescu-Duvaz, I.² Niculescu-Duvaz, D.³ Marais, R.⁴ Springer, C.J.⁵

8
- 79953312648
- C. Nucera, J. Lawler, and S. Parangi Cancer Res. 71 2011 2417
- (2011) Cancer Res. , vol.71 , pp. 2417
- Nucera, C.¹ Lawler, J.² Parangi, S.³

9
- 84859807701
- D.S. Hong, L. Vence, G. Falchook, L.G. Radvanyi, C. Liu, V. Goodman, J.J. Legos, S. Blackman, A. Scarmadio, R. Kurzrock, G. Lizee, and P. Hwu Clin. Cancer Res. 18 2012 2326
- (2012) Clin. Cancer Res. , vol.18 , pp. 2326
- Hong, D.S.¹ Vence, L.² Falchook, G.³ Radvanyi, L.G.⁴ Liu, C.⁵ Goodman, V.⁶ Legos, J.J.⁷ Blackman, S.⁸ Scarmadio, A.⁹ Kurzrock, R.¹⁰ Lizee, G.¹¹ Hwu, P.¹²

10
- 84863115580
- F. Su, W.D. Bradley, Q. Wang, H. Yang, L. Xu, B. Higgins, K. Kolinsky, K. Packman, M.J. Kim, K. Trunzer, R.J. Lee, K. Schostack, J. Carter, T. Albert, S. Germer, J. Rosinski, M. Martin, M.E. Simcox, B. Lestini, D. Heimbrook, and G. Bollag Cancer Res. 72 2012 969
- (2012) Cancer Res. , vol.72 , pp. 969
- Su, F.¹ Bradley, W.D.² Wang, Q.³ Yang, H.⁴ Xu, L.⁵ Higgins, B.⁶ Kolinsky, K.⁷ Packman, K.⁸ Kim, M.J.⁹ Trunzer, K.¹⁰ Lee, R.J.¹¹ Schostack, K.¹² Carter, J.¹³ Albert, T.¹⁴ Germer, S.¹⁵ Rosinski, J.¹⁶ Martin, M.¹⁷ Simcox, M.E.¹⁸ Lestini, B.¹⁹ Heimbrook, D.²⁰ Bollag, G.²¹ more..

11
- 80051931318
- M.W. Holladay, B.T. Campbell, M.W. Rowbottom, Q. Chao, K.G. Sprankle, A.G. Lai, S. Abraham, E. Setti, R. Faraoni, L. Tran, R.C. Armstrong, R.N. Gunawardane, M.F. Gardner, M.D. Cramer, D. Gitnick, M.A. Ator, B.D. Dorsey, B.R. Ruggeri, M. Williams, S.S. Bhagwat, and J. James Bioorg. Med. Chem. Lett. 21 2011 5342
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5342
- Holladay, M.W.¹ Campbell, B.T.² Rowbottom, M.W.³ Chao, Q.⁴ Sprankle, K.G.⁵ Lai, A.G.⁶ Abraham, S.⁷ Setti, E.⁸ Faraoni, R.⁹ Tran, L.¹⁰ Armstrong, R.C.¹¹ Gunawardane, R.N.¹² Gardner, M.F.¹³ Cramer, M.D.¹⁴ Gitnick, D.¹⁵ Ator, M.A.¹⁶ Dorsey, B.D.¹⁷ Ruggeri, B.R.¹⁸ Williams, M.¹⁹ Bhagwat, S.S.²⁰ James, J.²¹ more..

12
- 84859471412
- R. Kudchadkar, K.H. Paraiso, and K.S. Smalley Cancer J. 18 2012 124
- (2012) Cancer J. , vol.18 , pp. 124
- Kudchadkar, R.¹ Paraiso, K.H.² Smalley, K.S.³

13
- 84873725962
- A. Nourry, A. Zambon, L. Davies, I. Niculescu-Duvaz, H.P. Dijkstra, D. Menard, C. Gaulon, D. Niculescu-Duvaz, B.M. Suijkerbuijk, F. Friedlos, H.A. Manne, R. Kirk, S. Whittaker, R. Marais, and C.J. Springer J. Med. Chem. 2010 1964 53
- (1964) J. Med. Chem. , vol.2010 , pp. 53
- Nourry, A.¹ Zambon, A.² Davies, L.³ Niculescu-Duvaz, I.⁴ Dijkstra, H.P.⁵ Menard, D.⁶ Gaulon, C.⁷ Niculescu-Duvaz, D.⁸ Suijkerbuijk, B.M.⁹ Friedlos, F.¹⁰ Manne, H.A.¹¹ Kirk, R.¹² Whittaker, S.¹³ Marais, R.¹⁴ Springer, C.J.¹⁵

14
- 42949149240
- J. Tsai, J.T. Lee, W. Wang, J. Zhang, H. Cho, S. Mamo, R. Bremer, S. Gillette, J. Kong, N.K. Haass, K. Sproesser, L. Li, K.S. Smalley, D. Fong, Y.L. Zhu, A. Marimuthu, H. Nguyen, B. Lam, J. Liu, I. Cheung, J. Rice, Y. Suzuki, C. Luu, C. Settachatgul, R. Shellooe, J. Cantwell, S.H. Kim, J. Schlessinger, K.Y. Zhang, B.L. West, B. Powell, G. Habets, C. Zhang, P.N. Ibrahim, P. Hirth, D.R. Artis, M. Herlyn, and G. Bollag Proc. Natl. Acad. Sci. U.S.A. 105 2008 3041
- (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 3041
- Tsai, J.¹ Lee, J.T.² Wang, W.³ Zhang, J.⁴ Cho, H.⁵ Mamo, S.⁶ Bremer, R.⁷ Gillette, S.⁸ Kong, J.⁹ Haass, N.K.¹⁰ Sproesser, K.¹¹ Li, L.¹² Smalley, K.S.¹³ Fong, D.¹⁴ Zhu, Y.L.¹⁵ Marimuthu, A.¹⁶ Nguyen, H.¹⁷ Lam, B.¹⁸ Liu, J.¹⁹ Cheung, I.²⁰ more..

15
- 84875471175
- 07-13
- Thomson Pharma, 2012-07-13.
- (2012) Thomson Pharma

16
- 84859183431
- H. Shi, G. Moriceau, X. Kong, M.K. Lee, H. Lee, R.C. Koya, C. Ng, T. Chodon, R.A. Scolyer, K.B. Dahlman, J.A. Sosman, R.F. Kefford, G.V. Long, S.F. Nelson, A. Ribas, and R.S. Lo Nat. Commun. 3 2012 724
- (2012) Nat. Commun. , vol.3 , pp. 724
- Shi, H.¹ Moriceau, G.² Kong, X.³ Lee, M.K.⁴ Lee, H.⁵ Koya, R.C.⁶ Ng, C.⁷ Chodon, T.⁸ Scolyer, R.A.⁹ Dahlman, K.B.¹⁰ Sosman, J.A.¹¹ Kefford, R.F.¹² Long, G.V.¹³ Nelson, S.F.¹⁴ Ribas, A.¹⁵ Lo, R.S.¹⁶

17
- 84866307676
- K.H. Paraiso, and K.S. Smalley Cancer Discovery 2 2012 390
- (2012) Cancer Discovery , vol.2 , pp. 390
- Paraiso, K.H.¹ Smalley, K.S.²

18
- 77954373338
- A. Boni, A.P. Cogdill, P. Dang, D. Udayakumar, C.N. Njauw, C.M. Sloss, C.R. Ferrone, K.T. Flaherty, D.P. Lawrence, D.E. Fisher, H. Tsao, and J.A. Wargo Cancer Res. 70 2010 5213
- (2010) Cancer Res. , vol.70 , pp. 5213
- Boni, A.¹ Cogdill, A.P.² Dang, P.³ Udayakumar, D.⁴ Njauw, C.N.⁵ Sloss, C.M.⁶ Ferrone, C.R.⁷ Flaherty, K.T.⁸ Lawrence, D.P.⁹ Fisher, D.E.¹⁰ Tsao, H.¹¹ Wargo, J.A.¹²

19
- 80052604878
- H. Park, H. Choi, and S. Hong Bioorg. Med. Chem. Lett. 21 2011 5753
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5753
- Park, H.¹ Choi, H.² Hong, S.³

20
- 77952716960
- A. Nicholls, G.B. McGaughey, R.P. Sheridan, A.C. Good, G. Warren, M. Mathieu, S.W. Muchmore, S.P. Brown, J.A. Grant, J.A. Haigh, N. Nevins, A.N. Jain, and B. Kelley J. Med. Chem. 53 2010 3862
- (2010) J. Med. Chem. , vol.53 , pp. 3862
- Nicholls, A.¹ McGaughey, G.B.² Sheridan, R.P.³ Good, A.C.⁴ Warren, G.⁵ Mathieu, M.⁶ Muchmore, S.W.⁷ Brown, S.P.⁸ Grant, J.A.⁹ Haigh, J.A.¹⁰ Nevins, N.¹¹ Jain, A.N.¹² Kelley, B.¹³

21
- 84865112323
- Z. Xu, G. Yan, G. Wang, B. Li, J. Zhu, P. Sun, X. Zhang, C. Luo, H. Wang, and W. Zhu Bioorg. Med. Chem. Lett. 22 2012 5428
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 5428
- Xu, Z.¹ Yan, G.² Wang, G.³ Li, B.⁴ Zhu, J.⁵ Sun, P.⁶ Zhang, X.⁷ Luo, C.⁸ Wang, H.⁹ Zhu, W.¹⁰

22
- 84865435981
- X. Kong, J. Qin, Z. Li, A. Vultur, L. Tong, E. Feng, G. Rajan, S. Liu, J. Lu, Z. Liang, M. Zheng, W. Zhu, H. Jiang, M. Herlyn, H. Liu, R. Marmorstein, and C. Luo Org. Biomol. Chem. 10 2012 7402
- (2012) Org. Biomol. Chem. , vol.10 , pp. 7402
- Kong, X.¹ Qin, J.² Li, Z.³ Vultur, A.⁴ Tong, L.⁵ Feng, E.⁶ Rajan, G.⁷ Liu, S.⁸ Lu, J.⁹ Liang, Z.¹⁰ Zheng, M.¹¹ Zhu, W.¹² Jiang, H.¹³ Herlyn, M.¹⁴ Liu, H.¹⁵ Marmorstein, R.¹⁶ Luo, C.¹⁷

23
- 82355160719
- J. Caballero, J.H. Alzate-Morales, and A. Vergara-Jaque J. Chem. Inf. Model. 51 2011 2920
- (2011) J. Chem. Inf. Model. , vol.51 , pp. 2920
- Caballero, J.¹ Alzate-Morales, J.H.² Vergara-Jaque, A.³

24
- 13244266921
- C.A. Lipinski Drug Discovery Today 1 2004 337
- (2004) Drug Discovery Today , vol.1 , pp. 337
- Lipinski, C.A.¹

25
- 77956513286
- G. Bollag, P. Hirth, J. Tsai, J. Zhang, P.N. Ibrahim, H. Cho, W. Spevak, C. Zhang, Y. Zhang, G. Habets, E.A. Burton, B. Wong, G. Tsang, B.L. West, B. Powell, R. Shellooe, A. Marimuthu, H. Nguyen, K.Y. Zhang, D.R. Artis, J. Schlessinger, F. Su, B. Higgins, R. Iyer, K. D'Andrea, A. Koehler, M. Stumm, P.S. Lin, R.J. Lee, J. Grippo, I. Puzanov, K.B. Kim, A. Ribas, G.A. McArthur, J.A. Sosman, P.B. Chapman, K.T. Flaherty, X. Xu, K.L. Nathanson, and K. Nolop Nature 467 2010 596
- (2010) Nature , vol.467 , pp. 596
- Bollag, G.¹ Hirth, P.² Tsai, J.³ Zhang, J.⁴ Ibrahim, P.N.⁵ Cho, H.⁶ Spevak, W.⁷ Zhang, C.⁸ Zhang, Y.⁹ Habets, G.¹⁰ Burton, E.A.¹¹ Wong, B.¹² Tsang, G.¹³ West, B.L.¹⁴ Powell, B.¹⁵ Shellooe, R.¹⁶ Marimuthu, A.¹⁷ Nguyen, H.¹⁸ Zhang, K.Y.¹⁹ Artis, D.R.²⁰ more..

26
- 84875462351
- Glide New York, NY
- Glide, version 5.5, Schrödinger, LLC., New York, NY, 2009.
- (2009) Version 5.5, Schrödinger, LLC.

27
- 77955423078
- M.O. Duffey, R. Adams, C. Blackburn, R.W. Chau, S. Chen, K.M. Galvin, K. Garcia, A.E. Gould, P.D. Greenspan, S. Harrison, S.C. Huang, M.S. Kim, B. Kulkarni, S. Langston, J.X. Liu, L.T. Ma, S. Menon, M. Nagayoshi, R.S. Rowland, T.J. Vos, T. Xu, J.J. Yang, S. Yu, and Q. Zhang Bioorg. Med. Chem. Lett. 20 2010 4800
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4800
- Duffey, M.O.¹ Adams, R.² Blackburn, C.³ Chau, R.W.⁴ Chen, S.⁵ Galvin, K.M.⁶ Garcia, K.⁷ Gould, A.E.⁸ Greenspan, P.D.⁹ Harrison, S.¹⁰ Huang, S.C.¹¹ Kim, M.S.¹² Kulkarni, B.¹³ Langston, S.¹⁴ Liu, J.X.¹⁵ Ma, L.T.¹⁶ Menon, S.¹⁷ Nagayoshi, M.¹⁸ Rowland, R.S.¹⁹ Vos, T.J.²⁰ more..

28
- 79960360055
- J.C. Stellwagen, G.M. Adjabeng, M.R. Arnone, S.H. Dickerson, C. Han, K.R. Hornberger, A.J. King, R.A. Mook Jr., K.G. Petrov, T.R. Rheault, C.M. Rominger, O.W. Rossanese, K.N. Smitheman, A.G. Waterson, and D.E. Uehling Bioorg. Med. Chem. Lett. 21 2011 4436
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 4436
- Stellwagen, J.C.¹ Adjabeng, G.M.² Arnone, M.R.³ Dickerson, S.H.⁴ Han, C.⁵ Hornberger, K.R.⁶ King, A.J.⁷ Mook, Jr.R.A.⁸ Petrov, K.G.⁹ Rheault, T.R.¹⁰ Rominger, C.M.¹¹ Rossanese, O.W.¹² Smitheman, K.N.¹³ Waterson, A.G.¹⁴ Uehling, D.E.¹⁵

29
- 78149247725
- X. Wang, D.M. Berger, E.J. Salaski, N. Torres, M. Dutia, C. Hanna, Y. Hu, J.I. Levin, D. Powell, D. Wojciechowicz, K. Collins, E. Frommer, and J. Lucas J. Med. Chem. 53 2010 7874
- (2010) J. Med. Chem. , vol.53 , pp. 7874
- Wang, X.¹ Berger, D.M.² Salaski, E.J.³ Torres, N.⁴ Dutia, M.⁵ Hanna, C.⁶ Hu, Y.⁷ Levin, J.I.⁸ Powell, D.⁹ Wojciechowicz, D.¹⁰ Collins, K.¹¹ Frommer, E.¹² Lucas, J.¹³

30
- 84863217361
- R.A. Smith, J. Dumas, L. Adnane, and S.M. Wilhelm Curr. Top. Med. Chem. 1071 2006 6
- (2006) Curr. Top. Med. Chem. , vol.1071 , pp. 6
- Smith, R.A.¹ Dumas, J.² Adnane, L.³ Wilhelm, S.M.⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.