Ion channels and transporters in cancer: Pathophysiology, regulation, and clinical potential

Cancer Research

Volumn 73, Issue 6, 2013, Pages 1658-1661

  Pedersen, Stine Falsig ^a   Stock, Christian ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ASTEMIZOLE; BETA INTEGRIN; BICARBONATE; BIOLOGICAL MARKER; CARBONATE DEHYDRATASE IX; CARRIER PROTEIN; CATHEPSIN; CHLORIDE CHANNEL; CLC3 CHANNEL; GIRENTUXIMAB; GROWTH FACTOR RECEPTOR; HYPOXIA ACTIVATED PRODRUG; ION CHANNEL AND TRANSPORTER; LACTIC ACID; PHENYTOIN; PHOSPHOTRANSFERASE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV10.1; PURINERGIC P2X7 RECEPTOR; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.7; SODIUM PROTON EXCHANGE PROTEIN 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR 6; VASCULOTROPIN A;

ACID SECRETION; ALKALINITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; CALCIUM CELL LEVEL; CANCER CELL; CANCER GROWTH; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RESISTANCE; CANCER SURVIVAL; CARCINOGENESIS; CELL ADHESION; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL DIVISION; CELL HYPOXIA; CELL INTERACTION; CELL INVASION; CELL METABOLISM; CELL MIGRATION; CELL MOTILITY; CELL NUCLEUS; CELL PH; CHLORIDE TRANSPORT; CHROMATIN STRUCTURE; COLORECTAL CANCER; CONFERENCE PAPER; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME ACTIVITY; EVIDENCE BASED MEDICINE; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GLIOMA CELL; HUMAN; IN VIVO STUDY; ION CURRENT; ION TRANSPORT; KIDNEY CARCINOMA; MELANOMA; METASTASIS; NEAR INFRARED SPECTROSCOPY; NEOPLASM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TARGETING; PROTON TRANSPORT; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; TUMOR VOLUME;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; HUMANS; ION CHANNELS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS;

EID: 84875446405     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-4188     Document Type: Conference Paper

References (11)

1. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
2. Hoffmann EK, Lambert IH, Pedersen SF. Physiology of cell volume regulation in vertebrates. Physiol Rev 2009;89:193-277.
3. Habela CW, Sontheimer H. Cytoplasmic volume condensation is an integral part of mitosis. Cell Cycle 2007;6:1613-20.
4. Watkins S, Sontheimer H. Unique biology of gliomas: challenges and opportunities. Trends Neurosci 2012;35:546-56.
5. Pardo LA, Gomez-Varela D, Major F, Sansuk K, Leurs R, Downie BR, et al. Approaches targeting K(V)10.1 open a novel window for cancer diagnosis and therapy. Curr Med Chem 2012;19: 675-82.
6. Kohl T, Lorinczi E, Pardo LA, Stuhmer W. Rapid internalization of the oncogenic K+ channel K(V)10.1. PLoS ONE 2011;6:e26329.
7. Bortner CD, Cidlowski JA. Cell shrinkage and monovalent cation fluxes: role in apoptosis. Arch Biochem Biophys 2007;462:176-88.
8. Schwab A, Fabian A, Hanley PJ, Stock C. Role of ion channels and transporters in cell migration. Physiol Rev 2012;92:1865-913.
9. Alexander S, Friedl P. Cancer invasion and resistance: interconnected processes of disease progression and therapy failure. Trends Mol Med 2012;18:13-26.
10. Xu R, Boudreau A, Bissell MJ. Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev 2009;28:167-76.
11. Boedtkjer E, Moreira JM, Mele M, Vahl P, Wielenga VT, Christiansen PM, et al. Contribution of Na+, HCO3-cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7). Int J Cancer 2013;132:1288-99.