Enhancing the osteogenic efficacy of human bone marrow aspirate: Concentrating osteoprogenitors using wave-assisted filtration

Cytotherapy

Volumn 15, Issue 2, 2013, Pages 242-252

  Dawson, Jonathan I ^a   Smith, James O ^a,b   Aarvold, Alexander ^a,b   Ridgway, Jonathan N ^c   Curran, Steven J ^c   Dunlop, Douglas G ^a,b   Oreffo, Richard O C ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c Smith and Nephew Research Centre   (United Kingdom)

Author keywords

Bone marrow aspirate; Bone marrow stem cells; Bone regeneration; Colony forming unit fibroblastoid; Mesenchymal stem cells; Osteoprogenitors; Tissue engineering

Indexed keywords

ADIPOGENESIS; ADULT; AGED; ARTICLE; BONE DEVELOPMENT; BONE GRAFT; BONE MARROW BIOPSY; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL LINEAGE; CHONDROGENESIS; CLINICAL ARTICLE; COHORT ANALYSIS; COLONY FORMING UNIT F; CONCENTRATION (PARAMETERS); ERYTHROCYTE; FEMALE; FLOW CYTOMETRY; FRACTURE HEALING; HEALING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; OSTEOCYTE; PLASMA VOLUME; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; TISSUE ENGINEERING;

EID: 84875439394     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2012.09.004     Document Type: Article

References (53)

1. Dawson JI, Oreffo ROC. Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering. Arch Biochem Biophys. 2008;473:124-31.
2. Stock UA, Vacanti JP. Tissue engineering: current state and prospects. Annu Rev Med. 2001;52:443-51.
3. Smith JO, Aarvold A, Tayton ER, Dunlop DG, Oreffo ROC. Skeletal tissue regeneration: current approaches, challenges, and novel reconstructive strategies for an aging population. Tissue Eng Part B Rev. 2011;17:307-20.
4. Block MS, Baughman DG. Reconstruction of severe anterior maxillary defects using distraction osteogenesis, bone grafts, and implants. J Oral Maxillofac Surg. 2005;63:291-7.
5. Nade S, Burwell RG. Decalcified bone as a substrate for osteogenesis: an appraisal of the interrelation of bone and marrow in combined grafts. J Bone Joint Surg Br. 1977; 59:189-96.
6. Badiavas EV, Falanga V. Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol. 2003;139:510-6.
7. Docquier P, Delloye C. Treatment of aneurysmal bone cysts by introduction of demineralized bone and autogenous bone marrow. J Bone Joint Surg Am. 2005;87:2253-8.
8. Rougraff B, Kling T. Treatment of active unicameral bone cysts with percutaneous injection of demineralized bone matrix and autogenous bone marrow. J Bone Joint Surg Am. 2002;84:921-9.
9. Warnke P, Springer I, Wiltfang J, Acil Y, Eufinger H, Wehmöller M, et al. Growth and transplantation of a custom vascularised bone graft in a man. Lancet. 2004;364:766-70.
10. Connolly J, Guse R, Tiedeman J, Dehne R. Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop. 1991:259-70.
11. Tilley S, Bolland BJRF, Partridge K, New AMR, Latham JM, Dunlop DG, et al. Taking tissue-engineering principles into theater: augmentation of impacted allograft with human bone marrow stromal cells. Regen Med. 2006;1:685-92.
12. Aarvold A, Smith JO, Tayton ER, Tilley S, Dawson JI, Lanham SA, et al. Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case. Regen Med. 2011;6:461-7.
13. Bruder SP, Fox BS. Tissue engineering of bone: cell based strategies. Clin Orthop. 1999;367:S68-83.
14. Muschler GF, Midura RJ. Connective tissue progenitors: practical concepts for clinical applications. Clin Orthop. 2002; 395:66-80.
15. Muschler G, Boehm C, Easley K. Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am. 1997; 79:1699-709.
16. Muschler GF, Nitto H, Boehm CA, Easley KA. Age and gender related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors. J Orthop Res. 2001;19:117-25.
17. Nöth U, Osyczka AM, Tuli R, Hickok NJ, Danielson KG, Tuan RS. Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J Orthop Res. 2002; 20:1060-9.
18. Tuli R, Tuli S, Nandi S, Wang ML, Alexander PG, Haleem- Smith H, et al. Characterization of multipotential mesenchymal progenitor cells derived from human trabecular bone. Stem Cells. 2003;21:681-93.
19. Hernigou P, Poignard A, Manicom O, Mathieu G, Rouard H. The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone. J Bone Joint Surg Br. 2005;87:896-902.
20. Jäger M, Herten M, Fochtmann U, Fischer J, Hernigou P, Zilkens C, et al. Bridging the gap: bone marrow aspiration concentrate reduces autologous bone grafting in osseous defects. J Orthop Res. 2011;29:173-80.
21. Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med. 2001;344:385-6.
22. Connolly JF, Guse R, Lippiello L, Dehne R. Development of an osteogenic bone-marrow preparation. J Bone Joint Surg Am. 1989;71:684-91.
23. Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions: influence of the number and concentration of progenitor cells. J Bone Joint Surg Am. 2005;87:1430-7.
24. Ridgway J, Butcher A, Chen PS, Horner A, Curran S. Novel technology to provide an enriched therapeutic cell concentrate from bone marrow aspirate. Biotechnol Prog. 2010;26: 1741-8.
25. Bianco P, Kuznetsov SA, Riminucci M. Gehron Robey P. Postnatal skeletal stem cells. Methods Enzymol. 2006;419: 117-48.
26. Smith J, Sengers B, Aarvold A, Tayton E, Dunlop D, Oreffo R. Tantalum trabecular metal - addition of human skeletal cells to enhance bone implant interface strength and clinical application [published online ahead of print June 4, 2012]. J Tissue Eng Regen Med.
27. Cox G, Boxall SA, Giannoudis PV, Buckley CT, Roshdy T, Churchman SM, et al. High abundance of CD271 multipotential stromal cells (MSCs) in intramedullary cavities of long bones. Bone. 2012;50:510-7.
28. Horn P, Bork S, Diehlmann A,Walenda T, Eckstein V, Ho A, et al. Isolation of human mesenchymal stromal cells is more efficient by red blood cell lysis. Cytotherapy. 2008;10: 676-85.
29. Cuthbert R, Boxall SA, Tan HB, Giannoudis PV, McGonagle D, Jones E. Single-platform quality control assay to quantify multipotential stromal cells in bone marrow aspirates prior to bulk manufacture or direct therapeutic use. Cytotherapy. 2012;14:431-40.
30. Stolzing A, Jones E, McGonagle D, Scutt A. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev. 2008;129:163-73.
31. D'Ippolito G, Schiller PC, Ricordi C, Roos BA, Howard GA. Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Miner Res. 1999;14:1115-22.
32. Stenderup K, Justesen J, Eriksen EF, Rattan SIS, Kassem M. Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis. J Bone Miner Res. 2001;16:1120-9.
33. Oreffo R, Bord S, Triffitt JT. Skeletal progenitor cells and ageing human populations. Clin Sci. 1998;94:549-55.
34. Hernigou P, Poignard A, Zilber S, Rouard H. Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Indian J Orthop. 2009;43:40-5.
35. Pittenger MF,Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-7.
36. Mackay AM, Beck SC, Murphy JM, Barry FP, Chichester CO, Pittenger MF. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. 1998;4:415-28.
37. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 1998;238:265-72.
38. JaiswalN, Haynesworth SE, Caplan AI, Bruder SP. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem. 1997;64:295-312.
39. McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 2004;6:483-95.
40. Lu H, Guo L, Wozniak MJ, Kawazoe N, Tateishi T, Zhang X, et al. Effect of cell density on adipogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2009;381:322-7.
41. Holy CE, Shoichet MS, Davies JE. Engineering threedimensional bone tissue in vitro using biodegradable scaffolds: investigating initial cell-seeding density and culture period. J Biomed Mater Res. 2000;51:376-82.
42. Lode A, Bernhardt A, Gelinsky M. Cultivation of human bone marrow stromal cells on three-dimensional scaffolds of mineralized collagen: influence of seeding density on colonization, proliferation and osteogenic differentiation. J Tissue Eng Regen Med. 2008;2:400-7.
43. Bolland BJRF, Partridge K, Tilley S, New AMR, Dunlop DG, Oreffo ROC. Biological and mechanical enhancement of impacted allograft seeded with human bone marrow stromal cells: potential clinical role in impaction bone grafting. Regen Med. 2006;1:457-67.
44. Sengers BG, Dawson JI, Oreffo ROC. Characterisation of human bone marrow stromal cell heterogeneity for skeletal regeneration strategies using a two-stage colony assay and computational modelling. Bone. 2010;46:496-503.
45. Phinney D, Donald G. Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy. J Cell Biochem. 2012;113:2806-12.
46. Anna V, Mandeep V, Frank P, Elise F, Jay R. Mesenchymal stem cell concentration and bone repair: potential pitfalls from bench to bedside. J Bone Joint Surg Am. 2009;91: 1073-83.
47. Jayakumar P, Di Silvio L. Osteoblasts in bone tissue engineering. Proc Inst Mech Eng H. 2010;224:1415-40.
48. Kasten P, Vogel J, Beyen I, Weiss S, Niemeyer P, Leo A, et al. Effect of platelet-rich plasma on the in vitro proliferation and osteogenic differentiation of human mesenchymal stem cells on distinct calcium phosphate scaffolds: the specific surface area makes a difference. J Biomat Appl. 2008;23:169-88.
49. Nishimoto S, Oyama T, Matsuda K. Simultaneous concentration of platelets and marrow cells: a simple and useful technique to obtain source cells and growth factors for regenerative medicine. Wound Repair Regen. 2007;15: 156-62.
50. Connolly J, Guse R, Lippiello L, Dehne R. Development of an osteogenic bone-marrow preparation. J Bone Joint Surg Am. 1989;71:684-91.
51. Block JE. The role and effectiveness of bone marrow in osseous regeneration. Med Hypotheses. 2005;65:740-7.
52. Centeno CJ, Kisiday J, Freeman M, Schultz Jr A. Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: a case study. Pain Physician. 2006;9: 253-6.
53. Kohlman-Trigoboff D, Lawson JH, Murphy MP. Stem cell use in a patient with an ischemic foot ulcer: a case study. J Vasc Nurs. 2006;24:56-61.