The role and effectiveness of bone marrow in osseous regeneration

Medical Hypotheses

Volumn 65, Issue 4, 2005, Pages 740-747

  Block, Jon E ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE CELL; BONE DEFECT; BONE GRAFT; BONE MARROW; BONE MARROW CELL; BONE MATRIX; BONE REGENERATION; BONE TRANSPLANTATION; CELL ACTIVITY; CELL CULTURE; CENTRIFUGATION; CERAMICS; EXPERIMENTAL MODEL; FRACTURE HEALING; HUMAN; LONG BONE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; SPINE FUSION; STEM CELL; SURGICAL TECHNIQUE; XENOGRAFT;

ANIMALS; BONE MARROW; BONE REGENERATION; BONE TRANSPLANTATION; HUMANS; MESENCHYMAL STEM CELLS;

EID: 22544476224     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.04.026     Document Type: Article

References (112)

1. S.P. Bruder, and B.S. Fox Tissue engineering of bone. Cell based strategies Clin Orthop 367 1999 S68-83
2. R.O. Oreffo, and J.T. Triffitt Future potentials for using osteogenic stem cells and biomaterials in orthopedics Bone 25 1999 5S 9S
3. J.E. Fleming Jr., C.N. Cornell, and G.F. Muschler Bone cells and matrices in orthopedic tissue engineering Orthop Clin North Am 31 2000 357 374
4. G.F. Muschler, and R.J. Midura Connective tissue progenitors: practical concepts for clinical applications Clin Orthop 395 2002 66 80
5. R.G. Burwell Studies in the transplantation of bone. 7. The fresh composite homograft-autograft of cancelloue bone: an analysis of factors leading to osteogenesis in marrow transplants and in marrow-containing bone grafts J Bone Joint Surg Br 46 1964 110 140
6. R.G. Burwell Studies in the transplantation of bone. 8. Treated composite homograft-autografts of cancellous bone: an analysis of inductive mechanisms in bone transplantation J Bone Joint Surg Br 48 1966 532 566
7. J.C. Gray, and M.W. Elves Early osteogenesis in compact bone isografts: a quantitative study of contributions of the different graft cells Calcif Tissue Int 29 1979 225 237
8. J.C. Gray, and M.W. Elves Donor cells' contribution to osteogenesis in experimental cancellous bone grafts Clin Orthop 163 1982 261 271
9. J. Cummine, L. Armstrong, and S. Nade Osteogenesis after bone and bone marrow transplantation. Studies of cellular behaviour using combined myelo-osseous grafts in the subscorbutic guinea pig Acta Orthop Scand 54 1983 235 241
10. S. Nade Osteogenesis after bone and bone marrow transplantation. II. The initial cellular events following transplantation of decalcified allografts of cancellous bone Acta Orthop Scand 48 1977 572 579
11. D.J. Prockop Marrow stromal cells as stem cells for nonhematopoietic tissues Science 276 1997 71 74
12. R.G. Burwell The function of bone marrow in the incorporation of a bone graft Clin Orthop 200 1985 125 141
13. B.A. Ashton, F. Abdullah, and J. Cave Characterization of cells with high alkaline phosphatase activity derived from human bone and marrow: preliminary assessment of their osteogenicity Bone 6 1985 313 319
14. J.N. Beresford Osteogenic stem cells and the stromal system of bone and marrow Clin Orthop 240 1989 270 280
15. S.P. Bruder, N. Jaiswal, and S.E. Haynesworth Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation J Cell Biochem 64 1997 278 294
16. S.P. Bruder, D.J. Fink, and A.I. Caplan Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy J Cell Biochem 56 1994 283 294
17. S.P. Bruder, N. Jaiswal, N.S. Ricalton, J.D. Mosca, K.H. Kraus, and S. Kadiyala Mesenchymal stem cells in osteobiology and applied bone regeneration Clin Orthop 355 1998 S247-256
18. A.I. Caplan Mesenchymal stem cells J Orthop Res 9 1991 641 650
19. A.J. Friedenstein, R.K. Chailakhyan, and U.V. Gerasimov Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers Cell Tissue Kinet 20 1987 263 272
20. J. Goshima, V.M. Goldberg, and A.I. Caplan The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks Clin Orthop 262 1991 298 311
21. S.E. Haynesworth, J. Goshima, V.M. Goldberg, and A.I. Caplan Characterization of cells with osteogenic potential from human marrow Bone 13 1992 81 88
22. N. Jaiswal, S.E. Haynesworth, A.I. Caplan, and S.P. Bruder Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro J Cell Biochem 64 1997 295 312
23. S. Kadiyala, R.G. Young, M.A. Thiede, and S.P. Bruder Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro Cell Transplant 6 1997 125 134
24. A.K. Majors, C.A. Boehm, H. Nitto, R.J. Midura, and G.F. Muschler Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation J Orthop Res 15 1997 546 557
25. M. Owen Marrow stromal stem cells J Cell Sci Suppl 10 1988 63 76
26. M. Owen, and A.J. Friedenstein Stromal stem cells: marrow-derived osteogenic precursors Ciba Found Symp 136 1988 42 60
27. M.F. Pittenger, A.M. Mackay, and S.C. Beck Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
28. D.J. Rickard, M. Kassem, T.E. Hefferan, G. Sarkar, T.C. Spelsberg, and B.L. Riggs Isolation and characterization of osteoblast precursor cells from human bone marrow J Bone Miner Res 11 1996 312 324
29. D.J. Simmons, P.A. Lesker, and J.C. Ellsasser Survival of osteocompetent marrow cells in vitro and the effect of PHA-stimulation on osteoinduction in composite bone grafts Proc Soc Exp Biol Med 148 1975 986 990
30. J. Becerra, J.A. Andrades, D.C. Ertl, N. Sorgente, and M.E. Nimni Demineralized bone matrix mediates differentiation of bone marrow stromal cells in vitro: effect of age of cell donor J Bone Miner Res 11 1996 1703 1714
31. H. Hirano, and M.R. Urist Bone-forming and bone-resorbing cell lines derived from bone marrow in tissue culture Clin Orthop 154 1981 234 248
32. G.F. Muschler, C. Boehm, and K. Easley Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume J Bone Joint Surg Am 79 1997 1699 1709
33. G.F. Muschler, H. Nitto, C.A. Boehm, and K.A. Easley Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors J Orthop Res 19 2001 117 125
34. H. Ronningen, L.F. Solheim, E. Barth, and N. Langeland Osteogenesis promoted by bone matrix combined with marrow. Titanium implants studied in rats Acta Orthop Scand 57 1986 15 18
35. A.J. Friedenstein, K.V. Petrakova, A.I. Kurolesova, and G.P. Frolova Heterotopic transplants of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues Transplantation 6 1968 230 247
36. C.A. Pfeiffer Development of bone from transplanted marrow in mice Anat Rec 102 1948 225 243
37. S.N. Bhaskar, D.E. Cutright, and R.E. Boyers Autogenous bone marrow transplants in the rat Oral Surg Oral Med Oral Pathol 29 1970 472 479
38. T.S. Lindholm, O.S. Nilsson, and T.C. Lindholm Extraskeletal and intraskeletal new bone formation induced by demineralized bone matrix combined with bone marrow cells Clin Orthop 171 1982 251 255
39. M. Tavassoli, and W.H. Crosby Transplantation of marrow to extramedullary sites Science 161 1968 54 56
40. J. Cummine, and S. Nade Osteogenesis after bone and bone-marrow transplantation. I. Studies with combined myelo-osseous grafts in the guinea pig Acta Orthop Scand 48 1977 15 24
41. S. Nade Bone-graft surgery reappraised: the contribution of the cell to ultimate success Br J Surg 57 1970 752 756
42. S. Nade, and R.G. Burwell Decalcified bone as a substrate for osteogenesis. An appraisal of the interrelation of bone and marrow in combined grafts J Bone Joint Surg Br 59 1977 189 196
43. S. Nade Clinical implications of cell function in osteogenesis. A reappraisal of bone-graft surgery Ann R Coll Surg Engl 61 1979 189 194
44. A.J. Friedenstein, S. Piatetzky II, and K.V. Petrakova Osteogenesis in transplants of bone marrow cells J Embryol Exp Morphol 16 1966 381 390
45. B.A. Ashton, T.D. Allen, C.R. Howlett, C.C. Eaglesom, A. Hattori, and M. Owen Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo Clin Orthop 151 1980 294 307
46. R.W. Budenz, and G.W. Bernard Osteogenesis and leukopoiesis within diffusion-chamber implants of isolated bone marrow subpopulations Am J Anat 159 1980 455 474
47. K.A. Johnson, C.R. Howlett, C.R. Bellenger, and P. Armati-Gulson Osteogenesis by canine and rabbit bone marrow in diffusion chambers Calcif Tissue Int 42 1988 113 118
48. E. Green, C. Hinton, and J.T. Triffitt The effect of decalcified bone matrix on the osteogenic potential of bone marrow Clin Orthop 205 1986 292 298
49. A.D. Dorr, W.C. Moloney, G. Dowd, and A.E. Boschetti Bone and marrow transplants in the rat Blood 18 1961 423 430
50. H. Ohgushi, V.M. Goldberg, and A.I. Caplan Heterotopic osteogenesis in porous ceramics induced by marrow cells J Orthop Res 7 1989 568 578
51. R. Salama, R.D. Burwell, and I.R. Dickson Recombined grafts of bone and marrow. The beneficial effect upon osteogenesis of impregnating xenograft (heterograft) bone with autologous red marrow J Bone Joint Surg Br 55 1973 402 417
52. D.J. Simmons, J.C. Ellsasser, H. Cummins, and P. Lesker The bone inductive potential of a composite bone allograft-marrow autograft in rabbits Clin Orthop 97 1973 237 247
53. T.S. Lindholm, and M.R. Urist A quantitative analysis of new bone formation by induction in compositive grafts of bone marrow and bone matrix Clin Orthop 150 1980 288 300
54. H. Ronningen, L.F. Solheim, and N. Langeland Bone formation enhanced by induction. Bone growth in titanium implants in rats Acta Orthop Scand 56 1985 67 71
55. J. Goshima, V.M. Goldberg, and A.I. Caplan The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells Clin Orthop 269 1991 274 283
56. S. Nade, L. Armstrong, E. McCartney, and B. Baggaley Osteogenesis after bone and bone marrow transplantation. The ability of ceramic materials to sustain osteogenesis from transplanted bone marrow cells: preliminary studies Clin Orthop 181 1983 255 263
57. H. Ohgushi, M. Okumura, S. Tamai, E.C. Shors, and A.I. Caplan Marrow cell induced osteogenesis in porous hydroxyapatite and tricalcium phosphate: a comparative histomorphometric study of ectopic bone formation J Biomed Mater Res 24 1990 1563 1570
58. M. Okumura, H. Ohgushi, and S. Tamai Bonding osteogenesis in coralline hydroxyapatite combined with bone marrow cells Biomaterials 12 1991 411 416
59. M. Alvis, P. Lalor, and M.K. Brown Osteoinduction by a collagen mineral composite combined with isologous bone marrow in a subcutaneous rat model Orthopedics 26 2003 77 80
60. J.M. Lane, and H.S. Sandhu Current approaches to experimental bone grafting Orthop Clin North Am 18 1987 213 225
61. J.M. Lane, E. Tomin, and M.P. Bostrom Biosynthetic bone grafting Clin Orthop 367 1999 S107 S117
62. M. Gebhart, and J. Lane A radiographical and biomechanical study of demineralized bone matrix implanted into a bone defect of rat femurs with and without bone marrow Acta Orthop Belg 57 1991 130 143
63. J.M. Lane, A.W. Yasko, and E. Tomin Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair Clin Orthop 361 1999 216 227
64. H. Ohgushi, V.M. Goldberg, and A.I. Caplan Repair of bone defects with marrow cells and porous ceramic. Experiments in rats Acta Orthop Scand 60 1989 334 339
65. H. Plenk Jr., K. Hollmann, and K.H. Wilfert Experimental bridging of osseous defects in rats by the implantation of Kiel bone containing fresh autologous marrow J Bone Joint Surg Br 54 1972 735 743
66. K. Takagi, and M.R. Urist The role of bone marrow in bone morphogenetic protein-induced repair of femoral massive diaphyseal defects Clin Orthop 171 1982 224 231
67. J.R. Werntz, J.M. Lane, A.H. Burstein, R. Justin, R. Klein, and E. Tomin Qualitative and quantitative analysis of orthotopic bone regeneration by marrow J Orthop Res 14 1996 85 93
68. D. Wolff, V.M. Goldberg, and S. Stevenson Histomorphometric analysis of the repair of a segmental diaphyseal defect with ceramic and titanium fibermetal implants: effects of bone marrow J Orthop Res 12 1994 439 446
69. P. Aspenberg, J. Wittbjer, and K.G. Thorngren Pulverized bone matrix as an injectable bone graft in rabbit radius defects Clin Orthop 206 1986 261 269
70. P. Aspenberg, J. Wittbjer, and K.G. Thorngren Bone matrix and marrow versus cancellous bone in rabbit radial defects Arch Orthop Trauma Surg 106 1987 335 340
71. D. Gupta, S. Khanna, and S.M. Tuli Bridging large bone defects with a xenograft composited with autologous bone marrow. An experimental study Int Orthop 6 1982 79 85
72. C. Hamanishi, T. Yoshii, Y. Totani, and S. Tanaka Bone mineral density of lengthened rabbit tibia is enhanced by transplantation of fresh autologous bone marrow cells. An experimental study using dual X-ray absorptiometry Clin Orthop 303 1994 250 255
73. D. Paley, M.C. Young, A.M. Wiley, V.L. Fornasier, and R.W. Jackson Percutaneous bone marrow grafting of fractures and bony defects. An experimental study in rabbits Clin Orthop 208 1986 300 312
74. S. Sharma, N.K. Garg, A.J. Veliath, S. Subramanian, and K.K. Srivastava Percutaneous bone-marrow grafting of osteotomies and bony defects in rabbits Acta Orthop Scand 63 1992 166 169
75. T. Niedzwiedzki, Z. Dabrowski, H. Miszta, and M. Pawlikowski Bone healing after bone marrow stromal cell transplantation to the bone defect Biomaterials 14 1993 115 121
76. J. Wittbjer, B. Palmer, M. Rohlin, and K.G. Thorngren Osteogenetic activity in composite grafts of demineralized compact bone and marrow Clin Orthop 173 1983 229 238
77. J.J. Tiedman, B.S. Strates, L. Lippiello, and J.F. Connolly Enhanced skeletal healing by percutaneous injection of bone matrix and bone marrow Surgical Forum 39 1988 523 526
78. J.J. Tiedeman, J.F. Connolly, B.S. Strates, and L. Lippiello Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs Clin Orthop 268 1991 294 302
79. R.E. Grundel, M.W. Chapman, T. Yee, and D.C. Moore Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna Clin Orthop 266 1991 244 258
80. S. Palmer, B.S. Strates, and J.F. Connolly Repair of trephine defects in the aged by implants of bone matrix and marrow Surg Forum 38 1987 531 533
81. T.S. Lindholm, P. Ragni, and T.C. Lindholm Response of bone marrow stroma cells to demineralized cortical bone matrix in experimental spinal fusion in rabbits Clin Orthop 230 1988 296 302
82. G.F. Muschler, S. Negami, A. Hyodo, D. Gaisser, K. Easley, and H. Kambic Evaluation of collagen ceramic composite graft materials in a spinal fusion model Clin Orthop 328 1996 250 260
83. P. Ragni, T.S. Lindholm, and T.C. Lindholm Vertebral fusion dynamics in the thoracic and lumbar spine induced by allogenic demineralized bone matrix combined with autogenous bone marrow. An experimental study in rabbits Ital J Orthop Traumatol 13 1987 241 251
84. P. Ragni, P. Ala-Mononen, and T.S. Lindholm Spinal fusion induced by porous hydroxyapatite blocks (HA). Experimental comparative study with HA, demineralized bone matrix and autogenous bone marrow Ital J Orthop Traumatol 19 1993 133 144
85. W.R. Walsh, J. Harrison, and A. Loefler Mechanical and histologic evaluation of collagraft in an ovine lumbar fusion model Clin Orthop 375 2000 258 266
86. J.L. Russell, and J.E. Block Surgical harvesting of bone graft from the ilium: point of view Med Hypotheses 55 2000 474 479
87. J.C. Fernyhough, J.J. Schimandle, M.C. Weigel, C.C. Edwards, and A.M. Levine Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion Spine 17 1992 1474 1480
88. A.R. Gupta, N.R. Shah, T.C. Patel, and J.N. Grauer Perioperative and long-term complications of iliac crest bone graft harvesting for spinal surgery: a quantitative review of the literature Int Med J 8 2001 163 166
89. B.N. Summers, and S.M. Eisenstein Donor site pain from the ilium. A complication of lumbar spine fusion J Bone Joint Surg Br 71 1989 677 680
90. T.W. Bauer, and G.F. Muschler Bone graft materials. An overview of the basic science Clin Orthop 371 2000 10 27
91. S.D. Boden, and J.H. Schimandle Biologic enhancement of spinal fusion Spine 20 1995 113S 123S
92. J.F. Connolly Injectable bone marrow preparations to stimulate osteogenic repair Clin Orthop 313 1995 8 18
93. J.F. Connolly Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis Clin Orthop 355 1998 S257 S266
94. C.N. Cornell, and J.M. Lane Newest factors in fracture healing Clin Orthop 277 1992 297 311
95. T.A. Einhorn Enhancement of fracture-healing J Bone Joint Surg Am 77 1995 940 956
96. J.J. Tiedeman, W.W. Huurman, J.F. Connolly, and B.S. Strates Healing of a large nonossifying fibroma after grafting with bone matrix and marrow. A case report Clin Orthop 265 1991 302 305
97. J.J. Tiedeman, K.L. Garvin, T.A. Kile, and J.F. Connolly The role of a composite, demineralized bone matrix and bone marrow in the treatment of osseous defects Orthopedics 18 1995 1153 1158
98. R. Salama, and S.L. Weissman The clinical use of combined xenografts of bone and autologous red marrow. A preliminary report J Bone Joint Surg Br 60 1978 111 115
99. S. Wientroub, D. Goodwin, O. Khermosh, and R. Salama The clinical use of autologous marrow to improve osteogenic potential of bone grafts in pediatric orthopedics J Pediatr Orthop 9 1989 186 190
100. N.K. Garg, and S. Gaur Percutaneous autogenous bone-marrow grafting in congenital tibial pseudarthrosis J Bone Joint Surg Br 77 1995 830 831
101. J.H. Healey, P.A. Zimmerman, J.M. McDonnell, and J.M. Lane Percutaneous bone marrow grafting of delayed union and nonunion in cancer patients Clin Orthop 256 1990 280 285
102. J.F. Connolly, R. Guse, J. Tiedeman, and R. Dehne Autologous marrow injection for delayed unions of the tibia: a preliminary report J Orthop Trauma 3 1989 276 282
103. J.F. Connolly, R. Guse, J. Tiedeman, and R. Dehne Autologous marrow injection as a substitute for operative grafting of tibial nonunions Clin Orthop 266 1991 259 270
104. N.K. Garg, S. Gaur, and S. Sharma Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture Acta Orthop Scand 64 1993 671 672
105. A. Kocialkowski, W.A. Wallace, and H.G. Prince Clinical experience with a new artificial bone graft: preliminary results of a prospective study Injury 21 1990 142 144
106. M.W. Chapman, R. Bucholz, and C. Cornell Treatment of acute fractures with a collagen-calcium phosphate graft material. A randomized clinical trial J Bone Joint Surg Am 79 1997 495 502 [see comments]
107. C.N. Cornell, J.M. Lane, and M. Chapman Multicenter trial of collagraft as bone graft substitute J Orthop Trauma 5 1991 1 8
108. C.N. Cornell Initial clinical experience with use of collagraft as a bone graft substitute Tech Orthop 7 1992 55 63
109. C.N. Cornell Proper design of clinical trials for the assessment of bone graft substitutes Clin Orthop 355 1998 S347 S352
110. S.P. Bruder, K.H. Kraus, V.M. Goldberg, and S. Kadiyala The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects J Bone Joint Surg Am 80 1998 985 996
111. S.P. Bruder, A.A. Kurth, M. Shea, W.C. Hayes, N. Jaiswal, and S. Kadiyala Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells J Orthop Res 16 1998 155 162
112. J. Connolly, R. Guse, L. Lippiello, and R. Dehne Development of an osteogenic bone-marrow preparation J Bone Joint Surg Am 71 1989 684 691