Pharmacologic protein kinase Cα inhibition uncouples human platelet-stimulated angiogenesis from collagen-induced aggregation

Journal of Pharmacology and Experimental Therapeutics

Volumn 345, Issue 1, 2013, Pages 15-24

  De La Rosa, Cesar Moncada ^a   Radziwon Balicka, Aneta ^a   El Sikhry, Haitham ^a   Seubert, John ^a,b   Ruvolo, Peter P ^c   Radomski, Marek W ^d   Jurasz, Paul ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF TEXAS   (United States)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; MYRISTOYL PHENYLALANYLALANYLARGINYLLYSYLGLYCYLALANYLLEUCYLARGINYLGLUTAMINE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ALPHA INHIBITOR; PROTEIN KINASE C BETA; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CHEMOLUMINESCENCE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SPECIFICITY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MYRISTYLATION; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; TRANSMISSION ELECTRON MICROSCOPY;

ANGIOGENESIS INHIBITORS; BLOOD PLATELETS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELLS, CULTURED; COLLAGEN; CYTOPLASMIC GRANULES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; MICROSCOPY, FLUORESCENCE; NEOVASCULARIZATION, PHYSIOLOGIC; PLATELET AGGREGATION; PROTEIN KINASE C-ALPHA; THROMBOSPONDIN 1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84875438399     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.200881     Document Type: Article

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