Estimating the requirement for manipulation of medicines to provide accurate doses for children

European Journal of Hospital Pharmacy

Volumn 20, Issue 1, 2013, Pages 3-7

  Nunn, Anthony ^a   Richey, Roberta ^a   Shah, Utpal ^a,b   Barker, Catrin ^a   Craig, Jean ^c   Peak, Matthew ^a   Ford, James ^b   Turner, Mark ^d  

^a ALDER HEY CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMLODIPINE; ANTIBIOTIC AGENT; ATROPINE; CLOBAZAM; DICLOFENAC; DOBUTAMINE; DOMPERIDONE; DOPAMINE; FENTANYL; FLEET ENEMA; FUROSEMIDE; HYDROCORTISONE; LEVOMEPROMAZINE; LEVOTHYROXINE; MIDAZOLAM; MORPHINE; OMEPRAZOLE; PHENOBARBITAL; RANITIDINE; SUXAMETHONIUM; TEICOPLANIN; TOCOPHEROL; URSODEOXYCHOLIC ACID; VECURONIUM; VITAMIN D;

ARTICLE; DRUG INFORMATION; HOSPITAL PHARMACY; HUMAN; INTENSIVE CARE UNIT; PHARMACIST; PUBLICATION; TRANSDERMAL PATCH;

EID: 84875437613     PISSN: 20479956     EISSN: 20479964     Source Type: Journal    
DOI: 10.1136/ejhpharm-2012-000133     Document Type: Article

References (22)

1. Waller DG Off-label and unlicensed prescribing for children: have we made any progress? Br J Clin Pharmacol 2007;64:1-2. doi:10.1111/j.1365-2125.2007.02987.x
2. Richey RH, Donnell C, Shah UU, et al. An investigation of drug manipulation for dose accuracy in paediatric practice: the MODRIC study. Arch Dis Child 2011;96:e1. doi:10.1136/adc.2011.211243.20
3. Tan E, Cranswick NE, Rayner CR, et al. Dosing information for paediatric patients: are they really "therapeutic orphans"? Med J Aust 2003;179:195-8.
4. Paparella S Identified safety risks with splitting and crushing oral medications. J Emerg Nurs 2010;36:156-7.
5. Prot S, Fontan JE, Alberti C, et al. Drug administration errors and their determinants in pediatric in-patients. Int J Qual Health Care 2005;17:381-9.
6. Uppal N, Yasseen B, Seto W, et al. Drug formulations that require less than 0.1 mL of stock solution to prepare doses for infants and children. CMAJ 2011;183: E246-8.
7. Skwierczynski C, Conroy S How long does it take to administer oral medicines to children? Paediatr Perinat Drug Ther 2008;8:145-9.
8. Richey RH, Craig JV, Shah UU, et al. The manipulation of drugs to obtain the required dose: systematic review protocol. J Adv Nurs 2011;68:2103-12.
9. Rosenzweig EB, Ivy DD, Widlitz A, et al. Long-term bosentan treatment in children with pulmonary arterial hypertension. J Am Coll Cardiol 2006;47:1915.
10. Horn L, Kuhn RJ, Kanga JF Evaluation of the reproducibility of tablet splitting to provide accurate doses for the pediatric population. J Pediatr Pharm Pract 1999;4:38-42.
11. Shah RB, Collier JS, Sayeed VA, et al. Tablet splitting of a narrow therapeutic index drug: a case with levothyroxine sodium. AAPS PharmSciTech 2010;11:1359-67.
12. Broadhurst EC, Ford JL, Nunn AJ, et al. Dose uniformity of samples prepared from dispersible aspirin tablets for paediatric use. Eur J Hosp Pharm Sci 2008;14:27-31.
13. Verrue C, Mehuys E, Boussery K, et al. Tablet-splitting: a common yet not so innocent practice. J Adv Nurs 2011;67:26-32.
14. Kim TW, Rognerud CL, Ou C-N Accuracy in the alteration of acetaminophen suppositories. Anesth Analg 2005;100:1303-5.
15. Beringer RM, Thompson JP, Parry S, et al. Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines. Arch Dis Child 2011;96:307-8.
16. Chappell K, Newnam C Potential tenfold drug overdoses on a neonatal unit. Arch Dis Child Fetal Neonatal Ed 2004;89:F483-4.
17. Allegaert K, Anderson BJ, Vrancken M, et al. Impact of a paediatric vial on the magnitude of systematic medication errors in neonates. Paed Perinat Drug Ther 2006;7:59-63.
18. Anon Intravenous paracetamol (Perfalgan): risk of accidental overdose, especially in infants and neonates. Drug Saf Update 2010;3:2. http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON088171 (accessed 4 Aug 2012).
19. British National Formulary for Children 2010-2011. London: BMJ Group, Pharmaceutical Press, RCPCH Publications, 2010.
20. Caldwell N, Rackham O Children's doses should be measurable (letter). Arch Dis Child 2010;95:313.
21. World Health Organization (WHO). Antiretroviral therapy for HIV infection in infants and children: towards universal access. Recommendations for a public health approach: 2010 revision. Geneva: WHO, 2010. http://www.who.int/hiv/pub/paediatric/infants2010/en/index.html (accessed 6 Oct 2011).
22. European Parliament. Regulation (EC) No 1901/2006 of the European Parliament and of the Council of 12 December 2006 on medicinal products for paediatric use. Official Journal of the European Union 27/12/2006:L378/1-19. http://ec.europa.eu/health/files/eudralex/vol-1/reg_2006_1901/reg_2006_1901_en.pdf (accessed 6 Oct 2011).