Comparison of ELISA and LC-MS/MS for the measurement of flunixin plasma concentrations in beef cattle after intravenous and subcutaneous administration

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 11, 2013, Pages 2679-2686

  Shelver, Weilin L ^a   Tell, Lisa A ^b   Wagner, Sarah ^c   Wetzlich, Scott E ^b   Baynes, Ronald E ^d   Riviere, Jim E ^d,e   Smith, David J ^a  

^a USDA ARS Red River Valley Agricultural Research Center   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTH DAKOTA STATE UNIVERSITY   (United States)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

^e KANSAS STATE UNIVERSITY   (United States)

Author keywords

administration; cattle; concentration; elimination; ELISA; flunixin; pharmacokinetics

Indexed keywords

AREA UNDER THE CURVES; CATION-EXCHANGE SOLID-PHASE EXTRACTION; CATTLE; ELIMINATION; ELISA; FLUNIXIN; LINEAR CALIBRATION CURVE; PHARMACOKINETIC PARAMETERS;

CONCENTRATION (PROCESS); IMMUNOLOGY; MANAGEMENT; PHARMACOKINETICS; PLASMAS;

PARAMETER ESTIMATION;

CLONIXIN; DRUG DERIVATIVE; FLUNIXIN; NONSTEROID ANTIINFLAMMATORY AGENT; VETERINARY DRUG;

ANIMAL; ARTICLE; BLOOD; CATTLE; COMPARATIVE STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRADERMAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONIXIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; INJECTIONS, INTRAVENOUS; TANDEM MASS SPECTROMETRY; VETERINARY DRUGS;

BOS;

EID: 84875418819     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf304773p     Document Type: Article

References (35)

1. Deyrup, C. L.; Southern, K. J.; Cornett, J. A.; Shultz, C. E. E.; Cera, D. A. Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey J. Am. Vet. Med. Assoc. 2012, 241, 249-253
2. FSIS. 2008 FSIS National Residue Program Data; USDA, FSIS: Washington, DC, 2008; p 90; http://www.fsis.usda.gov/PDF/2008-Red-Book.pdf.
3. FSIS. 2009 FSIS National Residue Program Data; USDA, FSIS: Washington, DC, 2009; p 110; http://www.fsis.usda.gov/PDF/2009-Red-Book.pdf
4. FSIS. Residue repeat violator list for use by FSIS inspectionprogram personnel part I. (2012; www.fsis.usda.gov/PDF/residue-IPP.PDF (accessed Oct 2012).
5. U.S. FDA Warningletter W/L 42-11 http://www.fda.gov/ICECI/ EnforcementActions/WarningLetters/ucm257579.htm
6. U.S. FDA Warning letter 2012-DET-01 http://www.fda.gov/ICECI/ EnforcementActions/WarningLetters/ucm276922.htm
7. Smith, G. W.; Davis, J. L.; Tell, L. A.; Webb, A. I.; Riviere, J. E. Extralabel use of nonsteroidal anti-inflammatory drugs in cattle J. Am. Vet. Med. Assoc. 2008, 232, 697-701
8. Wasfi, I. A.; Boni, N. S.; Abdel Hadi, A. A.; Elghazali, M.; Zorob, O.; Alkatheeri, N. A. Pharmacokinetics, metabolism and urinary detection time of flunixin after intravenous administration in camels J. Vet. Pharmacol. Ther. 1998, 21, 203-208
9. Rantala, M.; Kaartinen, L.; Välimäki, E.; Stryman, M.; Hiekkaranta, M.; Niemi, A.; Saari, L.; Pyörälä, S. Efficacy and pharmacokinetics of enrofloxacin and flunixin meglumine for treatment of cows with experimentally induced Escherichia coli mastitis J. Vet. Pharmacol. Ther. 2002, 25, 251-258
10. Odensvik, K. Pharmacokinetics of flunixin and its effect on prostaglandin F2 alpha metabolite concentrations after oral and intravenous administration in heifers J. Vet. Pharmacol. Ther. 1995, 18, 254-259
11. Anderson, K. L.; Neff-Davis, C. A.; Davis, L. E.; Bass, F. D. Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuxcular and intravenous administrations Am. J. Vet. Res. 1990, 51, 1464-1467
12. Odensvik, K.; Johansson, M. High-performance liquid chromatography method for determination of flunixin in bovine plasma and pharmacokinetics after single and repeated doses of the drug Am. J. Vet. Res. 1995, 56, 489-495
13. Soma, L. R.; Behrend, E.; Ruby, J.; Sweeney, R. W. Disposition and excretion of flunixin meglumine in horses Am. J. Vet. Res. 1988, 49, 1894-1898
14. Cheng, Z.; McKeller, Q.; Nolan, A.; Lees, P. Preliminary pharmacokinetic and pharmacodynamic studies on flunixin meglumine in donkeys Vet. Res. Commun. 1996, 20, 469-472
15. Königsson, K.; Törneke, K.; Engeland, I. V.; Odensvik, K.; Kindahl, H. Pharmacokinetics and pharmacodynamic effects of flunixin after intravenous, intramuscuclar and oral administration to dairy goats Acta Vet. Scand. 2003, 44, 153-159
16. Cheng, Z.; McKeller, Q.; Nolan, A. Pharmacokinetics studies of flunixin meglumine and phenylbutazone in plasma, exudates and transudate in sheep J. Vet. Pharmacol. Ther. 1998, 21, 315-321
17. Lees, P.; Taylor, P. M. Pharmacodynamics and pharmacokinetics of flunixin in the cat Br. Vet. J. 1991, 147, 298-305
18. Yu, Z.-G.; Jiang, C.-M.; Guo, Y.-G.; Hu, Y.-Y.; Chen, D.-J. Pharmacokinetics of flunixin meglumine after intravenous and intramuscular administration in pigs Agric. Sci. China 2007, 6, 1396-1401
19. Hwang, Y.; Yun, H. Effects of acute hepatic and renal failure on pharmacokinetics of flunixin meglumine in rats Exp. Anim. 2011, 60, 187-191
20. Ogino, T.; Arai, T. Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in icr mice Exp. Anim. 2007, 56, 79-84
21. Baert, K.; De Backer, P. Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species Comp. Biochem. Physiol., C 2003, 134, 25-33
22. Elmas, M.; Yazar, E.; Uney, K.; Karabacak, A. Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits Vet. Res. Commun. 2006, 30, 73-81
23. Lohuis, J. A.C.M.; Van Werven, T.; Brand, A.; Van Miert, A. S. J. P. A. M.; Rohde, E.; Ludwig, B.; Heizmann, P.; Rehm, W. F. Pharmacodynamics and pharmacokinetics of carprofen, a non-steroidal anti-inflammatory drug, in healthy cows and cows with Escherichia coli endotoxin-induced mastitis J. Vet. Pharmacol. Ther. 1991, 14, 219-229
24. U.S. FDA. HEXASOL Injection, Oxytetracycline and Flunixin Meglumine Injectable Solution, Beef and Non-Lactating Dairy Cattle; Freedom of Information Summary: NADA141-312; U.S. FDA: Washington, DC, 2011.
25. U.S. FDA. RESFLOR GOLD, Florfenicol and Flunixin Meglumine (In 2-Pyrrolidone and Triacetin) Injectable Solution, Beef and Non-lactating Dairy Cattle; Freedom of Information Summary: NADA141-299; U.S. FDA: Washington, DC, 2009.
26. LaCroix, M. Z.; Gayrard, V.; Picard-Hagen, N.; Toutain, P. L. Comparative bioavailability between two routes of administration of florfenicol and flunixin in cattle Rev. Med. Vet. 2011, 162, 321-324
27. Kissell, L. W.; Smith, G. W.; Leavens, T. L.; Baynes, R. E.; Wu, H.; Riviere, J. E. Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle J. Dairy Sci. 2012, 95, 7151-7157
28. 14C-Flunixin J. Agric. Food Chem. 2003, 50, 7308-7313
29. Brady, T. C.; Yang, T. J.; Hyde, W. G.; Kind, A. J.; Hill, D. W. Detection of flunixin in greyhound urine by a kinetic enzyme-linked immunosorbent assay J. Anal. Toxicol. 1997, 21, 190-196
30. Jedziniak, P.; Szprengier-Juszkiewicz, T.; Olejnik, M.; Jaroszewski, J. Determination of flunixin and 5-hydroxyflunixin in bovine plasma with HPLC-UV- method development, validation, and verification Bull. Vet. Inst. Pulawy 2007, 51, 261-266
31. Luo, Y.; Rudy, J. A.; Uboh, C. E.; Soma, L. R.; Guan, F.; Enright, J. M.; Tsang, D. S. Quantification and confirmation of flunixin in equine plasma by liquid chromatography-quadrupole time-of-flight tandem mass spectrometry J. Chromatogr., B 2004, 801, 173-84
32. United States Department of Agriculture, Food Safety and Inspection Service, Office of Public Health Science. Screening of Flunixin Residues by ELISA; CLG-FLX 3.01; USDA: Washington, DC, 2011.
33. United States Department of Agriculture, Food Safety and Inspection Service, Office of Public Health Science. Determination and Confirmation of Flunixin by HPLC/ESI-MS/MS; CLG-FLX 4.03; USDA: Washington, DC, 2012.
34. Buur, J. L.; Baynes, R. E.; Smith, G.; Riviere, J. E. Pharmacokinetics of flunixin meglumine in swine after intervenous dosing J. Vet Pharmacol. Ther. 2006, 29, 437-440
35. Pellegrini-Masini, A.; Poppenga, R. H.; Sweeney, R. W. Disposition of flunixin meglumine injectable preparation administered orally to healthy horses J. Vet. Pharmacol. Ther. 2004, 27, 183-186