Imaging of endogenous exchangeable proton signals in the human brain using frequency labeled exchange transfer imaging

Magnetic Resonance in Medicine

Volumn 69, Issue 4, 2013, Pages 966-973

  Yadav, Nirbhay N ^a,b   Jones, Craig K ^a,b   Hua, Jun ^a,b   Xu, Jiadi ^a,b   Van Zijl, Peter C M ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

amide; amine; APT; CEST; fast chemical exchange; FLEX; hydroxyl

Indexed keywords

AMIDES; AMINES; BRAIN; CHEMICAL SHIFT; MAGNETIC RESONANCE IMAGING; MAGNETIZATION; MOLECULES; PROTEINS; TIME DOMAIN ANALYSIS;

CEST; CHEMICAL EXCHANGE; CHEMICAL EXCHANGE SATURATION TRANSFER; FLEX; HYDROXYL; INFORMATION CONTENTS; MAGNETIZATION TRANSFER; MAGNETIZATION TRANSFER CONTRASTS;

SIGNAL DETECTION;

AMIDE; AMINE; EGG WHITE; PROTON;

ARTICLE; CONTROLLED STUDY; FREQUENCY ANALYSIS; FREQUENCY LABELED EXCHANGE TRANSFER IMAGING; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; NEUROIMAGING; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 84875370272     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24655     Document Type: Article

References (32)

1. Sun PZ, Zhou J, Sun W, Huang J, van Zijl PCM,. Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab 2007; 27: 1129-1136.
2. Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PCM,. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 2003; 9: 1085-1090.
3. Ward K, Balaban R,. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST). Magn Reson Med 2000; 44: 799-802.
4. Liu G, Li Y, Sheth VR, Pagel MD,. Imaging in vivo extracellular pH with a single paramagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent. Mol Imaging 2012; 11: 47-57.
5. Delli-Castelli D, Terreno E, Aime S,. Ybiii-HPDO3A: a dual pH- and temperature-responsive CEST agent. Angew Chem Int Ed 2011; 50: 1798-1800.
6. Ward KM, Aletras AH, Balaban RS,. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson 2000; 143: 79-87.
7. van Zijl PCM, Yadav NN,. Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med 2011; 65: 927-948.
8. Zhou J, van Zijl PCM,. Chemical exchange saturation transfer imaging and spectroscopy. Prog Nucl Magn Reson Spectrosc 2006; 48: 109-136.
9. Sherry AD, Woods M,. Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. Annu Rev Biomed Eng 2008; 10: 391-411.
10. Jones CK, Schlosser MJ, van Zijl PCM, Pomper MG, Golay X, Zhou J,. Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med 2006; 56: 585-592.
11. Zhou J, Tryggestad E, Wen Z, et al. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med 2011; 17: 130-134.
12. Friedman JI, McMahon MT, Stivers JT, van Zijl PCM,. Indirect detection of labile solute proton spectra via the water signal using frequency-labeled exchange (FLEX) transfer. J Am Chem Soc 2010; 132: 1813-1815.
13. Lin C-Y, Yadav NN, Friedman JI, Ratnakar J, Sherry AD, van Zijl PCM,. Using frequency-labeled exchange transfer to separate out conventional magnetization transfer effects from exchange transfer effects when detecting paracest agents. Magn Reson Med 2012; 67: 906-911.
14. Yadav NN, Jones CK, Xu J, Bar-Shir A, Gilad AA, McMahon MT, van Zijl PCM,. Detection of rapidly exchanging compounds using on-resonance frequency-labeled exchange (FLEX) transfer. Magn Reson Med 2012; 68: 1048-1055.
15. Ernst RR, Bodenhausen G, Wokaun A,. Principles of nuclear magnetic resonance in one and two dimensions. Oxford: Oxford University Press; 1988.
16. Cavanagh J, Fairbrother WJ, Palmer AG, Skelton MRNJ,. Protein NMR spectroscopy: principles and practice. Amsterdam: Academic Press; 2007.
17. Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC,. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 2009; 61: 1441-1450.
18. Byrd R, Lu P, Nocedal J, Zhu C,. A limited memory algorithm for bound constrained optimization. SIAM J Sci Computing 1995; 16: 1190-1208.
19. Zhou J, Yan K, Zhu H,. A simple model for understanding the origin of the amide proton transfer MRI signal in tissue. Appl Magn Reson 2012; 42: 393-402.
20. Zhu H, Jones CK, Van Zijl PCM, Barker PB, Zhou J,. Fast 3d chemical exchange saturation transfer (CEST) imaging of the human brain. Magn Reson Med 2010; 64: 638-644.
21. Haris M, Nanga RPR, Singh A, Cai K, Kogan F, Hariharan H, Reddy R,. Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. NMR Biomed 2012; 25: 1305-1309.
22. Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA, Reddy R,. Magnetic resonance imaging of glutamate. Nat Med 2012; 18: 302-306.
23. Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA,. Assessment of relative brain iron concentrations using t2-weighted and T2*-weighted MRI at 3 tesla. Magn Reson Med 1994; 32: 335-341.
24. Jones CK, Polders D, Hua J, Zhu H, Hoogduin HJ, Zhou J, Luijten P, van Zijl PCM,. In vivo three-dimensional whole-brain pulsed steady-state chemical exchange saturation transfer at 7 T. Magn Reson Med 2012; 67: 1579-1589.
25. Malucelli E, Manners DN, Testa C, Tonon C, Lodi R, Barbiroli B, Iotti S,. Pitfalls and advantages of different strategies for the absolute quantification of n-acetyl aspartate, creatine and choline in white and grey matter by 1H-MRS. NMR Biomed 2009; 22: 1003-1013.
26. Ling W, Regatte RR, Navon G, Jerschow A,. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagcest). Proc Natl Acad Sci USA 2008; 105: 2266-2270.
27. Jin T, Wang P, Zong X, Kim S-G,. MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T. Magn Reson Med 2013; 69: 760-770.
28. Walker-Samuel S, Ramasawmy R, Torrealdea F, et al. Quantitative imaging of tumour glucose uptake using glucosecest: comparison with 18f-fdg autoradiography In Proceedings of the 20th Annual Meeting ISMRM, Melbourne, Australia, 2012. p. 182.
29. Chan KWY, McMahon MT, Kato Y, Liu G, Bulte JWM, Bhujwalla ZM, Artemov D, van Zijl PCM,. Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer. Magn Reson Med 2012; 68: 1764-1773.
30. Zhang S, Merritt M, Woessner DE, Lenkinski RE, Sherry AD,. Paracest agents: modulating MRI contrast via water proton exchange. Acc Chem Res 2003; 36: 783-790.
31. Aime S, Castelli DD, Crich SG, Gianolio E, Terreno E,. Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications. Acc Chem Res 2009; 42: 822-831.
32. Yoo B, Pagel MD,. An overview of responsive mri contrast agents for molecular imaging. Front Biosci 2008; 13: 1733-1752.