Rotator cuff healing after continuous subacromial bupivacaine infusion: An in vivo rabbit study

Journal of Shoulder and Elbow Surgery

Volumn 22, Issue 4, 2013, Pages 489-499

  Friel, Nicole A ^a   Wang, Vincent M ^a   Slabaugh, Mark A ^b   Wang, FanChia ^a   Chubinskaya, Susan ^a   Cole, Brian J ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b WILFORD HALL MEDICAL CENTER   (United States)

Author keywords

Animal Model; Basic Science Study; Biomechanics Histology; Bupivacaine; Enthesis; Local anesthetic; Myotoxicity; Rotator cuff; Subacromial

Indexed keywords

ADRENALIN; BUPIVACAINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CONTINUOUS INFUSION; CONTROLLED STUDY; EXPERIMENTAL RABBIT; FRACTURE HEALING; HISTOLOGY; IN VIVO STUDY; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; ROTATOR CUFF; ROTATOR CUFF INJURY; SKELETAL MUSCLE; SUPRASPINATUS MUSCLE; TENSILE STRENGTH;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; MALE; MUSCLE, SKELETAL; RABBITS; ROTATOR CUFF; WOUND HEALING;

EID: 84875363625     PISSN: 10582746     EISSN: 15326500     Source Type: Journal    
DOI: 10.1016/j.jse.2012.04.014     Document Type: Article

References (61)

1. Anderson S.L., Buchko J.Z., Taillon M.R., Ernst M.A. Chondrolysis of the glenohumeral joint after infusion of bupivacaine through an intra-articular pain pump catheter: a report of 18 cases. Arthroscopy 2010, 26:451-461. 10.1016/j.arthro.2010.01.022.
2. Bailie D.S., Ellenbecker T. Severe chondrolysis after shoulder arthroscopy: a case series. J Shoulder Elbow Surg 2009, 18:742-747. 10.1016/j.jse.2008.10.017.
3. Banerjee S.S., Pulido P., Adelson W.S., Fronek J., Hoenecke H.R. The efficacy of continuous bupivacaine infiltration following arthroscopic rotator cuff repair. Arthroscopy 2008, 24:397-402. 10.1016/j.arthro.2007.10.002.
4. Benoit P.W., Belt W.D. Destruction and regeneration of skeletal muscle after treatment with a local anaesthetic, bupivacaine (Marcaine). J Anat 1970, 107:547-556.
5. Benoit P.W., Yagiela A., Fort N.F. Pharmacologic correlation between local anesthetic-induced myotoxicity and disturbances of intracellular calcium distribution. Toxicol Appl Pharmacol 1980, 52:187-198.
6. Bjorkenheim J.M. Structure and function of the rabbit's supraspinatus muscle after resection of its tendon. Acta Orthop Scand 1989, 60:461-463.
7. Bogatch M.T., Ferachi D.G., Kyle B., Popinchalk S., Howell M.H., Ge D., et al. Is chemical incompatibility responsible for chondrocyte death induced by local anesthetics?. Am J Sports Med 2010, 38:520-526. 10.1177/0363546509349799.
8. Carlson B.M., Shepard B., Komorowski T.E. A histological study of local anesthetic-induced muscle degeneration and regeneration in the monkey. J Orthop Res 1990, 8:485-494. 10.1002/jor.1100080404.
9. Carpenter J.E., Thomopoulos S., Flanagan C.L., DeBano C.M., Soslowsky L.J. Rotator cuff defect healing: a biomechanical and histologic analysis in an animal model. J Shoulder Elbow Surg 1998, 7:599-605.
10. Cherng C.H., Wong C.S., Wu C.T., Yeh C.C. Intramuscular bupivacaine injection dose-dependently increases glutamate release and muscle injury in rats. Acta Anaesthesiol Taiwan 2010, 48:8-14. 10.1016/S1875-4597(10)60003-3.
11. Chu C.R., Izzo N.J., Coyle C.H., Papas N.E., Logar A. The in vitro effects of bupivacaine on articular chondrocytes. J Bone Joint Surg Br 2008, 90:814-820. 10.1302/0301-620X.90B6.20079.
12. Chu C.R., Izzo N.J., Papas N.E., Fu F.H. In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes. Arthroscopy 2006, 22:693-699. 10.1016/j.arthro.2006.05.006.
13. Ciccone W.J., Busey T.D., Weinstein D.M., Walden D.L., Elias J.J. Assessment of pain relief provided by interscalene regional block and infusion pump after arthroscopic shoulder surgery. Arthroscopy 2008, 24:14-19. 10.1016/j.arthro.2007.07.021.
14. Cohen D.B., Kawamura S., Ehteshami J.R., Rodeo S.A. Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing. Am J Sports Med 2006, 34:362-369. 10.1177/0363546505280428.
15. Dragoo J.L., Korotkova T., Kanwar R., Wood B. The effect of local anesthetics administered via pain pump on chondrocyte viability. Am J Sports Med 2008, 36:1484-1488. 10.1177/0363546508318190.
16. Fabis J., Danilewicz M., Omulecka A. Rabbit supraspinatus tendon detachment: effects of size and time after tenotomy on morphometric changes in the muscle. Acta Orthop Scand 2001, 72:282-286.
17. Fabis J., Kordek P., Bogucki A., Mazanowska-Gajdowicz J. Function of the rabbit supraspinatus muscle after large detachment of its tendon: 6-week, 3-month, and 6-month observation. J Shoulder Elbow Surg 2000, 9:211-216.
18. Foster A.H., Carlson B.M. Myotoxicity of local anesthetics and regeneration of the damaged muscle fibers. Anesth Analg 1980, 59:727-736.
19. Fredrickson M.J., Krishnan S., Chen C.Y. Postoperative analgesia for shoulder surgery: a critical appraisal and review of current techniques. Anaesthesia 2010, 65:608-624. 10.1111/j.1365-2044.2009.06231.x.
20. Galatz L.M., Sandell L.J., Rothermich S.Y., Das R., Mastny A., Havlioglu N., et al. Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. J Orthop Res 2006, 24:541-550. 10.1002/jor.20067.
21. Gomoll A.H., Kang R.W., Williams J.M., Bach B.R., Cole B.J. Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy 2006, 22:813-819. 10.1016/j.arthro.2006.06.006.
22. Gomoll A.H., Yanke A.B., Kang R.W., Chubinskaya S., Williams J.M., Bach B.R., et al. Long-term effects of bupivacaine on cartilage in a rabbit shoulder model. Am J Sports Med 2009, 37:72-77. 10.1177/0363546508323748.
23. Grumet R.C., Hadley S., Diltz M.V., Lee T.Q., Gupta R. Development of a new model for rotator cuff pathology: the rabbit subscapularis muscle. Acta Orthop 2009, 80:97-103. 10.1080/17453670902807425.
24. Gupta A., Lattermann C., Busam M., Riff A., Bach B.R., Wang V.M. Biomechanical evaluation of bioabsorbable versus metallic screws for posterior cruciate ligament inlay graft fixation: a comparative study. Am J Sports Med 2009, 37:748-753. 10.1177/0363546508328106.
25. Gupta R., Lee T.Q. Contributions of the different rabbit models to our understanding of rotator cuff pathology. J Shoulder Elbow Surg 2007, 16(5 Suppl):S149-S157. 10.1016/j.jse.2007.05.002.
26. Haasio J., Tuominen M., Rosenberg P.H. Continuous interscalene brachial plexus block during and after shoulder surgery. Ann Chir Gynaecol 1990, 79:103-107.
27. Hansen B.P., Beck C.L., Beck E.P., Townsley R.W. Postarthroscopic glenohumeral chondrolysis. Am J Sports Med 2007, 35:1628-1634. 10.1177/0363546507304136.
28. Hogan Q., Dotson R., Erickson S., Kettler R., Hogan K. Local anesthetic myotoxicity: a case and review. Anesthesiology 1994, 80:942-947.
29. Ide J., Kikukawa K., Hirose J., Iyama K., Sakamoto H., Fujimoto T., et al. The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon. J Shoulder Elbow Surg 2009, 18:391-398. 10.1016/j.jse.2009.01.013.
30. Karpie J.C., Chu C.R. Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro. Am J Sports Med 2007, 35:1621-1627. 10.1177/0363546507304719.
31. Koike Y., Trudel G., Curran D., Uhthoff H.K. Delay of supraspinatus repair by up to 12 weeks does not impair enthesis formation: a quantitative histologic study in rabbits. J Orthop Res 2006, 24:202-210. 10.1002/jor.20031.
32. Koike Y., Trudel G., Uhthoff H.K. Formation of a new enthesis after attachment of the supraspinatus tendon: A quantitative histologic study in rabbits. J Orthop Res 2005, 23:1433-1440. 10.1016/j.orthres.2005.02.015.1100230628.
33. Lin T.W., Cardenas L., Soslowsky L.J. Biomechanics of tendon injury and repair. J Biomech 2004, 37:865-877. 10.1016/j.jbiomech.2003.11.005.
34. McNickle A.G., L'heureux D.R., Provencher M.T., Romeo A.A., Cole B.J. Postsurgical Glenohumeral Arthritis in Young Adults. Am J Sports Med 2009 Jun 9, 37:1784-1791. 10.1177/0363546509333481.
35. Nho S.J., Cole B.J., Mazzocca A.D., Williams J.M., Romeo A.A., Bush-Joseph C.A., et al. Comparison of ultrasonic suture welding and traditional knot tying in a rabbit rotator cuff repair model. J Shoulder Elbow Surg 2006, 15:630-638. 10.1016/j.jse.2005.09.006.
36. Nouette-Gaulain K., Dadure C., Morau D., Pertuiset C., Galbes O., Hayot M., et al. Age-dependent bupivacaine-induced muscle toxicity during continuous peripheral nerve block in rats. Anesthesiology 2009, 111:1120-1127. 10.1097/ALN.0b013e3181bbc949.
37. Nouette-Gaulain K., Jose C., Capdevila X., Rossignol R. From analgesia to myopathy: when local anesthetics impair the mitochondrion. Int J Biochem Cell Biol 2011, 43:14-19. 10.1016/j.biocel.2010.10.005.
38. Padera R., Bellas E., Tse J.Y., Hao D., Kohane D.S. Local myotoxicity from sustained release of bupivacaine from microparticles. Anesthesiology 2008, 108:921-928. 10.1097/ALN.0b013e31816c8a48.
39. Park J.Y., Lee G.W., Kim Y., Yoo M.J. The efficacy of continuous intrabursal infusion with morphine and bupivacaine for postoperative analgesia after subacromial arthroscopy. Reg Anesth Pain Med 2002, 27:145-149.
40. Piper S.L., Kim H.T. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Am 2008, 90:986-991. 10.2106/JBJS.G.01033.
41. Rapley J.H., Beavis R.C., Barber F.A. Glenohumeral chondrolysis after shoulder arthroscopy associated with continuous bupivacaine infusion. Arthroscopy 2009, 25:1367-1373. 10.1016/j.arthro.2009.08.024.
42. Rodeo S.A., Potter H.G., Kawamura S., Turner A.S., Kim H.J., Atkinson B.L. Biologic augmentation of rotator cuff tendon-healing with use of a mixture of osteoinductive growth factors. J Bone Joint Surg Am 2007, 89:2485-2497. 10.2106/JBJS.C.01627.
43. Scheffel P.T., Clinton J., Lynch J.R., Warme W.J., Bertelsen A.L., Matsen F.A. Glenohumeral chondrolysis: a systematic review of 100 cases from the English language literature. J Shoulder Elbow Surg 2010, 19:944-949. 10.1016/j.jse.2010.01.023.
44. Scherb M.B., Han S.H., Courneya J.P., Guyton G.P., Schon L.C. Effect of bupivacaine on cultured tenocytes. Orthopedics 2009, 32:26.
45. Soslowsky L.J., Carpenter J.E., DeBano C.M., Banerji I., Moalli M.R. Development and use of an animal model for investigations on rotator cuff disease. J Shoulder Elbow Surg 1996, 5:383-392.
46. Tetzlaff J.E., Brems J., Dilger J. Intraarticular morphine and bupivacaine reduces postoperative pain after rotator cuff repair. Reg Anesth Pain Med 2000, 25:611-614.
47. Tuominen M., Haasio J., Hekali R., Rosenberg P.H. Continuous interscalene brachial plexus block: clinical efficacy, technical problems and bupivacaine plasma concentrations. Acta Anaesthesiol Scand 1989, 33:84-88.
48. Uhthoff H.K., Matsumoto F., Trudel G., Himori K. Early reattachment does not reverse atrophy and fat accumulation of the supraspinatus-an experimental study in rabbits. J Orthop Res 2003, 21:386-392. 10.1016/S0736-0266(02)00208-5.
49. Uhthoff H.K., Sano H., Trudel G., Ishii H. Early reactions after reimplantation of the tendon of supraspinatus into bone. A study in rabbits. J Bone Joint Surg Br 2000, 82:1072-1076.
50. Uhthoff H.K., Seki M., Backman D.S., Trudel G., Himori K., Sano H. Tensile strength of the supraspinatus after reimplantation into a bony trough: an experimental study in rabbits. J Shoulder Elbow Surg 2002, 11:504-509.
51. Van Thiel G.S., Wang V.M., Wang F.C., Nho S.J., Piasecki D.P., Bach B.R., et al. Biomechanical similarities among subscapularis repairs after shoulder arthroplasty. J Shoulder Elbow Surg 2010, 19:657-663. 10.1016/j.jse.2010.01.014.
52. Watson R, Hartzell J, Badman B, Ghivizanni S, Sahajpal D, Wright TW. Local anesthetic toxicity and cultured fibroblasts. Presented at the Closed ASES Meeting, 2008. September 3-6, 2008. Santa Barbara, CA.
53. Webb D., Guttmann D., Cawley P., Lubowitz J.H. Continuous infusion of a local anesthetic versus interscalene block for postoperative pain control after arthroscopic shoulder surgery. Arthroscopy 2007, 23:1006-1011. 10.1016/j.arthro.2007.04.008.
54. Yagiela J.A., Benoit P.W., Buoncristiani R.D., Peters M.P., Fort N.F. Comparison of myotoxic effects of lidocaine with epinephrine in rats and humans. Anesth Analg 1981, 60:471-480.
55. Yokoya S., Mochizuki Y., Nagata Y., Deie M., Ochi M. Tendon-bone insertion repair and regeneration using polyglycolic acid sheet in the rabbit rotator cuff injury model. Am J Sports Med 2008, 36:1298-1309. 10.1177/0363546508314416.
56. Zhang C., Phamonvaechavan P., Rajan A., Poon D.Y., Topcu-Yilmaz P., Guyton D.L. Concentration-dependent bupivacaine myotoxicity in rabbit extraocular muscle. J AAPOS 2010, 14:323-327. 10.1016/j.jaapos.2010.05.009.
57. Zink W., Bohl J.R., Hacke N., Sinner B., Martin E., Graf B.M. The long term myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blocks. Anesth Analg 2005, 101:548-554. 10.1213/01.ANE.0000155956.59842.0A.
58. Zink W., Graf B.M. Benefit-risk assessment of ropivacaine in the management of postoperative pain. Drug Saf 2004, 27:1093-1114.
59. Zink W., Graf B.M. Local anesthetic myotoxicity. Reg Anesth Pain Med 2004, 29:333-340.
60. Zink W., Seif C., Bohl J.R., Hacke N., Braun P.M., Sinner B., et al. The acute myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blockades. Anesth Analg 2003, 97:1173-1179.
61. Zink W., Sinner B., Zausig Y., Graf B.M. Myotoxicity of local anaesthetics: experimental myth or clinical truth?. Anaesthesist 2007, 56:118-127. 10.1007/s00101-006-1121-5.