Targeted Ablation of miR-21 Decreases Murine Eosinophil Progenitor Cell Growth

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Lu, Thomas X ^a   Lim, Eun Jin ^a   Itskovich, Svetlana ^a   Besse, John A ^a   Plassard, Andrew J ^a   Mingler, Melissa K ^a   Rothenberg, Joelle A ^a   Fulkerson, Patricia C ^a   Aronow, Bruce J ^a   Rothenberg, Marc E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; LIPOCORTIN 5; MICRORNA 21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BHLHA15 GENE; CELL CYCLE REGULATION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMING UNIT; CONTROLLED STUDY; DOWN REGULATION; EOSINOPHIL COUNT; EOSINOPHIL PROGENITOR CELL GROWTH; EOSINOPHILIC ESOPHAGITIS; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GRB7 GENE; GROWTH REGULATION; HYAL1 GENE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MS4A3 GENE; NONHUMAN; PIK3R6 GENE; PSRC1 GENE; UPREGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; EOSINOPHILS; ESOPHAGITIS; FLOW CYTOMETRY; MICE; MICE, INBRED C57BL; MICRORNAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS;

EID: 84875334130     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059397     Document Type: Article

References (32)

1. Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, et al. (2008) Eosinophils: biological properties and role in health and disease. Clin Exp Allergy 38: 709-750.
2. Akuthota P, Weller PF, (2012) Eosinophils and disease pathogenesis. Semin Hematol 49: 113-119.
3. Iwasaki H, Mizuno S, Mayfield R, Shigematsu H, Arinobu Y, et al. (2005) Identification of eosinophil lineage-committed progenitors in the murine bone marrow. J Exp Med 201: 1891-1897.
4. Kouro T, Takatsu K, (2009) IL-5- and eosinophil-mediated inflammation: from discovery to therapy. Int Immunol 21: 1303-1309.
5. Rosas M, Dijkers PF, Lindemans CL, Lammers JW, Koenderman L, et al. (2006) IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization. J Leukoc Biol 80: 186-195.
6. Mori Y, Iwasaki H, Kohno K, Yoshimoto G, Kikushige Y, et al. (2009) Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. The Journal of experimental medicine 206: 183-193.
7. Navarro F, Lieberman J, (2010) Small RNAs guide hematopoietic cell differentiation and function. J Immunol 184: 5939-5947.
8. Georgantas RW, 3rd, Hildreth R, Morisot S, Alder J, Liu CG, et al (2007) CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A 104: 2750-2755.
9. Lu TX, Munitz A, Rothenberg ME, (2009) MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 182: 4994-5002.
10. Wu F, Zikusoka M, Trindade A, Dassopoulos T, Harris ML, et al. (2008) MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 135: 1624-1635.
11. Lu TX, Sherrill JD, Wen T, Plassard AJ, Besse JA, et al. (2012) MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers. J Allergy Clin Immunol 129: 1064-1075.
12. Lu TX, Hartner J, Lim EJ, Fabry V, Mingler MK, et al. (2011) MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol 187: 3362-3373.
13. Dyer KD, Moser JM, Czapiga M, Siegel SJ, Percopo CM, et al. (2008) Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow. J Immunol 181: 4004-4009.
14. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
15. Fulkerson PC, Fischetti CA, McBride ML, Hassman LM, Hogan SP, et al. (2006) A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc Natl Acad Sci U S A 103: 16418-16423.
16. Chen J, Bardes EE, Aronow BJ, Jegga AG, (2009) ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res 37: W305-311.
17. Kaimal V, Bardes EE, Tabar SC, Jegga AG, Aronow BJ, (2010) ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems. Nucleic Acids Res 38: W96-102.
18. Mishra A, Wang M, Pemmaraju VR, Collins MH, Fulkerson PC, et al. (2008) Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology 134: 204-214.
19. Mavi P, Rajavelu P, Rayapudi M, Paul RJ, Mishra A, (2012) Esophageal functional impairments in experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol 302: G1347-1355.
20. Krichevsky AM, Gabriely G, (2009) miR-21: a small multi-faceted RNA. J Cell Mol Med 13: 39-53.
21. Hatley ME, Patrick DM, Garcia MR, Richardson JA, Bassel-Duby R, et al. (2010) Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell 18: 282-293.
22. Papagiannakopoulos T, Shapiro A, Kosik KS, (2008) MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 68: 8164-8172.
23. Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, et al. (2002) Human HTm4 is a hematopoietic cell cycle regulator. J Clin Invest 109: 51-58.
24. Jia D, Sun Y, Konieczny SF, (2008) Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1. Gastroenterology 135: 1687-1697.
25. Wang Y, Chan DW, Liu VW, Chiu P, Ngan HY, (2010) Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis. Clin Cancer Res 16: 2529-2539.
26. Tan JX, Wang XY, Li HY, Su XL, Wang L, et al. (2011) HYAL1 overexpression is correlated with the malignant behavior of human breast cancer. Int J Cancer 128: 1303-1315.
27. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, et al. (2008) Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 283: 1026-1033.
28. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, et al. (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658.
29. Pan X, Wang ZX, Wang R, (2010) MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol Ther 10: 1224-1232.
30. Zhu S, Wu H, Wu F, Nie D, Sheng S, et al. (2008) MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 18: 350-359.
31. Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, et al. (1999) Identification of a novel mouse p53 target gene DDA3. Oncogene 18: 7765-7774.
32. Lu S, Mukkada VA, Mangray S, Cleveland K, Shillingford N, et al. (2012) MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One 7: e40676.