Leukocyte adhesion deficiency type I in a mixed-breed dog

Journal of Veterinary Diagnostic Investigation

Volumn 25, Issue 2, 2013, Pages 291-296

  Zimmerman, Kurt L ^a   McMillan, Kate ^a   Monroe, William E ^a   Sponenberg, D Phillip ^a   Evans, Nick ^c   Makris, Melissa ^b   Hammond, Sarah H ^a   Kanevsky Mullarky, Isis ^a   Boudreaux, Mary K ^d  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b Veterinary Teaching Hospital   (United States)

^c General Booth Veterinary Hospital   (United States)

^d AUBURN UNIVERSITY   (United States)

Author keywords

Beta2 integrin; canine; cluster of differentiation 18; Irish Setter; leukemoid; leukocyte adhesion deficiency

Indexed keywords

EID: 84875281263     PISSN: 10406387     EISSN: 19434936     Source Type: Journal    
DOI: 10.1177/1040638713478814     Document Type: Article

References (14)

1. Boudreaux MK,Wardrop KJ,Kiklevich V,et al.A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections.Thromb Haemost. 2010;103:475-477.
2. Creevy KE,Bauer TR,Tuschong LM,et al.Canine leukocyte adhesion deficiency colony for investigation of novel hematopoietic therapies.Vet Immunol Immunopathol. 2003;94:11-22.
3. Debenham SL,Millington A,Kijast J,et al.Canine leucocyte adhesion deficiency in Irish red and white setters.J Small Anim Pract. 2002;43:74-75.
4. Foureman P,Whiteley M,Giger U.Canine leukocyte adhesion deficiency: presence of the Cys36Ser beta-2 integrin mutation in an affected US Irish Setter cross-breed dog and in US Irish Red and White Setters.J Vet Intern Med. 2002;16:518-523.
5. Giger U,Boxer LA,Simpson PJ,et al.Deficiency of leukocyte surface glycoproteins Mo1, LFA-1, and Leu M5 in a dog with recurrent bacterial infections: an animal model.Blood. 1987;69:1622-1630.
6. Gu YC,Bauer TR,Ackermann MR,et al.The genetic immunodeficiency disease, leukocyte adhesion deficiency, in humans, dogs, cattle, and mice.Comp Med. 2004;54:363-372.
7. Jain NCEssentials of veterinary hematology. Philadelphia, PA: Lea & Febiger; 1993:222-246.
8. Jobling AI,Ryan J,Augusteyn RC.The frequency of the canine leukocyte adhesion deficiency (CLAD) allele within the Irish Setter population of Australia.Aust Vet J. 2003;81:763-765.
9. Kijas JM,Bauer TR,Gäfvert S,et al.A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency.Genomics. 1999;61:101-107.
10. Kijas JM,Juneja RK,Gäfvert S,Andersson L.Detection of the causal mutation for canine leukocyte adhesion deficiency (CLAD) using pyrosequencing.Anim Genet. 2000;31:326-328.
11. Kobayashi S,Sato R,Abe Y,et al.Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation.Vet Immunol Immunopathol. 2009;130:187-196.
12. Robbins SL,Kumar V,Cotran RSRobbins and Cotran's pathologic basis of disease. 2010, Acute and chronic inflammation. In: Robbins and Cotran's pathologic basis of disease, 8th ed., pp. 48-78. Saunders Elsevier, Philadelphia, PA.Philadelphia, PA: Saunders Elsevier; 2010:48-78.
13. Trowald-Wigh G,Ekman S,Hansson K,et al.Clinical, radiological and pathological features of 12 Irish setters with canine leucocyte adhesion deficiency.J Small Anim Pract. 2000;41:211-217.
14. Weiss DJSchalm's veterinary hematology. 2010, Neutrophil function disorders. In: Schalm's veterinary hematology, ed. WeissDJWardropKJSchalmOW, 6th ed., pp. 275-280. Wiley-Blackwell, Ames, IA.Weiss DJWardrop KJSchalm OW, ed. Ames, IA: Wiley-Blackwell; 2010:275-280.