15-Deoxy-Δ12,14-prostaglandin J2 induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines

International Journal of Molecular Medicine

Volumn 31, Issue 4, 2013, Pages 778-788

  Li, Haili ^a,b   Narahara, Hisashi ^a  

^a OITA UNIVERSITY   (Japan)

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

15 deoxy 12,14 prostaglandin J2; Apoptosis; Cell cycle; Endometrial cancer; Microarray

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ALDO KETO REDUCTASE FAMILY 1 MEMBER C3; ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE 2A; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; ENZYME INDUCTION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROSTAGLANDIN D2;

EID: 84875270211     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1268     Document Type: Article

References (18)

1. Reinhardt MJ: Gynecologic tumors. Recent Results Cancer Res 170: 141-150, 2008.
2. Obel JC, Friberg G and Fleming GF: Chemotherapy in endometrial cancer. Clin Adv Hematol Oncol 4: 459-468, 2006.
3. Hill EK and Dizon DS: Medical therapy of endometrial cancer: current status and promising novel treatments. Drugs 72: 705-713, 2012.
4. Ota K, Ito K, Suzuki T, et al: Peroxisome proliferator-activated receptor gamma and growth inhibition by its ligands in uterine endometrial carcinoma. Clin Cancer Res 12: 4200-4208, 2006
5. Xin B, Yokoyama Y, Shigeto T, Futagami M and Mizunuma H: Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers. Cancer 110: 791-800, 2007.
6. Yang YC, Tsao YP, Ho TC and Choung IP: Peroxisome proliferator-activated receptor-gamma agonists cause growth arrest and apoptosis in human ovarian carcinoma cell lines. Int J Gynecol Cancer 17: 418-425, 2007.
7. Nosjean O and Boutin JA: Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part? Cell Signal 14: 573-583, 2002.
8. 2 is a ligand for the adipocyte determination factor PPAR?. Cell 83: 803-812, 1995.
9. 2 metabolite binds peroxisome proliferator-activated receptor g and promotes adipocyte differentiation. Cell 83: 813-819, 1995.
10. 2. Cell Biol Int 35: 1089-1096, 2011.
11. 2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. Clin Cancer Res 15: 5414-5425, 2009.
12. Mansure JJ, Nassim R and Kassouf W: Peroxisome proliferator-activated receptor gamma in bladder cancer: a promising therapeutic target. Cancer Biol Ther 8: 6-15, 2009.
13. Beissbarth T and Speed TP: GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics20: 1464-1465, 2004.
14. Rimon G, Bazenet CE, Philpott KL and Rubin LL: Increased surface phosphatidylserine is an early marker of neuronal apoptosis. J Neurosci Res 48: 563-570, 1997.
15. Chen Y, Kramer DL, Diegelman P, Vujcic S and Porter CW: Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res 61: 6437-6444, 2001.
16. Zakharov V, Lin HK, Azzarello J, et al: Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma. Int J Clin Exp Pathol 3: 608-617, 2010.
17. Gray TA, MacLaine NJ, Michie CO, et al: Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models. J Immunol Methods 378: 20-32, 2012.
18. Eyler C E, Wu Q, Yan K, et al: Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell 146: 53-66, 2011.