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Volumn 72, Issue 5, 2012, Pages 705-713

Medical therapy of endometrial cancer: Current status and promising novel treatments

Author keywords

Angiogenesis inhibitors; Doxorubicin; Endometrial cancer; Epothilones; Paclitaxel

Indexed keywords

ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; EPOTHILONE DERIVATIVE; ERLOTINIB; ESTROGEN; EVEROLIMUS; GEFITINIB; IXABEPILONE; K RAS PROTEIN; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MEDROXYPROGESTERONE; MEGESTROL ACETATE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE; PROTEIN P16; PROTEIN P53; RIDAFOROLIMUS; SORAFENIB; SUNITINIB; TAMOXIFEN; TEMSIROLIMUS; TRASTUZUMAB;

EID: 84858785303     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11631840-000000000-00000     Document Type: Review
Times cited : (37)

References (68)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • Jemal A, Seigel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin 2010; 60 (5): 277-300
    • (2010) CA Cancer J Clin , vol.60 , Issue.5 , pp. 277-300
    • Jemal, A.1    Seigel, R.2    Xu, J.3
  • 2
    • 37049013701 scopus 로고    scopus 로고
    • Cancer incidence and mortality in relation to body mass index in the Million Women Study: Cohort study
    • Reeves GK, Pirie K, Beral V, et al. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ 2007; 335 (7630): 1134
    • (2007) BMJ , vol.335 , Issue.7630 , pp. 1134
    • Reeves, G.K.1    Pirie, K.2    Beral, V.3
  • 3
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    • DOI 10.1016/S0140-6736(08)60269-X, PII S014067360860269X
    • Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and metaanalysis of prospective observational studies. Lancet 2008; 371: 569-78 (Pubitemid 351232031)
    • (2008) The Lancet , vol.371 , Issue.9612 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 4
    • 81855170040 scopus 로고    scopus 로고
    • Understanding obesity and endometrial cancer risk: Opportunities for prevention
    • Dec
    • Schmandt RE, Iglesias DA, Co NN, et al. Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol 2011 Dec; 205 (6): 518-25
    • (2011) Am J Obstet Gynecol , vol.205 , Issue.6 , pp. 518-25
    • Schmandt, R.E.1    Iglesias, D.A.2    Co, N.N.3
  • 5
    • 33646410147 scopus 로고    scopus 로고
    • Comparison of uterine malignancies that develop during and following tamoxifen therapy
    • Ferguson SE, Soslow RA, Amsterdam A, et al. Comparison of uterine malignancies that develop during and following tamoxifen therapy. Gynecol Oncol 2006; 101 (2): 322-6
    • (2006) Gynecol Oncol , vol.101 , Issue.2 , pp. 322-6
    • Ferguson, S.E.1    Soslow, R.A.2    Amsterdam, A.3
  • 7
    • 79955550125 scopus 로고    scopus 로고
    • Revised FIGO staging system for endometrial cancer
    • Lewin SN. Revised FIGO staging system for endometrial cancer. Clin Obstet Gynecol 2011; 54 (2): 215-8
    • (2011) Clin Obstet Gynecol , vol.54 , Issue.2 , pp. 215-8
    • Lewin, S.N.1
  • 8
    • 40749126861 scopus 로고    scopus 로고
    • Endometrial cancer
    • DOI 10.1097/AOG.0b013e318162f690, PII 0000625020080200000027
    • Sorosky JI. Endometrial cancer. Obstet Gynecol 2008; 111: 436-47 (Pubitemid 351653438)
    • (2008) Obstetrics and Gynecology , vol.111 , Issue.PART 1 , pp. 436-447
    • Sorosky, J.I.1
  • 9
    • 22544448651 scopus 로고    scopus 로고
    • ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists,number 65, August 2005: Management of endometrial cancer
    • American College of Obstetricians and Gynecologists Aug
    • American College of Obstetricians and Gynecologists. ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer. Obstet Gynecol 2005 Aug; 106 (2): 413-25
    • (2005) Obstet Gynecol , vol.106 , Issue.2 , pp. 413-25
  • 10
    • 69449098469 scopus 로고    scopus 로고
    • Intravaginal brachytherapy in FIGO stage i low-risk endometrial cancer: A controlled randomized study
    • Sorbe B, Nordström B, Mäenpä ä J, et al. Intravaginal brachytherapy in FIGO stage I low-risk endometrial cancer: a controlled randomized study. Int J Gynecol Cancer 2009; 19 (5): 873-8
    • (2009) Int J Gynecol Cancer , vol.19 , Issue.5 , pp. 873-8
    • Sorbe, B.1    Nordström, B.2    Mäenpää, J.3
  • 12
    • 1342321840 scopus 로고    scopus 로고
    • A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: A Gynecologic Oncology Group study
    • DOI 10.1016/j.ygyno.2003.11.048
    • Keys HM, Roberts JA, Brunetto VL, et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2004; 92: 744-51 (Pubitemid 38251372)
    • (2004) Gynecologic Oncology , vol.92 , Issue.3 , pp. 744-751
    • Keys, H.M.1    Roberts, J.A.2    Brunetto, V.L.3    Zaino, R.J.4    Spirtos, N.M.5    Bloss, J.D.6    Pearlman, A.7    Maiman, M.A.8    Bell, J.G.9
  • 14
    • 58149186453 scopus 로고    scopus 로고
    • Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): Pooled trial results, systematic review, and meta-analysis
    • Blake P, Swart Am, Orton J, et al. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis. Lancet 2009; 373: 137-46
    • (2009) Lancet , vol.373 , pp. 137-46
    • Blake, P.1    Am, S.2    Orton, J.3
  • 15
    • 77649130174 scopus 로고    scopus 로고
    • Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): An open-label, non-inferiority, randomised trial
    • Nout RA, Smit VT, Putter H, et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial. Lancet 2010; 375: 816-23
    • (2010) Lancet , vol.375 , pp. 816-23
    • Nout, R.A.1    Smit, V.T.2    Putter, H.3
  • 16
    • 84856376656 scopus 로고    scopus 로고
    • External pelvic and vaginal irradiation versus vaginal irradiation alone as postoperative therapy in medium-risk endometrial carcinoma: A prospective randomised study
    • Sorbe B, Horvath G, AnderssonH, et al. External pelvic and vaginal irradiation versus vaginal irradiation alone as postoperative therapy in medium-risk endometrial carcinoma: a prospective randomised study. Int J Radiat Oncol Biol Phys 2011; 82 (3): 1249-55
    • (2011) Int J Radiat Oncol Biol Phys , vol.82 , Issue.3 , pp. 1249-55
    • Sorbe, B.1    Anderssonh H.G2
  • 17
    • 4644277448 scopus 로고    scopus 로고
    • Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: A literature review
    • DOI 10.1016/j.ygyno.2004.06.045, PII S0090825804005086
    • Ramirez PT, Frumovitz M, Bodurka DC, et al. Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: a literature review. Gynecol Oncol 2004; 95: 133-8 (Pubitemid 39286288)
    • (2004) Gynecologic Oncology , vol.95 , Issue.1 , pp. 133-138
    • Ramirez, P.T.1    Frumovitz, M.2    Bodurka, D.C.3    Sun, C.C.4    Levenback, C.5
  • 19
    • 0035863402 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of advanced or recurrent endometrial carcinoma: A Gynecologic Oncology Group study
    • Thigpen T, Brady MF, Homesley HD, et al. Tamoxifen in the treatment of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol 2001; 19: 364-7 (Pubitemid 32112847)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.2 , pp. 364-367
    • Thigpen, T.1    Brady, M.F.2    Homesley, H.D.3    Soper, J.T.4    Bell, J.5
  • 20
    • 0742307280 scopus 로고    scopus 로고
    • Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: A Gynecologic Oncology Group study
    • DOI 10.1016/j.ygyno.2003.11.008
    • Fiorica JV, Brunetto VL, Hanjani P, et al. Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2004; 92: 10-4 (Pubitemid 38147365)
    • (2004) Gynecologic Oncology , vol.92 , Issue.1 , pp. 10-14
    • Fiorica, J.V.1    Brunetto, V.L.2    Hanjani, P.3    Lentz, S.S.4    Mannel, R.5    Andersen, W.6
  • 21
    • 0742324890 scopus 로고    scopus 로고
    • Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: A Gynecologic Oncology Group study
    • DOI 10.1016/j.ygyno.2003.09.018
    • Whitney CW, Brunetto VL, Zaino RJ, et al. Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2004; 92: 4-9 (Pubitemid 38147364)
    • (2004) Gynecologic Oncology , vol.92 , Issue.1 , pp. 4-9
    • Whitney, C.W.1    Brunetto, V.L.2    Zaino, R.J.3    Lentz, S.S.4    Sorosky, J.5    Armstrong, D.K.6    Lee, R.B.7
  • 22
    • 33644836069 scopus 로고    scopus 로고
    • Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: A gynecologic oncology group study
    • DOI 10.1200/JCO.2004.00.7617
    • Randall ME, Filiaci VL, Muss H, et al. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol 2006; 24: 36-44 (Pubitemid 46630491)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.1 , pp. 36-44
    • Randall, M.E.1    Filiaci, V.L.2    Muss, H.3    Spirtos, N.M.4    Mannel, R.S.5    Fowler, J.6    Thigpen, J.T.7    Benda, J.A.8    Mackey, D.9
  • 23
    • 37349026899 scopus 로고    scopus 로고
    • Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: A Japanese Gynecologic Oncology Group study
    • DOI 10.1016/j.ygyno.2007.09.029, PII S009082580700786X
    • Susumu N, Sagae S, Udagawa Y, et al. Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediateand high-risk endometrial cancer: a Japanese Gynecologic Oncology Group study. Gynecol Oncol 2008; 108: 226-33 (Pubitemid 350299451)
    • (2008) Gynecologic Oncology , vol.108 , Issue.1 , pp. 226-233
    • Susumu, N.1    Sagae, S.2    Udagawa, Y.3    Niwa, K.4    Kuramoto, H.5    Satoh, S.6    Kudo, R.7
  • 25
    • 60449095359 scopus 로고    scopus 로고
    • A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic Oncology Group study
    • Homesley HD, Filiaci V, Gibbons SK, et al. A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: a Gynecologic Oncology Group study. Gynecol Oncol 2009; 112: 543-52
    • (2009) Gynecol Oncol , vol.112 , pp. 543-52
    • Homesley, H.D.1    Filiaci, V.2    Gibbons, S.K.3
  • 26
    • 77955918294 scopus 로고    scopus 로고
    • Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer: Results from two randomized studies
    • Hogberg T, Signorelli M, Freire de Oliveira C, et al. Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer: results from two randomized studies. Eur J Cancer 2010; 46: 2422-31
    • (2010) Eur J Cancer , vol.46 , pp. 2422-31
    • Hogberg, T.1    Signorelli, M.2    Freire De Oliveira, C.3
  • 30
    • 34447536870 scopus 로고    scopus 로고
    • Systemic chemotherapy for uterine carcinoma: Metastatic and adjuvant
    • DOI 10.1200/JCO.2007.10.8431
    • Fleming GF. Systematic chemotherapy for uterine carcinoma: metastatic and adjuvant. J Clin Oncol 2007; 25: 2983-90 (Pubitemid 47123163)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.20 , pp. 2983-2990
    • Fleming, G.F.1
  • 31
    • 0030220145 scopus 로고    scopus 로고
    • A phase II trial of paclitaxel in patients with advanced or recurrent adenocarcinoma of the endometrium: A Gynecologic Oncology Group Study
    • DOI 10.1006/gyno.1996.0227
    • Ball HG, Blessing JA, Lentz SS, et al. A phase II trial of paclitaxel in patients with advanced or recurrent adenocarcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol 1996; 62: 278-81 (Pubitemid 26274811)
    • (1996) Gynecologic Oncology , vol.62 , Issue.2 , pp. 278-281
    • Ball, H.G.1    Blessing, J.A.2    Lentz, S.S.3    Mutch, D.G.4
  • 32
    • 0037342140 scopus 로고    scopus 로고
    • Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: A Gynecologic Oncology Group study
    • DOI 10.1016/S0090-8258(02)00068-9
    • Lincoln S, Blessing JA, Lee RB, et al. Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2003; 88: 277-81 (Pubitemid 36335809)
    • (2003) Gynecologic Oncology , vol.88 , Issue.3 , pp. 277-281
    • Lincoln, S.1    Blessing, J.A.2    Lee, R.B.3    Rocereto, T.F.4
  • 34
    • 4444273372 scopus 로고    scopus 로고
    • Phase III randomized trial of doxorubicin + cisplatin versus doxorubicin + 24-h paclitaxel + filgrastim in endometrial carcinoma: A gynecologic oncology group study
    • DOI 10.1093/annonc/mdh316
    • Fleming GF, Filiaci VL, Bentley RC, et al. Phase III randomized trial of doxorubicin+cisplatin versus doxorubicin+24-h paclitaxel+filgrastim in endometrial carcinoma: a Gynecologic Oncology Group study. Ann Oncol 2004; 15: 1173-8 (Pubitemid 39199303)
    • (2004) Annals of Oncology , vol.15 , Issue.8 , pp. 1173-1178
    • Fleming, G.F.1    Filiaci, V.L.2    Bentley, R.C.3    Herzog, T.4    Sorosky, J.5    Vaccarello, L.6    Gallion, H.7
  • 36
    • 0030018666 scopus 로고    scopus 로고
    • Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) production, physico-chemical and biological properties
    • Gerth K, Bedorf N, Hoe G, et al. Epothilones A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J Antibiot 1996; 49: 560-3 (Pubitemid 26235665)
    • (1996) Journal of Antibiotics , vol.49 , Issue.6 , pp. 560-563
    • Gerth, K.1    Bedorf, N.2    Hofle, G.3    Irschik, H.4    Reichenbach, H.5
  • 37
    • 58749113261 scopus 로고    scopus 로고
    • Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors
    • Rivera E, Lee J, Davies A. Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors. Oncologist 2008; 13: 1207-23
    • (2008) Oncologist , vol.13 , pp. 1207-23
    • Rivera, E.1    Lee, J.2    Davies, A.3
  • 38
    • 53149127645 scopus 로고    scopus 로고
    • Preclinical discovery of ixabepilone, a highly active antineoplastic agent
    • Lee FY, Borzilleri R, Fairchild CR, et al. Preclinical discovery of ixabepilone, a highly active antineoplastic agent. Cancer Chemother Pharmacol 2008; 63: 157-66
    • (2008) Cancer Chemother Pharmacol , vol.63 , pp. 157-66
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 39
    • 58149331055 scopus 로고    scopus 로고
    • Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models
    • Lee F, Covello KL, Castaneda S, et al. Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models. Clin Cancer Res 2008; 14 (24): 8123-31
    • (2008) Clin Cancer Res , vol.14 , Issue.24 , pp. 8123-31
    • Lee, F.1    Covello, K.L.2    Castaneda, S.3
  • 41
    • 20144377696 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer
    • Galsky MD, Small EJ, Oh WK, et al. Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer. J Clin Oncol 2005; 23: 1439-46
    • (2005) J Clin Oncol , vol.23 , pp. 1439-46
    • Galsky, M.D.1    Small, E.J.2    Oh, W.K.3
  • 43
    • 43049105410 scopus 로고    scopus 로고
    • A randomized phase II study of ixabepilone (BMS-247550) given daily × 5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck: An Eastern Cooperative Oncology Group study
    • DOI 10.1093/annonc/mdm591
    • Burtness BA, Manola J, Axelrod R, et al., Eastern Cooperative Oncology Group. A randomized phase II study of ixabepilone (BMS-247550) given daily · 5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck: an Eastern Cooperative Oncology Group study. Ann Oncol 2008; 19: 977-83 (Pubitemid 351627317)
    • (2008) Annals of Oncology , vol.19 , Issue.5 , pp. 977-983
    • Burtness, B.A.1    Manola, J.2    Axelrod, R.3    Argiris, A.4    Forastiere, A.A.5
  • 47
    • 67650302853 scopus 로고    scopus 로고
    • Phase II trial of ixabepilone as second line treatment in advanced endometrial cancer: Gynecologic Oncology Group trial 129-P
    • Dizon DS, Blessing JA, McMeekin DS, et al. Phase II trial of ixabepilone as second line treatment in advanced endometrial cancer: Gynecologic Oncology Group trial 129-P. J Clin Oncol 2009; 27: 3104-8
    • (2009) J Clin Oncol , vol.27 , pp. 3104-8
    • Dizon, D.S.1    Blessing, J.A.2    McMeekin, D.S.3
  • 50
    • 33750576103 scopus 로고    scopus 로고
    • Molecular and pathologic aspects of endometrial carcinogenesis
    • DOI 10.1200/JCO.2006.06.7173
    • Hecht J, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006; 24 (29): 4783-91 (Pubitemid 46630943)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.29 , pp. 4783-4791
    • Hecht, J.L.1    Mutter, G.L.2
  • 51
    • 0034978311 scopus 로고    scopus 로고
    • PTEN, a protean tumor suppressor
    • Mutter GL. PTEN, a protean tumor suppressor. Am J Pathol 2001; 158 (6): 1895-8 (Pubitemid 32545170)
    • (2001) American Journal of Pathology , vol.158 , Issue.6 , pp. 1895-1898
    • Mutter, G.L.1
  • 52
    • 61449282506 scopus 로고    scopus 로고
    • The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies
    • Bansal N, Yendluri V, Wenham RM. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Cancer Control 2009; 16 (1): 8-13
    • (2009) Cancer Control , vol.16 , Issue.1 , pp. 8-13
    • Bansal, N.1    Yendluri, V.2    Wenham, R.M.3
  • 53
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
    • Aug 20
    • Oza AM, Elit L, Tsao MS, et al. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol 2011 Aug 20; 29 (24): 3278-85
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3278-85
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3
  • 54
    • 37149010753 scopus 로고    scopus 로고
    • A phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer [abstract no. 5516]
    • Colombo N, McMeekin S, Schwartz P, et al. A phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer [abstract no. 5516]. J Clin Oncol 2007; 25: 278
    • (2007) J Clin Oncol , vol.25 , pp. 278
    • Colombo, N.1    McMeekin, S.2    Schwartz, P.3
  • 55
    • 78649592049 scopus 로고    scopus 로고
    • A phase 2 study of the oral mammalian target of rapamycin inhibitor everolimus in patients with recurrent endometrial carcinoma
    • Slomovitz BM, Lu KH, Johnson T, et al. A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma. Cancer 2010; 116 (23): 5415-9
    • (2010) Cancer , vol.116 , Issue.23 , pp. 5415-9
    • Slomovitz, B.M.1    Lu, K.H.2    Johnson, T.3
  • 56
    • 37549006796 scopus 로고    scopus 로고
    • Clinical and biological significance of vascular endothelial growth factor in endometrial cancer
    • Kamat AA, Merritt WM, Coffey D, et al. Clinical and biological significance of vascular endothelial growth factor in endometrial cancer. Clin Cancer Res 2007; 13: 7487-95
    • (2007) Clin Cancer Res , vol.13 , pp. 7487-95
    • Kamat, A.A.1    Merritt, W.M.2    Coffey, D.3
  • 57
    • 0035136974 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial carcinoma
    • DOI 10.1006/gyno.2000.6056
    • Hirai M, Nakagawara A, Oosaki T, et al. Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial carcinoma. Gynecol Oncol 2001; 80: 181-8 (Pubitemid 32158456)
    • (2001) Gynecologic Oncology , vol.80 , Issue.2 , pp. 181-188
    • Hirai, M.1    Nakagawara, A.2    Oosaki, T.3    Hayashi, Y.4    Hirono, M.5    Yoshihara, T.6
  • 58
    • 0034041965 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor and its receptors in endometrial carcinoma
    • DOI 10.1006/gyno.2000.5802
    • Yokoyama Y, Sato S, Futagami M, et al. Prognostic significance of vascular endothelial growth factor and its receptors in endometrial carcinoma. Gynecol Oncol 2000; 77: 413-8 (Pubitemid 30368560)
    • (2000) Gynecologic Oncology , vol.77 , Issue.3 , pp. 413-418
    • Yokoyama, Y.1    Sato, S.2    Futagami, M.3    Fukushi, Y.4    Sakamoto, T.5    Umemoto, M.6    Saito, Y.7
  • 60
    • 79957949444 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in recurrent or persistent endometrial Cancer: A Gynecologic Oncology Group Study
    • Aghajanian C, Sill MW, Darcy KM, et al. Phase II trial of bevacizumab in recurrent or persistent endometrial Cancer: a Gynecologic Oncology Group Study. J Clin Oncol 2011; 29 (16): 2259-65
    • (2011) J Clin Oncol , vol.29 , Issue.16 , pp. 2259-65
    • Aghajanian, C.1    Sill, M.W.2    Darcy, K.M.3
  • 61
    • 52049125733 scopus 로고    scopus 로고
    • Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148
    • Oza AM, Eisenhauer EA, Elit L, et al. Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148. J Clin Oncol 2008; 26: 4319-25
    • (2008) J Clin Oncol , vol.26 , pp. 4319-25
    • Oza, A.M.1    Eisenhauer, E.A.2    Elit, L.3
  • 62
    • 74249102857 scopus 로고    scopus 로고
    • Efficacy and safety of gefitinib (Iressa, ZD1839) and potential prognostic value of soluble EGFR, EGFR mutations and tumor markers in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer [abstract no. e16542]
    • Leslie KK, SillMW, Darcy KM, et al. Efficacy and safety of gefitinib (Iressa, ZD1839) and potential prognostic value of soluble EGFR, EGFR mutations and tumor markers in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer [abstract no. e16542]. J Clin Oncol 2009; 27 Suppl.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Leslie, K.K.1    Sillmw Darcy, K.M.2
  • 63
    • 79955637035 scopus 로고    scopus 로고
    • Phase II study of cetuximab (erbitux) in patients with progressive or recurrent endometrial cancer [abstract]
    • Slomovitz B, Schmeler K, Miller D, et al. Phase II study of cetuximab (erbitux) in patients with progressive or recurrent endometrial cancer [abstract]. Gynecol Oncol 2010; 116: 13 Suppl. 1
    • (2010) Gynecol Oncol , vol.116 , Issue.13 SUPPL. 1
    • Slomovitz, B.1    Schmeler, K.2    Miller, D.3
  • 65
    • 70749097152 scopus 로고    scopus 로고
    • Phase II trial of trastuzumab in women with advanced or recurrent HER2-positive endometrial carcinoma: A Gynecologic Oncology Group study
    • Fleming GF, Sill MW, Darcy KM, et al. Phase II trial of trastuzumab in women with advanced or recurrent HER2-positive endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2010; 116: 15-20
    • (2010) Gynecol Oncol , vol.116 , pp. 15-20
    • Fleming, G.F.1    Sill, M.W.2    Darcy, K.M.3
  • 66
    • 77949337347 scopus 로고    scopus 로고
    • A phase II study of sorafenib in advanced uterine carcinoma/ carcinosarcoma: A trial of the Chicago, PMH, and California Phase II Consortia
    • Nimeiri H, Oza AM, Morgan RJ, et al. A phase II study of sorafenib in advanced uterine carcinoma/carcinosarcoma: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 2010; 117: 37-40
    • (2010) Gynecol Oncol , vol.117 , pp. 37-40
    • Nimeiri, H.1    Oza, A.M.2    Morgan, R.J.3
  • 67
    • 84858757946 scopus 로고    scopus 로고
    • Phase II study of sorafenib (BAY 43-9006) in combination with gemcitabine in recurrent epithelial ovarian cancer: A PMH phase II consortium trial [abstract no. 5084]
    • Welch S, Hirte H, Schilder RJ, et al. Phase II study of sorafenib (BAY 43-9006) in combination with gemcitabine in recurrent epithelial ovarian cancer: a PMH phase II consortium trial [abstract no. 5084]. J Clin Oncol 2006; 24
    • (2006) J Clin Oncol , vol.24
    • Welch, S.1    Hirte, H.2    Schilder, R.J.3
  • 68
    • 74249087540 scopus 로고    scopus 로고
    • A phase II study of sunitinib in recurrent or metastatic endometrial carcinoma: A trial of the PMH Phase II consortium [abstract no. 5576]
    • Fleming GF, Morgan R, Wang L, et al. A phase II study of sunitinib in recurrent or metastatic endometrial carcinoma: a trial of the PMH Phase II consortium [abstract no. 5576]. J Clin Oncol 2009; 27
    • (2009) J Clin Oncol , vol.27
    • Fleming, G.F.1    Morgan, R.2    Wang, L.3


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