Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 12, 2013, Pages 4703-4707

  Thurner, Stefan ^a,b,c   Klimek, Peter ^a   Szell, Michael ^a,d   Duftschmid, Georg ^a   Endel, Gottfried ^e   Kautzky Willer, Alexandra ^a   Kasper, David C ^f  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b SANTA FE INSTITUTE   (United States)

^c INTERNATIONAL INSTITUTE FOR APPLIED SYSTEMS ANALYSIS   (Austria)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e Main Assoc of Austrian Social Security Institutions   (Austria)

^f UNIV KLIN KINDER JUGENDHEILKUNDE   (Austria)

Author keywords

Epidemic; Fetal development; Glucose tolerance; Intrauterine programming; Massive data analysis

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; AUSTRIA; DISEASE PREDISPOSITION; FEMALE; HIGH RISK POPULATION; HUMAN; HUNGER; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; QUANTITATIVE STUDY; RISK ASSESSMENT; SEX DIFFERENCE;

AGE FACTORS; AUSTRIA; DIABETES MELLITUS; FEMALE; HISTORY, 20TH CENTURY; HUMANS; MALE; RISK FACTORS; SEX FACTORS; STARVATION;

EID: 84875269038     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1215626110     Document Type: Article

References (41)

1. Unknown (Nov 1, 1919) Foreign comment: Dark days in Austria and Hungary. Literary Digest, p 21.
2. Kermack WO, McKendrick AG, McKinlay PL (1934) Death-rates in Great Britain and Sweden: Expression of specific mortality rates as products of two factors, and some consequences thereof. J Hyg (Lond) 34(4):433-457.
3. Schulz LC (2010) The Dutch Hunger Winter and the developmental origins of health and disease. Proc Natl Acad Sci USA 107(39):16757-16758.
4. de Rooij SR, et al. (2006) Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care 29(8):1897-1901.
5. Kahn HS, Graff M, Stein AD, Lumey LH (2009) A fingerprint marker from early gestation associated with diabetes in middle age: The Dutch Hunger Winter Families Study. Int J Epidemiol 38(1):101-109.
6. van Hoek M, Langendonk JG, de Rooij SR, Sijbrands EJ, Roseboom TJ (2009) Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism. Diabetes 58(6):1440-1444.
7. Hult M, et al. (2010) Hypertension, diabetes and overweight: Looming legacies of the Biafran famine. PLoS ONE 5(10):e13582.
8. Eriksson JG, Forsen TJ, Osmond C, Barker DJ (2003) Pathways of infant and childhood growth that lead to type 2 diabetes. Diabetes Care 26(11):3006-3010.
9. Stanner SA, Yudkin JS (2001) Fetal programming and the Leningrad Siege study. Twin Res 4(5):287-292.
10. Hales CN, Barker DJ (1992) Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia 35(7):595-601.
11. Terauchi Y, et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21(2):230-235.
12. Ozanne SE, et al. (2005) Low birthweight is associated with specific changes in muscle insulin-signalling protein expression. Diabetologia 48(3):547-552.
13. Rahier J, Wallon J, Henquin JC (1981) Cell populations in the endocrine pancreas of human neonates and infants. Diabetologia 20(5):540-546.
14. Hales CN, et al. (1991) Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 303(6809):1019-1022.
15. Gluckman PD, Hanson MA, Cooper C, Thornburg KL (2008) Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 359(1):61-73.
16. Kensara OA, et al.; Hertfordshire Study Group (2005) Fetal programming of body composition: Relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. Am J Clin Nutr 82(5):980-987.
17. Ravelli AC, et al. (1998) Glucose tolerance in adults after prenatal exposure to famine. Lancet 351(9097):173-177.
18. Hitman GA, Sudagani J (2004) Searching for genes in diabetes and the metabolic syndrome. Int J Clin Pract Suppl 58(143):3-8.
19. Singhal A, Lucas A (2004) Early origins of cardiovascular disease: Is there a unifying hypothesis? Lancet 363(9421):1642-1645.
20. de Rooij SR, Wouters H, Yonker JE, Painter RC, Roseboom TJ (2010) Prenatal undernutrition and cognitive function in late adulthood. Proc Natl Acad Sci USA 107(39): 16881-16886.
21. Gluckman PD, Hanson MA (2004) The developmental origins of the metabolic syndrome. Trends Endocrinol Metab 15(4):183-187.
22. Mittendorfer-Rutz E, Rasmussen F, Wasserman D (2004) Restricted fetal growth and adverse maternal psychosocial and socioeconomic conditions as risk factors for suicidal behaviour of offspring: A cohort study. Lancet 364(9440):1135-1140.
23. Dorda W, et al. (2011) Outcome Research Based on Performance Data of the Austrian Health System (Medical Univ of Vienna/Univ of Vienna, Vienna). German.
24. Haas H (1989) Austria and the allies: 1918-1919. Scientific Commission to Examine the History of the Republic of Austria, eds Ackerl I, Neck R (Verlag für Geschichte und Politik, Vienna), Vol 11. German.
25. Bray GA (2004) Medical consequences of obesity. J Clin Endocrinol Metab 89(6): 2583-2589.
26. Logue J, et al.; Scottish Diabetes Research Network Epidemiology Group (2011) Do men develop type 2 diabetes at lower body mass indices than women? Diabetologia 54(12):3003-3006.
27. Kautzky-Willer A, et al. (2012) Influence of increasing BMI on insulin sensitivity and secretion in normotolerant men and women of a wide age span. Obesity (Silver Spring) 20(10):1966-1973.
28. Westerbacka J, et al. (2004) Women and men have similar amounts of liver and intraabdominal fat, despite more subcutaneous fat in women: Implications for sex differences in markers of cardiovascular risk. Diabetologia 47(8):1360-1369.
29. Nielsen S, Guo Z, Johnson CM, Hensrud DD, Jensen MD (2004) Splanchnic lipolysis in human obesity. J Clin Invest 113(11):1582-1588.
30. Rathmann W, et al. (2009) Incidence of type 2 diabetes in the elderly German population and the effect of clinical and lifestyle risk factors: KORA S4/F4 cohort study. Diabet Med 26(12):1212-1219.
31. Balkau B (2000) The DECODE study. Diabetes epidemiology: Collaborative analysis of diagnostic criteria in Europe. Diabetes Metab 26(4):282-286.
32. Zambrano E, et al. (2006) A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol 571(Pt 1):221-230.
33. Sato R, et al. (2012) A cross-sectional study of glucose regulation in young adultswith very low birth weight: Impact of male gender on hyperglycaemia. BMJ Open 2(1):e000327.
34. Rosen T, Bateman D (2010) Male disadvantage in early life; the effects of gender in neonatal medicine. Principles of Gender Specific Medicine, ed Legato M (Elsevier, New York).
35. Gunderson E (2009) Childbearing and obesity in women: Weight before, during and after pregnancy. Obstet Gynecol Clin North Am 36(2):317-332.
36. Kautzky-Willer A, et al. (2008) The impact of risk factors and more stringent diagnostic criteria of gestational diabetes on outcomes in central European women. J Clin Endocrinol Metab 93(5):1689-1695.
37. Ansart S, et al. (2009) Mortality burden of the 1918-1919 influenza pandemic in Europe. Influenza Other Respir Viruses 3(3):99-106.
38. Taubenberger JK, Morens DM (2006) 1918 influenza: The mother of all pandemics. Emerg Infect Dis 12(1):15-22.
39. Alastalo H, et al. (2009) Cardiovascular health of Finnish war evacuees 60 years later. Ann Med 41(1):66-72.
40. Endel G (2011) Health systems research inAustria: Part 1. Social Security Online, Available at www.sozialversicherung.at/mediaDB/831485-Artikel- Gesundheitssystemforschungin-Oesterreich-Dr.Endel.pdf. German.
41. Austrian Institute of Economic Research (WIFO) (1962) Regional unemployment in Austria. WIFO-Monatsberichte 35(2):78-83.