Peptidomics methods for the identification of peptidase-substrate interactions

Current Opinion in Chemical Biology

Volumn 17, Issue 1, 2013, Pages 83-89

  Lone, Anna Mari ^a   Kim, Yun Gon ^b   Saghatelian, Alan ^a  

^a HARVARD UNIVERSITY   (United States)

^b Soongsil University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1; INSULINASE; PEPTIDASE; PROLYL ENDOPEPTIDASE INHIBITOR;

BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; DIABETES MELLITUS; DRUG TARGETING; ENZYME SUBSTRATE COMPLEX; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDOMICS; PROTEIN EXPRESSION; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PEPTIDES; PROTEOMICS; SUBSTRATE SPECIFICITY;

EID: 84875268891     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2012.10.038     Document Type: Review

References (32)

1. Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806. 10.1038/414799a.
2. De Felipe C., et al. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature 1998, 392:394-397.
3. Lin C.C.J., et al. An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E76-E83. 10.1073/pnas.1108903108.
4. Villalon C.M., Olesen J. The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. Pharmacol. Ther. 2009, 124:309-323. 10.1016/j.pharmthera.2009.09.003.
5. Szentirmai E., Hajdu I., Obal F., Krueger J.M. Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res. 2006, 1088:131-140. 10.1016/j.brainres.2006.02.072.
6. Ohno K., Sakurai T. Orexin neuronal circuitry: role in the regulation of sleep and wakefulness. Front. Neuroendocrinol. 2008, 29:70-87. 10.1016/j.yfrne.2007.08.001.
7. Cummings D.E., Overduin J. Gastrointestinal regulation of food intake. J. Clin. Invest. 2007, 117:13-23. 10.1172/jci30227.
8. MacDonald K., MacDonald T.M. The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans. Harv. Rev. Psychiatry 2010, 18:1-21. 10.3109/10673220903523615.
9. Zeeman G.G., KhanDawood F.S., Dawood M.Y. Oxytocin and its receptor in pregnancy and parturition: current concepts and clinical implications. Obstet. Gynecol. 1997, 89:873-883. 10.1016/s0029-7844(97)00056-2.
10. Takayanagi Y., et al. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:16096-16101. 10.1073/pnas.0505312102.
11. Kosfeld M., Heinrichs M., Zak P.J., Fischbacher U., Fehr E. Oxytocin increases trust in humans. Nature 2005, 435:673-676. 10.1038/nature03701.
12. Baumgartner T., Heinrichs M., Vonlanthen A., Fischbacher U., Fehr E. Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 2008, 58:639-650. 10.1016/j.neuron.2008.04.009.
13. Doupis J., Veves A. DPP4 inhibitors: a new approach in diabetes treatment. Adv. Ther. 2008, 25:627-643. 10.1007/s12325-008-0076-1.
14. Overall C.M., Blobel C.P. In search of partners: linking extracellular proteases to substrates. Nat. Rev. Mol. Cell Biol. 2007, 8:245-257. 10.1038/nrm2120.
15. Martens K., et al. PREPL: a putative novel oligopeptidase propelled into the limelight. Biol. Chem. 2006, 387:879-883. 10.1515/bc.2006.111.
16. Fricker L.D. Neuropeptide-processing enzymes: applications for drug discovery. AAPS J. 2005, 7.
17. Hook V., et al. Annual reviews. Annual Review of Pharmacology and Toxicology 2008, vol 48:393-423.
18. Leiting B., et al. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Biochem. J. 2003, 371:525-532. 10.1042/bj20021643.
19. Lim J., et al. Altered neuropeptide processing in prefrontal cortex of Cpe(fat/fat) mice: implications for neuropeptide discovery. J. Neurochem. 2006, 96:1169-1181. 10.1111/j.1471-4159.2005.03614.x.
20. Che F.Y., Biswas R., Fricker L.D. Relative quantitation of peptides in wild-type and Cpe(fat/fat) mouse pituitary using stable isotopic tags and mass spectrometry. J. Mass Spectrom. 2005, 40:227-237. 10.1002/jms.742.
21. Wardman J., Fricker L.D. Proprotein Convertases 2011, vol 768: Methods in Molecular Biology:307-323. Humana Press Inc., 999 Riverview Dr, Ste 208, Totowa, NJ 07512-1165 USA.
22. Tagore D.M., et al. Peptidase substrates via global peptide profiling. Nat. Chem. Biol. 2009, 5:23-25. 10.1038/nchembio.126.
23. Nolte W.M., Tagore D.M., Lane W.S., Saghatelian A. Peptidomics of prolyl endopeptidase in the central nervous system. Biochemistry 2009, 48:11971-11981. 10.1021/bi901637c.
24. Tinoco A.D., Tagore D.M., Saghatelian A. Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform. J. Am. Chem. Soc. 2010, 132:3819-3830. 10.1021/ja909524e.
25. Tenorio-Laranga J., Mannisto P.T., Storvik M., Van der Veken P., Garcia-Horsman J.A. Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney. Biochimie 2012, 94:1849-1859. 10.1016/j.biochi.2012.04.005.
26. Tenorio-Laranga J., Valero M.L., Mannisto P.T., del Pino M.S., Garcia-Horsman J.A. Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain. Anal. Biochem. 2009, 393:80-87. 10.1016/j.ab.2009.06.019.
27. Mentlein R., Gallwitz B., Schmidt W.E. Dipeptidylpeptidase-IV hydrolyzes gastric-inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur. J. Biochem. 1993, 214:829-835. 10.1111/j.1432-1033.1993.tb17986.x.
28. Tinoco A.D., et al. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. Biochemistry 2011, 50:2213-2222. 10.1021/bi2000033.
29. Kim Y.G., Lone A.M., Nolte W.M., Saghatelian A. Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:8523-8527. 10.1073/pnas.1203195109.
30. Smillie S.J., Brain S.D. Calcitonin gene-related peptide (CGRP) and its role in hypertension. Neuropeptides 2011, 45:93-104. 10.1016/j.npep.2010.12.002.
31. Neupert S., Rubakhin S.S., Sweedler J.V. Targeted single-cell microchemical analysis: MS-based peptidomics of individual paraformaldehyde-fixed and immunolabeled neurons. Chem. Biol. 2012, 19:1010-1019.
32. Yin P., Knolhoff A.M., Rosenberg H.J., Millet L.J., Gillette M.U., Sweedler J.V. Peptidomic analyses of mouse astrocytic cell lines and rat primary cultured astrocytes. J. Proteome Res. 2012, 11:3965-3973. 10.1021/pr201066t.