메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages 162-170

Interferon-associated hepatic steatosis is related to discrepancies in biochemical and virological responses of chronic hepatitis C to IFN-based therapy

Author keywords

Alanine aminotransferase; Discrepancy; HCV; Steatosis; Sustained virological response

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA2A INTERFERON; INTERFERON; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN; VIRUS RNA;

EID: 84875262688     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-012-9388-x     Document Type: Article
Times cited : (6)

References (32)
  • 1
    • 63049089916 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C in Asia: When East meets West
    • 19335784 10.1111/j.1440-1746.2009.05789.x 1:CAS:528:DC%2BD1MXltFCgtL8%3D
    • ML Yu WL Chuang 2009 Treatment of chronic hepatitis C in Asia: when East meets West J Gastroenterol Hepatol 24 336 345 19335784 10.1111/j.1440-1746.2009. 05789.x 1:CAS:528:DC%2BD1MXltFCgtL8%3D
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 336-345
    • Yu, M.L.1    Chuang, W.L.2
  • 2
    • 46249114151 scopus 로고    scopus 로고
    • Rapid virological response and treatment duration for chronic hepatitis C genotype 1 patients: A randomized trial
    • 18508296 10.1002/hep.22319 1:CAS:528:DC%2BD1cXotVagtro%3D
    • ML Yu CY Dai JF Huang, et al. 2008 Rapid virological response and treatment duration for chronic hepatitis C genotype 1 patients: a randomized trial Hepatology 47 1884 1893 18508296 10.1002/hep.22319 1:CAS:528: DC%2BD1cXotVagtro%3D
    • (2008) Hepatology , vol.47 , pp. 1884-1893
    • Yu, M.L.1    Dai, C.Y.2    Huang, J.F.3
  • 3
    • 34147207791 scopus 로고    scopus 로고
    • A randomised study of peginterferon and ribavirin for 16 versus 24 weeks in patients with genotype 2 chronic hepatitis C
    • 16956917 10.1136/gut.2006.102558 1:CAS:528:DC%2BD2sXks1Giu7g%3D
    • ML Yu CY Dai JF Huang, et al. 2007 A randomised study of peginterferon and ribavirin for 16 versus 24 weeks in patients with genotype 2 chronic hepatitis C Gut 56 553 559 16956917 10.1136/gut.2006.102558 1:CAS:528: DC%2BD2sXks1Giu7g%3D
    • (2007) Gut , vol.56 , pp. 553-559
    • Yu, M.L.1    Dai, C.Y.2    Huang, J.F.3
  • 4
    • 0036434344 scopus 로고    scopus 로고
    • Is delayed normalization of alanine aminotransferase a poor prognostic predictor in chronic hepatitis C patients treated with a combined interferon and ribavirin therapy?
    • 12423276 10.1046/j.1440-1746.2002.02874.x 1:CAS:528:DC%2BD38Xpsl2ms7w%3D
    • CH Hung CM Lee SN Lu, et al. 2002 Is delayed normalization of alanine aminotransferase a poor prognostic predictor in chronic hepatitis C patients treated with a combined interferon and ribavirin therapy? J Gastroenterol Hepatol 17 1307 1311 12423276 10.1046/j.1440-1746.2002.02874.x 1:CAS:528:DC%2BD38Xpsl2ms7w%3D
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 1307-1311
    • Hung, C.H.1    Lee, C.M.2    Lu, S.N.3
  • 5
    • 0027441113 scopus 로고
    • Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C
    • 7901531 10.1016/0140-6736(93)92187-X 1:STN:280:DyaK2c%2FkvVKmsw%3D%3D
    • JY Lau M Mizokami T Ohno, et al. 1993 Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C Lancet 342 1208 1209 7901531 10.1016/0140-6736(93)92187-X 1:STN:280:DyaK2c%2FkvVKmsw%3D%3D
    • (1993) Lancet , vol.342 , pp. 1208-1209
    • Lau, J.Y.1    Mizokami, M.2    Ohno, T.3
  • 6
    • 0031892672 scopus 로고    scopus 로고
    • Discordance between serum alanine aminotransferase (ALT) and virologic response to IFN-alpha2b in chronic hepatitis C patients with high and low pretreatment serum hepatitis C virus RNA titers
    • 9506457 10.1089/jir.1998.18.75 1:CAS:528:DyaK1cXhtlWrtLg%3D
    • LM Blatt MJ Tong JG McHutchison, et al. 1998 Discordance between serum alanine aminotransferase (ALT) and virologic response to IFN-alpha2b in chronic hepatitis C patients with high and low pretreatment serum hepatitis C virus RNA titers J Interferon Cytokine Res 18 75 80 9506457 10.1089/jir.1998.18.75 1:CAS:528:DyaK1cXhtlWrtLg%3D
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 75-80
    • Blatt, L.M.1    Tong, M.J.2    McHutchison, J.G.3
  • 7
    • 0141727874 scopus 로고    scopus 로고
    • Discrepancy in virological and biochemistry response of patients with chronic hepatitis HCV positive on treatment with PEG-IFN plus ribavirin
    • 14518725 1:CAS:528:DC%2BD3sXptFKisbY%3D
    • N Marino PL Blanc C Ble P Pierotti F Mazzotta 2003 Discrepancy in virological and biochemistry response of patients with chronic hepatitis HCV positive on treatment with PEG-IFN plus ribavirin J Biol Regul Homeost Agents 17 205 206 14518725 1:CAS:528:DC%2BD3sXptFKisbY%3D
    • (2003) J Biol Regul Homeost Agents , vol.17 , pp. 205-206
    • Marino, N.1    Blanc, P.L.2    Ble, C.3    Pierotti, P.4    Mazzotta, F.5
  • 8
    • 0027385067 scopus 로고
    • Characterization of the genomic sequence of type v (or 3a) hepatitis C virus isolates and PCR primers for specific detection
    • 7504073 10.1099/0022-1317-74-11-2385 1:CAS:528:DyaK2cXhvVChtr8%3D
    • H Okamoto H Tokita M Sakamoto, et al. 1993 Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection J Gen Virol 74 Pt 11 2385 2390 7504073 10.1099/0022-1317-74-11-2385 1:CAS:528:DyaK2cXhvVChtr8%3D
    • (1993) J Gen Virol , vol.74 , Issue.PART 11 , pp. 2385-2390
    • Okamoto, H.1    Tokita, H.2    Sakamoto, M.3
  • 9
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • 7308988 10.1002/hep.1840010511 1:STN:280:DyaL38%2FnsVagsA%3D%3D
    • RG Knodell KG Ishak WC Black, et al. 1981 Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis Hepatology 1 431 435 7308988 10.1002/hep.1840010511 1:STN:280:DyaL38%2FnsVagsA%3D%3D
    • (1981) Hepatology , vol.1 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3
  • 10
    • 0026072529 scopus 로고    scopus 로고
    • Classification of chronic viral hepatitis: A need for reassessment
    • Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 13:372-374
    • J Hepatol , vol.13 , pp. 372-374
    • Scheuer, P.J.1
  • 11
    • 0028235641 scopus 로고
    • Classification of chronic hepatitis: Diagnosis, grading and staging
    • 8188183 10.1002/hep.1840190629 1:STN:280:DyaK2c3ksFWisw%3D%3D
    • VJ Desmet M Gerber JH Hoofnagle M Manns PJ Scheuer 1994 Classification of chronic hepatitis: diagnosis, grading and staging Hepatology 19 1513 1520 8188183 10.1002/hep.1840190629 1:STN:280:DyaK2c3ksFWisw%3D%3D
    • (1994) Hepatology , vol.19 , pp. 1513-1520
    • Desmet, V.J.1    Gerber, M.2    Hoofnagle, J.H.3    Manns, M.4    Scheuer, P.J.5
  • 12
    • 0034619946 scopus 로고    scopus 로고
    • Peginterferon alfa-2a in patients with chronic hepatitis C
    • Zeuzem S, Feinman SV, Rasenack J et al. Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med. 343:1666-1672
    • N Engl J Med , vol.343 , pp. 1666-1672
    • Zeuzem, S.1    Feinman, S.V.2    Rasenack, J.3
  • 13
    • 17844403232 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing pegylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C
    • 11481625 10.1053/jhep.2001.26371 1:CAS:528:DC%2BD3MXmtVGqtLs%3D
    • KL Lindsay C Trepo T Heintges, et al. 2001 A randomized, double-blind trial comparing pegylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C Hepatology 34 395 403 11481625 10.1053/jhep.2001.26371 1:CAS:528:DC%2BD3MXmtVGqtLs%3D
    • (2001) Hepatology , vol.34 , pp. 395-403
    • Lindsay, K.L.1    Trepo, C.2    Heintges, T.3
  • 14
    • 0028469652 scopus 로고
    • Correlation between histological features of liver biopsy specimens and clinical effect of interferon on patients with chronic hepatitis C
    • 7521416 1:STN:280:DyaK2czlvFSgtA%3D%3D
    • N Kumagai S Kuramochi 1994 Correlation between histological features of liver biopsy specimens and clinical effect of interferon on patients with chronic hepatitis C Nippon Rinsho 52 1769 1773 7521416 1:STN:280: DyaK2czlvFSgtA%3D%3D
    • (1994) Nippon Rinsho , vol.52 , pp. 1769-1773
    • Kumagai, N.1    Kuramochi, S.2
  • 15
    • 0034871429 scopus 로고    scopus 로고
    • Development of pegylated interferons for the treatment of chronic hepatitis C
    • 11520253 10.2165/00063030-200115070-00001 1:CAS:528:DC%2BD3MXmvFOjtLs%3D
    • A Kozlowski SA Charles JM Harris 2001 Development of pegylated interferons for the treatment of chronic hepatitis C BioDrugs 15 419 429 11520253 10.2165/00063030-200115070-00001 1:CAS:528:DC%2BD3MXmvFOjtLs%3D
    • (2001) BioDrugs , vol.15 , pp. 419-429
    • Kozlowski, A.1    Charles, S.A.2    Harris, J.M.3
  • 16
    • 66149099243 scopus 로고    scopus 로고
    • Elevations in alanine aminotransferase levels late in the course of antiviral therapy in hepatitis C virus RNA-negative patients are associated with virological relapse
    • 19350657 10.1002/hep.22810 1:CAS:528:DC%2BD1MXlslKmtbg%3D
    • M Basso EG Giannini F Torre, et al. 2009 Elevations in alanine aminotransferase levels late in the course of antiviral therapy in hepatitis C virus RNA-negative patients are associated with virological relapse Hepatology 49 1442 1448 19350657 10.1002/hep.22810 1:CAS:528:DC%2BD1MXlslKmtbg%3D
    • (2009) Hepatology , vol.49 , pp. 1442-1448
    • Basso, M.1    Giannini, E.G.2    Torre, F.3
  • 17
    • 77749315806 scopus 로고    scopus 로고
    • Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection
    • 20207653 10.1136/gut.2009.199224
    • CY Dai JF Huang MY Hsieh WL Chuang ML Yu 2010 Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection Gut 59 418 20207653 10.1136/gut.2009.199224
    • (2010) Gut , vol.59 , pp. 418
    • Dai, C.Y.1    Huang, J.F.2    Hsieh, M.Y.3    Chuang, W.L.4    Yu, M.L.5
  • 18
    • 49349114385 scopus 로고    scopus 로고
    • Reappraisal of the characteristics of glucose abnormalities in patients with chronic hepatitis C infection
    • 18637090 10.1111/j.1572-0241.2008.01996.x 1:CAS:528:DC%2BD1cXhtFGhur3K
    • JF Huang ML Yu CY Dai, et al. 2008 Reappraisal of the characteristics of glucose abnormalities in patients with chronic hepatitis C infection Am J Gastroenterol 103 1933 1940 18637090 10.1111/j.1572-0241.2008.01996.x 1:CAS:528:DC%2BD1cXhtFGhur3K
    • (2008) Am J Gastroenterol , vol.103 , pp. 1933-1940
    • Huang, J.F.1    Yu, M.L.2    Dai, C.Y.3
  • 19
    • 44649166337 scopus 로고    scopus 로고
    • Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: A community-based study
    • 18486265 10.1016/j.jhep.2008.03.016 1:CAS:528:DC%2BD1cXmvFelsL8%3D
    • CY Dai WL Chuang CK Ho, et al. 2008 Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: a community-based study J Hepatol 49 9 16 18486265 10.1016/j.jhep.2008.03.016 1:CAS:528: DC%2BD1cXmvFelsL8%3D
    • (2008) J Hepatol , vol.49 , pp. 9-16
    • Dai, C.Y.1    Chuang, W.L.2    Ho, C.K.3
  • 20
    • 33644921299 scopus 로고    scopus 로고
    • Viral and metabolic factors influencing alanine aminotransferase activity in patients with chronic hepatitis C
    • 16487620 10.1016/j.jhep.2006.01.004 1:CAS:528:DC%2BD28XisFyqt7k%3D
    • D Prati ML Shiffman M Diago, et al. 2006 Viral and metabolic factors influencing alanine aminotransferase activity in patients with chronic hepatitis C J Hepatol 44 679 685 16487620 10.1016/j.jhep.2006.01.004 1:CAS:528: DC%2BD28XisFyqt7k%3D
    • (2006) J Hepatol , vol.44 , pp. 679-685
    • Prati, D.1    Shiffman, M.L.2    Diago, M.3
  • 21
    • 34248531497 scopus 로고    scopus 로고
    • Incidence and characterization of serum transaminases elevations in pegylated interferon and ribavirin treated patients with chronic hepatitis C
    • 17509097 10.1111/j.1365-2036.2007.03322.x 1:CAS:528:DC%2BD2sXot1Ckur4%3D
    • PH Thurairajah D Thorburn S Hubscher, et al. 2007 Incidence and characterization of serum transaminases elevations in pegylated interferon and ribavirin treated patients with chronic hepatitis C Aliment Pharmacol Ther 25 1293 1300 17509097 10.1111/j.1365-2036.2007.03322.x 1:CAS:528: DC%2BD2sXot1Ckur4%3D
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 1293-1300
    • Thurairajah, P.H.1    Thorburn, D.2    Hubscher, S.3
  • 22
    • 34347205995 scopus 로고    scopus 로고
    • Hepatitis C and steatosis
    • 17613353 10.1016/j.arcmed.2006.09.001
    • E Bjornsson P Angulo 2007 Hepatitis C and steatosis Arch Med Res 38 621 627 17613353 10.1016/j.arcmed.2006.09.001
    • (2007) Arch Med Res , vol.38 , pp. 621-627
    • Bjornsson, E.1    Angulo, P.2
  • 23
    • 23944462641 scopus 로고    scopus 로고
    • Mechanism of action of interferon and ribavirin in treatment of hepatitis C
    • 16107837 10.1038/nature04082 1:CAS:528:DC%2BD2MXotFent7c%3D
    • JJ Feld JH Hoofnagle 2005 Mechanism of action of interferon and ribavirin in treatment of hepatitis C Nature 436 967 972 16107837 10.1038/nature04082 1:CAS:528:DC%2BD2MXotFent7c%3D
    • (2005) Nature , vol.436 , pp. 967-972
    • Feld, J.J.1    Hoofnagle, J.H.2
  • 24
    • 70349976676 scopus 로고    scopus 로고
    • Cytokines-their pathogenic and therapeutic role in chronic viral hepatitis
    • 19527080 10.4321/S1130-01082009000500006 1:CAS:528:DC%2BD1MXpt1Slur4%3D
    • JR Larrubia S Benito-Martinez J Miquel-Plaza, et al. 2009 Cytokines-their pathogenic and therapeutic role in chronic viral hepatitis Rev Esp Enferm Dig 101 343 351 19527080 10.4321/S1130-01082009000500006 1:CAS:528: DC%2BD1MXpt1Slur4%3D
    • (2009) Rev Esp Enferm Dig , vol.101 , pp. 343-351
    • Larrubia, J.R.1    Benito-Martinez, S.2    Miquel-Plaza, J.3
  • 25
    • 46249111657 scopus 로고    scopus 로고
    • Hepatitis C virus infection: Molecular pathways to metabolic syndrome
    • 18446789 10.1002/hep.22269 1:CAS:528:DC%2BD1cXotVagtLw%3D
    • MY Sheikh J Choi I Qadri JE Friedman AJ Sanyal 2008 Hepatitis C virus infection: molecular pathways to metabolic syndrome Hepatology 47 2127 2133 18446789 10.1002/hep.22269 1:CAS:528:DC%2BD1cXotVagtLw%3D
    • (2008) Hepatology , vol.47 , pp. 2127-2133
    • Sheikh, M.Y.1    Choi, J.2    Qadri, I.3    Friedman, J.E.4    Sanyal, A.J.5
  • 26
    • 0034119793 scopus 로고    scopus 로고
    • Virologic factors related to interferon-alpha-induced thyroid dysfunction in patients with chronic hepatitis C
    • 10802518 10.1530/eje.0.1420431 1:CAS:528:DC%2BD3cXjslemu7o%3D
    • MC Hsieh ML Yu WL Chuang, et al. 2000 Virologic factors related to interferon-alpha-induced thyroid dysfunction in patients with chronic hepatitis C Eur J Endocrinol 142 431 437 10802518 10.1530/eje.0.1420431 1:CAS:528:DC%2BD3cXjslemu7o%3D
    • (2000) Eur J Endocrinol , vol.142 , pp. 431-437
    • Hsieh, M.C.1    Yu, M.L.2    Chuang, W.L.3
  • 27
    • 40449095897 scopus 로고    scopus 로고
    • Antinuclear antibody is associated with a more advanced fibrosis and lower RNA levels of hepatitis C virus in patients with chronic hepatitis C
    • 17545561 10.1136/jcp.2006.046276 1:CAS:528:DC%2BD1cXkt1yjtrs%3D
    • MY Hsieh CY Dai LP Lee, et al. 2008 Antinuclear antibody is associated with a more advanced fibrosis and lower RNA levels of hepatitis C virus in patients with chronic hepatitis C J Clin Pathol 61 333 337 17545561 10.1136/jcp.2006.046276 1:CAS:528:DC%2BD1cXkt1yjtrs%3D
    • (2008) J Clin Pathol , vol.61 , pp. 333-337
    • Hsieh, M.Y.1    Dai, C.Y.2    Lee, L.P.3
  • 28
    • 65449136656 scopus 로고    scopus 로고
    • Diagnosis, management, and treatment of hepatitis C: An update
    • 19330875 10.1002/hep.22759 1:CAS:528:DC%2BD1MXkslWjs7o%3D
    • MG Ghany DB Strader DL Thomas LB Seeff 2009 Diagnosis, management, and treatment of hepatitis C: an update Hepatology 49 1335 1374 19330875 10.1002/hep.22759 1:CAS:528:DC%2BD1MXkslWjs7o%3D
    • (2009) Hepatology , vol.49 , pp. 1335-1374
    • Ghany, M.G.1    Strader, D.B.2    Thomas, D.L.3    Seeff, L.B.4
  • 29
    • 75349105350 scopus 로고    scopus 로고
    • Hepatitis C virus viremia and low platelet count: A study in a hepatitis B & C endemic area in Taiwan
    • 20034694 10.1016/j.jhep.2009.11.017
    • CY Dai CK Ho JF Huang, et al. 2010 Hepatitis C virus viremia and low platelet count: A study in a hepatitis B & C endemic area in Taiwan J Hepatol 52 160 166 20034694 10.1016/j.jhep.2009.11.017
    • (2010) J Hepatol , vol.52 , pp. 160-166
    • Dai, C.Y.1    Ho, C.K.2    Huang, J.F.3
  • 30
    • 77956601192 scopus 로고    scopus 로고
    • Viral hepatitis infections in southern Taiwan: A multicenter community-based study
    • 20837342 10.1016/S1607-551X(10)70073-5
    • JF Yang CI Lin JF Huang, et al. 2010 Viral hepatitis infections in southern Taiwan: a multicenter community-based study Kaohsiung J Med Sci 26 461 469 20837342 10.1016/S1607-551X(10)70073-5
    • (2010) Kaohsiung J Med Sci , vol.26 , pp. 461-469
    • Yang, J.F.1    Lin, C.I.2    Huang, J.F.3
  • 31
    • 21044444721 scopus 로고    scopus 로고
    • Comparison of a 6-month course peginterferon alpha-2b plus ribavirin and interferon alpha-2b plus ribavirin in treating Chinese patients with chronic hepatitis C in Taiwan
    • 15850469 10.1111/j.1365-2893.2005.00590.x
    • SD Lee ML Yu PN Cheng, et al. 2005 Comparison of a 6-month course peginterferon alpha-2b plus ribavirin and interferon alpha-2b plus ribavirin in treating Chinese patients with chronic hepatitis C in Taiwan J Viral Hepat 12 283 291 15850469 10.1111/j.1365-2893.2005.00590.x
    • (2005) J Viral Hepat , vol.12 , pp. 283-291
    • Lee, S.D.1    Yu, M.L.2    Cheng, P.N.3
  • 32
    • 33645998724 scopus 로고    scopus 로고
    • A randomized trial of 24- vs. 48-week courses of PEG interferon alpha-2b plus ribavirin for genotype-1b-infected chronic hepatitis C patients: A pilot study in Taiwan
    • 16420512 10.1111/j.1478-3231.2005.01196.x 1:CAS:528:DC%2BD28XisFCmu70%3D
    • ML Yu CY Dai ZY Lin, et al. 2006 A randomized trial of 24- vs. 48-week courses of PEG interferon alpha-2b plus ribavirin for genotype-1b-infected chronic hepatitis C patients: a pilot study in Taiwan Liver Int 26 73 81 16420512 10.1111/j.1478-3231.2005.01196.x 1:CAS:528:DC%2BD28XisFCmu70%3D
    • (2006) Liver Int , vol.26 , pp. 73-81
    • Yu, M.L.1    Dai, C.Y.2    Lin, Z.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.