PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

Biochemical and Biophysical Research Communications

Volumn 431, Issue 4, 2013, Pages 734-739

  Kang, Shin Ae ^a,b   Lee, Seung Taek ^a  

^a Yonsei University   (South Korea)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

C Cbl; Oncoprotein; Phosphorylation; Proteasomal degradation; PTK6; Ubiquitin

Indexed keywords

CBL PROTEIN; PROTEASOME; PROTEIN TYROSINE KINASE; PTK6 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; UBIQUITINATION;

CATALYSIS; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-TYROSINE KINASES; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-CBL; TYROSINE;

EID: 84875260464     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.01.046     Document Type: Article

References (26)

1. Mitchell P.J., Barker K.T., Martindale J.E., Kamalati T., Lowe P.N., Page M.J., Gusterson B.A., Crompton M.R. Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. Oncogene 1994, 9:2383-2390.
2. Lee H., Kim M., Lee K.H., Kang K.N., Lee S.T. Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. Mol. Cells 1998, 8:401-407.
3. Lee S.-T., Strunk K.M., Spritz R.A. A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. Oncogene 1993, 8:3403-3410.
4. Brauer P.M., Tyner A.L. Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK. Biochim. Biophys. Acta 1806, 2010:66-73.
5. Ostrander J.H., Daniel A.R., Lange C.A. Brk/PTK6 signaling in normal and cancer cell models. Curr. Opin. Pharmacol. 2010, 10:662-669.
6. Kamalati T., Jolin H.E., Mitchell P.J., Barker K.T., Jackson L.E., Dean C.J., Page M.J., Gusterson B.A., Crompton M.R. Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. J. Biol. Chem. 1996, 271:30956-30963.
7. Ostrander J.H., Daniel A.R., Lofgren K., Kleer C.G., Lange C.A. Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells. Cancer Res. 2007, 67:4199-4209.
8. Castro N.E., Lange C.A. Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells. Breast Cancer Res. 2010, 12:R60.
9. Kamalati T., Jolin H.E., Fry M.J., Crompton M.R. Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. Oncogene 2000, 19:5471-5476.
10. Kang S.-A., Lee E.-S., Yoon H.Y., Randazzo P.A., Lee S.-T. PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1. J. Biol. Chem. 2010, 285:26013-26021.
11. Kim H.I., Lee S.-T. Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus. J. Biochem. 2009, 146:133-139.
12. Swaminathan G., Tsygankov A.Y. The Cbl family proteins: ring leaders in regulation of cell signaling. J. Cell. Physiol. 2006, 209:21-43.
13. Thien C.B., Langdon W.Y. Cbl: many adaptations to regulate protein tyrosine kinases. Nat. Rev. Mol. Cell Biol. 2001, 2:294-307.
14. Joazeiro C.A., Weissman A.M. RING finger proteins: mediators of ubiquitin ligase activity. Cell 2000, 102:549-552.
15. Yokouchi M., Kondo T., Sanjay A., Houghton A., Yoshimura A., Komiya S., Zhang H., Baron R. Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. J. Biol. Chem. 2001, 276:35185-35193.
16. Magnifico A., Ettenberg S., Yang C., Mariano J., Tiwari S., Fang S., Lipkowitz S., Weissman A.M. WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J. Biol. Chem. 2003, 278:43169-43177.
17. Kim H.I., Lee S.-T. An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6. J. Biol. Chem. 2005, 280:28973-28980.
18. Kang S.-A., Cho H.S., Yoon J.B., Chung I.K., Lee S.-T. Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells. Biochem. J. 2012, 447:313-320.
19. Kim H.I., Jung J., Lee E.-S., Kim Y.-C., Lee W., Lee S.-T. Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6. Biochem. Biophys. Res. Commun. 2007, 362:829-834.
20. Blom N., Gammeltoft S., Brunak S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol. 1999, 294:1351-1362.
21. Huang H.D., Lee T.Y., Tzeng S.W., Horng J.T. Kinase Phos: a web tool for identifying protein kinase-specific phosphorylation sites. Nucleic Acids Res. 2005, 33:W226-W229.
22. Tanaka S., Amling M., Neff L., Peyman A., Uhlmann E., Levy J.B., Baron R. C-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Nature 1996, 383:528-531.
23. Feshchenko E.A., Langdon W.Y., Tsygankov A.Y. Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J. Biol. Chem. 1998, 273:8323-8331.
24. Joazeiro C.A., Wing S.S., Huang H., Leverson J.D., Hunter T., Liu Y.C. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 1999, 286:309-312.
25. Bao J., Gur G., Yarden Y. Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors. Proc. Natl. Acad. Sci. USA 2003, 100:2438-2443.
26. Li X., Lu Y., Liang K., Hsu J.M., Albarracin C., Mills G.B., Hung M.C., Fan Z. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene 2012, 31:4372-4383.