Tracing and separating plasma components causing matrix effects in hydrophilic interaction chromatography-electrospray ionization mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 923-924, Issue , 2013, Pages 83-91

  Ekdahl, Anja ^a   Johansson, Maria C ^a   Ahnoff, Martin ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Electrospray ionization; Gradient elution; Hydrophilic interaction chromatography; Linear correlation analysis; Matrix effects; Principal component analysis

Indexed keywords

GRADIENT ELUTION; GRADIENT ELUTION MODE; HYDROPHILIC INTERACTION CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY-ELECTROSPRAY IONIZATION MASS SPECTROMETRY; LINEAR CORRELATION ANALYSIS; MASS SPECTRAL DATA; MATRIX EFFECTS; MOBILE PHASE BUFFER;

CHLORINE COMPOUNDS; CORRELATION METHODS; ELECTROSPRAY IONIZATION; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METAL IONS; PHOSPHOLIPIDS; PLASMAS; PRINCIPAL COMPONENT ANALYSIS; SEPARATION; UREA;

MATRIX ALGEBRA;

AMMONIUM ACETATE; AMMONIUM FORMATE; BETAINE; CHLORIDE ION; CHOLINE; CREATININE; PHOSPHORYLCHOLINE; PROLINE; SODIUM ION; SPHINGOMYELIN; UREA;

ARTICLE; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; CORRELATION ANALYSIS; ELECTROSPRAY MASS SPECTROMETRY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IONIZATION; LINEAR SYSTEM; MASS SPECTROMETER; PH; PLASMA; PRECIPITATION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SEPARATION TECHNIQUE;

BLOOD CHEMICAL ANALYSIS; CHLORIDES; CHROMATOGRAPHY, LIQUID; CREATININE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LYSOPHOSPHATIDYLCHOLINES; PRINCIPAL COMPONENT ANALYSIS; PROLINE; SODIUM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPHINGOMYELINS;

EID: 84875260034     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.02.013     Document Type: Article

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