The Gly-Ala repeat modulates the interaction of Epstein-Barr virus nuclear antigen-1 with cellular chromatin

Biochemical and Biophysical Research Communications

Volumn 431, Issue 4, 2013, Pages 706-711

  Coppotelli, Giuseppe ^a   Mughal, Nouman ^a   Masucci, Maria G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

AT hook; EBNA1; EBV; Gly Ala repeat; HMGA proteins

Indexed keywords

ALANINE; ARGININE; EPSTEIN BARR VIRUS ANTIGEN 1; GLYCINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERPHASE; MITOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; VIRUS LATENCY;

CELL LINE, TUMOR; CHROMATIN; DIPEPTIDES; EPSTEIN-BARR VIRUS INFECTIONS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HERPESVIRUS 4, HUMAN; HUMANS; INTERPHASE; MITOSIS; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE DELETION; VIRUS LATENCY;

HUMAN HERPESVIRUS 4;

EID: 84875248976     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.01.054     Document Type: Article

References (21)

1. Rickinson A.B., Kieff E. Epstein-Barr virus. Virology 1996, 2397-2446. Lippincott-Raven, Philadelphia. B.N. Fields, D.M. Knipe, P.M. Howley (Eds.).
2. Kieff E. Epstein-Barr virus and its replication. Fields Virology 1996, 2343-2396. Lippincott, Raven Publishers, Philadelphia. third ed. B.N. Fiels, D.M. Knipe, P.M. Howley (Eds.).
3. Leight E.R., Sugden B. EBNA-1: a protein pivotal to latent infection by Epstein-Barr virus. Rev. Med. Virol. 2000, 10:83-100.
4. Yates J., Warren N., Reisman D., Sugden B. A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells. Proc. Natl. Acad. Sci. USA 1984, 81:3806-3810.
5. Mackey D., Sugden B. The linking regions of EBNA1 are essential for its support of replication and transcription. Mol. Cell. Biol. 1999, 19:3349-3359.
6. Marechal V., Dehee A., Chikhi-Brachet R., Piolot T., Coppey-Moisan M., Nicolas J.C. Mapping EBNA-1 domains involved in binding to metaphase chromosomes. J. Virol. 1999, 73:4385-4392.
7. Sears J., Ujihara M., Wong S., Ott C., Middeldorp J., Aiyar A. The amino terminus of Epstein-Barr Virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomes. J. Virol. 2004, 78:11487-11505.
8. Falk K., Gratama J.W., Rowe M., Zou J.Z., Khanim F., Young L.S., Oosterveer M.A., Ernberg I. The role of repetitive DNA sequences in the size variation of Epstein-Barr virus (EBV) nuclear antigens, and the identification of different EBV isolates using RFLP and PCR analysis. J. Gen. Virol. 1995, 76(Pt 4):779-790.
9. Yin Y., Manoury B., Fahraeus R. Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1. Science 2003, 301:1371-1374.
10. Levitskaya J., Coram M., Levitsky V., Imreh S., Steigerwald-Mullen P.M., Klein G., Kurilla M.G., Masucci M.G. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 1995, 375:685-688.
11. Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 2001, 277:63-81.
12. Catez F., Yang H., Tracey K.J., Reeves R., Misteli T., Bustin M. Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol. Cell. Biol. 2004, 24:4321-4328.
13. Hung S.C., Kang M.S., Kieff E. Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1. Proc. Natl. Acad. Sci. USA 2001, 98:1865-1870.
14. Coppotelli G., Mughal N., Marescotti D., Masucci M.G. High avidity binding to DNA protects ubiquitylated substrates from proteasomal degradation. J. Biol. Chem. 2011, 286:19565-19575.
15. Lu F., Wikramasinghe P., Norseen J., Tsai K., Wang P., Showe L., Davuluri R.V., Lieberman P.M. Genome-wide analysis of host-chromosome binding sites for Epstein-Barr virus nuclear antigen 1 (EBNA1). J. Virol. 2010, 7:262.
16. Jourdan N., Jobart-Malfait A., Dos Reis G., Quignon F., Piolot T., Klein C., Tramier M., Coppey-Moisan M., Marechal V. Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis. J. Virol. 2012, 86:5314-5329.
17. Luijsterburg M.S., Dinant C., Lans H., Stap J., Wiernasz E., Lagerwerf S., Warmerdam D.O., Lindh M., Brink M.C., Dobrucki J.W., Aten J.A., Fousteri M.I., Jansen G., Dantuma N.P., Vermeulen W., Mullenders L.H., Houtsmuller A.B., Verschure P.J., van Driel R. Heterochromatin protein 1 is recruited to various types of DNA damage. J. Cell Biol. 2009, 185:577-586.
18. G. Coppotelli, N. Mughal, S. Callegari, R. Sompallae, L. Caja, M.S. Luijsterburg, N.P. Dantuma, A. Moustakas, M.G. Masucci, The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of High Mobility Group A proteins, Nucl. Acids Res. 2013, http://dx.doi.org/10.1093/nar/gkt032.
19. Martorelli D., Coppotelli G., Muraro E., Dolcetti R., Masucci M.G. Remodeling of the epitope repertoire of a candidate idiotype vaccine by targeting to lysosomal degradation in dendritic cells. Cancer Immunol. Immunother. 2011, 61:881-892.
20. Sompallae R., Callegari S., Kamranvar S.A., Masucci M.G. Transcription profiling of Epstein-Barr virus nuclear antigen (EBNA)-1 expressing cells suggests targeting of chromatin remodeling complexes. PLoS ONE 2010, 5:e12052.
21. Dresang L.R., Vereide D.T., Sugden B. Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomes. J. Virol. 2009, 83:2930-2940.