Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: Beneficial effect of their association

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 4, 2013, Pages 567-573

  Bueno, Lionel ^a   Beaufrand, Catherine ^a   Theodorou, Vassilia ^a   Andro Delestrain, Marie Christine ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

Author keywords

abdominal pain; alverine; permeability; simethicone; stress

Indexed keywords

ALVERINE CITRATE; SIMETHICONE;

ABDOMINAL PAIN; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON DILATATION; COLONIC HYPERSENSITIVITY; COLONIC PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG POTENTIATION; FEMALE; IMMOBILIZATION STRESS; INTESTINE MUCOSA PERMEABILITY; INTESTINE PARAMETERS; NONHUMAN; RAT;

ANIMALS; ANTIFOAMING AGENTS; COLIC; COLON; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DISEASE RESISTANCE; DRUG SYNERGISM; FEMALE; GASTROINTESTINAL AGENTS; INTESTINAL MUCOSA; IRRITABLE BOWEL SYNDROME; PARASYMPATHOLYTICS; PERMEABILITY; PROPYLAMINES; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SIMETHICONE; STRESS, PSYCHOLOGICAL;

EID: 84875239389     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12021     Document Type: Article

References (20)

1. Whitehead WE, Palsson OS,. Is rectal pain sensitivity a biological marker for irritable bowel syndrome? Psychological influences on pain perception. Gastroenterology 1998; 115: 1263-1271.
2. Törnblom H, et al,. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002; 123: 1972-1979.
3. Barbara G, et al,. A role for inflammation in irritable bowel syndrome? Gut 2002; 51 (S1): i41-i44.
4. Zhou Q, et al,. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain 2009; 146: 41-46.
5. Gecse K, et al,. Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity. Gut 2008; 57: 591-599.
6. Bouvier M, et al,. Effects of alverine on the spontaneous electrical activity and nervous control of the proximal colon of the rabbit. Gastroenterol Clin Biol 1992; 16: 334-338.
7. Abysique A, et al,. Effects of alverine citrate on cat intestinal mechanoreceptor responses to chemical and mechanical stimuli. Aliment Pharmacol Ther 1999; 13: 561-566.
8. Hayase M, et al,. Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol 2007; 152: 1228-1238.
9. Coelho AM, et al,. Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol 2001; 53: 1419-1426.
10. Danielsson B, Hwang CP,. Treatment of infantile colic with surface active substance (simethicone). Acta Paediatr Scand 1985; 74: 446-450.
11. Voepel-Lewis TD, et al,. Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants. J Clin Anesth 1998; 10: 91-94.
12. Coffin B, et al,. Efficacy of a simethicone, activated charcoal and magnesium oxide combination (Carbosymag®) in functional dyspepsia: results of a general practice-based randomized trial. Clin Res Hepatol Gastroenterol 2011; 35: 494-499.
13. Kaplan MA, et al,. Loperamide-simethicone vs loperamide alone, simethicone alone, and placebo in the treatment of acute diarrhea with gas-related abdominal discomfort. A randomized controlled trial. Arch Fam Med 1999; 8: 243-248.
14. Ait-Belgnaoui A, et al,. Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase. Pain 2005; 113: 141-147.
15. Wittmann T, et al,. Clinical trial: the efficacy of alverine citrate/simethicone combination on abdominal pain/discomfort in irritable bowel syndrome-a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 2010; 31: 615-624.
16. Trimble KC, et al,. Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 1995; 40: 1607-1613.
17. Bouin M, et al,. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology 2002; 122: 1771-1777.
18. Piche T, et al,. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut 2009; 58: 196-201.
19. Bueno L,. Protease activated receptor 2: a new target for IBS treatment. Eur Rev Med Pharmacol Sci 2008; 12 (Sl 1) 95-102. Review.
20. Ferrier L, et al,. Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice. Gastroenterology 2003; 125: 795-804.