Evolving mechanisms of action of alverine citrate on phasic smooth muscles

British Journal of Pharmacology

Volumn 152, Issue 8, 2007, Pages 1228-1238

  Hayase, M ^a   Hashitani, H ^a   Suzuki, H ^a   Kohri, K ^a   Brading, A F ^b  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Alverine; Ca sensitivity; L type Ca channel; Smooth muscle; Urinary bladder

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALVERINE CITRATE; CALCIUM CHANNEL L TYPE; CHARYBDOTOXIN; CYCLOPIAZONIC ACID;

ANIMAL TISSUE; ARTICLE; BLADDER; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG MECHANISM; FEMALE; GUINEA PIG; MALE; MUSCLE ACTION POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY;

ACTION POTENTIALS; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PARASYMPATHOLYTICS; PROPYLAMINES;

EID: 36949001132     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707496     Document Type: Article

References (20)

1. Abysique A, Lucchini S, Orsoni P, Mei N, Bouvier M (1999). Effects of alverine citrate on cat intestinal mechanoreceptor responses to chemical andmechanical stimuli. Aliment Pharmacol Ther 13: 561-566.
2. Bing W, Chang S, Hypolite JA, DiSanto ME, Zderic SA, Rolf L et al. (2003). Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase. Am J Physiol Renal Physiol 285: F990-F997.
3. Bouvier M, Grimaud JC, Abysique A, Chiarelli P (1992). Effects of alverine on the spontaneous electrical activity and nervous control of the proximal colon of the rabbit. Gastroenterol Clin Biol 16: 334-338.
4. Brading AF, Sibley GNA (1983). A superfusion apparatus to study field stimulation of smooth muscle from mammalian urinary bladder. J Physiol (London) 334: 11P-12P.
5. Coelho AM, Jacob L, Fioramonti J, Bueno L (2001). Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol 53: 1419-1426.
6. Durlu-Kandilci NT, Brading AF (2006). Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders. Br J Pharmacol 148: 376-384.
7. Hashitani H, Brading AF (2003). Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder. Br J Pharmacol 140: 159-169.
8. Hashitani H (2006). Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis. J Physiol 576: 707-714.
9. Hashitani H, Brading AF, Suzuki H (2004). Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 141: 183-193.
10. Hashitani H, Bramich NJ, Hirst GDS (2000). Mechanisms of excitatory neuromuscular transmission in the guinea-pig urinary bladder. J Physiol 524: 565-579.
11. 2+ channels and ryanodine receptors in guinea-pig urinary bladder myocytes. J Physiol 541: 483-492.
12. Herrera GM, Heppner TJ, Nelson MT (2000). Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. Am J Physiol Regul Integr Comp Physiol 279: R60-R68.
13. Maggi CA, Manzini S, Parlani M, Conte B, Giuliani S, Meli A (1988). The effect of nifedipine on spontaneous, drug-induced and reflexly-activated contractions of the rat urinary bladder: evidence for the participation of an intracellular calcium store to micturition contraction. Gen Pharmacol 19: 73-81.
14. 2+ channel antagonists and benzodiazepine receptor ligands in normal and skinned rat urinary bladder. Eur J Pharmacol 255: 157-165.
15. 2+ channel current in smooth muscle cells isolated from the guinea-pig detrusor. J Physiol 471: 107-127.
16. 2+ influx and intracellular Ca2p release in the muscarinic-mediated contraction of mammalian urinary bladder smooth muscle. BJU Int 98: 868-875.
17. 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res 93: 548-556.
18. 2+ sensitization in contraction of human bladder smooth muscle. J Urol 172: 748-752.
19. 2+ in carbachol-induced tonic contraction of the pig detrusor smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 350: 398-402.
20. Wu C, Bayliss M, Newgreen D, Mundy AR, Fry CH (1999). A comparison of the mode of action of ATP and carbachol on isolated human detrusor smooth muscle. J Urol 162: 1840-1847.