Race/ethnicity affects the probability of finding an HLA-A,-B,-C and-DRB1 allele-matched unrelated donor and likelihood of subsequent transplant utilization

Bone Marrow Transplantation

Volumn 48, Issue 3, 2013, Pages 346-350

  Pidala, J ^a,b   Kim, J ^a,b   Schell, M ^a,b   Lee, S J ^c   Hillgruber, R ^a   Nye, V ^a   Ayala, E ^a,b   Alsina, M ^a,b   Betts, B ^a,b   Bookout, R ^a,b   Fernandez, H F ^a,b   Field, T ^a,b   Locke, F L ^a,b   Nishihori, T ^a,b   Ochoa, J L ^a,b   Perez, L ^a,b   Perkins, J ^a,b   Shapiro, J ^a,b   Tate, C ^a,b   Tomblyn, M ^a,b   Anasetti, C ^a,b   more..

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

allogeneic hematopoietic cell transplantation; donor vs no donor analysis; HLA; race ethnicity; unrelated donor

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DRB1 ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALLELE; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; CAUCASIAN; CONTROLLED STUDY; ETHNICITY; FEMALE; GRAFT SURVIVAL; HLA TYPING; HODGKIN DISEASE; HUMAN; KARNOFSKY PERFORMANCE STATUS; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; OUTCOME ASSESSMENT; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PRIORITY JOURNAL; RACISM; RISK ASSESSMENT; RISK FACTOR; UNRELATED DONORS;

ADOLESCENT; ADULT; AGED; ALLELES; CONTINENTAL POPULATION GROUPS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; MALE; MIDDLE AGED; TRANSPLANTATION, HOMOLOGOUS; UNRELATED DONORS; YOUNG ADULT;

EID: 84875225288     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2012.150     Document Type: Article

References (23)

1. Karanes C, Nelson GO, Chitphakdithai P, Agura E, Ballen KK, Bolan CD et al. Twenty years of unrelated donor hematopoietic cell transplantation for adult recipients facilitated by the National Marrow Donor Program. Biol Blood Marrow Transplant 2008; 14(9 Suppl): 8-15.
2. Lee SJ, Klein J, Haagenson M, Baxter-Lowe LA, Confer DL, Eapen M et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007; 110: 4576-4583.
3. Barker JN, Byam CE, Kernan NA, Lee SS, Hawke RM, Doshi KA et al. Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities. Biol Blood Marrow Transplant 2010; 16: 1541-1548.
4. Brunstein CG, Fuchs EJ, Carter SL, Karanes C, Costa LJ, Wu J et al. Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood 2011; 118: 282-288.
5. Luznik L, O'Donnell PV, Symons HJ, Chen AR, Leffell MS, Zahurak M et al. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclopho-sphamide. Biol Blood Marrow Transplant 2008; 14: 641-650.
6. Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011; 117: 1061-1070.
7. Di Ianni M, Falzetti F, Carotti A, Terenzi A, Del Papa B, Perruccio K et al. Immu-noselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation. Best Pract Res Clin Haematol 2011; 24: 459-466.
8. Liu H, Rich ES, Godley L, Odenike O, Joseph L, Marino S et al. Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions. Blood 2011; 118: 6438-6445.
9. Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010; 16: 232-236.
10. Delaney M, Cutler CS, Haspel RL, Yeap BY, McAfee SL, Dey BR et al. High-resolution HLA matching in double-umbilical-cord-blood reduced-intensity transplantation in adults. Transfusion 2009; 49: 995-1002.
11. Frassoni F, Gualandi F, Podesta M, Raiola AM, Ibatici A, Piaggio G et al. Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study. Lancet Oncol 2008; 9: 831-839.
12. Barker JN, Scaradavou A, Stevens CE. Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood 2010; 115: 1843-1849.
13. Shpall EJ, Quinones R, Giller R, Zeng C, Baron AE, Jones RB et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002; 8: 368-376.
14. Shpall EJ, Bollard CM, Brunstein C. Novel cord blood transplant therapies. Biol Blood Marrow Transplant 2011; 17(1 Suppl): S39-S45.
15. Reisner Y, Hagin D, Martelli MF. Haploidentical hematopoietic transplantation: current status and future perspectives. Blood 2011; 118: 6006-6017.
16. Sorror ML, Maris MB, Storb R, Baron F, Sandmaier BM, Maloney DG et al. Hema-topoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 2005; 106: 2912-2919.
17. Artz AS. Comorbidity and beyond: pre-transplant clinical assessment. Bone Marrow Transplant 2005; 36: 473-474.
18. Artz AS, Pollyea DA, Kocherginsky M, Stock W, Rich E, Odenike O et al. Performance status and comorbidity predict transplant-related mortality after allo-geneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2006; 12: 954-964.
19. Baker KS, Davies SM, Majhail NS, Hassebroek A, Klein JP, Ballen KK et al. Race and socioeconomic status influence outcomes of unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant 2009; 15: 1543-1554.
20. Baker KS, Loberiza Jr. FR, Yu H, Cairo MS, Bolwell BJ, Bujan-Boza WA et al. Outcome of ethnic minorities with acute or chronic leukemia treated with hematopoietic stem-cell transplantation in the United States. J Clin Oncol 2005; 23: 7032-7042.
21. Serna DS, Lee SJ, Zhang MJ, Baker S, Eapen M, Horowitz MM et al. Trends in survival rates after allogeneic hematopoietic stem-cell transplantation for acute and chronic leukemia by ethnicity in the United States and Canada. J Clin Oncol 2003; 21: 3754-3760.
22. Silla L, Fischer GB, Paz A, Daudt LE, Mitto I, Katz B et al. Patient socioeconomic status as a prognostic factor for allo-SCT. Bone Marrow Transplant 2009; 43: 571-577.
23. Wheatley K, Gray R. Commentary: Mendelian randomization-An update on its use to evaluate allogeneic stem cell transplantation in leukaemia. Int J Epidemiol 2004; 33: 15-17.