Acrolein and chloroacetaldehyde: An examination of the cell and cell-free biomarkers of toxicity

Chemico-Biological Interactions

Volumn 202, Issue 1-3, 2013, Pages 259-266

  MacAllister, Stephanie L ^a   Martin Brisac, Nicolas ^a   Lau, Vincent ^a   Yang, Kai ^a   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Acrolein; Aldehyde dehydrogenase (ALDH); Chloroacetaldehyde (CAA); Glutathione (GSH); Protein carbonylation; Reactive oxygen species (ROS)

Indexed keywords

ACETYLCYSTEINE; ACROLEIN; ALBUMIN; ALDEHYDE DEHYDROGENASE; AMINOGUANIDINE; ASCORBIC ACID; BISULFITE; CHLOROACETALDEHYDE; CYANIDE; CYSTEINE; GLUTATHIONE; HYDRALAZINE; HYDROXYLAMINE; MESNA; PENICILLAMINE; SODIUM BOROHYDRIDE; TROLOX C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL FREE SYSTEM; CELL PROTECTION; CELL VIABILITY; CLINICAL EFFECTIVENESS; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; GENE REPRESSION; LIVER CELL; LIVER MICROSOME; MALE; NONHUMAN; PROTEIN CARBONYLATION; PROTEIN DEPLETION; RAT;

ACETALDEHYDE; ACROLEIN; ALDEHYDE DEHYDROGENASE; ANIMALS; BIOLOGICAL MARKERS; CELL-FREE SYSTEM; CYCLOPHOSPHAMIDE; HEPATOCYTES; HYDROGEN PEROXIDE; IFOSFAMIDE; MALE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; PROTEIN CARBONYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SERUM ALBUMIN, BOVINE;

BOVINAE; RATTUS;

EID: 84875221631     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.11.017     Document Type: Conference Paper

References (31)

1. J. Zhang, Q. Tian, and S. Zhou Clinical pharmacology of cyclophosphamide and ifosfamide Curr. Drug Ther. 1 2006 55 84
2. R.A. Fleming An overview of cyclophosphamide and ifosfamide pharmacology Pharmacotherapy 17 1997 146S 154S
3. B. Giraud, G. Hebert, A. Deroussent, G.J. Veal, G. Vassal, and A. Paci Oxazaphosphorines: new therapeutic strategies for an old class of drugs Expert Opin. Drug Metab. Toxicol. 6 2010 919 938
4. P.C. Burcham, and F. Fontaine Extensive protein carbonylation precedes acrolein-mediated cell death in mouse hepatocytes J. Biochem. Mol. Toxicol. 15 2001 309 316
5. A. Korkmaz, T. Topal, and S. Oter Pathophysiological aspects of cyclophosphamide and Ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation Cell Biol. Toxicol. 23 2007 303 312
6. C. Sood, and P.J. O'Brien Molecular mechanisms of chloroacetaldehyde- induced cytotoxicity in isolated rat hepatocytes Biochem. Pharmacol. 46 1993 1621 1626
7. Q. Zhu, Z. Sun, Y. Jiang, F. Chen, and M. Wang Acrolein scavengers: reactivity, mechanism and impact on health Mol. Nutr. Food Res. 55 2011 1375 1390
8. CCAC (Canadian Council on Animal Care), Guide to the Care and Use of Experimental Animals, Bradda Printing Services, ON, Canada, Ottawa, 1993.
9. P. Moldeus, J. Hogberg, and S. Orrenius Isolation and use of liver cells Methods Enzymol. 52 1978 60 71
10. S. Khan, and P.J. O'Brien 1-Bromoalkanes as new potent nontoxic glutathione depleters in isolated rat hepatocytes Biochem. Biophys. Res. Commun. 179 1991 436 441
11. G. Dallner Isolation of microsomal subfractions by use of density gradients Methods Enzymol. 52 1978 71 82
12. J.G. Joly, C. Doyon, and Y. Peasant Cytochrome P-450 measurement in rat liver homogenate and microsomes. Its use for correction of microsomal losses incurred by differential centrifugation Drug Metab. Dispos. 3 1975 577 586
13. R.L. Levine, D. Garland, C.N. Oliver, A. Amici, I. Climent, A. Lenz, B. Ahn, S. Shaltiel, and E.R. Stadtman Determination of carbonyl content in oxidatively modified proteins Methods Enzymol. 186 1990 464 478
14. H. Possel, H. Noack, W. Augustin, G. Keilhoff, and G. Wolf 2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation FEBS Lett. 416 1997 175 178
15. 2 fluxes within cells J. Biochem. Biophys. Methods 31 1996 59 67
16. Z. Jiang, A.C.S. Woollard, and S.P. Wolff Hydrogen peroxide production during experimental protein glycation FEBS 268 1990 69 71
17. J. Cai, A. Bhatnagar, and W.M. Pierce Jr. Protein modification by acrolein: formation and stability of cysteine adducts Chem. Res. Toxicol. 22 2009 708 716
18. S.L. Taylor, R.K. Bush, and J.A. Nordlee Sulfites D.D. Metcalfe, H.A. Sampson, R.A. Simon, Food Allergy: Adverse Reactions to Food and Food Additives 1997 Blackwell Scientific Boston 339 357
19. M.E. Gershwin, and T.E. Albertson Bronchial Asthma: A Guide for Practical Understanding and Treatment fifth ed. 2006 Human Press Inc New Jersey pp. 236
20. G.S. Kelly Clinical applications of N-acetylcysteine Alternat. Med. Rev. 3 1998 114 127
21. M. Yoshida, H. Tomitori, Y. Machi, M. Hagihara, K. Higashi, H. Goda, T. Ohya, M. Niitsu, K. Kashiwagi, and K. Igarashi Acrolein toxicity: comparison with reactive oxygen species Biochem. Biophys. Res. Commun. 378 2009 313 318
22. A. Tanel, and D.A. Averill-Bates Inhibition of acrolein-induced apoptosis by the antioxidant N-acetylcysteine J. Pharmacol. Exp. Ther. 321 2007 73 83
23. T. Cerny, and A. Küpfer The enigma of ifosfamide encephalopathy Ann. Oncol. 3 1992 679 681
24. E.L. Zaki, J.E. Springate, and M. Taub Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells Toxicol. In Vitro 17 2003 397 402
25. K. Chang, J. Uitto, E.A. Rowold, G.A. Grant, C. Kilo, and J.R. Williamson Increased collagen cross-linkages in experimental diabetes: reversal by beta aminopropionitrile and d-penicillamine Diabetes 29 1980 778 781
26. G.T. Wondrak, D. Cervantes-Laurean, M.J. Roberts, J.G. Qasem, M. Kim, E.L. Jacobson, and M.K. Jacobson Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress Biochem. Pharmacol. 63 2002 361 373
27. P.L. Wood, M.A. Khan, S.R. Kulow, S.A. Mahmood, and J.R. Moskal Neurotoxicity of reactive aldehydes: the concept of "aldehyde load" as demonstrated by neuroprotection with hydroxylamines Brain Res. 1095 2006 190 199
28. M.G. Sevag, M. Shelburne, and M. Ibsen Inhibition of catalase by hydroxylamine and ρ-hydroxylaminobenzenesulfonamide and the reversal of inhibition by serum, crystalline serum albumin, and hemin J. Biol. Chem. 144 1942 711 717
29. B. Poljsak, and P. Raspor The antioxidant and pro-oxidant activity of vitamin C and trolox in vitro: a comparative study J. Appl. Toxicol. 28 2008 183 188
30. C.G. Fraga, P.A. Motchnik, M.K. Shigenaga, H.J. Helbock, R.A. Jacob, and B.N. Ames Ascorbic acid protects against endogenous oxidative DNA damage in human sperm Proc. Natl. Acad. Sci. USA 88 1991 11003 11006
31. G. Fodor, R. Arnold, T. Mohacsi, I. Karle, and J. Flippenanderson A new role for l-ascorbic acid: Michael donor to alpha, beta-unsaturated carbonyl-compounds Tetrahedron 39 1983 2137 2145