Randomised clinical trial: The effects of daikenchuto, TU-100, on gastrointestinal and colonic transit, anorectal and bowel function in female patients with functional constipation

Alimentary Pharmacology and Therapeutics

Volumn 37, Issue 8, 2013, Pages 776-785

  Iturrino, J ^a,b   Camilleri, M ^a,b   Wong, B S ^a,b   Linker Nord, S J ^a   Burton, D ^a   Zinsmeister, A R ^c  

^a Clinical Enteric Neuroscience Translational and Epidemiological Research Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

^c Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERBACEOUS AGENT; TU 100; UNCLASSIFIED DRUG;

ABDOMINAL CRAMP; ABDOMINAL PAIN; ADULT; ANORECTAL PRESSURE; ARTICLE; BACKACHE; CLINICAL EVALUATION; CONSTIPATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FUNCTIONAL ASSESSMENT; GASTROINTESTINAL TRANSIT; HUMAN; INTESTINE FUNCTION; INTESTINE TRANSIT TIME; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SENSATION; STOMACH EMPTYING; TREATMENT DURATION; TREATMENT RESPONSE;

ADMINISTRATION, ORAL; ADULT; CONSTIPATION; DEFECATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; HUMANS; JAPAN; MEDICINE, EAST ASIAN TRADITIONAL; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; QUALITY OF LIFE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84875217914     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.12264     Document Type: Article

References (38)

1. Cohen MH,. Complementary and integrative medical therapies, the FDA, and the NIH: definitions and regulation. Dermatol Ther 2003; 16: 77-84.
2. Barnes PM, Bloom B, Nahin RL,. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report 2008; 12: 1-23.
3. Nahin RL, Barnes PM, Stussman BJ, et al,. Costs of complementary and alternative medicine (CAM) and frequency of visits to CAM practitioners: United States, 2007. Natl Health Stat Report 2009; 18: 1-14.
4. Langmead L, Rampton DS,. Review article: herbal treatment in gastrointestinal and liver disease-benefits and dangers. Aliment Pharmacol Ther 2001; 15: 1239-52.
5. Furukawa Y, Shiga Y, Hanyu N, Hashimoto Y, Mukai H, Nishikawa K,. Effect of Chinese herbal medicine on gastrointestinal motility and bowel obstruction. Jpn J Gastroenterol Surg 1995; 28: 956-60.
6. Itoh T, Yamakawa J, Mai M, Yamaguchi N, Kanda T,. The effect of the herbal medicine daikenchuto on postoperative ileus. J Int Med Res 2002; 30: 428-32.
7. Takeda T, Kamiura S, Kimura T,. Effectiveness of the herbal medicine daikenchuto for radiation-induced enteritis. J Altern Complement Med 2008; 14: 753-5.
8. Jin XL, Shibata C, Naito H, et al,. Intraduodenal and intrajejunal administration of the herbal medicine, dai-ken-chu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs. Dig Dis Sci 2001; 46: 1171-6.
9. Nakamura T, Sakai A, Isogami I, Noda K, Ueno K, Yano S,. Abatement of morphine-induced slowing in gastrointestinal transit by Dai-Kenchu-to, a traditional Japanese herbal medicine. Jpn J Pharmacol 2002; 88: 217-21.
10. Satoh K, Kase Y, Yuzurihara M, Mizoguchi K, Kurauchi K, Ishige A,. Effect of Dai-Kenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice. J Ethnopharmacol 2003; 86: 37-44.
11. Tokita Y, Yuzurihara M, Sakaguchi M, Satoh K, Kase Y,. The pharmacological effects of Daikenchuto, a traditional herbal medicine, on delayed gastrointestinal transit in rat postoperative ileus. J Pharm Sci 2007; 104: 303-10.
12. Satoh K, Hayakawa T, Kase Y, et al,. Mechanisms of contractile effect of Dai-kenchu-to in isolated guinea pig ileum. Dig Dis Sci 2001; 46: 250-6.
13. Manabe N, Camilleri M, Rao A, et al,. Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. Am J Physiol 2010; 298: G970-5.
14. Iwai N, Kume Y, Kimura O, Ono S, Aoi S, Tsuda T,. Effects of herbal medicine Dai-Kenchu-to on anorectal function in children with severe constipation. Eur J Pediatr Surg 2007; 17: 115-8.
15. Longstreth GF, Thompson WG, Houghton LA, et al,. Functional bowel disorders. In:, Drossman DA, Corazziari E, Delvaux M, et al., eds. Rome III: The Functional Gastrointestinal Disorders, 3rd ed. McLean, VA: Degnon Associates, 2006; 487-555.
16. Cremonini F, Mullan BP, Camilleri M, Burton DD, Rank MR,. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharmacol Ther 2002; 16: 1781-90.
17. Marquis P, De LaLoge C, Dubois D, McDermott A, Chassany O,. Development and validation of the patient assessment of constipation quality of life questionnaire. Scand J Gastroenterol 2005; 40: 540-51.
18. Burton DD, Camilleri M, Mullan BP, Forstrom LA, Hung JC,. Colonic transit scintigraphy labeled activated charcoal compared with ion exchange pellets. J Nucl Med 1997; 38: 1807-10.
19. Camilleri M, Colemont LJ, Phillips SF, et al,. Human gastric emptying and colonic filling of solids characterized by a new method. Am J Physiol 1989; 257 (2 Pt 1): G284-90.
20. Camilleri M, Zinsmeister AR,. Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders. Gastroenterology 1992; 103: 36-42.
21. Camilleri M, Zinsmeister AR, Greydanus MP, Brown ML, Proano M,. Towards a less costly but accurate test of gastric emptying and small bowel transit. Dig Dis Sci 1991; 36: 609-15.
22. Manabe N, Wong BS, Camilleri M, Burton D, McKinzie S, Zinsmeister AR,. Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort. Neurogastroenterol Motil 2010; 22: 293-e82.
23. Zinsmeister AR, Bharucha AE, Camilleri M,. Comparison of calculations to estimate gastric emptying half-time of solids in humans. Neurogastroenterol Motil 2012; 24: 1142-5.
24. Hammer HF, Phillips SF, Camilleri M, Hanson RB,. Rectal tone, distensibility, and perception: reproducibility and response to different distensions. Am J Physiol 1998; 274 (3 Pt 1): G584-90.
25. Camilleri M, McKinzie S, Busciglio I, et al,. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2008; 6: 772-81.
26. Lewis SJ, Healton KW,. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997; 32: 920-4.
27. Hayakawa T, Kase Y, Sato K, et al,. Pharmacological studies of the effect of Dai-kenchu-to on spontaneous contraction of isolated rabbit jejunum. J Smooth Muscle Res 1999; 35: 55-62.
28. Satoh K, Hashimoto K, Hayakawa T, et al,. Mechanism of atropine-resistant contraction induced by Dai-kenchu-to in guinea pig ileum. Jpn J Pharmacol 2001; 86: 32-7.
29. Horiuchi A, Nakayama Y, Tanaka N,. Effect of traditional Japanese medicine, Daikenchuto (TU-100), in patients with chronic constipation. Gastroenterol Res 2010; 3: 151-5.
30. Stivland T, Camilleri M, Vassallo M, et al,. Scintigraphic measurement of regional gut transit in idiopathic constipation. Gastroenterology 1991; 101: 107-15.
31. Deiteren A, Camilleri M, Burton D, McKinzie S, Rao A, Zinsmeister AR,. Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome. Dig Dis Sci 2010; 55: 384-91.
32. He CL, Burgart L, Wang L, et al,. Decreased interstitial cell of cajal volume in patients with slow-transit constipation. Gastroenterology 2000; 118: 14-21.
33. Lyford GL, He CL, Soffer E, et al,. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut 2002; 51: 496-501.
34. Ward SM, Sanders KM, Hirst GD,. Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles. Neurogastroenterol Motil 2004; 16 (Suppl. 1): 112-7.
35. Deiteren A, Camilleri M, Bharucha AE, et al,. Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions. Neurogastroenterol Motil 2010; 22: 415-23, e95.
36. Camilleri M,. Scintigraphic biomarkers for colonic dysmotility. Clin Pharmacol Ther 2010; 87: 748-53.
37. Varma MG, Wang JY, Berian JR, Patterson TR, McCrea GL, Hart SL,. The constipation severity instrument: a validated measure. Dis Colon Rectum 2008; 51: 162-72.
38. Cremonini F, Houghton LA, Camilleri M, et al,. Barostat testing of rectal sensation and compliance in humans: comparison of results across two centres and overall reproducibility. Neurogastroenterol Motil 2005; 17: 810-20.