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Volumn 87, Issue 6, 2010, Pages 748-753

Scintigraphic biomarkers for colonic dysmotility

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; ALOSETRON; ASIMADOLINE; BIOLOGICAL MARKER; BISACODYL; DEXLOXIGLUMIDE; INDIUM 111; LINACLOTIDE; LUBIPROSTONE; METHACRYLIC ACID; NEUROTROPHIN; PEXACERFONT; PRUCALOPRIDE; SEROTONIN 4 AGONIST; SOLABEGRON; TECHNETIUM 99M; TEGASEROD; UNCLASSIFIED DRUG; VELUSETRAG;

EID: 77952581741     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.23     Document Type: Review
Times cited : (44)

References (37)
  • 1
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred defnitions and conceptual framework
    • Biomarkers Defnitions Working Group.
    • Biomarkers Defnitions Working Group. Biomarkers and surrogate endpoints: preferred defnitions and conceptual framework. Clin. Pharmacol. Ther. 69, 89-95 (2001).
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 89-95
  • 2
    • 67650637670 scopus 로고    scopus 로고
    • Biomarkers: Principles, policies, and practice
    • Wagner, J.A. Biomarkers: principles, policies, and practice. Clin. Pharmacol. Ther. 86, 3-7 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.86 , pp. 3-7
    • Wagner, J.A.1
  • 3
    • 67650604373 scopus 로고    scopus 로고
    • The value, qualifcation, and regulatory use of surrogate end points in drug development
    • Lathia, C.D. et al. The value, qualifcation, and regulatory use of surrogate end points in drug development. Clin. Pharmacol. Ther. 86, 32-43 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.86 , pp. 32-43
    • Lathia, C.D.1
  • 4
    • 0023106493 scopus 로고
    • Emptying of the terminal ileum in intact humans. Infuence of meal residue and ileal motility
    • Spiller, R.C., Brown, M.L. & Phillips, S.F. Emptying of the terminal ileum in intact humans. Infuence of meal residue and ileal motility. Gastroenterology 92, 724-729 (1987).
    • (1987) Gastroenterology , vol.92 , pp. 724-729
    • Spiller, R.C.1    Brown, M.L.2    Phillips, S.F.3
  • 5
    • 0027485241 scopus 로고
    • Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea
    • von der Ohe, M.R., Camilleri, M., Kvols, L.K. & Thomforde, G.M. Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. N. Engl. J. Med. 329, 1073-1078 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1073-1078
    • Von Der Ohe, M.R.1    Camilleri, M.2    Kvols, L.K.3    Thomforde, G.M.4
  • 6
    • 45849087283 scopus 로고    scopus 로고
    • Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome
    • Camilleri, M. et al. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 6, 772-781 (2008).
    • (2008) Clin. Gastroenterol. Hepatol. , vol.6 , pp. 772-781
    • Camilleri, M.1
  • 7
    • 77952412440 scopus 로고    scopus 로고
    • Lower functional gastrointestinal disorders: Evidence of abnormal colonic transit in a 287 patient cohort
    • e-pub ahead of print 21 December 2009
    • Manabe, N., Wong, B.S., Camilleri, M., Burton, D., McKinzie, S. & Zinsmeister, A.R. Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort. Neurogastroenterol. Motil. (2009); e-pub ahead of print 21 December 2009.
    • (2009) Neurogastroenterol. Motil.
    • Manabe, N.1    Wong, B.S.2    Camilleri, M.3    Burton, D.4    McKinzie, S.5    Zinsmeister, A.R.6
  • 8
    • 0036791252 scopus 로고    scopus 로고
    • Performance characteristics of scintigraphic transit measurements for studies of experimental therapies
    • Cremonini, F., Mullan, B.P., Camilleri, M., Burton, D.D. & Rank, M.R. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment. Pharmacol. Ther. 16, 1781-1790 (2002).
    • (2002) Aliment. Pharmacol. Ther. , vol.16 , pp. 1781-1790
    • Cremonini, F.1    Mullan, B.P.2    Camilleri, M.3    Burton, D.D.4    Rank, M.R.5
  • 9
    • 76349098907 scopus 로고    scopus 로고
    • Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions
    • e-pub ahead of print 18 December 2009
    • Deiteren, A. et al. Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions. Neurogastroenterol. Motil. (2009); e-pub ahead of print 18 December 2009.
    • (2009) Neurogastroenterol. Motil.
    • Deiteren, A.1
  • 10
    • 42749097353 scopus 로고    scopus 로고
    • Efects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials
    • Andresen, V., Montori, V.M., Keller, J., West, C.P., Layer, P. & Camilleri, M. Efects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin. Gastroenterol. Hepatol. 6, 545-555 (2008).
    • (2008) Clin. Gastroenterol. Hepatol. , vol.6 , pp. 545-555
    • Andresen, V.1    Montori, V.M.2    Keller, J.3    West, C.P.4    Layer, P.5    Camilleri, M.6
  • 11
    • 0034089045 scopus 로고    scopus 로고
    • Tegaserod accelerates orocecal transit in patients with constipation- predominant irritable bowel syndrome
    • Prather, C.M., Camilleri, M., Zinsmeister, A.R., McKinzie, S. & Thomforde, G. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology 118, 463-468 (2000). (Pubitemid 30140843)
    • (2000) Gastroenterology , vol.118 , Issue.3 , pp. 463-468
    • Prather, C.M.1    Camilleri, M.2    Zinsmeister, A.R.3    McKinzie, S.4    Thomforde, G.5
  • 12
    • 0035121508 scopus 로고    scopus 로고
    • Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder
    • Bouras, E.P., Camilleri, M., Burton, D.D., Thomforde, G., McKinzie, S. & Zinsmeister, A.R. Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology 120, 354-360 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 354-360
    • Bouras, E.P.1    Camilleri, M.2    Burton, D.D.3    Thomforde, G.4    McKinzie, S.5    Zinsmeister, A.R.6
  • 13
    • 44349130441 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial to evaluate the efcacy, safety and efect on quality of life of prucalopride in severe chronic constipation
    • Camilleri, M., Kerstens, R., Rykx, A. & Vandeplassche, L. A randomized, placebo-controlled trial to evaluate the efcacy, safety and efect on quality of life of prucalopride in severe chronic constipation. N. Engl. J. Med. 358, 2344-2354 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2344-2354
    • Camilleri, M.1    Kerstens, R.2    Rykx, A.3    Vandeplassche, L.4
  • 14
    • 72449143707 scopus 로고    scopus 로고
    • Efects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation
    • e7
    • Manini, M.L. et al. Efects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation. Neurogastroenterol. Motil. 22, 42-9, e7 (2010).
    • (2010) Neurogastroenterol. Motil. , vol.22 , pp. 42-9
    • Manini, M.L.1
  • 15
    • 70350566903 scopus 로고    scopus 로고
    • T1389 TD-5108, a selective 5-HT4 agonist, is consistently better than placebo regardless of response defnition in patients with chronic constipation
    • Goldberg, M.R., Li, Y.-P., Pitzer, K., Johanson, J.F., Mangel, A.W., & Kitt, M.M. T1389 TD-5108, a selective 5-HT4 agonist, is consistently better than placebo regardless of response defnition in patients with chronic constipation. Gastroenterology 134, A545 (2008).
    • (2008) Gastroenterology , vol.134
    • Goldberg, M.R.1    Li, Y.-P.2    Pitzer, K.3    Johanson, J.F.4    Mangel, A.W.5    Kitt, M.M.6
  • 16
    • 70349685068 scopus 로고    scopus 로고
    • Efects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers
    • Manabe, N., Cremonini, F., Camilleri, M., Sandborn, W.J. & Burton, D.D. Efects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers. Aliment. Pharmacol. Ther. 30, 930-936 (2009).
    • (2009) Aliment. Pharmacol. Ther. , vol.30 , pp. 930-936
    • Manabe, N.1    Cremonini, F.2    Camilleri, M.3    Sandborn, W.J.4    Burton, D.D.5
  • 17
    • 33646261667 scopus 로고    scopus 로고
    • Efcacy and safety of bisacodyl in the acute treatment of constipation: A double-blind, randomized, placebo-controlled study
    • Kienzle-Horn, S., Vix, J.M., Schuijt, C., Peil, H., Jordan, C.C. & Kamm, M.A. Efcacy and safety of bisacodyl in the acute treatment of constipation: a double-blind, randomized, placebo-controlled study. Aliment. Pharmacol. Ther. 23, 1479-1488 (2006).
    • (2006) Aliment. Pharmacol. Ther. , vol.23 , pp. 1479-1488
    • Kienzle-Horn, S.1    Vix, J.M.2    Schuijt, C.3    Peil, H.4    Jordan, C.C.5    Kamm, M.A.6
  • 18
    • 0034234832 scopus 로고    scopus 로고
    • Recombinant human neurotrophic factors accelerate colonic transit and relieve constipation in humans
    • Coulie, B. et al. Recombinant human neurotrophic factors accelerate colonic transit and relieve constipation in humans. Gastroenterology 119, 41-50 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 41-50
    • Coulie, B.1
  • 19
    • 0037973518 scopus 로고    scopus 로고
    • Neurotrophin-3 improves functional constipation
    • Functional Constipation Study Investigators
    • Parkman, H.P. et al.; Functional Constipation Study Investigators. Neurotrophin-3 improves functional constipation. Am. J. Gastroenterol. 98, 1338-1347 (2003).
    • (2003) Am. J. Gastroenterol. , vol.98 , pp. 1338-1347
    • Parkman, H.P.1
  • 20
    • 33645837674 scopus 로고    scopus 로고
    • Efect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers
    • Camilleri, M. et al. Efect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G942-G947 (2006).
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290
    • Camilleri, M.1
  • 21
    • 37849024665 scopus 로고    scopus 로고
    • 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation
    • Johanson, J.F., Morton, D., Geenen, J. & Ueno, R. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am. J. Gastroenterol. 103, 170-177 (2008).
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 170-177
    • Johanson, J.F.1    Morton, D.2    Geenen, J.3    Multicenter, U.R.4
  • 22
    • 34248595894 scopus 로고    scopus 로고
    • Lubiprostone a locally acting chloride channel activator, in adult patients with chronic constipation: A double-blind, placebo-controlled, dose-ranging study to evaluate efcacy and safety
    • Johanson, J.F. & Ueno, R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efcacy and safety. Aliment. Pharmacol. Ther. 25, 1351-1361 (2007).
    • (2007) Aliment. Pharmacol. Ther. , vol.25 , pp. 1351-1361
    • Johanson, J.F.1    Ueno, R.2
  • 23
    • 40949131857 scopus 로고    scopus 로고
    • Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation
    • Johanson, J.F., Drossman, D.A., Panas, R., Wahle, A. & Ueno, R. Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment. Pharmacol. Ther. 27, 685-696 (2008).
    • (2008) Aliment. Pharmacol. Ther. , vol.27 , pp. 685-696
    • Johanson, J.F.1    Drossman, D.A.2    Panas, R.3    Wahle, A.4    Ueno, R.5
  • 24
    • 34848846152 scopus 로고    scopus 로고
    • Lubiprostone signifcantly improves symptom relief rates in adults with IBS
    • Drossman, D.A., Chey, W., Panas, R., Wahle, A., Scott, C. & Ueno, R. Lubiprostone signifcantly improves symptom relief rates in adults with IBS. Gastroenterology 132, 2586-2587 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2586-2587
    • Drossman, D.A.1    Chey, W.2    Panas, R.3    Wahle, A.4    Scott, C.5    Ueno, R.6
  • 25
    • 34548500315 scopus 로고    scopus 로고
    • Efect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
    • Andresen, V. et al. Efect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology 133, 761-768 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 761-768
    • Andresen, V.1
  • 26
    • 60749099506 scopus 로고    scopus 로고
    • Pilot study on the efect of linaclotide in patients with chronic constipation
    • Johnston, J.M. et al. Pilot study on the efect of linaclotide in patients with chronic constipation. Am. J. Gastroenterol. 104, 125-132 (2009).
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 125-132
    • Johnston, J.M.1
  • 27
    • 3242878696 scopus 로고    scopus 로고
    • Efect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome
    • Delvaux, M., Beck, A., Jacob, J., Bouzamondo, H., Weber, F.T. & Frexinos, J. Efect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther. 20, 237-246 (2004).
    • (2004) Aliment. Pharmacol. Ther. , vol.20 , pp. 237-246
    • Delvaux, M.1    Beck, A.2    Jacob, J.3    Bouzamondo, H.4    Weber, F.T.5    Frexinos, J.6
  • 28
    • 35548931920 scopus 로고    scopus 로고
    • Efcacy of on-demand asimadoline, a peripheral kappa-opioid agonist, in females with irritable bowel syndrome
    • Szarka, L.A. et al. Efcacy of on-demand asimadoline, a peripheral kappa-opioid agonist, in females with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 5, 1268-1275 (2007).
    • (2007) Clin. Gastroenterol. Hepatol. , vol.5 , pp. 1268-1275
    • Szarka, L.A.1
  • 29
    • 45549083888 scopus 로고    scopus 로고
    • Clinical trial: Asimadoline in the treatment of patients with irritable bowel syndrome
    • Mangel, A.W. et al. Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome. Aliment. Pharmacol. Ther. 28, 239-249 (2008).
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 239-249
    • Mangel, A.W.1
  • 30
    • 16844364043 scopus 로고    scopus 로고
    • Efect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: A pharmacodynamic and pharmacogenomic study
    • Cremonini, F. et al. Efect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study. Am. J. Gastroenterol. 100, 652-663 (2005).
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 652-663
    • Cremonini, F.1
  • 31
    • 0012122003 scopus 로고    scopus 로고
    • The efcacy and safety of the CCKA-receptor antagonist dexloxiglumide in IBS
    • D'Amato, M., Whorwell, P.J. & Thompson, D.G. The efcacy and safety of the CCKA-receptor antagonist dexloxiglumide in IBS. Gut 45 (suppl. 5), A258 (1999).
    • (1999) Gut , vol.45 , Issue.SUPPL. 5
    • D'Amato, M.1    Whorwell, P.J.2    Thompson, D.G.3
  • 32
    • 46749119725 scopus 로고    scopus 로고
    • A phase III, 6-month, double-blind, placebo-controlled, randomized withdrawal trial of the selective CCK-1 antagonist dexloxiglumide in constipation-predominant IBS: The Darwin study
    • Whorwell, P.J. et al. A phase III, 6-month, double-blind, placebo-controlled, randomized withdrawal trial of the selective CCK-1 antagonist dexloxiglumide in constipation-predominant IBS: the Darwin study. Gastroenterology 134, A157 (2008).
    • (2008) Gastroenterology , vol.134
    • Whorwell, P.J.1
  • 33
    • 67049095870 scopus 로고    scopus 로고
    • Do corticotropin releasing factor-1 receptors infuence colonic transit and bowel function in women with irritable bowel syndrome?
    • Sweetser, S. et al. Do corticotropin releasing factor-1 receptors infuence colonic transit and bowel function in women with irritable bowel syndrome? Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1299-G1306 (2009).
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.296
    • Sweetser, S.1
  • 34
    • 71549171009 scopus 로고    scopus 로고
    • A randomised, double blind, placebo (PLA) controlled, crossover study to evaluate the efcacy and safety of the corticotrophin releasing factor 1 (CRF1) receptor antagonist (RA) GW876008 in irritable bowel syndrome (IBS) patients
    • abstract
    • Duke, G.E., Mayer, E.A., Kelleher, D.L., Hicks, K.J., Boardley, R.L. & Alpers, D.H. A randomised, double blind, placebo (PLA) controlled, crossover study to evaluate the efcacy and safety of the corticotrophin releasing factor 1 (CRF1) receptor antagonist (RA) GW876008 in irritable bowel syndrome (IBS) patients. Neurogastroenterol. Motil. 21 (suppl.), 84 (abstract, 2009).
    • (2009) Neurogastroenterol. Motil. , vol.21 , Issue.SUPPL. , pp. 84
    • Duke, G.E.1    Mayer, E.A.2    Kelleher, D.L.3    Hicks, K.J.4    Boardley, R.L.5    Alpers, D.H.6
  • 35
    • 45849142177 scopus 로고    scopus 로고
    • Dose-response efect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health
    • Grudell, A.B. et al. Dose-response efect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G1114-G1119 (2008).
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.294
    • Grudell, A.B.1
  • 36
    • 71549143360 scopus 로고    scopus 로고
    • Randomized double-blind, placebo (PLA)-controlled, crossover study to evaluate efcacy and safety of the beta 3-adrenergic receptor agonist solabegron (SOL) in patients with irritable bowel syndrome (IBS)
    • abstract
    • Kelleher, D.L., Hicks, K.J., Cox, D.S., Williamson, R.R., Alpers, D.H. & Dukes, G.E. Randomized, double-blind, placebo (PLA)-controlled, crossover study to evaluate efcacy and safety of the beta 3-adrenergic receptor agonist solabegron (SOL) in patients with irritable bowel syndrome (IBS). Neurogastroenterol. Motil. 20 (suppl. 1), 131-132 (abstract, 2008).
    • (2008) Neurogastroenterol. Motil. , vol.20 , Issue.SUPPL. 1 , pp. 131-132
    • Kelleher, D.L.1    Hicks, K.J.2    Cox, D.S.3    Williamson, R.R.4    Alpers, D.H.5    Dukes, G.E.6
  • 37
    • 0036325415 scopus 로고    scopus 로고
    • Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome
    • Camilleri, M. et al. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology 123, 425-432 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 425-432
    • Camilleri, M.1


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