The treatment of hypogonadism in men of reproductive age

Fertility and Sterility

Volumn 99, Issue 3, 2013, Pages 718-724

  Kim, Edward D ^a   Crosnoe, Lindsey ^a   Bar Chama, Natan ^b   Khera, Mohit ^c   Lipshultz, Larry I ^c  

^a UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Hypogonadism; male fertility; selective estrogen receptor modulator

Indexed keywords

ANASTROZOLE; CHORIONIC GONADOTROPIN; CLOMIFENE CITRATE; ENCLOMIFENE; ENCLOMIFENE CITRATE; ESTROGEN RECEPTOR; LETROZOLE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TESTOSTERONE; TESTOSTERONE ENANTATE; TESTOSTERONE UNDECANOATE;

AGE; ARTICLE; AZOOSPERMIA; DRUG EFFICACY; DRUG SAFETY; HYPOGONADISM; LOW DRUG DOSE; PREGNANCY OUTCOME; PRIORITY JOURNAL; REPRODUCTION; SEMEN ANALYSIS; SPERMATOGENESIS; TESTIS; ADULT; FEMALE; HUMAN; MALE; MALE INFERTILITY; PATHOPHYSIOLOGY; PREGNANCY; REVIEW;

ADULT; FEMALE; HUMANS; HYPOGONADISM; INFERTILITY, MALE; MALE; PREGNANCY; PREGNANCY OUTCOME; SPERMATOGENESIS;

MLCS; MLOWN;

EID: 84875214799     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.10.052     Document Type: Article

References (36)

1. E.Y. Ko, K. Siddiqi, R.E. Brannigan, and E.S. Sabanegh Jr. Empirical medical therapy for idiopathic male infertility: a survey of the American Urological Association J Urol 187 2012 973 978
2. A.B. Araujo, G.R. Esche, V. Kupelian, A.B. O'Donnell, T.G. Travison, and R.E. Williams Prevalence of symptomatic androgen deficiency in men J Clin Endocrinol Metab 92 2007 4241 4247
3. D.J. Katz, O. Nabulsi, R. Tal, and J.P. Mulhall Outcomes of clomiphene citrate treatment in young hypogonadal men BJU Int 110 2012 573 578
4. F.C. Wu, A. Tajar, S.R. Pye, A.J. Silman, J.D. Finn, and T.W. O'Neill Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study J Clin Endocrinol Metab 93 2008 2737 2745
5. T. Mulligan, M.F. Frick, Q.C. Zuraw, A. Stemhagen, and C. McWhirter Prevalence of hypogonadism in males aged at least 45 years: the HIM study Int J Clin Pract 60 2006 762 769
6. D.J. Handelsman Testicular dysfunction in systemic disease Endocrinol Metab Clin North Am 23 1994 839 856
7. N. Nigro, and M. Christ-Crain Testosterone treatment in the aging male: myth or reality? Swiss Med Wkly 142 2012 w13539
8. P.Y. Liu, R.S. Swerdloff, P.D. Christenson, D.J. Handelsman, and C. Wang Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis Lancet 367 2006 1412 1420
9. B.R. Zirkin, R. Santulli, C.A. Awoniyi, and L.L. Ewing Maintenance of advanced spermatogenic cells in the adult rat testis: quantitative relationship to testosterone concentration within the testis Endocrinology 124 1989 3043 3049
10. R.I. McLachlan, L. O'Donnell, S.J. Meachem, P.G. Stanton, D.M. de Kretser, and K. Pratis Hormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive J Androl 23 2002 149 162
11. G.F. Weinbauer, and E. Nieschlag Gonadotrophin-releasing hormone analogue-induced manipulation of testicular function in the monkey Hum Reprod 8 Suppl 2 1993 45 50
12. S. Basaria Androgen abuse in athletes: detection and consequences J Clin Endocrinol Metab 95 2010 1533 1543
13. C.M. Fronczak, E.D. Kim, and A.B. Barqawi The insults of recreational drug abuse on male fertility J Androl 33 2012 515 528
14. WHO Task Force Contraceptive efficacy of testosterone-induced azoospermia in normal men Lancet 336 1990 955 959
15. J.N. Mills, E.D. Grober, M. Khera, D.M. Fenig, K. Sathymoorthy, and L.I. Lipshultz Recovery of spermatogenesis after exogenous testosterone administration. [Abstract 1910.] J Urol 179 2008 656 657
16. R.A. Anderson, A.M. Wallace, A.T. Kicman, and F.C. Wu Comparison between testosterone oenanthate-induced azoospermia and oligozoospermia in a male contraceptive study. IV. Suppression of endogenous testicular and adrenal androgens Hum Reprod 12 1997 1657 1662
17. C. Wang, A. Leung, L. Superlano, B. Steiner, and R.S. Swerdloff Oligozoospermia induced by exogenous testosterone is associated with normal functioning residual spermatozoa Fertil Steril 68 1997 149 153
18. Y. Gu, X. Liang, W. Wu, M. Liu, S. Song, and L. Cheng Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men J Clin Endocrinol Metab 94 2009 1910 1915
19. W. Shelly, M.W. Draper, V. Krishnan, M. Wong, and R.B. Jaffe Selective estrogen receptor modulators: an update on recent clinical findings Obstet Gynecol Surv 63 2008 163 181
20. J.S. Tenover, and W.J. Bremner The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men J Androl 12 1991 258 263
21. A.T. Guay, S. Bansal, and G.J. Heatley Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo controlled trial with clomiphene citrate J Clin Endocrinol Metab 80 1995 3546 3552
22. F. Taylor, and L. Levine Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and treatment cost J Sex Med 7 1 Pt. 1 2010 269 276
23. A. Guay, J. Jacobson, J.B. Perez, M.B. Hodge, and E. Velasquez Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit? Int J Impot Res 15 2003 156 165
24. A. Shabsigh, Y. Kang, and R. Shabsigh Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism J Sex Med 2 2005 716 721
25. P.J. Turek, R.H. Williams, and J.H. Gilbaugh III The reversibility of anabolic steroid-induced azoospermia J Urol 153 1995 1628
26. M. Depenbusch, S. von Eckardstein, M. Simoni, and E. Nieschlag Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone Eur J Endocrinol 147 2002 617 624
27. M.Y. Roth, S.T. Page, and K. Lin Dose-dependent increase in intratesticular testosterone by very low-dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency J Clin Endocrinol Metab 95 2010 3806 3813
28. A.D. Coviello, A.M. Matsumoto, W.J. Bremner, K.L. Herbst, J.K. Amory, and B.D. Anawalt Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression J Clin Endocrinol Metab 90 2005 2595 2602
29. Avila D, Gittens PR, Hwang K, Weedin JW, Rumohr JA, Lipshultz LI. Low dose human chorionic gonadotropin prevents azoospermia and maintains fertility in hypogonadal men on testosterone replacement therapy. Poster Session I: Male Reproductive Urology. Abstract P-120. Presented at the 66th Annual Meeting of the American Society for Reproductive Medicine, Denver, CO, Oct 23-27, 2010.
30. J.D. Raman, and P.N. Schlegel Aromatase inhibitors for male infertility J Urol 167 2 Pt 1 2002 624 629
31. R. Ramasamy, J.A. Ricci, G.D. Palermo, L.V. Gosden, Z. Rosenwaks, and P.N. Schlegel Successful fertility treatment for Klinefelter's syndrome J Urol 182 2009 1108 1113
32. M. Cakan, M. Aldemir, M. Topcuoglu, and U. Altuǧ Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men Urol Int 83 2009 446 451
33. B. Saylam, O. Efesoy, and S. Cayan The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men Fertil Steril 95 2011 809 811
34. S.A. Burnett-Bowie, K.C. Roupenian, M.E. Dere, H. Lee, and B.Z. Leder Effects of aromatase inhibition in hypogonadal older men: a randomized, double-blind, placebo-controlled trial Clin Endocrinol (Oxf) 94 2008 4785 4792
35. A.T. Guay, J.B. Perez, W.A. Fitaihi, and M. Vereb Testosterone treatment in hypogonadal men: prostate-specific antigen level and risk of prostate cancer Endocrinol Pract 6 2000 132 138
36. S.A. Burnett-Bowie, E.A. McKay, H. Lee, and B.Z. Leder Effects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levels J Clin Endocrinol Metab 94 2009 4785 4792