The forgotten clinical investigation;La olvidada investigación clínica

Medicina Clinica

Volumn 140, Issue 7, 2013, Pages 325-331

  Pons, Joan Maria Vianney ^a,b,c   Rodés, Joan ^d   Andreu, Antoni ^e   Arenas, Joaquín ^e  

^a Avaluació i Qualitat en Salut ^*  (Spain)

^b GENERALITAT DE CATALUNYA   (Spain)

^c CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL RESEARCH;

CAREER CHOICE; CLINICAL TRIALS AS TOPIC; COMPARATIVE EFFECTIVENESS RESEARCH; EDUCATION, MEDICAL; HUMANS; SPAIN; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84875214468     PISSN: 00257753     EISSN: 15788989     Source Type: Journal    
DOI: 10.1016/j.medcli.2012.10.011     Document Type: Article

References (64)

1. I. Mittra Why is modern medicine stuck in a rut? Perspect Biol Med 52 2009 500 517
2. R. Porter The greatest benefit to mankind. A medical history of humanity 1998 WW Norton & Company New York, USA
3. Le Fanu J. The rise and fall of modern medicine. London: Abacus; 2004.
4. R. Moynihan, and M. Sweet Medicine, the media and monetary interests: the need for transparency and professionalism Med J Aust 173 2000 631 634 (Pubitemid 32041106)
5. D.M. Cain, and A.S. Detsky Everyone's a little bit biased (even physicians) JAMA 299 2008 2893 2895 (Pubitemid 351930890)
6. J.W. Scannell, A. Blanckley, H. Boldon, and B. Warrington Diagnosing the decline in pharmaceutical R&D efficiency Nat Rev Drug Discov 11 2012 191 199
7. C. Escudero-Gómez, J.M. Estrada-Lorenzo, and P. Lázaro El impacto de la investigación en la práctica clínica Med Clin (Barc) 131 Supl 5 2008 25 29
8. D. Butler Crossing the valley of death Nature 453 2008 840 842
9. J.E. McClellan III, and H. Dorn Science and technology in world history. An introduction 1999 The Johns Hopkins University Press Baltimore, USA
10. W.I.B. Beveridge The art of scientific investigation 1957 Random House New York, USA
11. D.F. Horrobin Modern biomedical research: an internally self-consistent universe with little contact with medical reality? Nat Rev Drug Discov 2 2003 151 154 (Pubitemid 37361647)
12. A.E. Cohn Purposes in medical research: an introduction to the Journal of Clinical Investigation J Clin Invest 1 1924 1 11
13. J. Rees Clinical science: time for a new contract Clin Med 2 2002 423 425
14. M.A. Meyers Happy accidents. Serendipity in modern medical breakthroughs 2007 Arcade Publishing New York, USA
15. N.J. Roberts, J.T. Vogelstein, G. Parmigiani, K.W. Kinzler, B. Vogelstein, and V.E. Velculescu The predictive capacity of personal genome sequencing Sci Transl Med 4 2012 133ra58
16. D.J. Hunter, M.J. Khoury, and J.M. Drazen Letting the genome out of the bottle. Will we get our wish? N Engl J Med 358 2008 105 107
17. S.D. Ramsey, D.L. Veenstra, L.P. Garrison Jr., R. Carlson, P. Billings, and J. Carlson Toward evidence-based assessment for coverage and reimbursement of laboratory-based diagnostic and genetic tests Am J Manag Care 12 2006 197 202
18. P. Nightingale, and P. Martin The myth of the biotech revolution Trends Biotechnol 22 2004 564 569 (Pubitemid 39371137)
19. What happened to personalized medicine? Nat Biotechnol 30 2012 1
20. M. Grskovic, A. Javaherian, B. Strulovici, and G.Q. Daley Induced pluripotent stem cells - opportunities for disease modelling and drug discovery Nat Rev Drug Discov 10 2011 915 929 10.1038/nrd3577
21. C. Kilkenny, N. Parsons, E. Kadyszewski, M.F.W. Festing, I.C. Cuthill, and D. Fry Survey of the quality of experimental design, statistical analysis and reporting of research using animals PLoS One 4 2009 e7824
22. C. Kilkenny, W.J. Browne, I.C. Cuthill, M. Emerson, and D.G. Altman Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research PLoS Biol 8 2010 e1000412
23. H.B. Van der Worp, D.W. Howells, E.S. Sena, M.J. Porritt, S. Rewell, and V. O'Collins Can animal models of disease reliably inform human studies? PLoS Med 7 2010 e1000245
24. D.G. Hackam, and D.A. Redelmeier Translation of research evidence from animals to humans JAMA 296 2006 1731 1732 (Pubitemid 44547792)
25. D.E. Moerman Meaningful placebos. Controlling the uncontrollable N Engl J Med 365 2011 171 172
26. D. Moerman Meaning, medicine and the placebo effect 2002 Cambridge University Press Cambridge, UK
27. N. Christakis, and J. Fowler Connected. The amazing power of social networks and how they shape our lives 2011 Harper Press London, UK
28. D. Warsh El conocimiento y la riqueza de las naciones. El enigma del crecimiento económico, su historia y su explicación moderna 2008 Antoni Bosch Barcelona
29. Committee on Quality Health Care in America. Institute of Medicine., Crossing the quality chasm: a new health system for the 21st Century. Washington DC: The National Academy Press; 2001.
30. P. Glasziou, I. Chalmers, M. Rawlins, and P. McCulloch When are randomised trials unnecessary? Picking signal from noise BMJ 334 2007 349 351 (Pubitemid 46328045)
31. I. Evans, H. Thornton, and I. Chalmers Testing treatments. Better research for better healthcare 2006 Pinter & Martin London, UK
32. Kassirer JP. On the take. How medicine's complicity with big business can endanger your health. New York: Oxford University Press; 2005.
33. M. Goozner La píldora de los 800 millones de dólares 2006 Belacqwa Barcelona
34. Pérez-Mañá C, Llonch C, Farré M. Transparencia en la investigación clínica: registro de los ensayos clínicos y publicación de resultados. Med Clin (Barc). 2012;139:593-7.
35. H.C. Sox, and D. Rennie Seeding trials: just say no Ann Intern Med 149 2008 279 280
36. G. Caleb Seeding trials and the subordination of science Arch Intern Med 171 2011 1107 1108
37. S. Sismondo Pharmaceutical company funding and its consequences: a qualitative systematic review Contemp Clin Trials 29 2008 109 113 (Pubitemid 351248768)
38. J. Rodés The road to developing clinical trials: Barcelona liver unit's experience and the dedication to the dream Hepatology 2012 10.1002/hep.25833
39. Investigator-driven clinical trials. European Science Foundation. Strasbourg, March 2009.
40. A. Grove Rethinking clinical trials Science 333 2011 1679
41. D.A. Berry Bayesian clinical trials Nat Rev Drug Discov 5 2006 27 36
42. J. Orloff, F. Douglas, J. Pinheiro, S. Levinson, M. Branson, and P. Chaturvedi The future of drug development: advancing clinical trial design Nat Rev Drug Discov 8 2009 949 957
43. M. Zwarenstein, and A. Oxman Why are so few randomized trials useful, and what can be do about it? J Clin Epidemiol 59 2006 1125 1126 (Pubitemid 44485433)
44. T.I. Tosounidis, and G.M. Kontakis Clinical research: the patients' perspectives Injury 39 2008 631 635
45. S.R. Tunis, D.B. Stryer, and C.M. Clancy Practical clinical trials. Increasing the value of clinical research for decision making in clinical and health policy JAMA 290 2003 1624 1632 (Pubitemid 37430387)
46. H.C. Sox, and S.N. Goodman The methods of comparative efectiveness research Annu Rev Public Health 33 2012 425 445
47. J.M. Westfall, J. Mold, and L. Fagman Practice-based research. Blue highways on the NIH roadmap JAMA 297 2007 403 406 (Pubitemid 46155803)
48. H.J. DeMonaco, A. Ali, and E. von Hippel The major role of clinicians in the discovery of off-label drug therapies Pharmacotherapy 26 2006 323 332 (Pubitemid 43334671)
49. J. Woodcock, J.P. Griffin, and R.E. Behrman Development of novel combination therapies N Engl J Med 364 2011 985 987
50. J.M.V. Pons, and J. Rodés La configuración del conocimiento y la práctica médica actual Ars Medica Revista de Humanidades 4 2005 75 93
51. S.L. Archer The making of a physician-scientist - the process has a pattern: lessons from the lives of Nobel laureates in medicine and physiology Eur Heart J 28 2007 510 514 (Pubitemid 47343556)
52. Initial National Priorities for Comparative Effectiveness Research. Institute of Medicine. Report Brief. National Academy of Sciences. June, 2009.
53. I.R. McWhinney William Pickles Lecture 1996. The importance of being different Br J Gen Pract 46 1996 433 436 (Pubitemid 26245297)
54. I. Hetlevik Evidence-based medicine in general practice: a hindrance to optimal medical care Scand J Prim Health Care 22 2004 136 140 (Pubitemid 39294747)
55. B. Starfield Is patient-centered care the same as person-focused care? Perm J 15 2011 63 69
56. S.H. Woolf, and R.E. Johnson The break-even point: when medical advances are less important than improving the fidelity with which they are delivered Ann Fam Med 3 2005 545 552 (Pubitemid 43154841)
57. Jenicek MA. Physician's self-paced guide to critical thinking. Chicago: American Medical Association; 2006.
58. R. Glickman The future of the physician scientist J Clin Invest 76 1985 1293 1296
59. M.L. Gray, and J.V. Bonventre Training PhD researchers to translate science to clinical medicine: closing the gap from the other side Nat Med 8 2002 433 436 (Pubitemid 34546736)
60. J. Camí Impactolatría: diagnóstico y tratamiento Med Clin (Barc) 109 1997 515 524
61. D. Adam The counting house Nature 415 2002 726 729 (Pubitemid 34150470)
62. J.M. López-Piñero, and M.L. Terrada Los indicadores bibliométricos y la evaluación de la actividad médico-científica. IV. La aplicación de los indicadores Med Clin (Barc) 98 1992 384 388
63. On the proper use of bibliometrics to evaluate individual researchers. París: Académie des Sciencies, Institut de France; 2011.
64. A.C. Gelijns, and S.E. Gabriel Looking beyond translation. Integrating clinical research with medical practice N Engl J Med 366 2012 1659 1661