메뉴 건너뛰기




Volumn 20, Issue 2, 2013, Pages 178-188

Liraglutide for the treatment of type 2 diabetes: A clinical update

Author keywords

GLP 1 receptor agonist; Glucagon like peptide 1 (GLP 1) analog; Incretins; Liraglutide; NN2211; Type 2 diabetes

Indexed keywords

ANTIHYPERTENSIVE AGENT; EXENDIN 4; GLIMEPIRIDE; GLIMEPIRIDE PLUS METFORMIN; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INSULIN GLARGINE; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; METFORMIN PLUS ROSIGLITAZONE; PLACEBO; ROSIGLITAZONE; SITAGLIPTIN; TASPOGLUTIDE;

EID: 84875213764     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e3182204c16     Document Type: Article
Times cited : (23)

References (61)
  • 1
    • 33645823854 scopus 로고    scopus 로고
    • Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002
    • Saaddine JB, Cadwell B, Gregg EW, et al. Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002. Ann Intern Med. 2006;144: 465-474
    • (2006) Ann Intern Med , vol.144 , pp. 465-474
    • Saaddine, J.B.1    Cadwell, B.2    Gregg, E.W.3
  • 2
    • 33947408052 scopus 로고    scopus 로고
    • Why, when and how to initiate insulin therapy in patients with type 2 diabetes
    • Tibaldi J, Rakel RE. Why, when and how to initiate insulin therapy in patients with type 2 diabetes. Int J Clin Pract. 2007;61:633-644
    • (2007) Int J Clin Pract , vol.61 , pp. 633-644
    • Tibaldi, J.1    Rakel, R.E.2
  • 3
    • 38449115454 scopus 로고    scopus 로고
    • Actions of insulin beyond glycemic control: A perspective on insulin detemir
    • Tibaldi J. Actions of insulin beyond glycemic control: A perspective on insulin detemir. Adv Ther. 2007;24:868-882
    • (2007) Adv Ther , vol.24 , pp. 868-882
    • Tibaldi, J.1
  • 4
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: Glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696-1705
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 5
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsboll T, Agerso H, Krarup T, et al. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab. 2003;88:220-224
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3
  • 6
    • 0942287326 scopus 로고    scopus 로고
    • Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice
    • Ahren B. Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice. Am J Physiol Regul Integr Comp Physiol. 2004;286:R269-R272
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Ahren, B.1
  • 9
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-Acting GLP-1 derivative, in healthy men
    • Agerso H, Jensen LB, Elbrond B, et al. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-Acting GLP-1 derivative, in healthy men. Diabetologia. 2002;45:195-202
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3
  • 10
    • 77955820667 scopus 로고    scopus 로고
    • Population pharmacokinetics of liraglutide, a once-daily human glucagon-like peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide
    • Watson E, Jonker DM, Jacobsen LV, et al. Population pharmacokinetics of liraglutide, a once-daily human glucagon-like peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide. J Clin Pharmacol. 2010;50:886-894
    • (2010) J Clin Pharmacol , vol.50 , pp. 886-894
    • Watson, E.1    Jonker, D.M.2    Jacobsen, L.V.3
  • 11
    • 70849096647 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide
    • Jacobsen LV, Hindsberger C, Robson R, et al. Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. Br J Clin Pharmacol. 2009;68:898-905
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 898-905
    • Jacobsen, L.V.1    Hindsberger, C.2    Robson, R.3
  • 12
    • 80053582283 scopus 로고    scopus 로고
    • Mild renal impairment has no effect on the efficacy and safety of liraglutide
    • Davidson JA, Brett J, Falahati A, et al. Mild renal impairment has no effect on the efficacy and safety of liraglutide. Endocr Pract. 2010;1-31
    • (2010) Endocr Pract , pp. 1-31
    • Davidson, J.A.1    Brett, J.2    Falahati, A.3
  • 13
    • 0028906596 scopus 로고
    • Antihypertensive therapy in dyslipidemic men: Effects on coronary heart disease incidence and total mortality
    • Mä nttäri M, Tenkanen V, Alikoskin T, et al. Antihypertensive therapy in dyslipidemic men: Effects on coronary heart disease incidence and total mortality. Hypertension. 1995;25:47-52
    • (1995) Hypertension , vol.25 , pp. 47-52
    • Mänttäri, M.1    Tenkanen, V.2    Alikoskin, T.3
  • 14
    • 33745276226 scopus 로고    scopus 로고
    • An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon-like peptide-1 analogue liraglutide
    • Damholt B, Golor G, Wierich W, et al. An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon-like peptide-1 analogue liraglutide. J Clin Pharmacol. 2006;46:635-641
    • (2006) J Clin Pharmacol , vol.46 , pp. 635-641
    • Damholt, B.1    Golor, G.2    Wierich, W.3
  • 15
    • 78049354214 scopus 로고    scopus 로고
    • Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide
    • Flint A, Nazzal K, Jagielski P, et al. Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide. Br J Clin Pharmacol. 2010;70:807-814
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 807-814
    • Flint, A.1    Nazzal, K.2    Jagielski, P.3
  • 16
    • 78649694786 scopus 로고    scopus 로고
    • Co-Administration of liraglutide with insulin detemir demonstrates additive pharmacodynamic effects with no pharmacokinetic interaction
    • Morrow L, Hompesch M, Guthrie H, et al. Co-Administration of liraglutide with insulin detemir demonstrates additive pharmacodynamic effects with no pharmacokinetic interaction. Diabetes Obes Metab. 2011;13:75-80
    • (2011) Diabetes Obes Metab , vol.13 , pp. 75-80
    • Morrow, L.1    Hompesch, M.2    Guthrie, H.3
  • 17
    • 69949083472 scopus 로고    scopus 로고
    • Liraglutide: A once-daily incretin mimetic for the treatment of type 2 diabetes mellitus
    • Neumiller JJ, Campbell RK. Liraglutide: A once-daily incretin mimetic for the treatment of type 2 diabetes mellitus. Ann Pharmacother. 2009;43:1433-1444
    • (2009) Ann Pharmacother , vol.43 , pp. 1433-1444
    • Neumiller, J.J.1    Campbell, R.K.2
  • 18
    • 84875212651 scopus 로고    scopus 로고
    • Meta analyse des etudes lead (liraglutide effects & action on diabetes
    • Abstract PO32
    • Courreges JP. Meta analyse des etudes LEAD (Liraglutide Effects & Action on Diabetes) Diabetes Metab. 2010; 36(suppl 1):A36. Abstract PO32
    • (2010) Diabetes Metab , vol.36 , Issue.SUPPL. 1
    • Courreges, J.P.1
  • 19
    • 47649096171 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-based therapies: New developments and emerging data
    • Garber AJ. Glucagon-like peptide-1-based therapies: New developments and emerging data. Diabetes Obes Metab. 2008;10:22-36
    • (2008) Diabetes Obes Metab , vol.10 , pp. 22-36
    • Garber, A.J.1
  • 20
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a oncedaily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU
    • Marre M, Shaw J, Brandle M, et al. Liraglutide, a oncedaily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med. 2009;26:268-278
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3
  • 21
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study. Diabetes Care. 2009;32:84-90
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 22
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-Treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-Treatment trial. Lancet. 2009;373:473-481
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 23
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met + TZD
    • Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met + TZD). Diabetes Care. 2009;32: 1224-1230
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 24
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs. insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus: A randomised controlled trial (LEAD-5 met + SU
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs. insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus: A randomised controlled trial (LEAD-5 met + SU). Diabetologia. 2009;52:2046-2055
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 25
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374:39-47
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 26
    • 77956076972 scopus 로고    scopus 로고
    • Switching to oncedaily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents
    • Buse JB, Sesti G, Schmidt WE, et al. Switching to oncedaily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents. Diabetes Care. 2010;33:1300-1303
    • (2010) Diabetes Care , vol.33 , pp. 1300-1303
    • Buse, J.B.1    Sesti, G.2    Schmidt, W.E.3
  • 27
    • 72449154207 scopus 로고    scopus 로고
    • Adding liraglutide to oral antidiabetic drug therapy: Onset of treatment effects over time
    • Gallwitz B, Vaag A, Falahati A, et al. Adding liraglutide to oral antidiabetic drug therapy: Onset of treatment effects over time. Int J Clin Pract. 2010;64:267-276
    • (2010) Int J Clin Pract , vol.64 , pp. 267-276
    • Gallwitz, B.1    Vaag, A.2    Falahati, A.3
  • 28
    • 79953046494 scopus 로고    scopus 로고
    • The effect of diabetes duration on the response to liraglutide and glimepiride in type 2 diabetes
    • Abstract 722-P.
    • Garber A, Matthews D, Holst J, et al. The effect of diabetes duration on the response to liraglutide and glimepiride in type 2 diabetes. Diabetes. 2010;59(suppl 1):A197. Abstract 722-P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Garber, A.1    Matthews, D.2    Holst, J.3
  • 29
    • 84875216016 scopus 로고    scopus 로고
    • Reaching a clinically relevant composite endpoint of HbA1c target, 7% -no hypoglycaemia -no weight gain, with liraglutide vs. other T2D therapies
    • Abstract 593-P.
    • Charbonnel B, Thiriet CM, Guerci B. Reaching a clinically relevant composite endpoint of HbA1c target, 7% -no hypoglycaemia -no weight gain, with liraglutide vs. other T2D therapies. Diabetes. 2010;59(Suppl 1):A162. Abstract 593-P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Charbonnel, B.1    Thiriet, C.M.2    Guerci, B.3
  • 30
    • 79951906623 scopus 로고    scopus 로고
    • Liraglutide, a oncedaily human GLP-1 analogue, provides sustained improvements in glycaemic control and weight for two years as monotherapy compared with glimepiride in patients with type 2 diabetes
    • Garber A, Henry RR, Ratner R, et al. Liraglutide, a oncedaily human GLP-1 analogue, provides sustained improvements in glycaemic control and weight for two years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab. 2011; 13:348-356
    • (2011) Diabetes Obes Metab , vol.13 , pp. 348-356
    • Garber, A.1    Henry, R.R.2    Ratner, R.3
  • 31
    • 84875226813 scopus 로고    scopus 로고
    • Long-Term sustained glycaemic control with liraglutide and glimepiride (both plus metformin), with added benefits of weight loss and less hypoglycaemia with liraglutide: 2-year LEAD-2 data
    • September 27-October 1 Vienna, Austria. Abstract 3-OR.
    • Frid A, Hermansen K, Nauck M, et al. Long-Term sustained glycaemic control with liraglutide and glimepiride (both plus metformin), with added benefits of weight loss and less hypoglycaemia with liraglutide: 2-year LEAD-2 data. Presented at: European Association for the Study of Diabetes 45th Annual Meeting September 27-October 1, 2009; Vienna, Austria. Abstract 3-OR.
    • (2009) Presented at: European Association for the Study of Diabetes 45th Annual Meeting
    • Frid, A.1    Hermansen, K.2    Nauck, M.3
  • 32
    • 84875223888 scopus 로고    scopus 로고
    • Liraglutide improves beta-cell function as assessed by HOMA-B and proinsulin: Insulin ratio: Neta-Analysis of 6 clinical trials
    • Abstract 1513-P.
    • Matthews D, Vilsboll T, Courreges J-P, et al. Liraglutide improves beta-cell function as assessed by HOMA-B and proinsulin: Insulin ratio: Neta-Analysis of 6 clinical trials. Diabetes. 2010;59(suppl 1):A401. Abstract 1513-P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Matthews, D.1    Vilsboll, T.2    Courreges, J.-P.3
  • 33
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup A, Rossner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study. Lancet. 2009;374: 1606-1616
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rossner, S.2    Van Gaal, L.3
  • 34
    • 70450190143 scopus 로고    scopus 로고
    • Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
    • Jendle J, Nauck MA, Matthews DR, et al.Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab. 2009;11:1163-1172
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1163-1172
    • Jendle, J.1    Nauck, M.A.2    Matthews, D.R.3
  • 35
    • 84858116417 scopus 로고    scopus 로고
    • Liraglutide causes reductions in body weight both in patients with and without gastrointestinal side effects
    • Abstract 1886
    • Russell-Jones D, Sesti G, Garber A, et al. Liraglutide causes reductions in body weight both in patients with and without gastrointestinal side effects. Diabetes. 2010; 59(Suppl 1):A493. Abstract 1886-P
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Russell-Jones, D.1    Sesti, G.2    Garber, A.3
  • 36
    • 79955982968 scopus 로고    scopus 로고
    • The human GLP-1 analog, liraglutide, improves BMI and waist circumference in patients with type 2 diabetes: Neta-Analysis of six phase 3 trials
    • Abstract 1894-P
    • Zinman B, Colagiuri S, Madsbad S, et al. The human GLP-1 analog, liraglutide, improves BMI and waist circumference in patients with type 2 diabetes: Neta-Analysis of six phase 3 trials. Diabetes. 2010;59(Suppl 1):A495. Abstract 1894-P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Zinman, B.1    Colagiuri, S.2    Madsbad, S.3
  • 37
    • 0033852481 scopus 로고    scopus 로고
    • Preserving renal function in adults with hypertension and diabetes: A consensus approach
    • Bakris GL,Williams M, Dworkin L, et al. Preserving renal function in adults with hypertension and diabetes: A consensus approach. Am J Kidney Dis. 2000;36:646-661
    • (2000) Am J Kidney Dis , vol.36 , pp. 646-661
    • Bakris, G.L.1    Williams, M.2    Dworkin, L.3
  • 38
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001;345:851-860
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 39
    • 84875210041 scopus 로고    scopus 로고
    • Meta-Analysis of the effect of liraglutide, a once-daily human GLP-1 analogue, on systolic blood pressure in type 2 diabetes
    • Abstract P135
    • Madsbad S, Fonseca V, Plutzky J, et al. Meta-Analysis of the effect of liraglutide, a once-daily human GLP-1 analogue, on systolic blood pressure in type 2 diabetes. Diabet Med. 2010;27(suppl 1):77. Abstract P135
    • (2010) Diabet Med , vol.27 , Issue.SUPPL. 1 , pp. 77
    • Madsbad, S.1    Fonseca, V.2    Plutzky, J.3
  • 40
    • 84860112822 scopus 로고    scopus 로고
    • Liraglutide, a oncedaily human GLP-1 analog, lowers systolic blood pressure (SBP) independently of concomitant antihypertensive treatment
    • Abstract 296-OR.
    • Fonseca V, Plutzky J,Montanya E, et al. Liraglutide, a oncedaily human GLP-1 analog, lowers systolic blood pressure (SBP) independently of concomitant antihypertensive treatment. Diabetes. 2010;59(Suppl 1):A79. Abstract 296-OR.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Fonseca, V.1    Plutzky, J.2    Montanya, E.3
  • 41
    • 84875220546 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analog, reduces systolic blood pressure with minimal impact from weight loss in subjects with type 2 diabetes
    • June 19-22; San Diego, CA. Abstract P3-514
    • Henry R, Fonseca V, Tabanera YP. Liraglutide, a once-daily human GLP-1 analog, reduces systolic blood pressure with minimal impact from weight loss in subjects with type 2 diabetes. Presented at: 92nd Annual Endocrine Society Meeting, June 19-22, 2010; San Diego, CA. Abstract P3-514
    • (2010) Presented at: 92nd Annual Endocrine Society Meeting
    • Henry, R.1    Fonseca, V.2    Tabanera, Y.P.3
  • 42
    • 84875218074 scopus 로고    scopus 로고
    • In subjects with type 2 diabetes, liraglutide, a once-daily human GLP-1 analogue, reduces systolic blood pressure with negligible impact from weight loss
    • Abstract 1292
    • Fonseca VA, Henry RR, Tabanera Y, et al. In subjects with type 2 diabetes, liraglutide, a once-daily human GLP-1 analogue, reduces systolic blood pressure with negligible impact from weight loss. Diabetologia. 2010;53(suppl 1): S510. Abstract 1292
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1
    • Fonseca, V.A.1    Henry, R.R.2    Tabanera, Y.3
  • 43
    • 84875229984 scopus 로고    scopus 로고
    • Liraglutide is associated with reduced rates of hypoglycemic events versus glimepiride when achieving target HbA1c
    • Abstract 764-P.
    • Gough S, Madsbad S, Jensen K, et al. Liraglutide is associated with reduced rates of hypoglycemic events versus glimepiride when achieving target HbA1c. Diabetes. 2010;59(suppl 1):A208-A209. Abstract 764-P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Gough, S.1    Madsbad, S.2    Jensen, K.3
  • 44
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide-The FDA's review of a new antidiabetic therapy
    • Parks M, Rosebraugh C. Weighing risks and benefits of liraglutide-The FDA's review of a new antidiabetic therapy. N Engl J Med. 2010;362:774-777
    • (2010) N Engl J Med , vol.362 , pp. 774-777
    • Parks, M.1    Rosebraugh, C.2
  • 45
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study
    • Noel RA, Braun DK, Patterson RE, et al. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study. Diabetes Care. 2009;32:834-838
    • (2009) Diabetes Care , vol.32 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3
  • 47
    • 77950228684 scopus 로고    scopus 로고
    • Glucagonlike peptide-1 receptor agonists activate rodent thyroid Ccells causing calcitonin release and C-cell proliferation
    • Knudsen LB, Madsen LW, Andersen S, et al. Glucagonlike peptide-1 receptor agonists activate rodent thyroid Ccells causing calcitonin release and C-cell proliferation. Endocrinology. 2010;151:1473-1486
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Knudsen, L.B.1    Madsen, L.W.2    Andersen, S.3
  • 48
    • 79952284556 scopus 로고    scopus 로고
    • GLP-1 and calcitonin concentration in humans: Lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide
    • Hegedus L, Moses AC, Zdravkovic M, et al. GLP-1 and calcitonin concentration in humans: Lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. J Clin Endocrinol Metab. 2011;96:853-860
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 853-860
    • Hegedus, L.1    Moses, A.C.2    Zdravkovic, M.3
  • 49
    • 57649232757 scopus 로고    scopus 로고
    • Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue
    • Russell-Jones D, Foster C. Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue. Mol Cell Endocrinol. 2009;297:137-140
    • (2009) Mol Cell Endocrinol , vol.297 , pp. 137-140
    • Russell-Jones, D.1    Foster, C.2
  • 51
    • 78851469388 scopus 로고    scopus 로고
    • Frequency and magnitude of antibody formation are lower with liraglutide than exenatide: LEAD-6 results
    • Abstract 676-P.
    • Buse J, Montanya E, Brett J, et al. Frequency and magnitude of antibody formation are lower with liraglutide than exenatide: LEAD-6 results. Diabetes. 2010; 59(suppl 1):A184-A185. Abstract 676-P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Buse, J.1    Montanya, E.2    Brett, J.3
  • 52
    • 77954184211 scopus 로고    scopus 로고
    • Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: Results from a randomized controlled trial in patients with type 2 diabetes
    • Bode BW, Testa MA, Magwire M, et al. Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: Results from a randomized controlled trial in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12:604-612
    • (2010) Diabetes Obes Metab , vol.12 , pp. 604-612
    • Bode, B.W.1    Testa, M.A.2    Magwire, M.3
  • 53
    • 84858126551 scopus 로고    scopus 로고
    • Patient reported outcomes are superior in patients with type 2 diabetes (t2d) treated with liraglutide as compared to exenatide, when added tometformin, sulfonylurea or both
    • Abstract 1880-P.
    • Schmidt WE, Christiansen JS, Hammer M, et al. Patient reported outcomes are superior in patients with type 2 diabetes (T2D) treated with liraglutide as compared to exenatide, when added tometformin, sulfonylurea or both. Diabetes. 2009;58(suppl 1):A483-A484. Abstract 1880-P.
    • (2009) Diabetes , vol.58 , Issue.SUPPL. 1
    • Schmidt, W.E.1    Christiansen, J.S.2    Hammer, M.3
  • 54
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial. Lancet. 2010;375:1447-1456
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 55
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29:2638-2643
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3
  • 56
    • 34547660561 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, andmetformin on glycemic control in patients with type 2 diabetes
    • Goldstein BJ, Feinglos MN, Lunceford JK, et al. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, andmetformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;1979-1987
    • (2007) Diabetes Care , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3
  • 57
    • 43449096512 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes
    • Scott R, Loeys T, Davies MJ, et al. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2008; 10:959-969
    • (2008) Diabetes Obes Metab , vol.10 , pp. 959-969
    • Scott, R.1    Loeys, T.2    Davies, M.J.3
  • 58
    • 84875208872 scopus 로고    scopus 로고
    • Liraglutide promoted more weight loss with improved glycemic control than sitagliptin
    • Abstract 697-P.
    • Garber A, Thomsen A, Falahati A, et al. Liraglutide promoted more weight loss with improved glycemic control than sitagliptin. Diabetes. 2010;59(suppl 1):A190. Abstract 697-P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Garber, A.1    Thomsen, A.2    Falahati, A.3
  • 59
    • 84875225453 scopus 로고    scopus 로고
    • Liraglutide treatment for 1 year offers sustained and more effective glycemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes
    • June 25-29 Orlando, FL. Abstract 16-LB.
    • Pratley R, Nauck M, Bailey T, et al. Liraglutide treatment for 1 year offers sustained and more effective glycemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes. Presented at: 70th American Diabetes Association Scientific Sessions, June 25-29, 2010; Orlando, FL. Abstract 16-LB.
    • (2010) Presented at: 70th American Diabetes Association Scientific Sessions
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 60
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy a consensus statement of the american diabetes association and the european association for the study of diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy. A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32:193-203
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 61
    • 75549091263 scopus 로고    scopus 로고
    • Statement by an american association of clinical endocrinologists/ american college of endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control
    • Rodbard HW, Jellinger PS, Davidson JA, et al. Statement by an American Association of Clinical Endocrinologists/ American College of Endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control. Endocr Pract. 2009;15:540-559
    • (2009) Endocr Pract , vol.15 , pp. 540-559
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.