4D-PET/CT with [11C]-PK11195 and [11C]-d-deprenyl does not identify the chronic inflammation in asymptomatic abdominal aortic aneurysms

European Journal of Vascular and Endovascular Surgery

Volumn 45, Issue 4, 2013, Pages 351-356

  Tegler, G ^a   Sorensen J ^a   Ericson, K ^a   Bjorck M ^a   Wanhainen, A ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

11C d deprenyl; 11C PK11195; Abdominal aortic aneurysm; Histology; Inflammation; Positron emission tomography

Indexed keywords

DEXTRO DEPRENYL C 11; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; AGED; ANEURYSM SURGERY; ARTICLE; CHRONIC INFLAMMATION; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED EMISSION TOMOGRAPHY; FOUR DIMENSIONAL COMPUTED TOMOGRAPHY; HUMAN; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MALE; MOLECULAR IMAGING; PATHOGENESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION;

AGED; AORTIC ANEURYSM, ABDOMINAL; AORTITIS; ASYMPTOMATIC DISEASES; BIOPSY; CARBON RADIOISOTOPES; CHRONIC DISEASE; HUMANS; ISOQUINOLINES; MACROPHAGES; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS; SELEGILINE;

EID: 84875210852     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2013.01.011     Document Type: Article

References (22)

1. N.A. Tamarina, W.D. McMillan, V.P. Shively, and W.H. Pearce Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta Surgery 122 2 1997 264 271
2. N.P. Kadoglou, and C.D. Liapis Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms Curr Med Res Opin 20 4 2004 419 432
3. T. Jacob, E. Ascher, A. Hingorani, Y. Gunduz, and S. Kallakuri Initial steps in the unifying theory of the pathogenesis of artery aneurysms J Surg Res 101 1 2001 37 43
4. G. Tegler, K. Ericson, J. Sörensen, M. Björck, and A. Wanhainen Inflammation in the walls of asymptomatic abdominal aortic aneurysms is not associated with increased metabolic activity detectable by 18-fluorodeoxglucose positron-emission tomography J Vasc Surg 56 3 2012 802 807
5. D. Palombo, S. Morbelli, G. Spinella, B. Pane, C. Marini, and N. Rousas A positron emission tomography/computed tomography (PET/CT) evaluation of asymptomatic abdominal aortic aneurysms: another point of view Ann Vasc Surg 26 4 2012 491 499
6. C. Marini, S. Morbelli, R. Armonino, G. Spinella, M. Riondato, and M. Massollo Direct relationship between cell density and FDG uptake in asymptomatic aortic aneurysm close to surgical threshold: an in vivo and in vitro study Eur J Nucl Med Mol Imaging 39 1 2012 91 101
7. G. Le Fur, M.L. Perrier, N. Vaucher, F. Imbault, A. Flamier, and J. Benavides Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies Life Sci 32 16 1983 1839 1847
8. V. Papadopoulos, M. Baraldi, T.R. Guilarte, T.B. Knudsen, J.J. Lacapere, and P. Lindemann Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function Trends Pharmacol Sci 27 8 2006 402 409
9. F. Zavala, J. Haumont, and M. Lenfant Interaction of benzodiazepines with mouse macrophages Eur J Pharmacol 106 3 1984 561 566
10. F. Pugliese, O. Gaemperli, A.R. Kinderlerer, F. Lamare, J. Shalhoub, and A.H. Davies Imaging of vascular inflammation with [11C]-PK11195 and positron emission tomography/computed tomography angiography J Am Coll Cardiol 56 8 2010 653 661
11. C.J. van der Laken, E.H. Elzinga, M.A. Kropholler, C.F. Molthoff, J.W. van der Heijden, and K. Maruyama Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography Arthritis Rheum 58 11 2008 3350 3355
12. T. Danfors, M. Bergstrom, N. Feltelius, H. Ahlstrom, G. Westerberg, and B. Langstrom Positron emission tomography with 11C-D-deprenyl in patients with rheumatoid arthritis. Evaluation of knee joint inflammation before and after intra-articular glucocorticoid treatment Scand J Rheumatol 26 1 1997 43 48
13. C. Linnman, L. Appel, M. Fredrikson, T. Gordh, A. Soderlund, and B. Langstrom Elevated [11C]-D-deprenyl uptake in chronic whiplash associated disorder suggests persistent musculoskeletal inflammation PLoS One 6 4 2011 e19182
14. D.J. Flavell, D.B. Jones, and D.H. Wright Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody J Histochem Cytochem 35 11 1987 1217 1226
15. J.F. Matthias Bechtel, F. Noack, F. Sayk, A.W. Erasmi, C. Bartels, and H.H. Sievers Histopathological grading of ascending aortic aneurysm: comparison of patients with bicuspid versus tricuspid aortic valve J Heart Valve Dis 12 1 2003 54 59
16. A.E. Koch, G.K. Haines, R.J. Rizzo, J.A. Radosevich, R.M. Pope, and P.G. Robinson Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response Am J Pathol 137 5 1990 1199 1213
17. L. Arnaud, J. Haroche, A. Mathian, G. Gorochov, and Z. Amoura Pathogenesis of Takayasu's arteritis: a 2011 update Autoimmun Rev 11 1 2011 61 67
18. K.H. Ly, A. Regent, M.C. Tamby, and L. Mouthon Pathogenesis of giant cell arteritis: more than just an inflammatory condition? Autoimmun Rev 9 10 2010 635 645
19. N. Komatsu, and H. Takayanagi Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints Front Immunol 3 2012 77
20. N. Vetti, J. Krakenes, G.E. Eide, J. Rorvik, N.E. Gilhus, and A. Espeland MRI of the alar and transverse ligaments in whiplash-associated disorders (WAD) grades 1-2: high-signal changes by age, gender, event and time since trauma Neuroradiology 51 4 2009 227 235
21. C.S. Chamberlain, E.M. Leiferman, K.E. Frisch, S. Wang, X. Yang, and S.L. Brickson The influence of interleukin-4 on ligament healing Wound Repair Regen: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 19 3 2011 426 435
22. C.S. Chamberlain, E.M. Leiferman, K.E. Frisch, S. Wang, X. Yang, and N. van Rooijen The influence of macrophage depletion on ligament healing Connect Tissue Res 52 3 2011 203 211