Direct relationship between cell density and FDG uptake in asymptomatic aortic aneurysm close to surgical threshold: An in vivo and in vitro study

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 39, Issue 1, 2012, Pages 91-101

  Marini, Cecilia ^a,b,e   Morbelli, Silvia ^c   Armonino, Riccardo ^c   Spinella, Giovanni ^d   Riondato, Mattia ^c   Massollo, Michela ^c   Sarocchi, Francesca ^e   Pane, Bianca ^d   Augeri, Carla ^c   Abete, Luca ^e   Ghigliotti, Giorgio ^c   Palmieri, Daniela ^d   Fiz, Francesco ^c   Cittadini, Giuseppe ^d   Fulcheri, Ezio ^e   Palombo, Domenico ^d   Sambuceti, Gianmario ^c  

^a CNR   (Italy)

^b Genoa Section   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

Author keywords

Abdominal aortic aneurysm; Atherosclerosis; FDG uptake; Positron emission tomography computed tomography

Indexed keywords

ACETYLSALICYLIC ACID; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DNA; FLUORODEOXYGLUCOSE F 18; TICLOPIDINE; DIAGNOSTIC AGENT; GLUCOSE;

ADULT; AGED; ANEURYSM SURGERY; AORTA ANEURYSM; AORTA SURGERY; AORTA WALL; ARTERY DIAMETER; ARTICLE; ASYMPTOMATIC DISEASE; AUTORADIOGRAPHY; CELL DENSITY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA SYNTHESIS; FEMALE; FREEZING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; POSITRON EMISSION TOMOGRAPHY; ABDOMINAL AORTA ANEURYSM; CELL COUNT; CELL SURVIVAL; CRYOPRESERVATION; METABOLISM; PATHOLOGY; SCINTISCANNING; TRANSPORT AT THE CELLULAR LEVEL;

AGED; AGED, 80 AND OVER; AORTIC ANEURYSM, ABDOMINAL; ASYMPTOMATIC DISEASES; AUTORADIOGRAPHY; BIOLOGICAL TRANSPORT; CELL COUNT; CELL SURVIVAL; CRYOPRESERVATION; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; MALE;

EID: 84858730185     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-011-1955-1     Document Type: Article

References (34)

1. Ballard DJ, Filardo G, Fowkes G, Powell JT. Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev 2008;4:CD001835.
2. Lederle FA. Abdominal aortic aneurysm - open versus endovascular repair. N Engl J Med 2004;351:1677-9. (Pubitemid 39350429)
3. Anidjar S, Salzmann JL, Gentric D, Lagneau P, Camilleri JP, Michel JB. Elastase-induced experimental aneurysms in rats. Circulation 1990;82:973-81. (Pubitemid 20316749)
4. Ocana E, Bohórquez JC, Pérez-Requena J, Brieva JA, Rodríguez C. Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms. Atherosclerosis 2003;170:39-48. (Pubitemid 37083562)
5. Koch AE, Haines GK, Rizzo RJ, Radosevich JA, Pope RM, Robinson PG, et al. Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response. Am J Pathol 1990;137:1199-213.
6. Henderson EL, Geng Y-J, Sukhova GK, Whittemore AD, Knox J, Libby P. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation 1999;99:96-104. (Pubitemid 29035963)
7. Koch AE, Kunkel SL, Pearce WH, Shah MR, Parikh D, Evanoff HL, et al. Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms. Am J Pathol 1993;142:1423-31. (Pubitemid 24058129)
8. Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 1995;15:1145-51.
9. Goodall S, Crowther M, Hemingway DM, Bell PR, Thompson MM. Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms. Circulation 2001;104:304-9. (Pubitemid 32666952)
10. Carrell TW, Burnand KG, Wells GM, Clements JM, Smith A. Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms. Circulation 2002;105:477-82. (Pubitemid 34141705)
11. Annabi B, Shédid D, Ghosn P, Kenigsberg RL, Desrosiers RR, Bojanowski MW, et al. Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. J Vasc Surg 2002;35:539-46. (Pubitemid 44718601)
12. Reeps C, Essler M, Pelisek J, Seidl S, Eckstein HH, Krause BJ. Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J Vasc Surg 2008;48:417-23.
13. Kotze CW, Menezes LJ, Endozo R, Groves AM, Ell PJ, Yusuf SW. Increased metabolic activity in abdominal aortic aneurysm detected by 18F- fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Eur J Vasc Endovasc Surg 2009;38:93-9.
14. Sakalihasan N, Hustinx R, Limet R. Contribution of PET scanning to the evaluation of abdominal aortic aneurysm. Semin Vasc Surg 2004;17:144-53. (Pubitemid 38858149)
15. Truijers M, Kurvers HAJM, Bredie SJH, Oyen WJG, Blankensteijn JD. In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall. J Endovasc Ther 2008;15:462-7.
16. Palombo D, Morbelli S, Spinella G, et al. A positron emission/computed tomography (PET/CT) evaluation of asymptomatic abdominal aortic aneurysms: another point of view. Ann Vasc Surg 2011; in press.
17. Laitinen I, Marjamäki P, Haaparanta M, Savisto N, Laine VJ, Soini SL, et al. Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries. Eur J Nucl Med Mol Imaging 2006;33:1461-7. (Pubitemid 44885412)
18. Boellaard R, O'Doherty MJ, Weber WA, Mottaghy FM, Lonsdale MN, Stroobants SG, et al. FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0. Eur J Nucl Med Mol Imaging 2010;37:181-200.
19. Rudd JH, Myers KS, Bansilal S, Machac J, Rafique A, Farkouh M, et al. (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials. J Am Coll Cardiol 2007;50:892-6. (Pubitemid 47268746)
20. Rudd JH, Myers KS, Bansilal S, Machac J, Pinto CA, Tong C, et al. Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med 2008;49:871-8. (Pubitemid 351793426)
21. Izquierdo-Garcia D, Davies JR, Graves MJ, Rudd JH, Gillard JH, Weissberg PL, et al. Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: reproducibility, partial volume correction, and correlation between methods. Stroke 2009;40:86-93.
22. Ellison RC, Zhang Y, Wagenknecht LE, Eckfeldt JH, Hopkins PN, Pankow JS, et al. Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aorta. Am J Cardiol 2005;95:1180-6. (Pubitemid 40616420)
23. Siegel CL, Cohan RH, Korobkin M, Alpern MB, Courneya DL, Leder RA. Abdominal aortic aneurysm morphology: CT features in patients with ruptured and nonruptured aneurysms. AJR Am J Roentgenol 1994;163:1123-9. (Pubitemid 24355705)
24. Rudd JH, Warburton EA, Fryer TD, Jones HA, Clark JC, Antoun N, et al. Imaging atherosclerotic plaque inflammation with [18F]- fluorodeoxyglucose positron emission tomography. Circulation 2002;105:2708-11. (Pubitemid 34615139)
25. Ogawa M, Ishino S, Mukai T, Asano D, Teramoto N, Watabe H, et al. (18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study. J Nucl Med 2004;45:1245-50. (Pubitemid 47611672)
26. Walter MA, Melzer RA, Schindler C, Müller-Brand J, Tyndall A, Nitzsche EU. The value of [18F]FDG-PET in the diagnosis of large-vessel vasculitis and the assessment of activity and extent of disease. Eur J Nucl Med Mol Imaging 2005;32:674-81. (Pubitemid 40897490)
27. van der Vliet JA, Boll AP. Abdominal aortic aneurysm. Lancet 1997;349:863-6. (Pubitemid 27129225)
28. Daugherty A, Cassis LA. Mechanisms of abdominal aortic aneurysm formation. Curr Atheroscler Rep 2002;4:222-7.
29. Satta J, Laurila A, Pääkko P, Haukipuro K, Sormunen R, Parkkila S, et al. Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study. Eur J Vasc Endovasc Surg 1998;15:313-9. (Pubitemid 28205989)
30. Stella A, Gargiulo M, Pasquinelli G, Preda P, Faggioli GL, Cenacchi G, et al. The cellular component in the parietal infiltrate of inflammatory abdominal aortic aneurysms (IAAA). Eur J Vasc Surg 1991;5:65-70.
31. Tisell LE, Oden A, Muth A, Altiparmak G, Mõlne J, Ahlman H, et al. The Ki67 index a prognostic marker in medullary thyroid carcinoma. Br J Cancer 2003;89:2093-7. (Pubitemid 38030908)
32. Annovazzi A, Bonanno E, Arca M, D'Alessandria C, Marcoccia A, Spagnoli LG, et al. 99mTc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques. Eur J Nucl Med Mol Imaging 2006;33:117-26. (Pubitemid 43152877)
33. Zubal G, Fujibayashi Y, Maruoka N, Omata N, Yonekura Y. Automated kinetic analysis of FDG uptake in living rat brain slices from dynamic positron autoradiography. Cancer Biother Radiopharm 2003;18:405-11. (Pubitemid 36917882)
34. Colin S, Mascarelli F, Jeanny JC, Vienet R, Bouche G, Courtois Y, et al. Comparative study in vivo and in vitro of uniformly 14C-labelled and 125I-labelled recombinant fibroblast growth factor 2. Eur J Biochem 1997;249:473-80. (Pubitemid 27455789)