Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 4, 2013, Pages 1815-1822

  Konrad, Christian ^a   Queener, Sherry F ^a   Wek, Ronald C ^a   Sullivan, William J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; GUANABENZ; INITIATION FACTOR 2ALPHA; SALUBRINAL; THAPSIGARGIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYZOITE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SURVIVAL; TACHYZOITE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 84875206408     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01899-12     Document Type: Article

References (26)

1. Montoya JG, Liesenfeld O. 2004. Toxoplasmosis. Lancet 363:1965-1976.
2. Skariah S, McIntyre MK, Mordue DG. 2010. Toxoplasma gondii: determinants of tachyzoite to bradyzoite conversion. Parasitol. Res. 107:253-260.
3. Sullivan WJ, Jr, Jeffers V. 2012. Mechanisms of Toxoplasma gondii persistence and latency. FEMS Microbiol. Rev. 36:717-733.
4. Katlama C, De Wit S, O'Doherty E, Van Glabeke M, Clumeck N. 1996. Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. Clin. Infect. Dis. 22:268 -275.
5. Sullivan WJ, Jr, Narasimhan J, Bhatti MM, Wek RC. 2004. Parasitespecific eukaryotic initiation factor-2 (eIF2) kinase required for stressinduced translation control. Biochem. J. 380:523-531.
6. Narasimhan J, Joyce BR, Naguleswaran A, Smith AT, Livingston MR, Dixon SE, Coppens I, Wek RC, Sullivan WJ, Jr. 2008. Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii. J. Biol. Chem. 283:16591-16601.
7. Wek RC, Jiang HY, Anthony TG. 2006. Coping with stress: eIF2 kinases and translational control. Biochem. Soc. Trans. 34:7-11.
8. Joyce BR, Konrad C, Wek RC, Sullivan WJ, Jr. 2011. Translation control is critical during acute and chronic stages of toxoplasmosis infection. Expert Rev. Anti Infect. Ther. 9:1-3.
9. Konrad C, Wek RC, Sullivan WJ, Jr. 2011. A GCN2-like eukaryotic initiation factor-2 kinase increases the viability of extracellular Toxoplasma gondii parasites. Eukaryot. Cell 10:1403-1412.
10. Joyce BR, Queener SF, Wek RC, Sullivan WJ, Jr. 2010. Phosphorylation of eukaryotic initiation factor-2α promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii. Proc. Natl. Acad. Sci. U. S. A. 107:17200 -17205.
11. Zhang M, Joyce BR, Sullivan WJ, Jr, Nussenzweig V. 14 December 2012. Translational control in Plasmodium and Toxoplasma parasites. Eukaryot. Cell. doi:10.1128/EC.00296-12.
12. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. 2005. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307:935-939.
13. Holmes B, Brogden RN, Heel RC, Speight TM, Avery GS. 1983. Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 26:212-229.
14. Tsaytler P, Harding HP, Ron D, Bertolotti A. 2011. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 332:91-94.
15. Costa JM, Pautas C, Ernault P, Foulet F, Cordonnier C, Bretagne S. 2000. Real-time PCR for diagnosis and follow-up of Toxoplasma reactivation after allogeneic stem cell transplantation using fluorescence resonance energy transfer hybridization probes. J. Clin. Microbiol. 38:2929-2932.
16. Neil MJ. 2011. Clonidine: clinical pharmacology and therapeutic use in pain management. Curr. Clin. Pharmacol. 6:280 -287.
17. Soete M, Camus D, Dubremetz JF. 1994. Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro. Exp. Parasitol. 78:361-370.
18. Radke JR, Donald RG, Eibs A, Jerome ME, Behnke MS, Liberator P, White MW. 2006. Changes in the expression of human cell division autoantigen- 1 influence Toxoplasma gondii growth and development. PLoS Pathog. 2:e105. doi:10.1371/journal.ppat.0020105.
19. Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. 2001. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 7:1165-1176.
20. Bohne W, Heesemann J, Gross U. 1994. Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion. Infect. Immun. 62:1761-1767.
21. Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. 2009. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat. Chem. Biol. 5:765-771.
22. Zhang M, Mishra S, Sakthivel R, Rojas M, Ranjan R, Sullivan WJ, Jr, Fontoura BM, Menard R, Dever TE, Nussenzweig V. 2012. PK4, a eukaryotic initiation factor 2alpha (eIF2alpha) kinase, is essential for the development of the erythrocytic cycle of Plasmodium. Proc. Natl. Acad. Sci. U. S. A. 109:3956 -3961.
23. Lirussi D, Matrajt M. 2011. RNA granules present only in extracellular Toxoplasma gondii increase parasite viability. Int. J. Biol. Sci. 7:960 -967.
24. Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ, Jr, Roos DS, Fontoura BM, Menard R, Winzeler EA, Nussenzweig V. 2010. The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J. Exp. Med. 207:1465-1474.
25. Chow C, Cloutier S, Dumas C, Chou MN, Papadopoulou B. 2011. Promastigote to amastigote differentiation of Leishmania is markedly delayed in the absence of PERK eIF2alpha kinase-dependent eIF2alpha phosphorylation. Cell. Microbiol. 13:1059 -1077.
26. Tonelli RR, Augusto Lda S, Castilho BA, Schenkman S. 2011. Protein synthesis attenuation by phosphorylation of eIF2alpha is required for the differentiation of Trypanosoma cruzi into infective forms. PLoS One 6:e27904. doi:10.1371/journal.pone.0027904.