Asymmetric synthesis of cis-2,5-disubstituted pyrrolidine, the core scaffold of β3-AR agonists

Organic Letters

Volumn 15, Issue 6, 2013, Pages 1342-1345

  Xu, Feng ^a   Chung, John Y L ^a   Moore, Jeffery C ^a   Liu, Zhuqing ^a   Yoshikawa, Naoki ^a   Hoerrner, R Scott ^a   Lee, Jaemoon ^a   Royzen, Maksim ^a   Cleator, Ed ^b   Gibson, Andrew G ^b   Dunn, Robert ^a   Maloney, Kevin M ^a   Alam, Mahbub ^b   Goodyear, Adrian ^b   Lynch, Joseph ^a   Yasuda, Nobuyashi ^a   Devine, Paul N ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOALCOHOL; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; IMINE; PYRROLIDINE DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGENATION; OXIDATION REDUCTION REACTION; STEREOISOMERISM; SYNTHESIS;

ADRENERGIC BETA-3 RECEPTOR AGONISTS; AMINO ALCOHOLS; CATALYSIS; HYDROGENATION; IMINES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PYRROLIDINES; STEREOISOMERISM;

EID: 84875194159     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol400252p     Document Type: Article

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