Transplantation of differentiated bone marrow stromal cells promotes motor functional recovery in rats with stroke

Neurological Research

Volumn 35, Issue 3, 2013, Pages 320-328

  Huang, Wen ^a   Mo, Xuean ^a   Qin, Chao ^a   Zheng, Jinou ^a   Liang, Zhijian ^a   Zhang, Cheng ^b  

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Bone marrow stromal cells; Brain derived neurotrophic factor; Middle cerebral artery occlusion; Transplantation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; FLUORESCEIN SODIUM; MICROTUBULE ASSOCIATED PROTEIN; NESTIN; NEURON SPECIFIC ENOLASE; NEURONAL APOPTOSIS INHIBITORY PROTEIN; TRIPHENYLTETRAZOLIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL ISOLATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; INFARCTION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; NEUROLOGIC EXAMINATION; NONHUMAN; PROTEIN EXPRESSION; RAT; SENSORIMOTOR FUNCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MOTOR ACTIVITY; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; STROKE;

EID: 84875190253     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132812Y.0000000151     Document Type: Article

References (29)

1. Haghani K, Bakhtiyari S, Nouri AM. In vitro study of the differentiation of bone marrow stromal cells into cardiomyo-cyte-like cells. Mol Cell Biochem. 2012;361:315-320.
2. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol. 2000; 164:247-256.
3. Li Y, Chen J, Wang L, Lu M, Chopp M. Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology. 2001;56:1666-1672.
4. Lu D, Mahmood A, Wang L, Li Y, Lu M, Chopp M. Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport. 2001;12:559-563.
5. Shen LH, Li Y, Chopp M. Astrocytic endogenous glial cell derived neurotrophic factor production is enhanced by bone marrow stromal cell transplantation in the ischemic boundary zone after stroke in adult rats. Glia. 2010;58:1074-1081.
6. Fierro FA, Kalomoiris S, Sondergaard CS, Nolta JA. Effects on proliferation and differentiation of multipotent bone marrow stromal cells engineered to express growth factors for combined cell and gene therapy. Stem Cells. 2011;29:1727-1737.
7. Matsuse D, Kitada M, Ogura F, Wakao S, Kohama M, Kira J, et al. Combined transplantation of bone marrow stromal cell-derived neural progenitor cells with a collagen sponge and basic fibroblast growth factor releasing microspheres enhances recovery after cerebral ischemia in rats. Tissue Eng Part A. 2011;17:1993-2004.
8. Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Kobune M, Hirai S, et al. BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther. 2004;9:189-197.
9. Schabitz WR, Sommer C, Zoder W, Kiessling M, Schwaninger M, Schwab S. Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke. 2000;31:2212-2217.
10. Schabitz WR, Schwab S, Spranger M, Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1997;17:500-506.
11. Yamashita K, Wiessner C, Lindholm D, Thoenen H, Hossmann KA. Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat. Metab Brain Dis. 1997;12:271-280.
12. Chen J, Li Y, Chopp M. Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology. 2000;39:711-716.
13. Black IB, Woodbury D. Adult rat and human bone marrow stromal stem cells differentiate into neurons. Blood Cells Mol Dis. 2001;27:632-636.
14. Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, Low WC. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol. 2002;174:11-20.
15. Huang W, Zhang C, Chen SL, Zhang WX, Yao XL, Zeng Y, et al. [Brain-derived neurotrophic factor induces rat bone marrow stromal cells to differentiate into neuron-like cells in vitro]. Di Yi Jun Yi Da Xue Xue Bao. 2004;24:854-858.
16. Xu H, Miki K, Ishibashi S, Inoue J, Sun L, Endo S, et al. Transplantation of neuronal cells induced from human mesenchymal stem cells improves neurological functions after stroke without cell fusion. J Neurosci Res. 2010;88:3598-3609.
17. Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995; 26:627-634; discussion 635.
18. Shichinohe H, Kuroda S, Sugiyama T, Ito M, Kawabori M. Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats. Dement Geriatr Cogn Disord. 2010;30:293-301.
19. Chen JR, Cheng GY, Sheu CC, Tseng GF, Wang TJ, Huang YS. Transplanted bone marrow stromal cells migrate, differentiate and improve motor function in rats with experimentally induced cerebral stroke. J Anat. 2008;213:249-258.
20. Li N, Yang H, Lu L, Duan C, Zhao C, Zhao H. Spontaneous expression of neural phenotype and NGF, TrkA, TrkB genes in marrow stromal cells. Biochem Biophys Res Commun. 2007;356:561-568.
21. Harting MT, Jimenez F, Xue H, Fischer UM, Baumgartner J, Dash PK, et al. Intravenous mesenchymal stem cell therapy for traumatic brain injury. J Neurosurg 2009;110:1189-1197.
22. Gu W, Zhang F, Xue Q, Ma Z, Lu P, Yu B. Bone mesenchymal stromal cells stimulate neurite outgrowth of spinal neurons by secreting neurotrophic factors. Neurol Res. 2012;34:172-180.
23. Pandey A, Saxena K, Verma M, Bharosay A. Correlative study between neuron-specific enolase and blood sugar level in ischemic stroke patients. J Neurosci Rural Pract. 2011;2:50-54.
24. Schaarschmidt H, Prange HW, Reiber H. Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases. Stroke. 1994;25:558-565.
25. Missler U, Wiesmann M, Friedrich C, Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997;28:1956-1960.
26. Li Q, Zhang R, Ge YL, Mei YW, Guo YL. Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat. J Mol Neurosci. 2009;38:207-215.
27. Zhang S, Liu XZ, Liu ZL, Wang YM, Hu QL, Ma TZ, et al. Stem cells modified by brain-derived neurotrophic factor to promote stem cells differentiation into neurons and enhance neuromotor function after brain injury. Chin J Traumatol. 2009;12:195-199.
28. Pulera MR, Adams LM, Liu H, Santos DG, Nishimura RN, Yang F, et al. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke. 1998;29:2622-2630.
29. Chen J, Li Y, Katakowski M, Chen X, Wang L, Lu D, et al. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res. 2003;73:778-786.